Anemia in cardiac surgery: Next target for mortality and morbidity improvement?

Asian Cardiovascular and Thoracic Annals

Volumn 24, Issue 1, 2016, Pages 12-17

  Padmanabhan, Hari ^a   Aktuerk, Dincer ^a   Brookes, Matthew J ^a,b   Nevill, Alan M ^b   Ng, Alex ^a   Cotton, James ^a   Luckraz, Heyman ^a  

^a ROYAL WOLVERHAMPTON HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

Anemia; Blood transfusion; Cardiac surgical procedures; Hospital mortality; Length of stay

Indexed keywords

AGED; ANEMIA; BLOOD TRANSFUSION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTIVE SURGERY; FEMALE; HEART SURGERY; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; POSTOPERATIVE PERIOD; RENAL REPLACEMENT THERAPY; RESPIRATION CONTROL; SURGICAL INFECTION; ADVERSE EFFECTS; BLOOD; CHI SQUARE DISTRIBUTION; HEALTH CARE QUALITY; HEART DISEASES; HOSPITAL MORTALITY; LENGTH OF STAY; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDY; RISK FACTOR; STATISTICAL MODEL; TIME FACTOR; TOTAL QUALITY MANAGEMENT; TREATMENT OUTCOME; TRENDS;

AGED; ANEMIA; CARDIAC SURGICAL PROCEDURES; CHI-SQUARE DISTRIBUTION; ELECTIVE SURGICAL PROCEDURES; FEMALE; HEART DISEASES; HOSPITAL MORTALITY; HUMANS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; POSTOPERATIVE COMPLICATIONS; QUALITY IMPROVEMENT; QUALITY INDICATORS, HEALTH CARE; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84949921047     PISSN: 02184923     EISSN: 18165370     Source Type: Journal    
DOI: 10.1177/0218492315618032     Document Type: Conference Paper

References (24)

1. Hung M, Besser M, Sharples LD, Nair SK, Klein AA,. The prevalence and association with transfusion, intensive care unit stay and mortality of pre-operative anaemia in a cohort of cardiac surgery patients. Anaesthesia 2011; 66: 812-818.
2. Zindrou D, Taylor KM, Bagger JP,. Preoperative haemoglobin concentration and mortality rate after coronary artery bypass surgery. Lancet 2002; 359: 1747-1748.
3. van Straten AH, Hamad MA, van Zundert AJ, Martens EJ, Schonberger JP, de Wolf AM,. Preoperative hemoglobin level as a predictor of survival after coronary artery bypass grafting: a comparison with the matched general population. Circulation 2009; 120: 118-125.
4. Karkouti K, Wijeysundera DN, Beattie WS,. Reducing Bleeding in Cardiac Surgery (RBC) Investigators. Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation 2008; 117: 478-484.
5. Kulier A, Levin J, Moser R, et al. Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery. Circulation 2007; 116: 471-479.
6. De Santo L, Romano G, Della Corte A, et al. Preoperative anemia in patients undergoing coronary artery bypass grafting predicts acute kidney injury. J Thorac Cardiovasc Surg 2009; 138: 965-970.
7. Boening A, Boedeker RH, Scheibelhut C, Rietzschel J, Roth P, Schonburg M,. Anemia before coronary artery bypass surgery as additional risk factor increases the perioperative risk. Ann Thorac Surg 2011; 92: 805-810.
8. Ranucci M, Di Dedda U, Castelvecchio S, Menicanti L, Frigiola A, Pelissero G,. Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis. Ann Thorac Surg 2012; 94: 1134-1141.
9. Nutritional anaemia. Report of a WHO Scientific Group. World Health Organization Technical Report Series 1968; 405: 5 - 37.
10. Southey D, Mishra PK, Nevill A, Aktuerk D, Luckraz H,. Continuity of care by cardiothoracic nurse practitioners: Impact on outcome. Asian Cardiovasc Thorac Ann 2014; 22: 944-947.
11. Tinmouth A, Fergusson D, Yee IC, Hebert PC,. Clinical consequences of red cell storage in the critically ill. Transfusion 2006; 46: 2014-2027.
12. Valtis DJ,. Defective gas-transport function of stored red blood-cells. Lancet 1954; 266: 119-124.
13. Valeri CR, Hirsch NM,. Restoration in vivo of erythrocyte adenosine triphosphate, 2,3-diphosphoglycerate, potassium ion, and sodium ion concentrations following the transfusion of acid-citrate-dextrose-stored human red blood cells. J Lab Clin Med 1969; 73: 722-733.
14. Dern RJ, Brewer GJ, Wiorkowski JJ,. Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability. J Lab Clin Med 1967; 69: 968-978.
15. DeFoe GR, Ross CS, Olmstead EM, et al. Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group. Ann Thorac Surg 2001; 71: 769-776.
16. Swaminathan M, Phillips-Bute BG, Conlon PJ, Smith PK, Newman MF, Stafford-Smith M,. The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery. Ann Thorac Surg 2003; 76: 784-791.
17. Karkouti K, Beattie WS, Wijeysundera DN, et al. Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery. J Thorac Cardiovasc Surg 2005; 129: 391-400.
18. Surgenor SD, Kramer RS, Olmstead EM, et al. The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgery. Anesth Analg 2009; 108: 1741-1746.
19. Ranucci M, Baryshnikova E, Castelvecchio S, Pelissero G,. Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Ann Thorac Surg 2013; 96: 478-485.
20. Koch CG, Li L, Duncan AI, et al. Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med 2006; 34: 1608-1616.
21. van Straten AH, Bekker MW, Soliman Hamad MA, et al. Transfusion of red blood cells: the impact on short-term and long-term survival after coronary artery bypass grafting, a ten-year follow-up. Interact Cardiovasc Thorac Surg 2010; 10: 37-42.
22. Sowade O, Warnke H, Scigalla P, et al. Avoidance of allogeneic blood transfusions by treatment with epoetin beta (recombinant human erythropoietin) in patients undergoing open-heart surgery. Blood 1997; 89: 411-418.
23. Kiyama H, Ohshima N, Imazeki T, Yamada T,. Autologous blood donation with recombinant human erythropoietin in anemic patients. Ann Thorac Surg 1999; 68: 1652-1656.
24. Cladellas M, Farre N, Comin-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol 2012; 110: 1021-1026.