Triglycerides to high-density lipoprotein cholesterol ratio is an independent predictor of incident fatty liver; a population-based cohort study

Liver International

Volumn 36, Issue 5, 2016, Pages 713-720

  Fukuda, Yukiko ^a   Hashimoto, Yoshitaka ^a   Hamaguchi, Masahide ^a   Fukuda, Takuya ^a   Nakamura, Naoto ^a   Ohbora, Akihiro ^b   Kato, Takahiro ^b   Kojima, Takao ^b   Fukui, Michiaki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b ASAHI UNIVERSITY   (Japan)

Author keywords

Epidemiology; Insulin resistance; Metabolic syndrome; Non alcoholic fatty liver disease; TG HDL ratio

Indexed keywords

ALCOHOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ARTICLE; COHORT ANALYSIS; ECHOGRAPHY; FEMALE; FOLLOW UP; HUMAN; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; BLOOD; JAPAN; MIDDLE AGED; ODDS RATIO; RECEIVER OPERATING CHARACTERISTIC; STATISTICAL MODEL;

ADULT; CHOLESTEROL, HDL; COHORT STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; JAPAN; LOGISTIC MODELS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; ODDS RATIO; ROC CURVE; TRIGLYCERIDES; ULTRASONOGRAPHY;

EID: 84949034984     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12977     Document Type: Article

References (34)

1. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-19.
2. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
3. Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol 2009; 104: 861-7.
4. Fukuda T, Hamaguchi M, Kojima T, et al. The impact of nonalcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals. Liver Int 2016; 36: 275-83.
5. Musso G, Gambino R, Tabibian JH, et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis. PLoS Med 2014; 11: e1001680.
6. Hamaguchi M, Kojima T, Takeda N, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007; 13: 1579-84.
7. Hashimoto Y, Hamaguchi M, Kojima T, et al. The modest alcohol consumption reduces the incidence of fatty liver in men: a population-based large-scale cohort study. J Gastroenterol Hepatol 2015; 30: 546-52.
8. Speliotes EK, Massaro JM, Hoffmann U, et al. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010; 51: 1979-87.
9. Tomizawa M, Kawanabe Y, Shinozaki F, et al. Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes. Biomed. Rep. 2014; 2: 633-6.
10. Zelber-Sagi S, Salomone F, Yeshua H, et al. Non-high-density lipoprotein cholesterol independently predicts new onset of non-alcoholic fatty liver disease. Liver Int 2014; 34: e128-35.
11. Kim-Dorner SJ, Deuster PA, Zeno SA, Remaley AT, Poth M. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism 2010; 59: 299-304.
12. Mackey RH, Mora S, Bertoni AG, et al. Lipoprotein Particles and Incident Type 2 Diabetes in the multi-ethnic study of atherosclerosis. Diabetes Care 2015; 38: 628-36.
13. Tohidi M, Hatami M, Hadaegh F, Azizi F. Triglycerides and triglycerides to high-density lipoprotein cholesterol ratio are strong predictors of incident hypertension in Middle Eastern women. J Hum Hypertens 2012; 26: 525-32.
14. Sung KC, Reaven G, Kim S. Ability of the plasma concentration ratio of triglyceride/high-density lipoprotein cholesterol to identify increased cardio-metabolic risk in an east Asian population. Diabetes Res Clin Pract 2014; 105: 96-101.
15. Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005; 143: 722-8.
16. Shimomura T, Wakabayashi I. Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes. Cardiovasc Diabetol 2013; 12: 104.
17. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8: 521-33.
18. Hamaguchi M, Kojima T, Ohbora A, et al. Protective effect of alcohol consumption for fatty liver but not metabolic syndrome. World J Gastroenterol 2012; 18: 156-67.
19. Aaron DJ, Kriska AM, Dearwater SR, et al. Reproducibility and validity of an epidemiologic questionnaire to assess past year physical activity in adolescents. Am J Epidemiol 1995; 142: 191-201.
20. Ryu S, Chang Y, Kim DI, Kim WS, Suh BS. gamma-Glutamyltransferase as a predictor of chronic kidney disease in nonhypertensive and nondiabetic Korean men. Clin Chem 2007; 53: 71-7.
21. Hamaguchi M, Kojima T, Itoh Y, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol 2007; 102: 2708-15.
22. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
23. Ota T, Takamura T, Hirai N, Kobayashi K. Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese. Diabetes Care 2002; 25: 1252-3.
24. Hashimoto Y, Tanaka M, Kimura T, et al. Hemoglobin concentration and incident metabolic syndrome: a population-based large-scale cohort study. Endocrine 2015; 50: 390-6.
25. Hashimoto Y, Tanaka M, Okada H, et al. Metabolically Healthy Obesity and Risk of Incident CKD. Clin J Am Soc Nephrol 2015; 10: 578-83.
26. Hermans MP, Bouenizabila E, Ahn SA, Rousseau MF. How to transform a metabolic syndrome score into an insulin sensitivity value? Diabetes Metab Res Rev 2016; 32: 87-94.
27. Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-51.
28. Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-92.
29. Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 2014; 146: 726-35.
30. Kojima S, Watanabe N, Numata M, Ogawa T, Matsuzaki S. Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background. J Gastroenterol 2003; 38: 954-61.
31. Frezza M, di PC, Pozzato G, et al. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med 1990; 322: 95-9.
32. Becker U, Deis A, Sørensen TI, et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology 1996; 23: 1025-9.
33. Mostafa SA, Davies MJ, Morris DH, et al. The Association of the Triglyceride-to-HDL Cholesterol Ratio with Insulin Resistance in White European and South Asian Men and Women. PLoS ONE 2012; 7: e50931.
34. Gasevic D, Frohlich J, Mancini GB, Lear SA. The association between triglyceride to high-density-lipoprotein cholesterol ratio and insulin resistance in a multiethnic primary prevention cohort. Metabolism 2012; 61: 583-9.