IL-10Rα expression is post-transcriptionally regulated by MIR-15a, MIR-185, and MIR-211 in melanoma

BMC Medical Genomics

Volumn 8, Issue 1, 2015, Pages

  Venza, Isabella ^a   Visalli, Maria ^a   Beninati, Concetta ^a,b   Benfatto, Salvatore ^a   Teti, Diana ^a   Venza, Mario ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cutaneous melanoma; IL 10; IL 10R ; IL 10R ; MiRNAs; Uveal melanoma

Indexed keywords

INTERLEUKIN 10; MICRORNA; MICRORNA 15A; MICRORNA 185; MICRORNA 211; UNCLASSIFIED DRUG; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 10 RECEPTOR BETA; MIRN15 MICRORNA, HUMAN; MIRN185 MICRORNA, HUMAN; MIRN211 MICRORNA, HUMAN;

ADULT; AGED; ARTICLE; CANCER CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; CUTANEOUS MELANOMA; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE SILENCING; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL 10 GENE; IL 10RALPHA GENE; IL 10RBETA GENE; LUCIFERASE ASSAY; MALE; MELANOMA; MELANOMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCRIPTION REGULATION; UPREGULATION; UVEA MELANOMA; WESTERN BLOTTING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; SKIN TUMOR; TUMOR CELL LINE; UVEA TUMOR;

AGED; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-10; INTERLEUKIN-10 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-10 RECEPTOR BETA SUBUNIT; MALE; MELANOMA; MICRORNAS; MIDDLE AGED; SKIN NEOPLASMS; TRANSCRIPTION, GENETIC; UVEAL NEOPLASMS;

EID: 84949256996     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/s12920-015-0156-3     Document Type: Article

References (24)

1. Trifunović J, Miller L, Debeljak Ž, Horvat V. Pathologic patterns of interleukin 10 expression-a review. Biochem Med (Zagreb). 2015;25:36-48.
2. Kim R, Emi M, Tanabe K, Arihiro K. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res. 2006;66:5527-36.
3. Mocellin S, Marincola FM, Young HA. Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol. 2005;78:1043-51.
4. Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy-review of a new approach. Pharmacol Rev. 2003;55:241-69.
5. Krüger-Krasagakes S, Krasagakis K, Garbe C, Schmitt E, Hüls C, Blankenstein T, et al. Expression of interleukin 10 in human melanoma. Br J Cancer. 1994;70:1182-5.
6. Gérard CM, Bruyns C, Delvaux A, Baudson N, Dargent JL, Goldman M, et al. Loss of tumorigenicity and increased immunogenicity induced by interleukin-10 gene transfer in B16 melanoma cells. Hum Gene Ther. 1996;7:23-31.
7. Yue FY, Dummer R, Geertsen R, Hofbauer G, Laine E, Manolio S, et al. Interleukin-10 is a growth factor for human melanoma cells and downregulates HLA class-I, HLA class-II and ICAM-1 molecules. Int J Cancer. 1997;71:630-7.
8. Huang S, Xie K, Bucana CD, Ullrich SE, Bar-Eli M. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin Cancer Res. 1996;2:1969-79.
9. Chen Q, Daniel V, Maher DW, Hersey P. Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. Int J Cancer. 1994;56:755-60.
10. Fujii S, Shimizu K, Shimizu T, Lotze MT. Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ. Blood. 2001;98:2143-51.
11. Aftab MN, Dinger ME, Perera RJ. The role of microRNAs and long noncoding RNAs in the pathology, diagnosis, and management of melanoma. Arch Biochem Biophys. 2014;563:60-70.
12. Bolpetti A, Silva JS, Villa LL, Lepique AP. Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth. BMC Immunol. 2010;11:27.
13. Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, et al. Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. J Biol Chem. 2004;279:54358-68.
14. Wiguna AP, Walden P. Role of IL-10 and TGF-β in melanoma. Exp Dermatol. 2015;24:209-14.
15. Rowbottom AW, Lepper MA, Garland RJ, Cox CV, Corley EG. Interleukin-10-induced CD8 cell proliferation. Immunology. 1999;98:80-9.
16. Lázár-Molnár E, Hegyesi H, Tóth S, Falus A. Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine. 2000;12:547-54.
17. Reiche J, Pauli G, Ellerbrok H. Differential expression of human endogenous retrovirus K transcripts in primary human melanocytes and melanoma cell lines after UV irradiation. Melanoma Res. 2010;20:435-40.
18. Chartrain M, Riond J, Stennevin A, Van den Berghe I, Gomes B, Lamant L, et al. Melanoma chemotherapy leads to the selection of ABCB5-expressing cells. PLoS One. 2012;7:e36762.
19. Venza M, Visalli M, Catalano T, Fortunato C, Oteri R, Teti D, et al. Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma. Biochem Biophys Res Commun. 2013;441:743-50.
20. LePoole IC, Van Den Wungaard RM, Westerhof W, Verkruisen RP, Dutrieux RP, Dingermans KP, et al. Phagocytosis by normal human melanocytes in vitro. Exp Cell Res. 1993;205:388-95.
21. Papa CM, Kligman AM. The behavior of melanocytes in inflammation. J Invest Dermatol. 1965;45:465-74.
22. Venza M, Dell'Aversana C, Visalli M, Altucci L, Teti D, Venza I. Identification of microRNA expression patterns in cutaneous and uveal melanoma cell lines. Tumori. 2014;100:e4-7.
23. Pekarsky Y, Croce CM. Role of miR-15/16 in CLL. Cell Death Differ. 2015;22:6-11.
24. Greenberg E, Hershkovitz L, Itzhaki O, Hajdu S, Nemlich Y, Ortenberg R, et al. Regulation of cancer aggressive features in melanoma cells by microRNAs. PLoS One. 2011;6:e18936.