Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins

American Journal of Clinical Nutrition

Volumn 102, Issue 6, 2015, Pages 1468-1474

  Allen, Lindsay H ^a,b   Hampel, Daniela ^a,b   Shahab Ferdows, Setareh ^a   York, Emily R ^a,b   Adair, Linda S ^c   Flax, Valerie L ^c   Tegha, Gerald ^e   Chasela, Charles S ^e,f   Kamwendo, Debbie ^e   Jamieson, Denise J ^d   Bentley, Margaret E ^c  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of North Carolina   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^f UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Antiretrovirals; B vitamins; Breast milk; Human milk; Ultraperformance liquid chromatography tandem mass spectrometry

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYANOCOBALAMIN; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; NICOTINAMIDE; NICOTINIC ACID; PYRIDOXAL; PYRIDOXINE; RIBOFLAVIN; THIAMINE; FAT INTAKE; VITAMIN B COMPLEX;

ADULT; ARTICLE; BREAST MILK; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY REFERENCE INTAKE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID BASED NUTRIENT SUPPLEMENT; MAJOR CLINICAL STUDY; MALAWIAN; RANDOMIZED CONTROLLED TRIAL; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; DIETARY SUPPLEMENT; DRUG EFFECTS; FAT INTAKE; HIV INFECTIONS; LACTATION; MALAWI; MATERNAL NUTRITION; PRACTICE GUIDELINE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY COMPLICATIONS, INFECTIOUS; SECRETION (PROCESS); VITAMIN B DEFICIENCY; WORLD HEALTH ORGANIZATION; YOUNG ADULT;

ADULT; ANTI-HIV AGENTS; DIETARY FATS; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HUMANS; LACTATION; MALAWI; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MILK, HUMAN; PRACTICE GUIDELINES AS TOPIC; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY COMPLICATIONS, INFECTIOUS; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY; WORLD HEALTH ORGANIZATION; YOUNG ADULT;

EID: 84948799608     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.105106     Document Type: Article

References (38)

1. World Health Organization. Guidelines on HIV and infant feeding 2010: principles and recommendations for infant feeding in the context of HIV and a summary of evidence. Geneva (Switzerland): WHO; 2010
2. Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana. JAMA 2006;296:794-805
3. Palombi L, Marazzi MC, Voetberg A, Magid NA. Treatment acceleration program and the experience of the DREAM program in prevention of mother-to-child transmission of HIV. AIDS 2007;21: S65-71
4. Kilewo C, Karlsson K, Ngarina M, Massawe A, Lyamuya E, Swai A, Lipyoga R, Mhalu F, Biberfeld G. Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. J Acquir Immune Defic Syndr 2009;52:406-16
5. Peltier CA, Ndayisaba GF, Lepage P, Van Griensven J, Leroy V, Omes C, Ndimubanzi PC, Courteille O. Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal motherto-child transmission in Rwanda. AIDS 2009;23:2415-23
6. Shapiro RL, Hughes M, Ogwu A, Kitch D, Lockman S, Moffat C, Makhema J, Moyo S, Thior I, McIntosh K. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med 2010;362: 2282-94
7. Kumwenda NI, Hoover DR, Mofenson LM, Thigpen MC, Kafulafula G, Li Q, Mipando L, Nkanaunena K, Mebrahtu T, Bulterys M. Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008;359:119-29
8. Chasela CS, Hudgens MG, Jamieson DJ, Kayira D, Hosseinipour MC, Kourtis AP, Martinson F, Tegha G, Knight RJ, Ahmed YI. Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. N Engl J Med 2010;362:2271-81
9. Bedri A, Gudetta B, Isehak A, Kumbi S, Lulseged S, Mengistu Y. Six Week Extended-Dose Nevirapine (SWEN) Study Team. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet 2008;372:300-13
10. de Pee S, Semba RD. Role of nutrition in HIV infection: review of evidence for more effective programming in resource-limited settings. Food Nutr Bull 2010;31:313S-44S
11. Kayira D, Bentley ME, Wiener J, Mkhomawanthu C, King CC, Chitsulo P, Chigwenembe M, Ellington S, Hosseinipour MC, Kourtis AP. A lipidbased nutrient supplement mitigates weight loss among HIV-infected women in a factorial randomized trial to prevent mother-to-child transmission during exclusive breastfeeding. Am J Clin Nutr 2012;95:759-65
12. Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr 2012;3:362-9
13. Lartey A, Manu A, Brown KH, Dewey KG. Predictors of micronutrient status among six-to twelve-month-old breast-fed Ghanaian infants. J Nutr 2000;130:199-207
14. Allen LH, Graham JM. Assuring micronutrient adequacy in the diets of young infants. In: Delange FM, West KP Jr, editors. Micronutrient deficiencies in the first months of life. Basel (Switzerland): S. Karger AG; 2003. p. 55-88
15. Institute of Medicine. Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington (DC): National Academy Press; 1998
16. van der Horst C, Chasela C, Ahmed Y, Hoffman I, Hosseinipour M, Knight R, Fiscus S, Hudgens M, Kazembe P, Bentley M. Modifications of a large HIV prevention clinical trial to fit changing realities: a case study of the Breastfeeding, Antiretroviral, and Nutrition (BAN) protocol in Lilongwe, Malawi. Contemp Clin Trials 2009;30:24-33
17. Jamieson DJ, Chasela CS, Hudgens MG, King CC, Kourtis AP, Kayira D, Hosseinipour MC, Kamwendo DD, Ellington SR, Wiener JB, et al. Maternal and infant antiretroviral regimens to prevent postnatal HIV-1 transmission: 48-week follow-up of the BAN randomised controlled trial. Lancet 2012;379:2449-58
18. Phuka JC, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, Ashorn P. Postintervention growth of Malawian children who received 12-mo dietary complementation with a lipid-based nutrient supplement or maize-soy flour. Am J Clin Nutr 2009;89:382-90
19. Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002;16:1935-44
20. World Health Organization. HIV and infant feeding: guidelines for decision-makers. Geneva (Switzerland): WHO; 2003
21. Hampel D, York ER, Allen LH. Ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk. J Chromatogr B Analyt Technol Biomed Life Sci 2012;903:7-13
22. Stuetz W, Carrara VI, McGready R, Lee SJ, Biesalski HK, Nosten FH. Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population. PLoS One 2012;7:e36280
23. Stuetz W, Carrara VI, McGready R, Lee SJ, Erhardt JG, Breuer J, Biesalski HK, Nosten FH. Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp. Eur J Nutr 2012;51:425-34
24. Hampel D, Shahab-Ferdows S, Domek JM, Siddiqua T, Raqib R, Allen LH. Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk. Food Chem 2014;153:60-5
25. Roughead ZK, McCormick DB. Flavin composition of human milk. Am J Clin Nutr 1990;52:854-7
26. Sakurai T, Furukawa M, Asoh M, Kanno T, Kojima T, Yonekubo A. Fat-soluble and water-soluble vitamin contents of breast milk from Japanese women. J Nutr Sci Vitaminol (Tokyo) 2005;51:239-47
27. Thakwalakwa C, Ashorn P, Phuka J, Cheung YB, Briend A, Puumalainen T, Maleta K. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi. J Nutr 2010;140:2008-13
28. Young VR. Setting Dietary Reference Intakes for micronutrients for healthy North American infants: a process of trials and errors. In: Delange FM, West KP, eds. Micronutrient deficiencies in the first months of life. Basel (Switzerland): S. Karger AG; 2003. p. 35-53
29. Duggan C, Srinivasan K, Thomas T, Samuel T, Rajendran R, Muthayya S, Finkelstein JL, Lukose A, Fawzi W, Allen LH, et al. Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr 2014;144:758-64
30. Siddiqua TJ, Ahmad SM, Ahsan KB, Rashid M, Roy A, Rahman SM, Shahab-Ferdows S, Hampel D, Ahmed T, Allen LH, et al. Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. Eur J Nutr 2015 Feb 4 (Epub ahead of print; DOI:10.1007/s00394-015-0845-x)
31. Shapiro RL, Holland DT, Capparelli E, Lockman S, Thior I, Wester C, Stevens L, Peter T, Essex M, Connor JD. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis 2005;192:720-7
32. Corbett AH, Kayira D, White NR, Davis NL, Kourtis AP, Chasela C, Martinson F, Phiri G, Musisi B, Kamwendo D, et al. Antiretroviral pharmacokinetics in mothers and breastfeeding infants from 6 to 24 weeks post partum: results of the BAN Study. Antivir Ther 2014;19: 587-95
33. Zeh C, Weidle PJ, Nafisa L, Lwamba HM, Okonji J, Anyango E, Bondo P, Masaba R, Fowler MG, Nkengasong JN. HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis. PLoS Med 2011;8:e1000430
34. Ahmed S, Kim MH, Abrams EJ. Risks and benefits of lifelong antiretroviral treatment for pregnant and breastfeeding women: a review of the evidence for the Option B+ approach. Curr Opin HIVAIDS 2013;8: 474-89
35. World Health Organization. Use of antiretroviral drugs for treating pregnant women and preventing HIV infections in infants: executive summary. Geneva (Switzerland): WHO; 2012
36. Childs K, Welz T, Samarawickrama A, Post FA. Effects of vitamin D deficiency and combination antiretroviral therapy on bone in HIVpositive patients. AIDS 2012;26:253-62
37. Paltiel O, Falutz J, Veilleux M, Rosenblatt DS, Gordon K. Clinical correlates of subnormal vitamin B12 concentrations in patients infected with the human immunodeficiency virus. Am J Hematol 1995; 49:318-22
38. Woods MN, Tang AM, Forester J, Jones C, Hendricks K, Ding B, Knox TA. Effect of dietary intake and protease inhibitors on serum vitamin B12 levels in a cohort of human immunodeficiency virus-positive patients. Clin Infect Dis 2003;37:S124-31