Polyfunctional Specific Response to Echinococcus Granulosus Associates to the Biological Activity of the Cysts

PLoS Neglected Tropical Diseases

Volumn 9, Issue 11, 2015, Pages

  Petrone, Linda ^a   Vanini, Valentina ^a   Petruccioli, Elisa ^a   Ettorre, Giuseppe Maria ^a   Schininà, Vincenzo ^a   Busi Rizzi, Elisa ^a   Ludovisi, Alessandra ^b   Corpolongo, Angela ^a   Ippolito, Giuseppe ^a   Pozio, Edoardo ^b   Teggi, Antonella ^c   Goletti, Delia ^a  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ECHINOCOCCOSIS; ECHINOCOCCUS GRANULOSUS; ECHOGRAPHY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PROSPECTIVE STUDY; ANIMAL; CD4+ T LYMPHOCYTE; IMMUNOLOGY; MIDDLE AGED; SECRETION (PROCESS); T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; ECHINOCOCCOSIS; ECHINOCOCCUS GRANULOSUS; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; T-LYMPHOCYTE SUBSETS;

EID: 84949516360     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004209     Document Type: Article

References (34)

1. Petrone L, Cuzzi G, Colace L, Ettorre GM, Busi-Rizzi E, Schinina V, et al. Cystic echinococcosis in a single tertiary care center in Rome, Italy. Biomed Res Int. 2013;2013:978146. doi: 10.1155/2013/978146 24151631
2. Mezioug D, Touil-Boukoffa C, Cytokine profile in human hydatidosis: possible role in the immunosurveillance of patients infected with E.granulosus. Parasite. 2009 Mar;16(1):57–64. 19353953
3. Rigano R, Profumo E, Di Felice G, Ortona E, Teggi A, Siracusano A, In vitro production of cytokines by peripheral blood mononuclear cells from hydatid patients. Clin Exp Immunol. 1995 Mar;99(3):433–9. 7882566
4. Rigano R, Profumo E, Ioppolo S, Notargiacomo S, Ortona E, Teggi A, et al. Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease. Clin Exp Immunol. 1995 Nov;102(2):281–5. 7586679
5. Rigano R, Profumo E, Ioppolo S, Notargiacomo S, Teggi A, Siracusano A, Serum cytokine detection in the clinical follow up of patients with cystic echinococcosis. Clin Exp Immunol. 1999 Mar;115(3):503–7. 10193425
6. Amri M, Mezioug D, Touil-Boukoffa C, Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response. Eur Cytokine Netw. 2009 Jun;20(2):63–8. doi: 10.1684/ecn.2009.0154 19541591
7. Shepherd JC, Aitken A, McManus DP, A protein secreted in vivo by Echinococcus granulosus inhibits elastase activity and neutrophil chemotaxis. Mol Biochem Parasitol. 1991 Jan;44(1):81–90. 2011156
8. Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, et al. Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect Immun. 2001 Jan;69(1):288–96. 11119517
9. Rigano R, Buttari B, Profumo E, Ortona E, Delunardo F, Margutti P, et al. Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response. Infect Immun. 2007 Apr;75(4):1667–78. 17210662
10. Rigano R, Buttari B, De Falco E, Profumo E, Ortona E, Margutti P, et al. Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol. 2004 Jan;26(1):45–52. 15198645
11. Petrone L, Vanini V, Petruccioli E, Ettorre GM, Busi Rizzi E, Schinina V, et al. IL-4 specific-response in whole blood associates with human Cystic Echinococcosis and cyst activity. J Infect. 2015 Mar;70(3):299–306. doi: 10.1016/j.jinf.2014.10.009 25444973
12. Prezzemolo T, Guggino G, La Manna MP, Di Liberto D, Dieli F, Caccamo N, Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis. Front Immunol. 2014 Apr 22;5:180. doi: 10.3389/fimmu.2014.00180 24795723
13. Harari A, Rozot V, Enders FB, Perreau M, Stalder JM, Nicod LP, et al. Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med. 2011 Mar;17(3):372–6. doi: 10.1038/nm.2299 21336285
14. Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'rie T, et al. Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol. 2011 Sep 1;187(5):2222–32. doi: 10.4049/jimmunol.1101122 21775682
15. Petruccioli E, Petrone L, Vanini V, Sampaolesi A, Gualano G, Girardi E, et al. IFNgamma/TNFalpha specific-cells and effector memory phenotype associate with active tuberculosis. J Infect. 2013 Jun;66(6):475–86. doi: 10.1016/j.jinf.2013.02.004 23462597
16. Chiacchio T, Petruccioli E, Vanini V, Cuzzi G, Pinnetti C, Sampaolesi A, et al. Polyfunctional T-cells and effector memory phenotype are associated with active TB in HIV-infected patients. J Infect. 2014 Jun 26.
17. WHO Informal Working GroupInternational classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003 Feb;85(2):253–61. 12606104
18. Hosch W, Junghanss T, Stojkovic M, Brunetti E, Heye T, Kauffmann GW, et al. Metabolic viability assessment of cystic echinococcosis using high-field 1H MRS of cyst contents. NMR Biomed. 2008 Aug;21(7):734–54. doi: 10.1002/nbm.1252 18384178
19. Kannanganat S, Ibegbu C, Chennareddi L, Robinson HL, Amara RR, Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J Virol. 2007 Aug;81(16):8468–76. 17553885
20. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006 Jun 15;107(12):4781–9. 16467198
21. Makedonas G, Betts MR, Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV. Immunol Rev. 2011 Jan;239(1):109–24. doi: 10.1111/j.1600-065X.2010.00968.x 21198668
22. Ciuffreda D, Comte D, Cavassini M, Giostra E, Buhler L, Perruchoud M, et al. Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication. Eur J Immunol. 2008 Oct;38(10):2665–77. doi: 10.1002/eji.200838336 18958874
23. Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di Carlo P, Titone L, et al. Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol. 2010 Aug;40(8):2211–20. doi: 10.1002/eji.201040455 20540114
24. Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, Flynn BJ, et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med. 2007 Jul;13(7):843–50. 17558415
25. Macedo AB, Sanchez-Arcila JC, Schubach AO, Mendonca SC, Marins-Dos-Santos A, de Fatima Madeira M, et al. Multifunctional CD4(+) T cells in patients with American cutaneous leishmaniasis. Clin Exp Immunol. 2012 Mar;167(3):505–13. doi: 10.1111/j.1365-2249.2011.04536.x 22288594
26. Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJ, van Gemert GJ, et al. Protection against a malaria challenge by sporozoite inoculation. N Engl J Med. 2009 Jul 30;361(5):468–77. doi: 10.1056/NEJMoa0805832 19641203
27. Roestenberg M, Teirlinck AC, McCall MB, Teelen K, Makamdop KN, Wiersma J, et al. Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study. Lancet. 2011 May 21;377(9779):1770–6. doi: 10.1016/S0140-6736(11)60360-7 21514658
28. Albareda MC, De Rissio AM, Tomas G, Serjan A, Alvarez MG, Viotti R, et al. Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults. PLoS Negl Trop Dis. 2013 Dec 12;7(12):e2575. doi: 10.1371/journal.pntd.0002575 24349591
29. Tamarozzi F, Meroni V, Genco F, Piccoli L, Tinelli C, Filice C, et al. Ex vivo assessment of serum cytokines in patients with cystic echinococcosis of the liver. Parasite Immunol. 2010 Sep-Oct;32(9–10):696–700. doi: 10.1111/j.1365-3024.2010.01236.x 20691021
30. Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, et al. Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response. J Clin Invest. 2015 May;125(5):1827–38. doi: 10.1172/JCI77990 25822019
31. Cannas A, Calvo L, Chiacchio T, Cuzzi G, Vanini V, Lauria FN, et al. IP-10 detection in urine is associated with lung diseases. BMC Infect Dis. 2010 Nov 22;10:333,2334-10-333. doi: 10.1186/1471-2334-10-333 21092156
32. Petrone L, Chiacchio T, Vanini V, Petruccioli E, Cuzzi G, Di Giacomo C, et al. High urine IP-10 levels associate with chronic HCV infection. J Infect. 2014 Jun;68(6):591–600. doi: 10.1016/j.jinf.2014.02.008 24582930
33. Petrone L, Cannas A, Aloi F, Nsubuga M, Sserumkuma J, Nazziwa RA, et al. Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children. Biomed Res Int. 2015.
34. Chiacchio T, Petruccioli E, Vanini V, Butera O, Cuzzi G, Petrone L, et al. Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood. PLoS One. 2011;6(11):e27539. doi: 10.1371/journal.pone.0027539 22102905