Enzymatic depletion of the polysialic acid moiety associated with the neural cell adhesion molecule inhibits antidepressant efficacy

Neuropsychopharmacology

Volumn 41, Issue 6, 2016, Pages 1670-1680

  Wainwright, Steven R ^a   Barha, Cindy K ^a,d   Hamson, Dwayne K ^a   Epp, Jonathan R ^b   Chow, Carmen ^a   Lieblich, Stephanie E ^a   Rutishauser, Urs ^c   Galea, Liisa A M ^a,d  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONEURAMINIDASE N; FLUOXETINE; NERVE CELL ADHESION MOLECULE; POLYSIALIC ACID; SIALIDASE; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; CORTICOSTERONE; ENDO-ALPHA-SIALIDASE; GLYCOSIDASE; NERVE CELL ADHESION MOLECULE L1; POLYSIALYL NEURAL CELL ADHESION MOLECULE; SIALIC ACID DERIVATIVE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; ATTENUATION; BACTERIOPHAGE; CHRONIC UNPREDICTABLE STRESS; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; HIPPOCAMPUS; MALE; MOLECULAR PATHOLOGY; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; ANIMAL; BLOOD; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; FLUOXETINE; GLYCOSIDE HYDROLASES; HIPPOCAMPUS; MALE; NEURAL CELL ADHESION MOLECULE L1; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; SIALIC ACIDS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 84949920794     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.337     Document Type: Article

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