Intravenous thrombolysis is effective in young adults: Results from the Baden-Wuerttemberg stroke registry

Frontiers in Neurology

Volumn 6, Issue NOV, 2015, Pages

  Reuter, Björn ^a,b   Gumbinger, Christoph ^c   Sauer, Tamara ^b   Wiethölter, Horst ^d   Bruder, Ingo ^e   Diehm, Curt ^f   Ringleb, Peter A ^c   Kern, Rolf ^g   Hacke, Werner ^c   Hennerici, Michael G ^b   Schoser, K ^h   Daffertshofer, M ⁱ   Neumaier, S ^j   Muller Jenz B ^k   Drewitz, E ^l  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d Klinikum Stuttgart Burgerhospital   (Germany)

^e Rehabilitation and Organization Division   (Germany)

^f Max Grundig Klinik   (Germany)

^g Department of Pediatrics   (Germany)

^h Klinikum Tuttlingen   (Germany)

ⁱ Stadtklinik Baden Baden ^*  (Germany)

^j Medical Services of Health Insurance Freiburg   (Germany)

^k Medical Services of Health Insurance Stuttgart   (Germany)

^l KLINIKUM STUTTGART   (Germany)

more..

Author keywords

Acute stroke; Age; Epidemiology of stroke; IV thrombolysis; Stroke unit concept; Young adults

Indexed keywords

FIBRINOLYTIC AGENT;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CONVALESCENCE; DISEASE REGISTRY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FIBRINOLYTIC THERAPY; GERMANY; HOSPITAL CARE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OBSERVATIONAL STUDY; RANKIN SCALE; RETROSPECTIVE STUDY;

EID: 84949789132     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2015.00229     Document Type: Article

References (21)

1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the global burden of disease study 2010. Lancet (2014) 383:245-54. doi: 10.1016/S0140-6736(13)61953-4.
2. Medin J, Nordlund A, Ekberg K; Swedish Hospital Discharge Register. Increasing stroke incidence in Sweden between 1989 and 2000 among persons aged 30 to 65 years: evidence from the Swedish hospital discharge register. Stroke (2004) 35:1047-51. doi:10.1161/01.STR.0000125866.78674.96.
3. Appelros P, Jonsson F, Asplund K, Eriksson M, Glader EL, Asberg KH, et al. Trends in baseline patient characteristics during the years 1995-2008: observations from riks-stroke, the Swedish stroke register. Cerebrovasc Dis (2010) 30:114-9. doi:10.1159/000314714.
4. George MG, Tong X, Kuklina EV, Labarthe DR. Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008. Ann Neurol (2011) 70:713-21. doi:10.1002/ana.22539.
5. Kissela BM, Khoury JC, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Age at stroke: temporal trends in stroke incidence in a large, biracial population. Neurology (2012) 79:1781-7. doi:10.1212/WNL.0b013e318270401d.
6. Kansara A, Chaturvedi S, Bhattacharya P. Thrombolysis and outcome of young stroke patients over the last decade: insights from the nationwide inpatient sample. J Stroke Cerebrovasc Dis (2013) 22:799-804. doi:10.1016/j.jstrokecerebrovasdis.2012.05.002.
7. Gumbinger C, Reuter B, Wietholter H, Bruder I, Rode S, Drewitz E, et al. A consecutive and prospective stroke database covers the state of Baden-Wuerttemberg with 10.8 million inhabitants in Germany. Neuroepidemiology (2013) 41:161-8. doi:10.1159/000354356.
8. Ferro JM, Massaro AR, Mas JL. Aetiological diagnosis of ischaemic stroke in young adults. Lancet Neurol (2010) 9:1085-96. doi:10.1016/S1474-4422(10)70251-9.
9. Singhal AB, Biller J, Elkind MS, Fullerton HJ, Jauch EC, Kittner SJ, et al. Recognition and management of stroke in young adults and adolescents. Neurology (2013) 81:1089-97. doi:10.1212/WNL.0b013e3182a4a451.
10. von Sarnowski B, Putaala J, Grittner U, Gaertner B, Schminke U, Curtze S, et al. Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the stroke in young Fabry patients study. Stroke (2013) 44:119-25. doi:10.1161/STROKEAHA.112.665190.
11. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke (2013) 44:870-947. doi:10.1161/STR.0b013e318284056a.
12. GeQiK. Jahresauswertungen. Available from: http://www.geqik.de/index.php?id=343 (accessed 13/08/2015).
13. Toni D, Ahmed N, Anzini A, Lorenzano S, Brozman M, Kaste M, et al. Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR. Neurology (2012) 78:880-7. doi:10.1212/WNL.0b013e31824d966b.
14. Reuter B, Gumbinger C, Sauer T, Wiethölter H, Bruder I, Rode S, et al. Intravenous thrombolysis for acute ischemic stroke in the elderly: data from the Baden-Wuerttemberg stroke registry. Eur J Neurol (2015). doi:10.1111/ene.12829.
15. Gumbinger C, Reuter B, Sauer T, Hacke W, Ringleb P. Differences in standardized thrombolysis rates according to stroke level are mainly explained by restriction of thrombolysis to patients >80 years and with preexisting disabilities. European Stroke Organization Conference 2015. Glasgow (2015). p. 1366.
16. I. S. T. Collaborative Group, Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet (2012) 379:2352-63. doi:10.1016/S0140-6736(12)60768-5.
17. Putaala J, Metso TM, Metso AJ, Makela E, Haapaniemi E, Salonen O, et al. Thrombolysis in young adults with ischemic stroke. Stroke (2009) 40:2085-91. doi:10.1161/STROKEAHA.108.541185.
18. Ji R, Schwamm LH, Pervez MA, Singhal AB. Ischemic stroke and transient ischemic attack in young adults: risk factors, diagnostic yield, neuroimaging, and thrombolysis. JAMA Neurol (2013) 70:51-7. doi:10.1001/jamaneurol.2013.575.
19. Prefasi D, Fuentes B, Martinez-Sanchez P, Rodriguez-Sanz A, Ruiz-Ares G, Sanz-Cuesta B, et al. Intravenous thrombolysis in stroke patients under 55 years of age: is there a different effect according to etiology and severity? J Thromb Thrombolysis (2014) 37:557-64. doi:10.1007/s11239-013-0984-y.
20. Mishra NK, Ahmed N, Andersen G, Egido JA, Lindsberg PJ, Ringleb PA, et al. Thrombolysis in very elderly people: controlled comparison of SITS international stroke thrombolysis registry and virtual international stroke trials archive. BMJ (2010) 341:c6046. doi:10.1136/bmj.c6046.
21. Ovbiagele B, Saver JL. Day-90 acute ischemic stroke outcomes can be derived from early functional activity level. Cerebrovasc Dis (2010) 29:50-6. doi:10.1159/000255974.