메뉴 건너뛰기




Volumn , Issue , 2005, Pages 53-72

Metabolic Modeling Analysis of Brain Metabolism

Author keywords

Combination Pools; Isotopomers; Least squares Fitting; Metabolic model; Metabolic pools; Michaelis Menten kinetics; Target data

Indexed keywords


EID: 84948742841     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0470020520.ch4     Document Type: Chapter
Times cited : (1)

References (45)
  • 7
    • 0035065635 scopus 로고    scopus 로고
    • 1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders
    • Bluml, S., Moreno, A., Hwang, J. H., and Ross, B. D. (2001a) 1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders. NMR Biomed 14: 19-32
    • (2001) NMR Biomed , vol.14 , pp. 19-32
    • Bluml, S.1    Moreno, A.2    Hwang, J.H.3    Ross, B.D.4
  • 8
    • 0034744085 scopus 로고    scopus 로고
    • [1-13C]glucose MRS in chronic hepatic encephalopathy in man
    • Bluml, S., Moreno-Torres, A., and Ross, B. D. (2001b) [1-13C]glucose MRS in chronic hepatic encephalopathy in man. Magn Reson Med 45: 981-993
    • (2001) Magn Reson Med , vol.45 , pp. 981-993
    • Bluml, S.1    Moreno-Torres, A.2    Ross, B.D.3
  • 9
    • 0018590713 scopus 로고
    • 13C nuclear magnetic resonance studies of anaerobic glycolysis in suspensions of yeast cells
    • den Hollander, J. A., Brown, T. R., Ugurbil, K., and Shulman, R. G. (1979) 13C nuclear magnetic resonance studies of anaerobic glycolysis in suspensions of yeast cells. Proc Natl Acad Sci USA 76: 6096-6100
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 6096-6100
    • den Hollander, J.A.1    Brown, T.R.2    Ugurbil, K.3    Shulman, R.G.4
  • 10
    • 0014966329 scopus 로고
    • A simulation study of brain compartments
    • II. Atom-by-atom simulation of the metabolism of specifically labeled glucose and acetate
    • Dzubow, L., and Garfinkel, D. (1970) A simulation study of brain compartments. II. Atom-by-atom simulation of the metabolism of specifically labeled glucose and acetate. Brain Res 23: 407-417
    • (1970) Brain Res , vol.23 , pp. 407-417
    • Dzubow, L.1    Garfinkel, D.2
  • 13
    • 0034814676 scopus 로고    scopus 로고
    • A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    • Gruetter, R., Seaquist, E. R., and Ugurbil, K. (2001) A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol Endocrinol Metab 281: E100-112
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E100-E112
    • Gruetter, R.1    Seaquist, E.R.2    Ugurbil, K.3
  • 14
    • 0003021136 scopus 로고
    • Intermediary metabolism of carbohydrates and other fuels
    • I. In: Biochem J (Lajtha A, ed.), New York: Plenum Press
    • Hawkins, R. A., and Mans, A. M. (1983) Intermediary metabolism of carbohydrates and other fuels. I. In: Biochem J (Lajtha A, ed.), New York: Plenum Press, pp 259-294
    • (1983) , pp. 259-294
    • Hawkins, R.A.1    Mans, A.M.2
  • 16
    • 0033547045 scopus 로고    scopus 로고
    • Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C] glucose with or without ammonium acetate
    • Kanamatsu, T., and Tsukada, Y. (1999) Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C] glucose with or without ammonium acetate. Brain Res 841: 11-19
    • (1999) Brain Res , vol.841 , pp. 11-19
    • Kanamatsu, T.1    Tsukada, Y.2
  • 18
    • 0036522961 scopus 로고    scopus 로고
    • Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    • Lebon, V., Petersen, K. F., Cline, G. W., Shen, J., Mason, G. F., Dufour, S., Behar, K. L., Shulman, G. I., and Rothman, D. L. (2002) Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 22: 1523-1531
    • (2002) J Neurosci , vol.22 , pp. 1523-1531
    • Lebon, V.1    Petersen, K.F.2    Cline, G.W.3    Shen, J.4    Mason, G.F.5    Dufour, S.6    Behar, K.L.7    Shulman, G.I.8    Rothman, D.L.9
  • 19
    • 0343052764 scopus 로고    scopus 로고
    • Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts
    • Lewandowski, E. D., Yu, X., LaNoue, K. F., White, L. T., Doumen, C., and O'Donnell, J. M. (1997) Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts. Circ Res 81: 165-175
    • (1997) Circ Res , vol.81 , pp. 165-175
    • Lewandowski, E.D.1    Yu, X.2    LaNoue, K.F.3    White, L.T.4    Doumen, C.5    O'Donnell, J.M.6
  • 20
    • 0026608455 scopus 로고
    • NMR determination of intracerebral glucose concentration and transport kinetics in rat brain in vivo
    • Mason, G. F., Behar, K. L., Rothman, D. L., and Shulman, R. G. (1992a) NMR determination of intracerebral glucose concentration and transport kinetics in rat brain in vivo. J Cereb Blood Flow Metab 12: 448-455
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 448-455
    • Mason, G.F.1    Behar, K.L.2    Rothman, D.L.3    Shulman, R.G.4
  • 22
    • 0028798036 scopus 로고
    • Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR
    • Mason, G. F., Gruetter, R., Rothman, D. L., Behar, K. L., Shulman, R. G., and Novotny, E. J. (1995) Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 15: 12-25
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 12-25
    • Mason, G.F.1    Gruetter, R.2    Rothman, D.L.3    Behar, K.L.4    Shulman, R.G.5    Novotny, E.J.6
  • 23
    • 0035964893 scopus 로고    scopus 로고
    • Decrease in GABA synthesis rate in rat cortex following vigabatrin administration correlates with the decrease in GAD67 protein
    • Mason, G. F., Martin, D. L., Martin, S. B., Manor, D., Sibson, N. R., Patel, A., Rothman, D. L., and Behar, K. L. (2001) Decrease in GABA synthesis rate in rat cortex following vigabatrin administration correlates with the decrease in GAD67 protein. Brain Res 914: 81-91
    • (2001) Brain Res , vol.914 , pp. 81-91
    • Mason, G.F.1    Martin, D.L.2    Martin, S.B.3    Manor, D.4    Sibson, N.R.5    Patel, A.6    Rothman, D.L.7    Behar, K.L.8
  • 24
    • 0026563676 scopus 로고
    • NMR determination of TCA cycle rate and α-ketoglutarate/glutamate exchange rate in rat brain
    • Mason, G. F., Rothman, D. L., Behar, K. L., and Shulman, R. G. (1992b) NMR determination of TCA cycle rate and α-ketoglutarate/glutamate exchange rate in rat brain. J Cereb Blood Flow Metab 12: 434-447
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 434-447
    • Mason, G.F.1    Rothman, D.L.2    Behar, K.L.3    Shulman, R.G.4
  • 25
    • 0023655334 scopus 로고
    • J Biol Chem
    • Melzer, E., and Schmidt, H.-L. (1987). J Biol Chem 262: 8159
    • (1987) , vol.262 , pp. 8159
    • Melzer, E.1    Schmidt, H.-L.2
  • 26
    • 0034951375 scopus 로고    scopus 로고
    • Alternative 1-(13)C glucose infusion protocols for clinical (13)C MRS examinations of the brain
    • Moreno, A., Bluml, S., Hwang, J. H., and Ross, B. D. (2001a) Alternative 1-(13)C glucose infusion protocols for clinical (13)C MRS examinations of the brain. Magn Reson Med 46: 39-48
    • (2001) Magn Reson Med , vol.46 , pp. 39-48
    • Moreno, A.1    Bluml, S.2    Hwang, J.H.3    Ross, B.D.4
  • 27
    • 0035089253 scopus 로고    scopus 로고
    • Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion
    • Moreno, A., Ross, B. D., and Bluml, S. (2001b) Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion. J Neurochem 77: 347-350
    • (2001) J Neurochem , vol.77 , pp. 347-350
    • Moreno, A.1    Ross, B.D.2    Bluml, S.3
  • 28
    • 0017600519 scopus 로고
    • Transport of metabolic substrates through the blood-brain barrier
    • Pardridge, W. M., and Oldendorf, W. H. (1977) Transport of metabolic substrates through the blood-brain barrier. J Neurochem 28: 5-12
    • (1977) J Neurochem , vol.28 , pp. 5-12
    • Pardridge, W.M.1    Oldendorf, W.H.2
  • 29
    • 0038650885 scopus 로고    scopus 로고
    • In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
    • Rothman, D. L., Behar, K. L., Hyder, F., and Shulman, R. G. (2003) In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol 65: 401-427
    • (2003) Annu Rev Physiol , vol.65 , pp. 401-427
    • Rothman, D.L.1    Behar, K.L.2    Hyder, F.3    Shulman, R.G.4
  • 32
    • 84940009390 scopus 로고
    • The Synaptic Organization of the Brain
    • Oxford: Oxford University Press
    • Shephard, G. M. (1994) The Synaptic Organization of the Brain. Oxford: Oxford University Press
    • (1994)
    • Shephard, G.M.1
  • 33
    • 0023696477 scopus 로고
    • Propionate metabolism in the rat heart by 13C n.m.r. spectroscopy
    • Sherry, A. D., Malloy, C. R., Roby, R. E., Rajagopal, A., and Jeffrey, F. M. (1988) Propionate metabolism in the rat heart by 13C n.m.r. spectroscopy. Biochem J 254: 593-598
    • (1988) Biochem J , vol.254 , pp. 593-598
    • Sherry, A.D.1    Malloy, C.R.2    Roby, R.E.3    Rajagopal, A.4    Jeffrey, F.M.5
  • 35
    • 0035109917 scopus 로고    scopus 로고
    • In vivo 13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2-13C]glucose infusion
    • Sibson, N. R., Mason, G. F., Shen, J., Cline, G. W., Herskovits, A. Z., Wall, J. E. M., Behar, K. L., Rothman, D. L., and Shulman, R. G. (2001) In vivo 13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2-13C]glucose infusion. J Neurochem 76: 975-989
    • (2001) J Neurochem , vol.76 , pp. 975-989
    • Sibson, N.R.1    Mason, G.F.2    Shen, J.3    Cline, G.W.4    Herskovits, A.Z.5    Wall, J.E.M.6    Behar, K.L.7    Rothman, D.L.8    Shulman, R.G.9
  • 38
    • 0029662102 scopus 로고    scopus 로고
    • Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling
    • Sonnewald, U., Westergaard, N., Jones, P., Taylor, A., Bachelard, H. S., and Schousboe, A. (1996) Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. J Neurochem 67: 2566-2572
    • (1996) J Neurochem , vol.67 , pp. 2566-2572
    • Sonnewald, U.1    Westergaard, N.2    Jones, P.3    Taylor, A.4    Bachelard, H.S.5    Schousboe, A.6
  • 39
    • 0029763251 scopus 로고    scopus 로고
    • Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo
    • Szczepaniak, L., Babcock, E. E., Malloy, C. R., and Sherry, A. D. (1996) Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo. Magn Reson Med 36: 451-457
    • (1996) Magn Reson Med , vol.36 , pp. 451-457
    • Szczepaniak, L.1    Babcock, E.E.2    Malloy, C.R.3    Sherry, A.D.4
  • 40
    • 0029828558 scopus 로고    scopus 로고
    • Approaches to studies on neuronal/glial relationships by 13C-MRS analysis
    • Taylor, A., McLean, M., Morris, P., and Bachelard, H. S. (1996) Approaches to studies on neuronal/glial relationships by 13C-MRS analysis. Dev Neurosci 18: 434-442
    • (1996) Dev Neurosci , vol.18 , pp. 434-442
    • Taylor, A.1    McLean, M.2    Morris, P.3    Bachelard, H.S.4
  • 41
    • 0024286069 scopus 로고
    • Biochemistry
    • Tipton, P. A., and Cleland, W. W. (1988). Biochemistry 27: 4325
    • (1988) , vol.27 , pp. 4325
    • Tipton, P.A.1    Cleland, W.W.2
  • 42
    • 0015071185 scopus 로고
    • A simulation study of brain compartments: metabolism of glutamate and related substances in mouse brain
    • Van den Berg, C. J., and Garfinkel, C. D. (1971) A simulation study of brain compartments: metabolism of glutamate and related substances in mouse brain. Biochem J 123: 211-218
    • (1971) Biochem J , vol.123 , pp. 211-218
    • Van den Berg, C.J.1    Garfinkel, C.D.2
  • 43
    • 0014526611 scopus 로고
    • Compartmentation of glutamate metabolism in brain: Evidence for the existence of two different tricarboxylic acid cycles in brain
    • Van den Berg, C. J., Krzalic, L. J., Mela, P., and H. Waelsch. (1970) Compartmentation of glutamate metabolism in brain: Evidence for the existence of two different tricarboxylic acid cycles in brain. Biochem J 113: 281-290
    • (1970) Biochem J , vol.113 , pp. 281-290
    • Van den Berg, C.J.1    Krzalic, L.J.2    Mela, P.3    H., Waelsch4
  • 44
    • 0033963798 scopus 로고    scopus 로고
    • Compartmentation of TCA cycle metabolism in cultured neocortical neurons revealed by 13C MR spectroscopy
    • Waagepetersen, H. S., Sonnewald, U., Larsson, O. M., and Schousboe, A. (2000) Compartmentation of TCA cycle metabolism in cultured neocortical neurons revealed by 13C MR spectroscopy. Neurochem Int 36: 349-358
    • (2000) Neurochem Int , vol.36 , pp. 349-358
    • Waagepetersen, H.S.1    Sonnewald, U.2    Larsson, O.M.3    Schousboe, A.4
  • 45
    • 0028859430 scopus 로고
    • Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts
    • Yu, X., White, L. T., Doumen, C., Damico, L. A., LaNoue, K. F., Alpert, N. M., and Lewandowski, E. D. (1995) Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys J 69: 2090-2102
    • (1995) Biophys J , vol.69 , pp. 2090-2102
    • Yu, X.1    White, L.T.2    Doumen, C.3    Damico, L.A.4    LaNoue, K.F.5    Alpert, N.M.6    Lewandowski, E.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.