Intracranial hemorrhage and other symptoms in infants associated with human parechovirus in Vienna, Austria

European Journal of Pediatrics

Volumn 174, Issue 12, 2015, Pages 1639-1647

  Kurz, Herbert ^a   Prammer, Ruth ^a   Bock, Wolfgang ^a   Ollerieth, Robert ^b   Bernert, Günther ^c   Zwiauer, Karl ^d   Aberle, Judith H ^e   Aberle, Stephan W ^e   Fazekas, Tamas ^f   Holter, Wolfgang ^f  

^a DANUBE HOSPITAL   (Austria)

^b WILHELMINEN HOSPITAL   (Austria)

^c Preyer Children's Hospital   (Austria)

^d Karl Landsteiner Institute for Implementation of Innovative Techniques in Cardiac Surgery   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

Human parechovirus; Infants; Intracerebral hemorrhage; Sepsis like illness

Indexed keywords

ARTICLE; AUSTRIA; BRAIN HEMORRHAGE; CLINICAL ARTICLE; FEVER; HUMAN; HUMAN PARECHOVIRUS; LEUKOCYTE COUNT; MIXED INFECTION; NEUROLOGIC DISEASE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SYMPTOMATOLOGY; VIRUS DETECTION; WHITE MATTER LESION; CENTRAL NERVOUS SYSTEM INFECTIONS; FEMALE; GENETICS; INFANT; INTRACRANIAL HEMORRHAGES; ISOLATION AND PURIFICATION; MALE; PARECHOVIRUS; PICORNAVIRIDAE INFECTIONS; RETROSPECTIVE STUDY; SEPSIS; VIROLOGY;

VIRUS RNA;

AUSTRIA; CENTRAL NERVOUS SYSTEM INFECTIONS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTRACRANIAL HEMORRHAGES; MALE; PARECHOVIRUS; PICORNAVIRIDAE INFECTIONS; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; RNA, VIRAL; SEPSIS;

EID: 84948587338     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-015-2583-8     Document Type: Article

References (40)

1. Aberle JH, Aberle SW, Pracher E, Hutter HP, Kundi M, Popow-Kraupp T (2005) Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response. Pediatr Infect Dis J 24(7):605–610
2. Aberle SW, Puchhammer-Stockl E (2002) Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol: Off Publ Pan Am Soc Clin Virol 25(Suppl 1):S79–85
3. Bangalore H, Ahmed J, Bible J, Menson EN, Durward A, Tong CY (2011) Abdominal distension: an important feature in human parechovirus infection. Pediatr Infect Dis J 30(3):260–262. doi:10.1097/INF.0b013e318207691c
4. Baumgarte S, de Souza Luna LK, Grywna K, Panning M, Drexler JF, Karsten C, Huppertz HI, Drosten C (2008) Prevalence, types, and RNA concentrations of human parechoviruses, including a sixth parechovirus type, in stool samples from patients with acute enteritis. J Clin Microbiol 46(1):242–248. doi:10.1128/JCM.01468-07
5. Benschop KS, Schinkel J, Minnaar RP, Pajkrt D, Spanjerberg L, Kraakman HC, Berkhout B, Zaaijer HL, Beld MG, Wolthers KC (2006) Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin Infect Dis: Off Publ Infect Dis Soc Am 42(2):204–210. doi:10.1086/498905
6. Boivin G, Abed Y, Boucher FD (2005) Human parechovirus 3 and neonatal infections. Emerg Infect Dis 11(1):103–105. doi:10.3201/eid1101.040606
7. Corless CE, Guiver M, Borrow R, Edwards-Jones V, Fox AJ, Kaczmarski EB, Mutton KJ (2002) Development and evaluation of a ‘real-time’ RT-PCR for the detection of enterovirus and parechovirus RNA in CSF and throat swab samples. J Med Virol 67(4):555–562. doi:10.1002/jmv.10138
8. Felsenstein S, Yang S, Eubanks N, Sobrera E, Grimm JP, Aldrovandi G (2014) Human parechovirus central nervous system infections in southern California children. Pediatr Infect Dis J 33(4):e87–91. doi:10.1097/INF.0000000000000112
9. Fischer TK, Midgley S, Dalgaard C, Nielsen AY (2014) Human parechovirus infection, Denmark. Emerg Infect Dis 20(1):83–87. doi:10.3201/eid2001.130569
10. Ghanem-Zoubi N, Shiner M, Shulman LM, Sofer D, Wolf D, Marva E, Kra-Oz Z, Shachor-Meyouhas Y, Averbuch D, Bechor-Fellner A, Barkai G, Kinarty A, Gershstein V, Ephros M (2013) Human parechovirus type 3 central nervous system infections in Israeli infants. J Clin Virol: Off Publ Pan Am Soc Clin Virol 58(1):205–210. doi:10.1016/j.jcv.2013.06.001
11. Gupta S, Fernandez D, Siddiqui A, Tong WC, Pohl K, Jungbluth H (2010) Extensive white matter abnormalities associated with neonatal parechovirus (HPeV) infection. Eur J Paediatr Neurol: EJPN: Off J Eur Paediatr Neurol Soc 14(6):531–534. doi:10.1016/j.ejpn.2009.12.007
12. Harvala H, Griffiths M, Solomon T, Simmonds P (2014) Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. J Infect 69(1):69–74. doi:10.1016/j.jinf.2014.02.017
13. Harvala H, McLeish N, Kondracka J, McIntyre CL, McWilliam Leitch EC, Templeton K, Simmonds P (2011) Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in Edinburgh: HPeV type 3 identified as the most common picornavirus type. J Med Virol 83(5):889–896. doi:10.1002/jmv.22023
14. Harvala H, Robertson I, McWilliam Leitch EC, Benschop K, Wolthers KC, Templeton K, Simmonds P (2008) Epidemiology and clinical associations of human parechovirus respiratory infections. J Clin Microbiol 46(10):3446–3453. doi:10.1128/JCM.01207-08
15. Harvala H, Simmonds P (2009) Human parechoviruses: biology, epidemiology and clinical significance. J Clin Virol: Off Publ Pan Am Soc Clin Virol 45(1):1–9. doi:10.1016/j.jcv.2009.03.009
16. Ito M, Yamashita T, Tsuzuki H, Takeda N, Sakae K (2004) Isolation and identification of a novel human parechovirus. J Gen Virol 85(Pt 2):391–398
17. Jaaskelainen AJ, Kolehmainen P, Kallio-Kokko H, Nieminen T, Koskiniemi M, Tauriainen S, Lappalainen M (2013) First two cases of neonatal human parechovirus 4 infection with manifestation of suspected sepsis, Finland. J Clin Virol: Off Publ Pan Am Soc Clin Virol 58(1):328–330. doi:10.1016/j.jcv.2013.06.010
18. Ljubin-Sternak S, Juretic E, Santak M, Plesa M, Forcic D, Vilibic-Cavlek T, Aleraj B, Mlinaric-Galinovic G (2011) Clinical and molecular characterization of a parechovirus type 1 outbreak in neonates in Croatia. J Med Virol 83(1):137–141. doi:10.1002/jmv.21848
19. Niesters HG (2004) Molecular and diagnostic clinical virology in real time. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis 10(1):5–11
20. Pineiro L, Vicente D, Montes M, Hernandez-Dorronsoro U, Cilla G (2010) Human parechoviruses in infants with systemic infection. J Med Virol 82(10):1790–1796. doi:10.1002/jmv.21878
21. Piralla A, Furione M, Rovida F, Marchi A, Stronati M, Gerna G, Baldanti F (2012) Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010. J Med Virol 84(4):686–690. doi:10.1002/jmv.23197
22. Radwan W, Sawaya R (2011) Intracranial haemorrhage associated with cerebral infections: a review. Scand J Infect Dis 43(9):675–682. doi:10.3109/00365548.2011.581304
23. Renna S, Bergamino L, Pirlo D, Rossi A, Furione M, Piralla A, Mascaretti M, Cristina E, Marazzi MG, Pietro PD (2014) A case of neonatal human parechovirus encephalitis with a favourable outcome. Brain Dev 36(1):70–73. doi:10.1016/j.braindev.2012.12.006
24. Rodriguez-Sainz A, Escalza-Cortina I, Guio-Carrion L, Matute-Nieves A, Gomez-Beldarrain M, Carbayo-Lozano G, Garcia-Monco JC (2013) Intracerebral hematoma complicating herpes simplex encephalitis. Clin Neurol Neurosurg 115(10):2041–2045. doi:10.1016/j.clineuro.2013.06.016
25. Schuffenecker I, Javouhey E, Gillet Y, Kugener B, Billaud G, Floret D, Lina B, Morfin F (2012) Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases. J Clin Virol: Off Publ Pan Am Soc Clin Virol 54(4):337–341. doi:10.1016/j.jcv.2012.04.016
26. Sedmak G, Nix WA, Jentzen J, Haupt TE, Davis JP, Bhattacharyya S, Pallansch MA, Oberste MS (2010) Infant deaths associated with human parechovirus infection in Wisconsin. Clin Infect Dis: Off Publ Infect Dis Soc Am 50(3):357–361. doi:10.1086/649863
27. Selvarangan R, Nzabi M, Selvaraju SB, Ketter P, Carpenter C, Harrison CJ (2011) Human parechovirus 3 causing sepsis-like illness in children from midwestern United States. Pediatr Infect Dis J 30(3):238–242. doi:10.1097/INF.0b013e3181fbefc8
28. Sharp J, Harrison CJ, Puckett K, Selvaraju SB, Penaranda S, Nix WA, Oberste MS, Selvarangan R (2013) Characteristics of young infants in whom human parechovirus, enterovirus or neither were detected in cerebrospinal fluid during sepsis evaluations. Pediatr Infect Dis J 32(3):213–216. doi:10.1097/INF.0b013e318276b328
29. Shoji K, Komuro H, Kobayashi Y, Shike T, Funaki T, Katsuta T, Miyata I, Saitoh A (2012) An infant with human parechovirus type 3 infection with a distinctive rash on the extremities. Pediatr Dermatol. doi:10.1111/j.1525-1470.2012.01819.x
30. Skram M, Skanke LH, Krokstad S, Nordbo SA, Nietsch L, Dollner H (2014) Severe parechovirus infection in Norwegian infants. Pediatr Infect Dis J. doi:10.1097/INF.0000000000000456
31. Tapia G, Cinek O, Witso E, Kulich M, Rasmussen T, Grinde B, Ronningen KS (2008) Longitudinal observation of parechovirus in stool samples from Norwegian infants. J Med Virol 80(10):1835–1842. doi:10.1002/jmv.21283
32. van der Sanden S, de Bruin E, Vennema H, Swanink C, Koopmans M, van der Avoort H (2008) Prevalence of human parechovirus in the Netherlands in 2000 to 2007. J Clin Microbiol 46(9):2884–2889. doi:10.1128/JCM.00168-08
33. van der Sanden SM, Koopmans MP, van der Avoort HG (2013) Detection of human enteroviruses and parechoviruses as part of the national enterovirus surveillance in the Netherlands, 1996-2011. Eur J Clin Microbiol Infect Dis: Off Publ Eur Soc Clin Microbiol 32(12):1525–1531. doi:10.1007/s10096-013-1906-9
34. van Zwol AL, Lequin M, Aarts-Tesselaar C, van der Eijk AA, Driessen GA, de Hoog M, Govaert P (2009) Fatal neonatal parechovirus encephalitis. BMJ Case Rep. doi:10.1136/bcr.05.2009.1883
35. Verboon-Maciolek MA, Groenendaal F, Hahn CD, Hellmann J, van Loon AM, Boivin G, de Vries LS (2008) Human parechovirus causes encephalitis with white matter injury in neonates. Ann Neurol 64(3):266–273. doi:10.1002/ana.21445
36. Verboon-Maciolek MA, Krediet TG, Gerards LJ, de Vries LS, Groenendaal F, van Loon AM (2008) Severe neonatal parechovirus infection and similarity with enterovirus infection. Pediatr Infect Dis J 27(3):241–245. doi:10.1097/INF.0b013e31815c1b07
37. Westerhuis B, Kolehmainen P, Benschop K, Nurminen N, Koen G, Koskiniemi M, Simell O, Knip M, Hyoty H, Wolthers K, Tauriainen S (2013) Human parechovirus seroprevalence in Finland and the Netherlands. J Clin Virol: Off Publ Pan Am Soc Clin Virol 58(1):211–215. doi:10.1016/j.jcv.2013.06.036
38. Wolthers KC, Benschop KS, Schinkel J, Molenkamp R, Bergevoet RM, Spijkerman IJ, Kraakman HC, Pajkrt D (2008) Human parechoviruses as an important viral cause of sepsis-like illness and meningitis in young children. Clin Infect Dis: Off Publ Infect Dis Soc Am 47(3):358–363. doi:10.1086/589752
39. Yuzurihara SS, Ao K, Hara T, Tanaka F, Mori M, Kikuchi N, Kai S, Yokota S (2013) Human parechovirus-3 infection in nine neonates and infants presenting symptoms of hemophagocytic lymphohistiocytosis. J Infect Chemother: Off J Jpn Soc Chemother 19(1):144–148. doi:10.1007/s10156-012-0420-9
40. Zhong H, Lin Y, Su L, Cao L, Xu M, Xu J (2013) Prevalence of human parechoviruses in central nervous system infections in children: a retrospective study in Shanghai, China. J Med Virol 85(2):320–326. doi:10.1002/jmv.23449