Exogenous SDF-1α Protects Human Myocardium from Hypoxia-Reoxygenation Injury via CXCR4

Cardiovascular Drugs and Therapy

Volumn 29, Issue 6, 2015, Pages 589-592

  Malik, A ^a   Bromage, D I ^a   He, Z ^a   Candilio, L ^a   Hamarneh, A ^a   Taferner, S ^a   Davidson, S M ^a   Yellon, D M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cardioprotection; CXCR4; Ischaemia reperfusion injury; SDF 1 ; Stromal derived factor

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; FEMALE; HEART ATRIUM; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING; MALE; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY;

EID: 84949321366     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-015-6622-5     Document Type: Article

References (10)

1. Gibson CM. NRMI and current treatment patterns for ST-elevation myocardial infarction. Am Heart J. 2004;148:S29–33.
2. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13–20.
3. Pedersen F, Butrymovich V, Kelbaek H, et al. Short- and long-term cause of death in patients treated with primary PCI for STEMI. J Am Coll Cardiol. 2014;64:2101–8.
4. Bromage DI, Davidson SM, Yellon DM. Stromal derived factor 1alpha: a chemokine that delivers a two-pronged defence of the myocardium. Pharmacol Ther. 2014;143:305–15.
5. Davidson SM, Selvaraj P, He D, et al. Remote ischaemic preconditioning involves signalling through the SDF-1alpha/CXCR4 signalling axis. Basic Res Cardiol. 2013;108:377.
6. Zaruba MM, Franz WM. Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy. Expert Opin Biol Ther. 2010;10:321–35.
7. Penn MS, Pastore J, Miller T, Aras R. SDF-1 in myocardial repair. Gene Ther. 2012;19:583–7.
8. Huang C, Gu H, Zhang W, Manukyan MC, Shou W, Wang M. SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. AMERICAN J Physiol Heart Circ Physiol. 2011;301:H1496–505.
9. Hu X, Dai S, Wu WJ, et al. Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circ. 2007;116:654–63.
10. Davidson SM, Hausenloy D, Duchen MR, Yellon DM. Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. Int J Biochem Cell Biol. 2006;38:414–9.