In-stent restenosis is associated with neointimal angiogenesis and macrophage infiltrates

Pathology Research and Practice

Volumn 210, Issue 12, 2014, Pages 1026-1030

  Zhang, MingChang ^a,b   Cresswell, Nathaniel ^c   Tavora, Fabio ^d   Mont, Erik ^e   Zhao, Ziqin ^a   Burke, Allen ^a,b  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND MEDICAL SYSTEM   (United States)

^c GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^d Messajana Heart and Lung Hospital   (Brazil)

^e Nova Scotia Medical Examiner Service   (Canada)

Author keywords

In stent restenosis; Macrophage inflammation; Neointimal angiogenesis

Indexed keywords

CD31 ANTIGEN; CD68 ANTIGEN; PARAFFIN;

ANGIOGENESIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BARE METAL STENT; CAUSE OF DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN-STENT RESTENOSIS; INCIDENTAL FINDING; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; NEOINTIMA; NEOINTIMAL ANGIOGENESIS; POSTHUMOUS CARE; RISK FACTOR; SCORING SYSTEM; VASCULAR STENT; ADVERSE EFFECTS; CORONARY BLOOD VESSEL; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PLAQUE, ATHEROSCLEROTIC; REGISTER; RESTENOSIS; STENT;

CORONARY RESTENOSIS; CORONARY VESSELS; FEMALE; HUMANS; MACROPHAGES; MALE; NEOINTIMA; NEOVASCULARIZATION, PATHOLOGIC; PLAQUE, ATHEROSCLEROTIC; REGISTRIES; STENTS;

EID: 84949114702     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2014.04.004     Document Type: Article

References (29)

1. Sigwart U., Puel J., Mirkovitch V., Joffre F., Kappenberger L. Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N. Engl. J. Med. 1987, 316:701-706.
2. Fischman D.L., Leon M.B., Baim D.S., et al. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators. N. Engl. J. Med. 1994, 331:496-501.
3. Serruys P.W., de Jaegere P., Kiemeneij F., et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group. N. Engl. J. Med. 1994, 331:489-495.
4. Fenton S.H., Fischman D.L., Savage M.P., et al. Long-term angiographic and clinical outcome after implantation of balloon-expandable stents in aortocoronary saphenous vein grafts. Am. J. Cardiol. 1994, 74:1187-1191.
5. Linnemeier T.J. The illusive ostial and proximal LAD. Catheter. Cardiovasc. Interv. 2000, 49:272-273.
6. Abizaid A., Kornowski R., Mintz G.S., et al. The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation. J. Am. Coll. Cardiol. 1998, 32:584-589.
7. Kastrati A., Schomig A., Elezi S., et al. Predictive factors of restenosis after coronary stent placement. J. Am. Coll. Cardiol. 1997, 30:1428-1436.
8. Goldberg S.L., Loussararian A., De Gregorio J., Di Mario C., Albiero R., Colombo A. Predictors of diffuse and aggressive intra-stent restenosis. J. Am. Coll. Cardiol. 2001, 37:1019-1025.
9. Kereiakes D., Linnemeier T.J., Baim D.S., et al. Usefulness of stent length in predicting in-stent restenosis (the MULTI-LINK stent trials). Am. J. Cardiol. 2000, 86:336-341.
10. Hsieh I.C., Chien C.C., Chang H.J., et al. Acute and long-term outcomes of stenting in coronary vessel>3.0mm, 3. 0-2.5mm, and<2.5mm. Catheter. Cardiovasc. Interv. 2001, 53:314-322.
11. de Feyter P.J., Kay P., Disco C., Serruys P.W. Reference chart derived from post-stent-implantation intravascular ultrasound predictors of 6-month expected restenosis on quantitative coronary angiography. Circulation 1999, 100:1777-1783.
12. Hoffmann R., Mintz G.S., Dussaillant G.R., et al. Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. Circulation 1996, 94:1247-1254.
13. Mach F. Toward new therapeutic strategies against neointimal formation in restenosis. Arterioscler. Thromb. Vasc. Biol. 2000, 20:1699-1700.
14. Grewe P.H., Deneke T., Machraoui A., Barmeyer J., Muller K.M. Acute and chronic tissue response to coronary stent implantation: pathologic findings in human specimen. J. Am. Coll. Cardiol. 2000, 35:157-163.
15. Kearney M., Pieczek A., Haley L., et al. Histopathology of in-stent restenosis in patients with peripheral artery disease. Circulation 1997, 95:1998-2002.
16. Virmani R., Farb A. Pathology of in-stent restenosis. Curr. Opin. Lipidol. 1999, 10:499-506.
17. Brasen J.H., Kivela A., Roser K., et al. Angiogenesis, vascular endothelial growth factor and platelet-derived growth factor-BB expression, iron deposition, and oxidation-specific epitopes in stented human coronary arteries. Arterioscler. Thromb. Vasc. Biol. 2001, 21:1720-1726.
18. Bradshaw S.H., Kennedy L., Dexter D.F., Veinot J.P. A practical method to rapidly dissolve metallic stents. Cardiovasc. Pathol. 2009, 18:127-133.
19. Isner J.M., Donaldson R.F. Coronary angiographic and morphologic correlation. Cardiol. Clin. 1984, 2:571-592.
20. Mintz G.S., Popma J.J., Pichard A.D., et al. Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Circulation 1996, 94:35-43.
21. Schwartz R.S., Huber K.C., Murphy J.G., et al. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J. Am. Coll. Cardiol. 1992, 19:267-274.
22. Edelman E.R., Rogers C. Pathobiologic responses to stenting. Am. J. Cardiol. 1998, 81:4E-6E.
23. Gill M., Dias S., Hattori K., et al. Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells. Circ. Res. 2001, 88:167-174.
24. Hausner E.A., Orsini J.A., Foster L.L., et al. Vascular endothelial growth factor in porcine coronary arteries following balloon angioplasty. J. Invest. Surg. 1999, 12:15-23.
25. Couper L.L., Bryant S.R., Eldrup-Jorgensen J., Bredenberg C.E., Lindner V. Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Circ. Res. 1997, 81:932-939.
26. Griffioen A.W., Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 2000, 52:237-268.
27. Farb A., Weber D.K., Kolodgie F.D., Burke A.P., Virmani R. Morphological predictors of restenosis after coronary stenting in humans. Circulation 2002, 105:2974-2980.
28. Shofti R., Tio F., Beyar R. Neointimal vascularization and intimal thickening in response to self-expanding stents: a swine model. Int. J. Cardiovasc. Intervent. 2004, 6:61-67.
29. Ganaha F., Kao E.Y., Wong H., et al. Stent-based controlled release of intravascular angiostatin to limit plaque progression and in-stent restenosis. J. Vasc. Interv. Radiol. 2004, 15:601-608.