Oral administration of gentamicin for prophylaxis of KPC-producing Klebsiella pneumoniae gut colonization in patients treated with a novel parenchymal-sparing liver surgery: the GEN Gut study

Intensive Care Medicine

Volumn 42, Issue 1, 2016, Pages 124-125

  Tascini, Carlo ^a   Urbani, Lucio ^a   Sbrana, Francesco ^b   Forfori, Francesco ^a   Licitra, Gabriella ^a   Leoni, Chiara ^a   Balestri, Riccardo ^a   Rossi, Elisabetta ^a   Fortunato, Simona ^a   Leonildi, Alessandro ^a   Puccini, Marco ^a   Di Paolo, Antonello ^c   Ripoli, Andrea ^b   Colombatto, Piero ^a   Menichetti, Francesco ^a   Buccianti, Piero ^a  

^a UNIVERSITY HOSPITAL OF PISA   (Italy)

^b Fondazione Toscana G Monasterio   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; GENTAMICIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM ISOLATION; HUMAN; INFECTION PREVENTION; INTESTINE FLORA; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LENGTH OF STAY; LETTER; LIVER RESECTION; LIVER SURGERY; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); ABDOMINAL SURGERY; ADVERSE EFFECTS; AGED; CHEMOPROPHYLAXIS; DRUG EFFECTS; FEMALE; GASTROINTESTINAL TRACT; KLEBSIELLA INFECTIONS; LIVER; MALE; MICROBIOLOGY; ORAL DRUG ADMINISTRATION; PROCEDURES; SURGERY;

ADMINISTRATION, ORAL; AGED; ANTI-BACTERIAL AGENTS; CHEMOPREVENTION; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; GASTROINTESTINAL TRACT; GENTAMICINS; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIVER; MALE; PILOT PROJECTS;

EID: 84948566153     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-4049-x     Document Type: Letter

References (5)

1. Tumbarello M, Viale P, Viscoli C, Trecarichi EM, Tumietto F, Marchese A, Spanu T, Ambretti S, Ginocchio F, Cristini F, Losito AR, Tedeschi S, Cauda R, Bassetti M (2012) Predictors of mortality in bloodstream infections caused by KPC-producing Klebsiella pneumoniae: importance of combination therapy. Clin Infect Dis 55:943–950
2. Timsit JF, Perner A, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Doig GS, Herridge M, Jaber S, Joannidis M, Papazian L, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Citerio G, Azoulay E (2015) Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics. Intensive Care Med 41:575–588
3. Tascini C, Sbrana F, Flammini S, Tagliaferri E, Arena F, Leonildi A, Ciullo I, Amadori F, Di Paolo A, Ripoli A, Lewis R, Rossolini GM, Menichetti F, GENGUT Study Group (2014) Oral gentamicin gut decontamination for prevention of KPC-producing Klebsiella pneumoniae infections: relevance of concomitant systemic antibiotic therapy. Antimicrob Agents Chemother 58:1972–1976
4. Urbani L, Masi G, Puccini M, Colombatto P, Vivaldi C, Balestri R, Marioni A, Prosperi V, Forfori F, Licitra G, Leoni C, Paolicchi A, Boraschi P, Lunardi A, Tascini C, Castagna M, Buccianti P (2015) Minor-but-complex liver resection: an alternative to major resections for colorectal liver metastases involving the hepato-caval confluence. Medicine (Baltimore) 94:e1188
5. Capone A, Giannella M, Fortini D, Giordano A, Meledandri M, Ballardini M, Venditti M, Bordi E, Capozzi D, Balice MP, Tarasi A, Parisi G, Lappa A, Carattoli A, Petrosillo N, SEERBIO-GRAB network (2013) High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect 19:E23–E30