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Volumn , Issue , 2008, Pages 386-399

Numbers Needed to Treat Derived from Meta-Analyses: Pitfalls and Cautions

Author keywords

Clinical setting; Meta analyses; Risk reductions; Systematic reviews; Treatment

Indexed keywords


EID: 84948762703     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470693926.ch20     Document Type: Chapter
Times cited : (12)

References (40)
  • 1
    • 0028908929 scopus 로고
    • The number needed to treat: a clinically useful measure of treatment effect
    • Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ 1995;310:452-4.
    • (1995) BMJ , vol.310 , pp. 452-454
    • Cook, R.J.1    Sackett, D.L.2
  • 2
    • 0023887476 scopus 로고
    • An assessment of clinically useful measures of the consequences of treatment
    • Laupacis A, Sackett DL, Roberts RS. An assessment of clinically useful measures of the consequences of treatment. N Engl J Med 1988;318:1728-33.
    • (1988) N Engl J Med , vol.318 , pp. 1728-1733
    • Laupacis, A.1    Sackett, D.L.2    Roberts, R.S.3
  • 3
    • 0029996601 scopus 로고    scopus 로고
    • Number-needed-to-treat analysis of the prevention of myocardial infarction and death by antidyslipidemic therapy
    • Rembold CM. Number-needed-to-treat analysis of the prevention of myocardial infarction and death by antidyslipidemic therapy. J Fam Practice 1996;42:577-86.
    • (1996) J Fam Practice , vol.42 , pp. 577-586
    • Rembold, C.M.1
  • 4
    • 33749210306 scopus 로고    scopus 로고
    • Review: statins prevent stroke, especially in patients with coronary heart disease
    • Review: statins prevent stroke, especially in patients with coronary heart disease. Evidence-Based Med 1998;3:10.
    • (1998) Evidence-Based Med , vol.3 , pp. 10
  • 5
    • 0030979149 scopus 로고    scopus 로고
    • Reductase inhibitor monotherapy and stroke prevention
    • Crouse JR III, Byington RP, Hoen HM, et al. Reductase inhibitor monotherapy and stroke prevention. Arch Intern Med 1997;157:1305-10.
    • (1997) Arch Intern Med , vol.157 , pp. 1305-1310
    • Crouse, J.R.1    Byington, R.P.2    Hoen, H.M.3
  • 6
    • 0003638576 scopus 로고    scopus 로고
    • Available in The Cochrane Library (database on disk and CDROM). The Cochrane Collaboration Issue 2. Oxford: Update Software
    • The Cochrane Database of Systematic Reviews. Available in The Cochrane Library (database on disk and CDROM). The Cochrane Collaboration Issue 2. Oxford: Update Software, 1999.
    • (1999) The Cochrane Database of Systematic Reviews
  • 7
    • 0032511955 scopus 로고    scopus 로고
    • for the North American Symptomatic Carotid Endarterectomy Trial Collaborators. Benefit of carotid endarterectomy in symptomatic patients with moderate or severe carotid stenosis
    • Barnett HJ, Taylor DW, Eliasziw M, et al. for the North American Symptomatic Carotid Endarterectomy Trial Collaborators. Benefit of carotid endarterectomy in symptomatic patients with moderate or severe carotid stenosis. N Engl J Med 1998;339:1415-25.
    • (1998) N Engl J Med , vol.339 , pp. 1415-1425
    • Barnett, H.J.1    Taylor, D.W.2    Eliasziw, M.3
  • 8
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. Results of AFCAPS/TexCAPS
    • Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. Results of AFCAPS/TexCAPS. JAMA 1998;279:1615-22.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 9
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia
    • Shepherd J, Cobbe S, Ford E, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. N Engl J Med 1995;333:1301-7.
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.2    Ford, E.3
  • 10
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
    • 4S Scandinavian Simvastatin Survival Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-9.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 11
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996;14:1001-9.
    • (1996) N Engl J Med , vol.14 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 12
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischemic Heart Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;339:1349-57.
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 13
    • 0013628077 scopus 로고    scopus 로고
    • Statins
    • Anonymous
    • Anonymous. Statins. Bandolier 1998;47:2-4.
    • (1998) Bandolier , vol.47 , pp. 2-4
  • 14
    • 0032494717 scopus 로고    scopus 로고
    • Confidence intervals for the number needed to treat
    • Altman DG. Confidence intervals for the number needed to treat. BMJ 1998;317:1309-12.
    • (1998) BMJ , vol.317 , pp. 1309-1312
    • Altman, D.G.1
  • 15
    • 0028120906 scopus 로고
    • Collaborative overview of randomized trials of antiplatelet therapy - I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomized trials of antiplatelet therapy - I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994;308:81-106.
    • (1994) BMJ , vol.308 , pp. 81-106
  • 16
    • 0021909115 scopus 로고
    • Beta blockade during and after myocardial infarction: an overview of the randomized trials
    • Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985;27:335-71.
    • (1985) Prog Cardiovasc Dis , vol.27 , pp. 335-371
    • Yusuf, S.1    Peto, R.2    Lewis, J.3    Collins, R.4    Sleight, P.5
  • 18
    • 0032759117 scopus 로고    scopus 로고
    • The number needed to treat: does it help clinical decision making?
    • Ebrahim S, Davey Smith G. The number needed to treat: does it help clinical decision making? J Human Hypertens 1999;13:721-4.
    • (1999) J Human Hypertens , vol.13 , pp. 721-724
    • Ebrahim, S.1    Davey Smith, G.2
  • 19
    • 0019442256 scopus 로고
    • British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns
    • Shaper AG, Pocock SJ, Walker M, Cohen NM, Wale CJ, Thomson AG. British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns. BMJ 1981;283:179-86.
    • (1981) BMJ , vol.283 , pp. 179-186
    • Shaper, A.G.1    Pocock, S.J.2    Walker, M.3    Cohen, N.M.4    Wale, C.J.5    Thomson, A.G.6
  • 21
    • 0011656465 scopus 로고    scopus 로고
    • Antihypertensive drug therapy in the elderly
    • Oxford: Update Software
    • Mulrow C, Lau J, Cornell J, Brand B. Antihypertensive drug therapy in the elderly. The Cochrane Library Issue 2. Oxford: Update Software, 1998.
    • (1998) The Cochrane Library , Issue.2
    • Mulrow, C.1    Lau, J.2    Cornell, J.3    Brand, B.4
  • 22
    • 0003178838 scopus 로고
    • MRC Trial of mild hypertension: principal findings
    • Medical Research Council Working Group. MRC Trial of mild hypertension: principal findings. BMJ 1985;291:97-104.
    • (1985) BMJ , vol.291 , pp. 97-104
  • 23
    • 0018570975 scopus 로고
    • Five-year findings of the Hypertension Detection and Follow-up Program. II. Mortality by race-sex and age
    • Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the Hypertension Detection and Follow-up Program. II. Mortality by race-sex and age. JAMA 1979;242:2572-7.
    • (1979) JAMA , vol.242 , pp. 2572-2577
  • 24
    • 0027754610 scopus 로고
    • The statistical basis of meta-analysis
    • Fleiss JL. The statistical basis of meta-analysis. Stat Meth Med Res 1993;2:121-45.
    • (1993) Stat Meth Med Res , vol.2 , pp. 121-145
    • Fleiss, J.L.1
  • 25
    • 0030720013 scopus 로고    scopus 로고
    • Meta-analysis: principles and procedures
    • Egger M, Davey Smith G, Phillips AN. Meta-analysis: principles and procedures. BMJ 1997;315:1533-7.
    • (1997) BMJ , vol.315 , pp. 1533-1537
    • Egger, M.1    Davey Smith, G.2    Phillips, A.N.3
  • 26
    • 84948813641 scopus 로고    scopus 로고
    • Poor reporting of length of follow up in clinical trials and systematic reviews
    • 25 June
    • D'Amico R, Deeks JJ, Altman DG. Poor reporting of length of follow up in clinical trials and systematic reviews. eBMJ 25 June 1999 http://www.bmj.com/cgi/eletters/318/7197/1548.
    • (1999) eBMJ
    • D'Amico, R.1    Deeks, J.J.2    Altman, D.G.3
  • 27
    • 0030736025 scopus 로고    scopus 로고
    • Strategies for the management of hypercholesterolaemia: a systematic review of the cost-effectiveness literature
    • Morris S, McGuire A, Caro J, Pettitt D. Strategies for the management of hypercholesterolaemia: a systematic review of the cost-effectiveness literature. J Health Serv Res Policy 1997;2:231-50.
    • (1997) J Health Serv Res Policy , vol.2 , pp. 231-250
    • Morris, S.1    McGuire, A.2    Caro, J.3    Pettitt, D.4
  • 28
    • 0030018049 scopus 로고    scopus 로고
    • Guidelines for managing raised blood pressure
    • Jackson RT, Sackett DL. Guidelines for managing raised blood pressure. BMJ 1996;313:64-5.
    • (1996) BMJ , vol.313 , pp. 64-65
    • Jackson, R.T.1    Sackett, D.L.2
  • 29
    • 0041295664 scopus 로고    scopus 로고
    • Meta-analysis: Beyond the grand mean?
    • Davey Smith G, Egger M, Phillips AN. Meta-analysis: Beyond the grand mean? BMJ 1997;315:1610-14.
    • (1997) BMJ , vol.315 , pp. 1610-1614
    • Davey Smith, G.1    Egger, M.2    Phillips, A.N.3
  • 30
    • 0029023726 scopus 로고
    • Can overall results of clinical trials be applied to all patients?
    • Rothwell PM. Can overall results of clinical trials be applied to all patients? Lancet 1995;345:1616-19.
    • (1995) Lancet , vol.345 , pp. 1616-1619
    • Rothwell, P.M.1
  • 31
    • 0029785769 scopus 로고    scopus 로고
    • The relation between treatment benefit and underlying risk in meta-analysis
    • Sharp SJ, Thompson SG, Altman DG. The relation between treatment benefit and underlying risk in meta-analysis. BMJ 1996;313:735-8.
    • (1996) BMJ , vol.313 , pp. 735-738
    • Sharp, S.J.1    Thompson, S.G.2    Altman, D.G.3
  • 32
    • 0029057799 scopus 로고
    • Early or deferred zidovudine therapy in HIVinfected patients without AIDS defining illness
    • Ioannidis JP, Cappelleri JC, Lau J, et al. Early or deferred zidovudine therapy in HIVinfected patients without AIDS defining illness. Ann Intern Med 1995;122:856-66.
    • (1995) Ann Intern Med , vol.122 , pp. 856-866
    • Ioannidis, J.P.1    Cappelleri, J.C.2    Lau, J.3
  • 33
    • 0000093848 scopus 로고    scopus 로고
    • Beta-blockade after myocardial infarction: systematic review and meta regression analysis
    • Freemantle N, Cleland J, Young P, Mason J, Harrison J. Beta-blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 1999;318:1730-7.
    • (1999) BMJ , vol.318 , pp. 1730-1737
    • Freemantle, N.1    Cleland, J.2    Young, P.3    Mason, J.4    Harrison, J.5
  • 34
    • 0032583625 scopus 로고    scopus 로고
    • General practitioners' perceptions of the route to evidence based medicine: a questionnaire survey
    • McColl A, Smith H, White P, Field J. General practitioners' perceptions of the route to evidence based medicine: a questionnaire survey. BMJ 1998;316:361-5.
    • (1998) BMJ , vol.316 , pp. 361-365
    • McColl, A.1    Smith, H.2    White, P.3    Field, J.4
  • 35
    • 0028908691 scopus 로고
    • Communicating the benefits of chronic preventative therapy: does the format of efficacy data determine patients' acceptance of treatment?
    • Hux JE, Naylor CD. Communicating the benefits of chronic preventative therapy: does the format of efficacy data determine patients' acceptance of treatment? Med Decis Making 1995;15:152-7.
    • (1995) Med Decis Making , vol.15 , pp. 152-157
    • Hux, J.E.1    Naylor, C.D.2
  • 36
    • 0028875866 scopus 로고
    • Evidence based purchasing: understanding results of clinical trials and systematic reviews
    • Fahey T, Griffiths S, Peters TJ. Evidence based purchasing: understanding results of clinical trials and systematic reviews. BMJ 1995;311:1056-60.
    • (1995) BMJ , vol.311 , pp. 1056-1060
    • Fahey, T.1    Griffiths, S.2    Peters, T.J.3
  • 37
    • 0028026704 scopus 로고
    • Influence of method of reporting study results on decision of physicians to prescribe drugs to lower cholesterol concentration
    • Bucher HC, Weinbacher M, Gyr K. Influence of method of reporting study results on decision of physicians to prescribe drugs to lower cholesterol concentration. BMJ 1994;309:761-4.
    • (1994) BMJ , vol.309 , pp. 761-764
    • Bucher, H.C.1    Weinbacher, M.2    Gyr, K.3
  • 38
    • 0029909372 scopus 로고    scopus 로고
    • Same information, different decisions: the influence of evidence on the management of hypertension in the elderly
    • Cranney M, Walley T. Same information, different decisions: the influence of evidence on the management of hypertension in the elderly. Br J Gen Pract 1996;46:661-3.
    • (1996) Br J Gen Pract , vol.46 , pp. 661-663
    • Cranney, M.1    Walley, T.2
  • 39
    • 0026491985 scopus 로고
    • Measured enthusiasm: does the method of reporting trial results alter perceptions of therapeutic effectiveness?
    • Naylor CD, Chen E, Strauss B. Measured enthusiasm: does the method of reporting trial results alter perceptions of therapeutic effectiveness? Ann Intern Med 1992;117:916-21.
    • (1992) Ann Intern Med , vol.117 , pp. 916-921
    • Naylor, C.D.1    Chen, E.2    Strauss, B.3
  • 40
    • 0033062516 scopus 로고    scopus 로고
    • Numbers needed to treat derived from meta-analyses -sometimes informative, usually misleading
    • Smeeth L, Haines A, Ebrahim S. Numbers needed to treat derived from meta-analyses -sometimes informative, usually misleading. BMJ 1999;318:1548-51.
    • (1999) BMJ , vol.318 , pp. 1548-1551
    • Smeeth, L.1    Haines, A.2    Ebrahim, S.3


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