메뉴 건너뛰기




Volumn , Issue , 2008, Pages 207-216

Mucus Hypersecretion and Mucus Clearance in Cough

Author keywords

Airway mucus; Cough; Mucociliary clearance; Mucus hypersecretion; Pathophysiology

Indexed keywords


EID: 84948799121     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470755846.ch20     Document Type: Chapter
Times cited : (4)

References (73)
  • 2
    • 0024315083 scopus 로고
    • Electrolyte and other chemical concentrations in tracheal airway surface liquid and mucus
    • Robinson NP, Kyle H, Webber SE et al. Electrolyte and other chemical concentrations in tracheal airway surface liquid and mucus. J Appl Physiol 1989; 66:2129-35.
    • (1989) J Appl Physiol , vol.66 , pp. 2129-2135
    • Robinson, N.P.1    Kyle, H.2    Webber, S.E.3
  • 3
    • 0030814886 scopus 로고    scopus 로고
    • Ion composition of airway surface liquid of patients with cystic fibrosis as compared to normal and disease-control subjects
    • Knowles M, Gatzy J, Boucher R. Ion composition of airway surface liquid of patients with cystic fibrosis as compared to normal and disease-control subjects. J Clin Invest 1997; 100: 2588-95.
    • (1997) J Clin Invest , vol.100 , pp. 2588-2595
    • Knowles, M.1    Gatzy, J.2    Boucher, R.3
  • 4
    • 0031026464 scopus 로고    scopus 로고
    • Airway and alveolar permeability and surface liquid thickness: theory
    • Widdicombe J. Airway and alveolar permeability and surface liquid thickness: theory. J Appl Physiol1997;82:3-12.
    • (1997) J Appl Physiol , vol.82 , pp. 3-12
    • Widdicombe, J.1
  • 5
    • 0032530370 scopus 로고    scopus 로고
    • Coordinated clearance of periciliary liquid and mucus from airway surface
    • Matsui H, Randell SH, Peretti SW et al. Coordinated clearance of periciliary liquid and mucus from airway surface. J Clin Invest 1998; 102: 1125-31.
    • (1998) J Clin Invest , vol.102 , pp. 1125-1131
    • Matsui, H.1    Randell, S.H.2    Peretti, S.W.3
  • 6
    • 0012565134 scopus 로고
    • Mucociliary clearance
    • Parent RA, ed, Boca Raton, FL:CRC Press
    • Wolff RK. Mucociliary clearance. In: Parent RA, ed. Comparative Biology of the Normal Lung. Boca Raton, FL:CRC Press, 1992: 659-80.
    • (1992) Comparative Biology of the Normal Lung , pp. 659-680
    • Wolff, R.K.1
  • 7
    • 0018869447 scopus 로고
    • Measurement of tracheal and bronchial mucus velocities in man:relation to lung clearance
    • Foster WM, Langenback EG, Bergofsky EH. Measurement of tracheal and bronchial mucus velocities in man:relation to lung clearance. J Appl Physiol 1980; 48:965-71.
    • (1980) J Appl Physiol , vol.48 , pp. 965-971
    • Foster, W.M.1    Langenback, E.G.2    Bergofsky, E.H.3
  • 8
    • 0025630699 scopus 로고
    • Coughenhanced mucus clearance in the normal lung
    • Bennett WD, Foster WM, Chapman WF. Coughenhanced mucus clearance in the normal lung. J Appl Physiol 1990; 69: 1670-5.
    • (1990) J Appl Physiol , vol.69 , pp. 1670-1675
    • Bennett, W.D.1    Foster, W.M.2    Chapman, W.F.3
  • 9
    • 0009716741 scopus 로고    scopus 로고
    • Cough and mucociliary transport of airway particulate in chronic obstructive lung disease
    • Groth ML, Macri K, Foster WM. Cough and mucociliary transport of airway particulate in chronic obstructive lung disease. Ann Occup Hyg 1997: 41 (S): 515-21.
    • (1997) Ann Occup Hyg , vol.41 , pp. 515-521
    • Groth, M.L.1    Macri, K.2    Foster, W.M.3
  • 10
    • 0000385474 scopus 로고
    • Measurement of the bronchial mucous gland layer a diagnostic yardstick in chronic bronchitis
    • Reid L. Measurement of the bronchial mucous gland layer a diagnostic yardstick in chronic bronchitis. Thorax 1960; 15: 132-41.
    • (1960) Thorax , vol.15 , pp. 132-141
    • Reid, L.1
  • 11
    • 0001934613 scopus 로고
    • The daily amount of tracheo-bronchial secretions in man
    • Toremalm NG. The daily amount of tracheo-bronchial secretions in man. Acta Otolaryngol 1960: 158 (S):43-53.
    • (1960) Acta Otolaryngol , vol.158 , pp. 43-53
    • Toremalm, N.G.1
  • 12
    • 0026604702 scopus 로고
    • Functions of proteins and lipids in airway secretions
    • Jacquot J, Hayem A, Galabert C. Functions of proteins and lipids in airway secretions. Eur Respir J 1992; 5:343-58.
    • (1992) Eur Respir J , vol.5 , pp. 343-358
    • Jacquot, J.1    Hayem, A.2    Galabert, C.3
  • 14
    • 0002619368 scopus 로고    scopus 로고
    • Airway mucus and mucociliary system
    • Middleton E, Reed CE, Busse WW, eds, St Louis, MO: CV Mosby
    • Fahy JV. Airway mucus and mucociliary system. In:Middleton E, Reed CE, Busse WW, eds. Allergy Principles and Practice. St Louis, MO: CV Mosby, 1998: 520-31.
    • (1998) Allergy Principles and Practice , pp. 520-531
    • Fahy, J.V.1
  • 15
    • 0035798685 scopus 로고    scopus 로고
    • MARCKS protein is a key molecule regulating mucin secretion in human airway epithelial cells in vitro
    • Li Y, Martin LD, Spizz G et al. MARCKS protein is a key molecule regulating mucin secretion in human airway epithelial cells in vitro. J Biol Chem 2001; 276: 40982-90.
    • (2001) J Biol Chem , vol.276 , pp. 40982-40990
    • Li, Y.1    Martin, L.D.2    Spizz, G.3
  • 16
    • 0027956153 scopus 로고
    • Airway goblet cell: responsive and adaptable front-line defenders
    • Rogers DF. Airway goblet cell: responsive and adaptable front-line defenders. Eur Respir J 1994; 7: 1690-706.
    • (1994) Eur Respir J , vol.7 , pp. 1690-1706
    • Rogers, D.F.1
  • 17
    • 0034069787 scopus 로고    scopus 로고
    • Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies
    • Nadel JA. Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies. Chest 2000; 117: 386S-89S.
    • (2000) Chest , vol.117 , pp. 386S-389S
    • Nadel, J.A.1
  • 18
  • 19
    • 0022388267 scopus 로고
    • Alteration of airway reactivity by mucus
    • King M, Kelly S, Cosio M. Alteration of airway reactivity by mucus. Respir Physiol 1985; 62: 47-59.
    • (1985) Respir Physiol , vol.62 , pp. 47-59
    • King, M.1    Kelly, S.2    Cosio, M.3
  • 20
    • 0024268336 scopus 로고
    • Airway responsiveness to inhaled and intravenous carbachol in sheep: effect of airway mucus
    • Kim CS, Eldridge MA, Wanner A. Airway responsiveness to inhaled and intravenous carbachol in sheep: effect of airway mucus. J Appl Physiol 1988; 65: 2744-51.
    • (1988) J Appl Physiol , vol.65 , pp. 2744-2751
    • Kim, C.S.1    Eldridge, M.A.2    Wanner, A.3
  • 21
    • 4243525592 scopus 로고
    • Mucus production and the ciliary escalator
    • Witschi H, Nettersheim P, eds, Boca Raton, FL: CRC Press
    • Last JA. Mucus production and the ciliary escalator. In:Witschi H, Nettersheim P, eds. Mechanisms in Respiratory Toxicology, Vol. 1. Boca Raton, FL: CRC Press, 1982:247-60.
    • (1982) Mechanisms in Respiratory Toxicology , vol.1 , pp. 247-260
    • Last, J.A.1
  • 22
    • 0021827413 scopus 로고
    • Ultrastructural organization of intraepithelial nerves in human airway tract
    • Laitinen A. Ultrastructural organization of intraepithelial nerves in human airway tract. Thorax 1985; 40: 488-92.
    • (1985) Thorax , vol.40 , pp. 488-492
    • Laitinen, A.1
  • 23
    • 0020354141 scopus 로고
    • Muscarinic receptors in lung and trachea: autoradiographic localization using quinuclidinyl benzilate
    • Barnes PJ, Nadel JA, Roberts JM, Basbaum CB. Muscarinic receptors in lung and trachea: autoradiographic localization using quinuclidinyl benzilate. Eur J Pharmacol 1983; 86: 103-6.
    • (1983) Eur J Pharmacol , vol.86 , pp. 103-106
    • Barnes, P.J.1    Nadel, J.A.2    Roberts, J.M.3    Basbaum, C.B.4
  • 24
    • 0020629879 scopus 로고
    • Adrenergic and cholinergic receptors in submucosal glands in ferret trachea: autoradiographic localization
    • Basbaum CB, Barnes PJ, Grillo M et al. Adrenergic and cholinergic receptors in submucosal glands in ferret trachea: autoradiographic localization. Eur J Respir Dis 1983; 64: 433-5.
    • (1983) Eur J Respir Dis , vol.64 , pp. 433-435
    • Basbaum, C.B.1    Barnes, P.J.2    Grillo, M.3
  • 25
    • 0021242150 scopus 로고
    • Muscarinic receptors: evidence for a non-uniform distribution in tracheal smooth muscle and exocrine glands
    • Basbaum CB, Grillo M, Widdicombe JH. Muscarinic receptors: evidence for a non-uniform distribution in tracheal smooth muscle and exocrine glands. J Neurol Sci 1984; 4: 508-20.
    • (1984) J Neurol Sci , vol.4 , pp. 508-520
    • Basbaum, C.B.1    Grillo, M.2    Widdicombe, J.H.3
  • 26
    • 0021042173 scopus 로고
    • Mapping of adrenergic receptors in mammalian trachea using an autoradiographic method
    • Barnes PJ, Basbaum CB. Mapping of adrenergic receptors in mammalian trachea using an autoradiographic method. Exp Lung Res 1983; 5: 183-92.
    • (1983) Exp Lung Res , vol.5 , pp. 183-192
    • Barnes, P.J.1    Basbaum, C.B.2
  • 27
    • 0026889012 scopus 로고
    • A technique to harvest viable tracheo-bronchial epithelial cells from living human donors
    • Kelsen SG, Mardini IA, Zhou S et al. A technique to harvest viable tracheo-bronchial epithelial cells from living human donors. Am J Respir Cell Mol Biol 1992; 67:66-72.
    • (1992) Am J Respir Cell Mol Biol , vol.67 , pp. 66-72
    • Kelsen, S.G.1    Mardini, I.A.2    Zhou, S.3
  • 28
    • 0022444841 scopus 로고
    • Visualization of vasoactive intestinal peptide receptors in human and guinea-pig lung
    • Carstairs JR, Barnes PJ. Visualization of vasoactive intestinal peptide receptors in human and guinea-pig lung. J Pharmacol Exp Ther 1986; 239: 240-55.
    • (1986) J Pharmacol Exp Ther , vol.239 , pp. 240-255
    • Carstairs, J.R.1    Barnes, P.J.2
  • 29
    • 0009715168 scopus 로고
    • Innervation of the airway mucosa and submucosa
    • Basbaum C. Innervation of the airway mucosa and submucosa. Semin Respir Med 1995; 308: 313.
    • (1995) Semin Respir Med , vol.308 , pp. 313
    • Basbaum, C.1
  • 30
    • 14444272786 scopus 로고    scopus 로고
    • Increased VIPpositive nerve fibers in the mucous glands of subjects with chronic bronchitis
    • Lucchini RE, Facchini F, Turato G et al. Increased VIPpositive nerve fibers in the mucous glands of subjects with chronic bronchitis. Am J Respir Crit Care Med 1997; 156:1963-8.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1963-1968
    • Lucchini, R.E.1    Facchini, F.2    Turato, G.3
  • 31
    • 0026043045 scopus 로고
    • Neuropeptides in the respiratory tract. I. State of art
    • Barnes PJ, Barianuk JN, Belvisi MG. Neuropeptides in the respiratory tract. I. State of art. Am Rev Respir Dis 1991; 144: 1187-98.
    • (1991) Am Rev Respir Dis , vol.144 , pp. 1187-1198
    • Barnes, P.J.1    Barianuk, J.N.2    Belvisi, M.G.3
  • 32
    • 0026529001 scopus 로고
    • Influence of inhaled atropine on lung mucociliary function in humans
    • Groth ML, Langenback EG, Foster WM. Influence of inhaled atropine on lung mucociliary function in humans. Am Rev Respir Dis 1992; 145: 215-9.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 215-219
    • Groth, M.L.1    Langenback, E.G.2    Foster, W.M.3
  • 33
    • 0017188802 scopus 로고
    • Effect of adrenergic agents and their mode of action on mucociliary clearance
    • Foster WM, Bergofsky EH, Bohning D et al. Effect of adrenergic agents and their mode of action on mucociliary clearance. J Appl Physiol 1876; 41: 146-52.
    • (1876) J Appl Physiol , vol.41 , pp. 146-152
    • Foster, W.M.1    Bergofsky, E.H.2    Bohning, D.3
  • 34
    • 0016264748 scopus 로고
    • Increased mucociliary transport by cholinergic stimulation
    • Camner P, Strandberg K, Philipson K. Increased mucociliary transport by cholinergic stimulation. Arch Environ Health 1974; 29: 220-4.
    • (1974) Arch Environ Health , vol.29 , pp. 220-224
    • Camner, P.1    Strandberg, K.2    Philipson, K.3
  • 35
    • 0023784119 scopus 로고
    • The effect of inhaled histamine on human tracheal mucus velocity and bronchial mucociliary clearance
    • Mussato DJ, Garrard CS, Lourenco RV. The effect of inhaled histamine on human tracheal mucus velocity and bronchial mucociliary clearance. Am Rev Respir Dis 1988; 138: 775-9.
    • (1988) Am Rev Respir Dis , vol.138 , pp. 775-779
    • Mussato, D.J.1    Garrard, C.S.2    Lourenco, R.V.3
  • 36
    • 0014864776 scopus 로고
    • Resistance to two-phase gas-liquid flow in airways
    • Clarke SW, Jones JG, Oliver DR. Resistance to two-phase gas-liquid flow in airways. J Appl Physiol 1970; 29:464-71.
    • (1970) J Appl Physiol , vol.29 , pp. 464-471
    • Clarke, S.W.1    Jones, J.G.2    Oliver, D.R.3
  • 37
    • 0022618708 scopus 로고
    • Cough: physiology, evaluation, and treatment
    • Banner AS. Cough: physiology, evaluation, and treatment. Lung 1986; 164: 79-92.
    • (1986) Lung , vol.164 , pp. 79-92
    • Banner, A.S.1
  • 38
    • 0018756032 scopus 로고
    • Elimination of test particles from the human tracheobronchial tract by voluntary coughing
    • Camner P, Mossberg M, Philipson K et al. Elimination of test particles from the human tracheobronchial tract by voluntary coughing. Scand J Respir Dis 1979; 60:56-62.
    • (1979) Scand J Respir Dis , vol.60 , pp. 56-62
    • Camner, P.1    Mossberg, M.2    Philipson, K.3
  • 39
    • 10544248232 scopus 로고
    • Mucociliary tracheal transport rates in man
    • Yeates D, Aspin N, Levinson H et al. Mucociliary tracheal transport rates in man. J Appl Physiol 1975; 39: 47-95.
    • (1975) J Appl Physiol , vol.39 , pp. 47-95
    • Yeates, D.1    Aspin, N.2    Levinson, H.3
  • 40
    • 0018146668 scopus 로고
    • Fluid mechanical experiments relevant to coughing
    • Scherer P, Burtz L. Fluid mechanical experiments relevant to coughing. J Biomech 1978; 11: 183-7.
    • (1978) J Biomech , vol.11 , pp. 183-187
    • Scherer, P.1    Burtz, L.2
  • 41
    • 0017737413 scopus 로고
    • Effects of exercise and eucapnic hyperventilation on bronchial clearance in man
    • Wolff RK, Dolovich MB, Obminski G, Newhouse MT. Effects of exercise and eucapnic hyperventilation on bronchial clearance in man. J Appl Physiol 1977;43:46-50.
    • (1977) J Appl Physiol , vol.43 , pp. 46-50
    • Wolff, R.K.1    Dolovich, M.B.2    Obminski, G.3    Newhouse, M.T.4
  • 42
    • 0029156366 scopus 로고
    • Neurophysiology of the cough reflex
    • Widdicombe JG. Neurophysiology of the cough reflex. Eur Respir J 1995; 8: 1193-202.
    • (1995) Eur Respir J , vol.8 , pp. 1193-1202
    • Widdicombe, J.G.1
  • 44
    • 0027450966 scopus 로고
    • The acute effect of ipratropium bromide bronchodilator therapy on cough clearance in COPD
    • Bennett WD, Chapman WF, Mascarella JM. The acute effect of ipratropium bromide bronchodilator therapy on cough clearance in COPD. Chest 1993; 103: 488-95.
    • (1993) Chest , vol.103 , pp. 488-495
    • Bennett, W.D.1    Chapman, W.F.2    Mascarella, J.M.3
  • 45
    • 0025319534 scopus 로고
    • Chronic cough: spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy
    • Irwin RS, Curley FJ, French CL. Chronic cough: spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990; 141: 640-7.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 640-647
    • Irwin, R.S.1    Curley, F.J.2    French, C.L.3
  • 46
    • 0034477390 scopus 로고    scopus 로고
    • Inhaled isotonic alkaline versus saline solution and radioaerosol clearance in chronic cough
    • Haidl P, Schonhofer B, Kohler D. Inhaled isotonic alkaline versus saline solution and radioaerosol clearance in chronic cough. Eur Respir J 2000; 16: 1102-8.
    • (2000) Eur Respir J , vol.16 , pp. 1102-1108
    • Haidl, P.1    Schonhofer, B.2    Kohler, D.3
  • 47
    • 0009716741 scopus 로고    scopus 로고
    • Cough and mucociliary transport of airway particulate in chronic obstructive lung disease
    • Groth ML, Macri K, Foster WM. Cough and mucociliary transport of airway particulate in chronic obstructive lung disease. Ann Occup Hyg 1997; 41(S1): 515-21.
    • (1997) Ann Occup Hyg , vol.41 , pp. 515-521
    • Groth, M.L.1    Macri, K.2    Foster, W.M.3
  • 48
    • 0027331602 scopus 로고
    • Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis
    • Linden M, Ramussen JB, Piitulainen E et al. Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis. Am Rev Resp Dis1993;148: 1226-32.
    • (1993) Am Rev Resp Dis , vol.148 , pp. 1226-1232
    • Linden, M.1    Ramussen, J.B.2    Piitulainen, E.3
  • 50
    • 0020619644 scopus 로고
    • The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease
    • Peto R, Speizer FE, Cochrane AL et al. The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Am Rev Respir Dis 1983; 128: 491-500.
    • (1983) Am Rev Respir Dis , vol.128 , pp. 491-500
    • Peto, R.1    Speizer, F.E.2    Cochrane, A.L.3
  • 51
    • 0017816443 scopus 로고
    • The relationship between structural changes in small airways and pulmonary function tests
    • Cosio M, Ghezo H, Hogg JC et al. The relationship between structural changes in small airways and pulmonary function tests. N Engl J Med 1978; 298: 1277-81.
    • (1978) N Engl J Med , vol.298 , pp. 1277-1281
    • Cosio, M.1    Ghezo, H.2    Hogg, J.C.3
  • 52
    • 0029947193 scopus 로고    scopus 로고
    • Copenhagen City Heart Study Group. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive disease mortality
    • Vestbo J, Prescott E, Lange P. Copenhagen City Heart Study Group. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive disease mortality. Am J Respir Crit Care Med 1996; 153: 1530-5.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1530-1535
    • Vestbo, J.1    Prescott, E.2    Lange, P.3
  • 53
    • 0021817853 scopus 로고
    • Disassociation of mucociliary function in central and peripheral airways of asymptomatic smokers
    • Foster WM, Langenback EG, Bergofsky EH. Disassociation of mucociliary function in central and peripheral airways of asymptomatic smokers. Am Rev Respir Dis 1985; 132: 633-9.
    • (1985) Am Rev Respir Dis , vol.132 , pp. 633-639
    • Foster, W.M.1    Langenback, E.G.2    Bergofsky, E.H.3
  • 54
    • 0009705571 scopus 로고
    • Pathologic changes in the peripheral airways of young cigarette smokers
    • Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974; 153: 629-32.
    • (1974) N Engl J Med , vol.153 , pp. 629-632
    • Niewoehner, D.E.1    Kleinerman, J.2    Rice, D.B.3
  • 55
    • 0027210915 scopus 로고
    • Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease
    • Smaldone GC, Foster WM, O'Riordan TG et al. Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease. Chest 1993; 103: 1390-6.
    • (1993) Chest , vol.103 , pp. 1390-1396
    • Smaldone, G.C.1    Foster, W.M.2    O'Riordan, T.G.3
  • 56
    • 0015846442 scopus 로고
    • Tracheobronchial clearance and chronic obstructive lung disease
    • Camner P, Mossberg B, Philipson K. Tracheobronchial clearance and chronic obstructive lung disease. Scand J Respir Dis 1978; 54: 272-81.
    • (1978) Scand J Respir Dis , vol.54 , pp. 272-281
    • Camner, P.1    Mossberg, B.2    Philipson, K.3
  • 57
    • 0017333985 scopus 로고
    • Tracheobronchial clearance and beta agonist stimulation in patients with chronic bronchitis
    • Mossberg B, Strandberg K, Philipson K et al. Tracheobronchial clearance and beta agonist stimulation in patients with chronic bronchitis. Scand J Respir Dis 1976; 57: 281-9.
    • (1976) Scand J Respir Dis , vol.57 , pp. 281-289
    • Mossberg, B.1    Strandberg, K.2    Philipson, K.3
  • 58
    • 0019198615 scopus 로고
    • Mucociliary transport in vivo and in vitro: relations to sputum properties in chronic bronchitis
    • Puchele E, Zahm JM, Girard F et al. Mucociliary transport in vivo and in vitro: relations to sputum properties in chronic bronchitis. Eur J Respir Dis 1980; 61: 254-64.
    • (1980) Eur J Respir Dis , vol.61 , pp. 254-264
    • Puchele, E.1    Zahm, J.M.2    Girard, F.3
  • 59
    • 0009715171 scopus 로고
    • Help for an overtaxed mucociliary system:managing abnormal mucus
    • Ziment I. Help for an overtaxed mucociliary system:managing abnormal mucus. J Respir Dis 1991; 12: 21-33.
    • (1991) J Respir Dis , vol.12 , pp. 21-33
    • Ziment, I.1
  • 60
    • 0035954121 scopus 로고    scopus 로고
    • Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review
    • Poole PJ, Black PN. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. Br Med J 2001; 322: 1271-83.
    • (2001) Br Med J , vol.322 , pp. 1271-1283
    • Poole, P.J.1    Black, P.N.2
  • 61
    • 0030058496 scopus 로고    scopus 로고
    • Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma
    • Shimure S, Andoh Y, Haraguchi M et al. Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. Eur Respir J 1996; 9:1395-401.
    • (1996) Eur Respir J , vol.9 , pp. 1395-1401
    • Shimure, S.1    Andoh, Y.2    Haraguchi, M.3
  • 62
    • 0029611346 scopus 로고
    • Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus
    • Sheehan JK, Richardson PS, Fung DC et al. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol 1995; 13: 748-56.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 748-756
    • Sheehan, J.K.1    Richardson, P.S.2    Fung, D.C.3
  • 63
    • 0018647505 scopus 로고
    • Imaging sites of airway obstruction and measuring functional responses to bronchodilator treatment in asthma
    • Chopra SK, Taplin GV, Tashkin DP et al. Imaging sites of airway obstruction and measuring functional responses to bronchodilator treatment in asthma. Thorax 1979; 34:493-500.
    • (1979) Thorax , vol.34 , pp. 493-500
    • Chopra, S.K.1    Taplin, G.V.2    Tashkin, D.P.3
  • 64
    • 0021350113 scopus 로고
    • Radionuclide demonstration of ventilatory abnormalities in mild asthma
    • Agnew JE, Bateman JRM, Pavia D et al. Radionuclide demonstration of ventilatory abnormalities in mild asthma. Clin Sci 1984; 66: 525-31.
    • (1984) Clin Sci , vol.66 , pp. 525-531
    • Agnew, J.E.1    Bateman, J.R.M.2    Pavia, D.3
  • 65
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordonez CL, Khashayar R, Wong HH et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001; 163: 517-23.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3
  • 66
    • 0023048730 scopus 로고
    • Airway mucus membrane: effects of beta-adrenergic and anticholinergic stimulations
    • Foster WM, Bergofsky EH. Airway mucus membrane: effects of beta-adrenergic and anticholinergic stimulations. Am J Med 1986; 81 (S5A): 28-35.
    • (1986) Am J Med , vol.81 , pp. 28-35
    • Foster, W.M.1    Bergofsky, E.H.2
  • 67
    • 84948806326 scopus 로고
    • Targeting of therapeutic aerosols in asthma: is poor penetration of aerosols associated with mucociliary dysfunction in central airways?
    • Groth ML, Ackner V, Foster WM. Targeting of therapeutic aerosols in asthma: is poor penetration of aerosols associated with mucociliary dysfunction in central airways? Am Rev Respir Dis 1991; 143:A634.
    • (1991) Am Rev Respir Dis , vol.143 , pp. A634
    • Groth, M.L.1    Ackner, V.2    Foster, W.M.3
  • 68
    • 84948757350 scopus 로고
    • Computer generated scintigraphy and mucociliary clearance in healthy and asthmatic patients
    • Mussato DJ, Chakravarthy VS, Masssey VJ et al. Computer generated scintigraphy and mucociliary clearance in healthy and asthmatic patients. Am Rev Respir Dis 1989; 139: A142.
    • (1989) Am Rev Respir Dis , vol.139 , pp. A142
    • Mussato, D.J.1    Chakravarthy, V.S.2    Masssey, V.J.3
  • 70
    • 0025847373 scopus 로고
    • Changes in mucociliary clearance during acute exacerbations of asthma
    • Messina MS, O'Riordan TG, Smaldone GC. Changes in mucociliary clearance during acute exacerbations of asthma. Am Rev Respir Dis 1991; 143: 993-7.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 993-997
    • Messina, M.S.1    O'Riordan, T.G.2    Smaldone, G.C.3
  • 71
    • 0034113824 scopus 로고    scopus 로고
    • State of the art:asthma from bronchoconstriction to airways inflammation and remodeling
    • Bousquet J, Jeffery PK, Busse WW et al. State of the art:asthma from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000; 161: 1720-45.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1720-1745
    • Bousquet, J.1    Jeffery, P.K.2    Busse, W.W.3
  • 73
    • 0035131224 scopus 로고    scopus 로고
    • Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
    • Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001; 163:511-6.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 511-516
    • Takeyama, K.1    Fahy, J.V.2    Nadel, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.