Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: A review of the literature and meta-analysis

Journal of Dermatological Science

Volumn 80, Issue 3, 2015, Pages 168-174

  Caini, Saverio ^a   Raimondi, Sara ^b   Johansson, Harriet ^b   De Giorgi, Vincenzo ^c   Zanna, Ines ^a   Palli, Domenico ^a   Gandini, Sara ^b  

^a CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cutaneous melanoma; Meta analysis; Non melanoma skin cancer; Review; Telomere length

Indexed keywords

BASAL CELL CARCINOMA; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; CUTANEOUS MELANOMA; DISEASE ASSOCIATION; HUMAN; MAXIMUM LIKELIHOOD METHOD; META ANALYSIS; NON MELANOMA SKIN CANCER; PATHOGENESIS; PERIPHERAL LEUKOCYTES TELOMERE LENGTH; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SENSITIVITY ANALYSIS; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; TELOMERE; GENETICS; LEUKOCYTE; MELANOMA; SKIN TUMOR; TELOMERE SHORTENING;

CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; HUMANS; LEUKOCYTES; MELANOMA; RISK FACTORS; SKIN NEOPLASMS; TELOMERE; TELOMERE SHORTENING;

EID: 84949724168     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2015.08.003     Document Type: Review

References (54)

1. Ferlay J., Steliarova-Foucher E., Lortet-Tieulent J., Rosso S., Coebergh J.W., Comber H., Forman D., Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer 2013, 49:1374-1403.
2. Lomas A., Leonardi-Bee J., Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br. J. Dermatol. 2012, 166:1069-1080.
3. Colombino M., Capone M., Lissia A., Cossu A., Rubino C., De G., iorgi V., Massi D., Fonsatti E., Staibano S., Nappi O., Pagani E., Casula M., Manca A., Sini M., Franco R., Botti G., Caracò C., Mozzillo N., Ascierto P.A., Palmieri G. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J. Clin. Oncol. 2012, 30:2522-2529.
4. Brash D.E., Ziegler A., Jonason A.S., Simon J.A., Kunala S., Leffell D.J. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J. Investig. Dermatol. Symp. Proc. 1996, 1:136-142.
5. Eisenberg D.T. An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. Am. J. Hum. Biol. 2011, 23:149-167.
6. Hiyama E., Hiyama K. Telomere and telomerase in stem cells. Br. J. Cancer 2007, 96:1020-1024.
7. Ma H., Zhou Z., Wei S., Liu Z., Pooley K.A., Dunning A.M., Svenson U., Roos G., Hosgood H.D., Shen M., Wei Q. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 2011, 6(6):e20466.
8. Haycock P.C., Heydon E.E., Kaptoge S., Butterworth A.S., Thompson A., Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 2014, 8:g4227.
9. Willeit P., Raschenberger J., Heydon E.E., Tsimikas S., Haun M., Mayr A., Weger S., Witztum J.L., Butterworth A.S., Willeit J., Kronenberg F., Kiechl S. Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One 2014, 9:e112483.
10. Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
11. Rode L., Nordestgaard B.G., Bojesen S.E. Peripheral blood leukocyte telomere length and mortality among 64 637 individuals from the general population. J. Natl. Cancer Inst. 2015, 107.
12. Boardman L.A., Litzelman K., Seo S., Johnson R.A., Vanderboom R.J., Kimmel G.W., Cunningham J.M., Gangnon R.E., Engelman C.D., Riegert-Johnson D.L., Potter J., Haile R., Buchanan D., Jenkins M.A., Rider D.N., Thibodeau S.N., Petersen G.M., Skinner H.G. The association of telomere length with colorectal cancer differs by the age of cancer onset. Clin. Transl. Gastroenterol. 2014, 6:e52.
13. Lan Q., Cawthon R., Gao Y., Hu W., Hosgood H.D., Barone-Adesi F., Ji B.T., Bassig B., Chow W.H., Shu X., Cai Q., Xiang Y., Berndt S., Kim C., Chanock S., Zheng W., Rothman N. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS One 2013, 8(3):e59230.
14. Wang S., Chen Y., Qu F., He S., Huang X., Jiang H., Jin T., Wan S., Xing J. Association between leukocyte telomere length and glioma risk: a case-control study. Neuro Oncol. 2014, 16:505-512.
15. Schürks M., Buring J., Dushkes R., Gaziano J.M., Zee R.Y., Kurth T. Telomere length and Parkinson's disease in men: a nested case-control study. Eur. J. Neurol. 2014, 21(1):93-99.
16. Wan S., Hann H.W., Myers R.E., Fu X., Hann R.S., Kim S.H., Tang H., Xing J., Yang H. Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis: a nested case-control analysis. Liver Int. 2012, 32:1233-1241.
17. Griewank K.G., Murali R., Schilling B., Schimming T., Möller I., Moll I., Schwamborn M., Sucker A., Zimmer L., Schadendorf D., Hillen U. TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma. PLoS One 2013, 8:e80354.
18. Huang F.W., Hodis E., Xu M.J., Kryukov G.V., Chin L., Garraway L.A. Highly recurrent TERT promoter mutations in human melanoma. Science 2013, 6122:957-959.
19. Vinagre J., Almeida A., Pópulo H., Batista R., Lyra J., Pinto V., Coelho R., Celestino R., Prazeres H., Lima L., Melo M., da Rocha A.G., Preto A., Castro P., Castro L., Pardal F., Lopes J.M., Santos L.L., Reis R.M., Cameselle-Teijeiro J., Sobrinho-Simões M., Lima J., Máximo V., Soares P. Frequency of TERT promoter mutations in human cancers. Nat. Commun. 2013, 4:2185.
20. Lauper J.M., Krause A., Vaughan T.L., Monnat R.J. Spectrum and risk of neoplasia in Werner syndrome: a systematic review. PLoS One 2013, 9709.
21. Bataille V., Kato B.S., Falchi M., Gardner J., Kimura M., Lens M., Perks U., Valdes A.M., Bennett D.C., Aviv A., Spector T.D. Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol. Biomarkers Prev. 2007, 16:1499-1502.
22. Gandini S., Sera F., Cattaruzza M.S., Pasquini P., Abeni D., Boyle P., Melchi C.F. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur. J. Cancer 2005, 41:28-44.
23. Qureshi A.A., Zhang M., Han J. Heterogeneity in host risk factors for incident melanoma and non-melanoma skin in a cohort of US women. J. Epidemiol. 2011, 21(3):197-203.
24. Taylor R.S., Ramirez R.D., Ogoshi M., Chaffins M., Piatyszek M.A., Shay J.W. Detection of telomerase activity in malignant and nonmalignant skin conditions. J. Invest. Dermatol. 1996, 106:759-765.
25. Parris C.N., Jezzard S., Silver A., MacKie R., McGregor J.M., Newbold R.F. Telomerase activity in melanoma and non-melanoma skin cancer. Br. J. Cancer 1999, 79:47-53.
26. Stroup D.F., Berlin J.A., Morton S.C., Olkin I., Williamson G.D., Rennie D., Moher D., Becker B.J., Sipe T.A., Thacker S.B. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000, 283:2008-2012.
27. Greenland S. Quantitative methods in the review of epidemiologic literature. Epidemiol. Rev. 1987, 9:1-30.
28. van Houwelingen H.C., Arends L.R., Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression. Stat. Med. 2002, 21:589-624.
29. Nan H., Du M., De V., ivo I., Manson J.E., Liu S., McTiernan A., Curb J.D., Lessin L.S., Bonner M.R., Guo Q., Qureshi A.A., Hunter D.J., Han J. Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 2011, 71:6758-6763.
30. Weischer M., Nordestgaard B.G., Cawthon R.M., Freiberg J.J., Tybjærg-Hansen A., Bojesen S.E. Short telomere length, cancer survival, and cancer risk in individuals. J. Natl. Cancer Inst. 2013, 105:459-468.
31. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002, 21:1539-1558.
32. Begg C.B., Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
33. Llorca-Cardeñosa M.J., Peña-Chilet M., Mayor M., Gomez-Fernandez C., Casado B., Martin-Gonzalez M., Carretero G., Lluch A., Martinez-Cadenas C., Ibarrola-Villava M., Ribas G. Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk. Eur. J. Cancer 2014, 50:3168-3177.
34. Anic G.M., Sondak V.K., Messina J.L., Fenske N.A., Zager J.S., Cherpelis B.S., Lee J.H., Fulp W.J., Epling-Burnette P.K., Park J.Y., Rollison D.E. Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. Cancer Epidemiol. 2013, 37:434-439.
35. Burke L.S., Hyland P.L., Pfeiffer R.M., Prescott J., Wheeler W., Mirabello L., Savage S.A., Burdette L., Yeager M., Chanock S., De Vivo I., Tucker M.A., Goldstein A.M., Yang X.R. Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. PLoS One 2013, 8:e71121.
36. Bodelon C., Pfeiffer R.M., Bollati V., Debbache J., Calista D., Ghiorzo P., Fargnoli M.C., Bianchi-Scarra G., Peris K., Hoxha M., Hutchinson A., Burdette L., Burke L., Fang S., Tucker M.A., Goldstein A.M., Lee J.E., Wei Q., Savage S.A., Yang X.R., Amos C., Landi M.T. On the interplay of telomeres, nevi and the risk of melanoma. PLoS One 2012, 7(12):e52466.
37. Liang G., Qureshi A.A., Guo Q., De V., ivo I., Han J. No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer. Cancer Epidemiol. Biomarkers Prev. 2011, 20:1043-1045.
38. Han J., Qureshi A.A., Prescott J., Guo Q., Ye L., Hunter D.J., De Vivo I. A prospective study of telomere length and the risk of skin cancer. J. Invest. Dermatol. 2009, 129:415-421.
39. Valdes A.M., Andrew T., Gardner J.P., Kimura M., Oelsner E., Cherkas L.F., Aviv A., Spector T.D. Obesity, cigarette smoking, and telomere length in women. Lancet 2005, 366:662-664.
40. Cherkas L.F., Hunkin J.L., Kato B.S., Richards J.B., Gardner J.P., Surdulescu G.L., Kimura M., Lu X., Spector T.D., Aviv A. The association between physical activity in leisure time and leukocyte telomere length. Arch. Intern. Med. 2008, 168:154-158.
41. Crous-Bou M., Fung T.T., Prescott J., Julin B., Du M., Sun Q., Rexrode K.M., Hu F.B., De Vivo I. Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ 2014, 349:g6674.
42. Kim S., Parks C.G., DeRoo L.A., Chen H., Taylor J.A., Cawthon R.M., Sandler D.P. Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol. Biomarkers Prev. 2009, 18:816-820.
43. Stacey S.N., Sulem P., Masson G., Gudjonsson S.A., Thorleifsson G., Jakobsdottir M., Sigurdsson A., Gudbjartsson D.F., Sigurgeirsson B., Benediktsdottir K.R., Thorisdottir K., Ragnarsson R., Scherer D., Hemminki K., Rudnai P., Gurzau E., Koppova K., Botella-Estrada R., Soriano V., Juberias P., Saez B., Gilaberte Y., Fuentelsaz V., Corredera C., Grasa M., Höiom V., Lindblom A., Bonenkamp J.J., van R., ossum M.M., Aben K.K., de V., ries E., Santinami M., Di M., auro M.G., Maurichi A., Wendt J., Hochleitner P., Pehamberger H., Gudmundsson J., Magnusdottir D.N., Gretarsdottir S., Holm H., Steinthorsdottir V., Frigge M.L., Blondal T., Saemundsdottir J., Bjarnason H., Kristjansson K., Bjornsdottir G., Okamoto I., Rivoltini L., Rodolfo M., Kiemeney L.A., Hansson J., Nagore E., Mayordomo J.I., Kumar R., Karagas M.R., Nelson H.H., Gulcher J.R., Rafnar T., Thorsteinsdottir U., Olafsson J.H., Kong A., Stefansson K. New common variants affecting susceptibility to basal cell carcinoma. Nat. Genet. 2009, 41:909-914.
44. Rafnar T., Sulem P., Stacey S.N., Geller F., Gudmundsson J., Sigurdsson A., Jakobsdottir M., Helgadottir H., Thorlacius S., Aben K.K., Blöndal T., Thorgeirsson T.E., Thorleifsson G., Kristjansson K., Thorisdottir K., Ragnarsson R., Sigurgeirsson B., Skuladottir H., Gudbjartsson T., Isaksson H.J., Einarsson G.V., Benediktsdottir K.R., Agnarsson B.A., Olafsson K., Salvarsdottir A., Bjarnason H., Asgeirsdottir M., Kristinsson K.T., Matthiasdottir S., Sveinsdottir S.G., Polidoro S., Höiom V., Botella-Estrada R., Hemminki K., Rudnai P., Bishop D.T., Campagna M., Kellen E., Zeegers M.P., de V., erdier P., Ferrer A., Isla D., Vidal M.J., Andres R., Saez B., Juberias P., Banzo J., Navarrete S., Tres A., Kan D., Lindblom A., Gurzau E., Koppova K., de V., egt F., Schalken J.A., van, der H., eijden H.F., Smit H.J., Termeer R.A., Oosterwijk E., van H., ooij O., Nagore E., Porru S., Steineck G., Hansson J., Buntinx F., Catalona W.J., Matullo G., Vineis P., Kiltie A.E., Mayordomo J.I., Kumar R., Kiemeney L.A., Frigge M.L., Jonsson T., Saemundsson H., Barkardottir R.B., Jonsson E., Jonsson S., Olafsson J.H., Gulcher J.R., Masson G., Gudbjartsson D.F., Kong A., Thorsteinsdottir U., Stefansson K. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat. Genet. 2009, 41:221-227.
45. Nan H., Qureshi A.A., Prescott J., De Vivo, Han J. Genetic variants in telomere-maintaining genes and skin cancer risk. Hum Genet. 2011, 129:247-253.
46. Bandyopadhyay D., Timchenko N., Suwa T., Hornsby P.J., Campisi J., Medrano E.E. The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells. Exp. Gerontol. 2001, 36:1265-1275.
47. Bennett D.C. Human melanocyte senescence and melanoma susceptibility genes. Oncogene 2003, 20:3063-3069.
48. Glaessl A., Bosserhoff A.K., Buettner R., Hohenleutner U., Landthaler M., Stolz W. Increase in telomerase activity during progression of melanocytic cells from melanocytic naevi to malignant melanomas. Arch. Dermatol. Res. 1999, 291:81-87.
49. Miracco C., Pacenti L., Santopietro R., Laurini L., Biagioli M., Luzi P. Evaluation of telomerase activity in cutaneous melanocytic proliferations. Hum. Pathol. 2000, 31:1018-1021.
50. Härle-Bachor C., Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:6476-6481.
51. Bailey S.M., Murnane J.P. Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006, 34:2408-2417.
52. Leufke C., Leykauf J., Krunic D., Jauch A., Holtgreve-Grez H., Böhm-Steuer B., Bröcker E.B., Mauch C., Utikal J., Hartschuh W., Purdie K.J., Boukamp P. The telomere profile distinguishes two classes of genetically distinct cutaneous squamous cell carcinomas. Oncogene 2014, 33:3506-3518.
53. Usher-Smith J.A., Emery J., Kassianos A.P., Walter F.M. Risk prediction models for melanoma: a systematic review. Cancer Epidemiol. Biomarkers Prev. 2014, 23:1450-1463.
54. Davies J.R., Chang Y.M., Bishop D.T., Armstrong B.K., Bataille V., Bergman W., Berwick M., Bracci P.M., Elwood J.M., Ernstoff M.S., Green A., Gruis N.A., Holly E.A., Ingvar C., Kanetsky P.A., Karagas M.R., Lee T.K., Le M., archand L., Mackie R.M., Olsson H., Østerlind A., Rebbeck T.R., Reich K., Sasieni P., Siskind V., Swerdlow A.J., Titus L., Zens M.S., Ziegler A., Gallagher R.P., Barrett J.H., Newton-Bishop J. Development and validation of a melanoma risk score based on pooled data from 16 case-control studies. Cancer Epidemiol. Biomarkers Prev. 2015, 24. Epub ahead of print].