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Volumn 32, Issue 4, 2016, Pages 391-404

DPP-4 inhibitors and risk of infections: A meta-analysis of randomized controlled trials

Author keywords

Dipeptidyl peptidase 4 inhibitor; Infection; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALOGLIPTIN; ALPHA GLUCOSIDASE INHIBITOR; LINAGLIPTIN; METFORMIN; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR;

EID: 84949266838     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2723     Document Type: Article
Times cited : (53)

References (104)
  • 1
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    • Yazbeck R, Howarth GS, Abbott CA. Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol Sci 2009; 30: 600-7.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 600-607
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 2
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 2007; 298: 194-206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 4
    • 79951701438 scopus 로고    scopus 로고
    • Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase
    • Willemen M, Mantel-Teeuwisse A, Straus S, Meyboom R, Egberts T, Leufkens H. Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase. Diabetes Care 2011; 34: 369-74.
    • (2011) Diabetes Care , vol.34 , pp. 369-374
    • Willemen, M.1    Mantel-Teeuwisse, A.2    Straus, S.3    Meyboom, R.4    Egberts, T.5    Leufkens, H.6
  • 6
    • 84860711211 scopus 로고    scopus 로고
    • Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Burant CF, Fleck P, Wilson C, Mekki Q, Pratley RE. Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes. J Clin Endocrinol Metab 2012; 97: 1615-1622.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1615-1622
    • DeFronzo, R.A.1    Burant, C.F.2    Fleck, P.3    Wilson, C.4    Mekki, Q.5    Pratley, R.E.6
  • 7
    • 80053422772 scopus 로고    scopus 로고
    • Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study
    • Kaku K, Itayasu T, Hiroi S, Hirayama M, Seino Y. Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study. Diabetes Obes Metab 2011; 13: 1028-1035.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 1028-1035
    • Kaku, K.1    Itayasu, T.2    Hiroi, S.3    Hirayama, M.4    Seino, Y.5
  • 8
    • 57649225147 scopus 로고    scopus 로고
    • Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study
    • Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 2009; 63: 46-55.
    • (2009) Int J Clin Pract , vol.63 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 9
    • 70349314675 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 2009; 25: 2361-2371.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2361-2371
    • Pratley, R.E.1    Reusch, J.E.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 10
    • 84920280347 scopus 로고    scopus 로고
    • Durability of the efficacy and safety of alogliptin compared with glipizide in type 2 diabetes mellitus: a 2-year study
    • Del Prato S, Camisasca R, Wilson C, Fleck P. Durability of the efficacy and safety of alogliptin compared with glipizide in type 2 diabetes mellitus: a 2-year study. Diabetes Obes Metab 2014; 16: 1239-46.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1239-1246
    • Del Prato, S.1    Camisasca, R.2    Wilson, C.3    Fleck, P.4
  • 11
    • 81855168272 scopus 로고    scopus 로고
    • Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension
    • Seino Y, Fujita T, Hiroi S, Hirayama M, Kaku K. Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension. Curr Med Res Opin 2011; 27(Suppl 3): 21-29.
    • (2011) Curr Med Res Opin , vol.27 , pp. 21-29
    • Seino, Y.1    Fujita, T.2    Hiroi, S.3    Hirayama, M.4    Kaku, K.5
  • 12
    • 84865996053 scopus 로고    scopus 로고
    • Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study
    • Seino Y, Miyata Y, Hiroi S, Hirayama M, Kaku K. Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study. Diabetes Obes Metab 2012; 14: 927-936.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 927-936
    • Seino, Y.1    Miyata, Y.2    Hiroi, S.3    Hirayama, M.4    Kaku, K.5
  • 13
    • 84886297885 scopus 로고    scopus 로고
    • Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatment: a randomized, double-blind, placebo-controlled trial
    • Barnett AH, Huisman H, Jones R, von Eynatten M, Patel S, Woerle HJ. Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatment: a randomized, double-blind, placebo-controlled trial. Lancet 2013; 382: 1413-23.
    • (2013) Lancet , vol.382 , pp. 1413-1423
    • Barnett, A.H.1    Huisman, H.2    Jones, R.3    von Eynatten, M.4    Patel, S.5    Woerle, H.J.6
  • 14
    • 84864757433 scopus 로고    scopus 로고
    • 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T, Bhattacharya S, Patel S, von Eynatten M, Dugi KA, Woerle HJ. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet 2012; 380: 475-483.
    • (2012) Lancet , vol.380 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3    Bhattacharya, S.4    Patel, S.5    von Eynatten, M.6    Dugi, K.A.7    Woerle, H.J.8
  • 15
    • 79953174825 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Gomis R, Espadero RM, Jones R, Woerle HJ, Dugi KA. Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2011; 13: 653-661.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 653-661
    • Gomis, R.1    Espadero, R.M.2    Jones, R.3    Woerle, H.J.4    Dugi, K.A.5
  • 16
    • 84862813117 scopus 로고    scopus 로고
    • Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Haak T, Meinicke T, Jones R, Weber S, von Eynatten M, Woerle HJ. Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2012; 14: 565-574.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 565-574
    • Haak, T.1    Meinicke, T.2    Jones, R.3    Weber, S.4    von Eynatten, M.5    Woerle, H.J.6
  • 17
    • 84858003503 scopus 로고    scopus 로고
    • Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study
    • Kawamori R, Inagaki N, Araki E, Watada H, Hayashi N, Horie Y, Sarashina A, Gong Y, von Eynatten M, Woerle HJ, Dugi KA. Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes Metab 2012; 14: 348-357.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 348-357
    • Kawamori, R.1    Inagaki, N.2    Araki, E.3    Watada, H.4    Hayashi, N.5    Horie, Y.6    Sarashina, A.7    Gong, Y.8    von Eynatten, M.9    Woerle, H.J.10    Dugi, K.A.11
  • 18
    • 84866183265 scopus 로고    scopus 로고
    • Efficacy and tolerability of linagliptin added to a sulfonylurea regimen in patients with inadequately controlled type 2 diabetes mellitus: an 18-week, multicenter, randomized, double-blind, placebo-controlled trial
    • Lewin AJ, Arvay L, Liu D, Patel S, von Eynatten M, Woerle HJ. Efficacy and tolerability of linagliptin added to a sulfonylurea regimen in patients with inadequately controlled type 2 diabetes mellitus: an 18-week, multicenter, randomized, double-blind, placebo-controlled trial. Clin Ther 2012; 34: 1909-1919.
    • (2012) Clin Ther , vol.34 , pp. 1909-1919
    • Lewin, A.J.1    Arvay, L.2    Liu, D.3    Patel, S.4    von Eynatten, M.5    Woerle, H.J.6
  • 19
    • 84873864348 scopus 로고    scopus 로고
    • Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study
    • McGill JB, Sloan L, Newman J, Patel S, Sauce C, von Eynatten M, Woerle HJ. Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study. Diabetes Care 2013; 36: 237-244.
    • (2013) Diabetes Care , vol.36 , pp. 237-244
    • McGill, J.B.1    Sloan, L.2    Newman, J.3    Patel, S.4    Sauce, C.5    von Eynatten, M.6    Woerle, H.J.7
  • 20
    • 80053072352 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study
    • Owens DR, Swallow R, Dugi KA, Woerle HJ. Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med 2011; 28: 1352-1361.
    • (2011) Diabet Med , vol.28 , pp. 1352-1361
    • Owens, D.R.1    Swallow, R.2    Dugi, K.A.3    Woerle, H.J.4
  • 21
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of beta-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial
    • Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle HJ, Dugi KA. Effect of linagliptin monotherapy on glycaemic control and markers of beta-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab 2011; 13: 258-267.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 258-267
    • Del Prato, S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.J.5    Dugi, K.A.6
  • 22
    • 84866651423 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin 2.5 mg twice daily versus 5 mg once daily in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, placebo-controlled trial
    • Ross SA, Rafeiro E, Meinicke T, Toorawa R, Weber-Born S, Woerle HJ. Efficacy and safety of linagliptin 2.5 mg twice daily versus 5 mg once daily in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, placebo-controlled trial. Curr Med Res Opin 2012; 28: 1465-74.
    • (2012) Curr Med Res Opin , vol.28 , pp. 1465-1474
    • Ross, S.A.1    Rafeiro, E.2    Meinicke, T.3    Toorawa, R.4    Weber-Born, S.5    Woerle, H.J.6
  • 23
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, Fleming D, Chen R. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin 2012; 28: 513-523.
    • (2012) Curr Med Res Opin , vol.28 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3    Fleming, D.4    Chen, R.5
  • 24
    • 68949212458 scopus 로고    scopus 로고
    • CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R. CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial. Int J Clin Pract 2009; 63: 1395-1406.
    • (2009) Int J Clin Pract , vol.63 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 25
    • 69549135336 scopus 로고    scopus 로고
    • Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • DeFronzo RA, Hissa MN, Garber AJ, Luiz Gross J, Yuyan Duan R, Ravichandran S, Chen RS. Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care 2009; 32: 1649-1655.
    • (2009) Diabetes Care , vol.32 , pp. 1649-1655
    • DeFronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3    Luiz Gross, J.4    Yuyan Duan, R.5    Ravichandran, S.6    Chen, R.S.7
  • 26
    • 78349292168 scopus 로고    scopus 로고
    • Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomized controlled trial
    • Göke B, Gallwitz B, Eriksson JG, Hellqvist Å, Gause-Nilsson I. Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomized controlled trial. Int J Clin Pract 2010; 64: 1619-31.
    • (2010) Int J Clin Pract , vol.64 , pp. 1619-1631
    • Göke, B.1    Gallwitz, B.2    Eriksson, J.G.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 27
  • 28
    • 79959217544 scopus 로고    scopus 로고
    • CV181013 Investigators. Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus
    • Hollander PL, Li J, Frederich R, Allen E, Chen R. CV181013 Investigators. Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus. Diab Vasc Dis Res 2011; 8: 125-35.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 125-135
    • Hollander, P.L.1    Li, J.2    Frederich, R.3    Allen, E.4    Chen, R.5
  • 29
    • 84898789442 scopus 로고    scopus 로고
    • A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea
    • Moses RG, Kalra S, Brook D, Sockler J, Monyak J, Visvanathan J, Montanaro M, Fisher SA. A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea. Diabetes Obes Metab 2014; 16: 443-50.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 443-450
    • Moses, R.G.1    Kalra, S.2    Brook, D.3    Sockler, J.4    Monyak, J.5    Visvanathan, J.6    Montanaro, M.7    Fisher, S.A.8
  • 30
    • 84863230449 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial
    • Pan CY, Yang W, Tou C, Gause-Nilsson I, Zhao J. Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Metab Res Rev 2012; 28: 268-275.
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 268-275
    • Pan, C.Y.1    Yang, W.2    Tou, C.3    Gause-Nilsson, I.4    Zhao, J.5
  • 31
    • 79955015666 scopus 로고    scopus 로고
    • CV181039 Investigators. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks
    • Pfützner A, Paz-Pacheco E, Allen E, Frederich R, Chen R. CV181039 Investigators. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks. Diabetes Obes Metab 2011; 13: 567-576.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 567-576
    • Pfützner, A.1    Paz-Pacheco, E.2    Allen, E.3    Frederich, R.4    Chen, R.5
  • 32
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naïve patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naïve patients with type 2 diabetes. Diabetes Obes Metab 2008; 10: 376-386.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 33
    • 70349333861 scopus 로고    scopus 로고
    • CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R. CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin 2009; 25: 2401-2411.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    Nepal, S.4    List, J.5    Chen, R.6
  • 36
    • 84896714099 scopus 로고    scopus 로고
    • A randomized controlled trial of the efficacy and safety of twice-daily saxagliptin plus metformin combination therapy in patients with type 2 diabetes and inadequate glycemic control on metformin monotherapy
    • White JL, Buchanan P, Li J, Frederich R. A randomized controlled trial of the efficacy and safety of twice-daily saxagliptin plus metformin combination therapy in patients with type 2 diabetes and inadequate glycemic control on metformin monotherapy. BMC Endocr Disord 2014; 24: 14-17.
    • (2014) BMC Endocr Disord , vol.24 , pp. 14-17
    • White, J.L.1    Buchanan, P.2    Li, J.3    Frederich, R.4
  • 37
    • 81255160603 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial
    • Yang W, Pan CY, Tou C, Zhao J, Gause-Nilsson I. Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Res Clin Pract 2011; 94: 217-224.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 217-224
    • Yang, W.1    Pan, C.Y.2    Tou, C.3    Zhao, J.4    Gause-Nilsson, I.5
  • 38
    • 84904963065 scopus 로고    scopus 로고
    • HARMONY 3 Study Group. HARMONY 3: 104-week randomized, double-blind, placebo-and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin
    • Ahrén B, Johnson SL, Stewart M, Cirkel DT, Yang F, Perry C, Feinglos MN. HARMONY 3 Study Group. HARMONY 3: 104-week randomized, double-blind, placebo-and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin. Diabetes Care 2014; 37: 2141-8.
    • (2014) Diabetes Care , vol.37 , pp. 2141-2148
    • Ahrén, B.1    Johnson, S.L.2    Stewart, M.3    Cirkel, D.T.4    Yang, F.5    Perry, C.6    Feinglos, M.N.7
  • 39
    • 33845472504 scopus 로고    scopus 로고
    • Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE. Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006; 29: 2632-2637.
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 40
    • 78650656671 scopus 로고    scopus 로고
    • Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial
    • Arechavaleta R, Seck T, Chen Y, Krobot KJ, O'Neill EA, Duran L, Kaufman KD, Williams-Herman D, Goldstein BJ. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2011; 13: 160-168.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 160-168
    • Arechavaleta, R.1    Seck, T.2    Chen, Y.3    Krobot, K.J.4    O'Neill, E.A.5    Duran, L.6    Kaufman, K.D.7    Williams-Herman, D.8    Goldstein, B.J.9
  • 42
    • 77955573674 scopus 로고    scopus 로고
    • DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • Bergenstal RM, Wysham C, Macconell L, Malloy J, Walsh B, Yan P, Wilhelm K, Malone J, Porter LE. DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010; 376: 431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6    Wilhelm, K.7    Malone, J.8    Porter, L.E.9
  • 43
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006; 29: 2638-2643.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 45
    • 84875221492 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes
    • Fonseca V, Staels B, Morgan JD, Shentu Y, Golm GT, Johnson-Levonas AO, Kaufman KD, Goldstein BJ, Steinberg H. Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes. J Diabetes Complications 2013; 27: 177-83.
    • (2013) J Diabetes Complications , vol.27 , pp. 177-183
    • Fonseca, V.1    Staels, B.2    Morgan, J.D.3    Shentu, Y.4    Golm, G.T.5    Johnson-Levonas, A.O.6    Kaufman, K.D.7    Goldstein, B.J.8    Steinberg, H.9
  • 46
    • 77954197187 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial
    • Iwamoto Y, Tajima N, Kadowaki T, et al. Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial. Diabetes Obes Metab 2010; 12: 613-622.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 613-622
    • Iwamoto, Y.1    Tajima, N.2    Kadowaki, T.3
  • 49
    • 33845489598 scopus 로고    scopus 로고
    • Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H. Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49: 2564-2571.
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 51
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2006; 28: 1556-1568.
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 52
    • 84859013614 scopus 로고    scopus 로고
    • DURATION-4 Study Group. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4): a 26-week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M, Kumar A, González JG, Chan M, Wolka AM, Boardman MK. DURATION-4 Study Group. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care 2012; 35: 252-8.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3    Kumar, A.4    González, J.G.5    Chan, M.6    Wolka, A.M.7    Boardman, M.K.8
  • 53
    • 77949387699 scopus 로고    scopus 로고
    • Sitagliptin Study 024 Group. Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study
    • Seck T, Nauck M, Sheng D, Sunga S, Davies MJ, Stein PP, Kaufman KD, Amatruda JM. Sitagliptin Study 024 Group. Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study. Int J Clin Pract 2010; 64: 562-76.
    • (2010) Int J Clin Pract , vol.64 , pp. 562-576
    • Seck, T.1    Nauck, M.2    Sheng, D.3    Sunga, S.4    Davies, M.J.5    Stein, P.P.6    Kaufman, K.D.7    Amatruda, J.M.8
  • 54
    • 43449096512 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Scott R, Loeys T, Davies MJ, Engel SS. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab 2008; 10: 959-969.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 55
    • 84888429343 scopus 로고    scopus 로고
    • Sitagliptin added to voglibose monotherapy improves glycemic control in patients with type 2 diabetes
    • Tajima N, Kadowaki T, Okamoto T, et al. Sitagliptin added to voglibose monotherapy improves glycemic control in patients with type 2 diabetes. J Diabetes Investig 2013; 27: 595-604.
    • (2013) J Diabetes Investig , vol.27 , pp. 595-604
    • Tajima, N.1    Kadowaki, T.2    Okamoto, T.3
  • 57
    • 70349761649 scopus 로고    scopus 로고
    • Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial-a primary care, type 2 diabetes study
    • Blonde L, Dagogo-Jack S, Banerji MA, Pratley RE, Marcellari A, Braceras R, Purkayastha D, Baron M. Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial-a primary care, type 2 diabetes study. Diabetes Obes Metab 2009; 11: 978-986.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 978-986
    • Blonde, L.1    Dagogo-Jack, S.2    Banerji, M.A.3    Pratley, R.E.4    Marcellari, A.5    Braceras, R.6    Purkayastha, D.7    Baron, M.8
  • 58
    • 37349054435 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study
    • Bolli G, Dotta F, Rochotte E, Cohen SE. Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study. Diabetes Obes Metab 2008; 10: 82-90.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 82-90
    • Bolli, G.1    Dotta, F.2    Rochotte, E.3    Cohen, S.E.4
  • 59
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007; 30: 890-895.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 60
    • 65449135133 scopus 로고    scopus 로고
    • Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naïve patients with type 2 diabetes mellitus
    • Bosi E, Dotta F, Jia Y, Goodman M. Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naïve patients with type 2 diabetes mellitus. Diabetes Obes Metab 2009; 11: 506-515.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 506-515
    • Bosi, E.1    Dotta, F.2    Jia, Y.3    Goodman, M.4
  • 61
    • 58149330590 scopus 로고    scopus 로고
    • Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    • Ferrannini E, Fonseca V, Zinman B, et al. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab 2009; 11: 157-166.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 157-166
    • Ferrannini, E.1    Fonseca, V.2    Zinman, B.3
  • 62
    • 77949356196 scopus 로고    scopus 로고
    • A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study
    • Filozof C, Gautier JF. A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study. Diabet Med 2010; 27: 318-326.
    • (2010) Diabet Med , vol.27 , pp. 318-326
    • Filozof, C.1    Gautier, J.F.2
  • 63
  • 64
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: 1 randomized, placebo-controlled study
    • Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: 1 randomized, placebo-controlled study. Diabetes Obes Metab 2007; 9: 166-74.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3    Rochotte, E.4    Dejager, S.5
  • 66
    • 67949105103 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    • Goodman M, Thurston H, Penman J. Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Horm Metab Res 2009; 41: 368-373.
    • (2009) Horm Metab Res , vol.41 , pp. 368-373
    • Goodman, M.1    Thurston, H.2    Penman, J.3
  • 67
    • 58349115426 scopus 로고    scopus 로고
    • Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus
    • Kikuchi M, Abe N, Kato M, Terao S, Mimori N, Tachibana H. Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2009; 83: 233-240.
    • (2009) Diabetes Res Clin Pract , vol.83 , pp. 233-240
    • Kikuchi, M.1    Abe, N.2    Kato, M.3    Terao, S.4    Mimori, N.5    Tachibana, H.6
  • 68
    • 80052551137 scopus 로고    scopus 로고
    • Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled tria
    • Lukashevich V, Schweizer A, Shao Q, Groop PH, Kothny W. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled tria. Diabetes Obes Metab 2011; 13: 947-54.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 947-954
    • Lukashevich, V.1    Schweizer, A.2    Shao, Q.3    Groop, P.H.4    Kothny, W.5
  • 69
    • 84898798397 scopus 로고    scopus 로고
    • Efficacy and safety of vildagliptin in patients with type 2 diabetes mellitus inadequately controlled with dual combination of metformin and sulphonylurea
    • Lukashevich V, Prato SD, Araga M, Kothny W. Efficacy and safety of vildagliptin in patients with type 2 diabetes mellitus inadequately controlled with dual combination of metformin and sulphonylurea. Diabetes Obes Metab 2014; 16: 403-9.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 403-409
    • Lukashevich, V.1    Prato, S.D.2    Araga, M.3    Kothny, W.4
  • 70
    • 84925743102 scopus 로고    scopus 로고
    • Efficacy and safety of vildagliptin as add-on to metformin in Japanese patients with type 2 diabetes mellitus
    • Odawara M, Hamada I, Suzuki M. Efficacy and safety of vildagliptin as add-on to metformin in Japanese patients with type 2 diabetes mellitus. Diabetes Ther 2014; 5: 169-81.
    • (2014) Diabetes Ther , vol.5 , pp. 169-181
    • Odawara, M.1    Hamada, I.2    Suzuki, M.3
  • 71
    • 41749106662 scopus 로고    scopus 로고
    • Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial
    • Pan C, Yang W, Barona JP, Wang Y, Niggli M, Mohideen P, Wang Y, Foley JE. Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet Med 2008; 25: 435-441.
    • (2008) Diabet Med , vol.25 , pp. 435-441
    • Pan, C.1    Yang, W.2    Barona, J.P.3    Wang, Y.4    Niggli, M.5    Mohideen, P.6    Wang, Y.7    Foley, J.E.8
  • 72
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract 2007; 76: 132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 73
    • 27744540889 scopus 로고    scopus 로고
    • Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response
    • Ristic S, Byiers S, Foley J, Holmes D. Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. Diabetes Obes Metab 2005; 7: 692-698.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 692-698
    • Ristic, S.1    Byiers, S.2    Foley, J.3    Holmes, D.4
  • 74
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Kim SW, Baron MA, Camisasca RP, Cressier F, Couturier A, Dejager S. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2007; 9: 175-185.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Kim, S.W.2    Baron, M.A.3    Camisasca, R.P.4    Cressier, F.5    Couturier, A.6    Dejager, S.7
  • 75
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care 2007; 30: 217-223.
    • (2007) Diabetes Care , vol.30 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 77
    • 34548118796 scopus 로고    scopus 로고
    • Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetes
    • Schweizer A, Couturier A, Foley JE, Dejager S. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetes. Diabet Med 2007; 24: 955-961.
    • (2007) Diabet Med , vol.24 , pp. 955-961
    • Schweizer, A.1    Couturier, A.2    Foley, J.E.3    Dejager, S.4
  • 78
    • 67649933635 scopus 로고    scopus 로고
    • Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    • Schweizer A, Dejager S, Bosi E. Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Obes Metab 2009; 11: 804-812.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 804-812
    • Schweizer, A.1    Dejager, S.2    Bosi, E.3
  • 79
    • 84881189911 scopus 로고    scopus 로고
    • Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomized, double-blind, placebo-controlled study
    • Strain WD, Lukashevich V, Kothny W, Hoellinger MJ, Paldánius PM. Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomized, double-blind, placebo-controlled study. Lancet 2013; 382: 409-16.
    • (2013) Lancet , vol.382 , pp. 409-416
    • Strain, W.D.1    Lukashevich, V.2    Kothny, W.3    Hoellinger, M.J.4    Paldánius, P.M.5
  • 81
    • 77953192546 scopus 로고    scopus 로고
    • An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    • Ligueros-Saylan M, Foley JE, Schweizer A, Couturier A, Kothny W. An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials. Diabetes Obes Metab 2010; 12: 495-509.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 495-509
    • Ligueros-Saylan, M.1    Foley, J.E.2    Schweizer, A.3    Couturier, A.4    Kothny, W.5
  • 82
    • 84871158996 scopus 로고    scopus 로고
    • Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis
    • Gooßen K, Gräber S. Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis. Diabetes Obes Metab 2012; 14: 1061-72.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 1061-1072
    • Gooßen, K.1    Gräber, S.2
  • 83
    • 84886584851 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis
    • Karagiannis T, Paschos P, Paletas K, Matthews DR, Tsapas A. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ 2012; 12: 344.
    • (2012) BMJ , vol.12 , pp. 344
    • Karagiannis, T.1    Paschos, P.2    Paletas, K.3    Matthews, D.R.4    Tsapas, A.5
  • 84
    • 84863457464 scopus 로고    scopus 로고
    • The efficacy and safety of vildagliptin in patients with type 2 diabetes: a meta-analysis of randomized clinical trials
    • Cai L, Cai Y, Lu ZJ, Zhang Y, Liu P. The efficacy and safety of vildagliptin in patients with type 2 diabetes: a meta-analysis of randomized clinical trials. J Clin Pharm Ther 2012; 37: 386-98.
    • (2012) J Clin Pharm Ther , vol.37 , pp. 386-398
    • Cai, L.1    Cai, Y.2    Lu, Z.J.3    Zhang, Y.4    Liu, P.5
  • 85
    • 84874397294 scopus 로고    scopus 로고
    • Efficacy of alogliptin in type 2 diabetes treatment: a meta-analysis of randomized double-blind controlled studies
    • Berhan A, Berhan Y. Efficacy of alogliptin in type 2 diabetes treatment: a meta-analysis of randomized double-blind controlled studies. BMC Endocr Disord 2013; 13: 9.
    • (2013) BMC Endocr Disord , vol.13 , pp. 9
    • Berhan, A.1    Berhan, Y.2
  • 87
    • 0031908130 scopus 로고    scopus 로고
    • The structure and function of CD26 in the T-cell immune response
    • Morimoto C, Schossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev 1998; 161: 55-70.
    • (1998) Immunol Rev , vol.161 , pp. 55-70
    • Morimoto, C.1    Schossman, S.F.2
  • 88
    • 0031573556 scopus 로고    scopus 로고
    • Determination of adenosine deaminase binding domain on CD26 and its immunoregulatory effect on T cell activation
    • Dong RP, Tachibana K, Hegen M, Munakata Y, Cho D, Schlossman SF, Morimoto C. Determination of adenosine deaminase binding domain on CD26 and its immunoregulatory effect on T cell activation. J Immunol 1997; 159: 6070-6.
    • (1997) J Immunol , vol.159 , pp. 6070-6076
    • Dong, R.P.1    Tachibana, K.2    Hegen, M.3    Munakata, Y.4    Cho, D.5    Schlossman, S.F.6    Morimoto, C.7
  • 90
    • 0023726623 scopus 로고
    • Direct evidence for the binding of rat liver DPP IV to collagen in vitro
    • Hanski C, Huhle T, Gossrau R, Reutter W. Direct evidence for the binding of rat liver DPP IV to collagen in vitro. Exp Cell Res 1988; 178: 64-72.
    • (1988) Exp Cell Res , vol.178 , pp. 64-72
    • Hanski, C.1    Huhle, T.2    Gossrau, R.3    Reutter, W.4
  • 91
    • 0025180521 scopus 로고
    • Human CD4 helper T cell activation:functional involvement of two distinct collagen receptors, 1FF7 and VLA integrin family
    • Dang NH, Torimoto Y, Schlossman SF, Morimoto C. Human CD4 helper T cell activation:functional involvement of two distinct collagen receptors, 1FF7 and VLA integrin family. J Exp Med 1990; 172: 649-52.
    • (1990) J Exp Med , vol.172 , pp. 649-652
    • Dang, N.H.1    Torimoto, Y.2    Schlossman, S.F.3    Morimoto, C.4
  • 92
    • 0021906263 scopus 로고
    • The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes
    • Schön E, Mansfeld HW, Demuth HU, Barh A, Ansorge S. The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes. Biomed Biochim Acta 1985; 44: K9-15.
    • (1985) Biomed Biochim Acta , vol.44 , pp. K9-15
    • Schön, E.1    Mansfeld, H.W.2    Demuth, H.U.3    Barh, A.4    Ansorge, S.5
  • 93
    • 0030952018 scopus 로고    scopus 로고
    • Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes
    • Reinhold D, Bank U, Bühling F, Täger M, Born I, Faust J, Neubert K, Ansorge S. Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes. Immunol Lett 1997; 58: 29-35.
    • (1997) Immunol Lett , vol.58 , pp. 29-35
    • Reinhold, D.1    Bank, U.2    Bühling, F.3    Täger, M.4    Born, I.5    Faust, J.6    Neubert, K.7    Ansorge, S.8
  • 95
    • 33845197433 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation
    • Reinhold D, Biton A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Int Immunopharmacol 2006; 6: 1935-42.
    • (2006) Int Immunopharmacol , vol.6 , pp. 1935-1942
    • Reinhold, D.1    Biton, A.2    Pieper, S.3    Lendeckel, U.4    Faust, J.5    Neubert, K.6    Bank, U.7    Täger, M.8    Ansorge, S.9    Brocke, S.10
  • 96
    • 1642577126 scopus 로고    scopus 로고
    • TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • Nakamura K1, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004; 172: 834-42.
    • (2004) J Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3    Pedersen, A.4    Harada, N.5    Nawata, H.6    Strober, W.7
  • 97
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
    • Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY, Green J, Kim SJ. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001; 49: 190-8.
    • (2001) Gut , vol.49 , pp. 190-198
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3    Park, S.H.4    Markowitz, S.5    Jung, H.Y.6    Green, J.7    Kim, S.J.8
  • 98
    • 84883609473 scopus 로고    scopus 로고
    • Effects of short-term sitagliptin treatment on immune parameters in healthy individuals, a randomized placebo-controlled study
    • Price JD1, Linder G, Li WP, Zimmermann B, Rother KI, Malek R, Alattar M, Tarbell KV. Effects of short-term sitagliptin treatment on immune parameters in healthy individuals, a randomized placebo-controlled study. Clin Exp Immunol 2013; 174: 120-8.
    • (2013) Clin Exp Immunol , vol.174 , pp. 120-128
    • Price, J.D.1    Linder, G.2    Li, W.P.3    Zimmermann, B.4    Rother, K.I.5    Malek, R.6    Alattar, M.7    Tarbell, K.V.8
  • 104
    • 41149118550 scopus 로고    scopus 로고
    • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione(B1 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione(B1 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 2008; 325: 175-82.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3    Tadayyon, M.4    Himmelsbach, F.5    Mark, M.6


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