Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software

Seizure

Volumn 33, Issue , 2015, Pages 8-12

  Batchelor, Hannah ^a   Appleton, Richard ^b   Hawcutt, Daniel B ^b,c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Paediatric; PBPK modelling; Pharmacokinetics; Phenytoin

Indexed keywords

PHENYTOIN; ANTICONVULSIVE AGENT;

AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CHILD; COMPUTER PROGRAM; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG INFUSION; DRUG MONITORING; HUMAN; HUMAN EXPERIMENT; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; NORMAL HUMAN; PRIORITY JOURNAL; BIOLOGICAL MODEL; DOSE RESPONSE; EPILEPSY; INTRAVENOUS DRUG ADMINISTRATION; PEDIATRICS; PRESCHOOL CHILD; SOFTWARE;

ADMINISTRATION, INTRAVENOUS; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; HUMANS; MODELS, BIOLOGICAL; PEDIATRICS; PHENYTOIN; SOFTWARE;

EID: 84948949627     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2015.10.006     Document Type: Article

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