메뉴 건너뛰기




Volumn 9, Issue 11, 2015, Pages 10979-10990

Peptide-Conjugated Gold Nanoprobe: Intrinsic Nanozyme-Linked Immunsorbant Assay of Integrin Expression Level on Cell Membrane

Author keywords

enzyme linked immunosorbent assay; gold nanoparticles; membrane protein quantification; nanozyme; two photon imaging

Indexed keywords

BIOLOGICAL MEMBRANES; CELL CULTURE; CELL MEMBRANES; CELLS; ENZYMES; GOLD; MASS SPECTROMETRY; MEMBRANES; METAL NANOPARTICLES; NANOPARTICLES; NANOPROBES; PEPTIDES; PHOTONS; PROTEINS; RELIABILITY ANALYSIS;

EID: 84948429865     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b04261     Document Type: Article
Times cited : (103)

References (42)
  • 1
    • 53849144620 scopus 로고    scopus 로고
    • Strategies for Discovering Novel Cancer Biomarkers Through Utilization of Emerging Technologies
    • Kulasingam, V.; Diamandis, E. P. Strategies for Discovering Novel Cancer Biomarkers Through Utilization of Emerging Technologies Nat. Clin. Pract. Oncol. 2008, 5, 588-599 10.1038/ncponc1187
    • (2008) Nat. Clin. Pract. Oncol. , vol.5 , pp. 588-599
    • Kulasingam, V.1    Diamandis, E.P.2
  • 2
    • 84929379023 scopus 로고    scopus 로고
    • Cancer Biomarker Detection: Recent Achievements and Challenges
    • Wu, L.; Qu, X. Cancer Biomarker Detection: Recent Achievements and Challenges Chem. Soc. Rev. 2015, 44, 2963-2997 10.1039/C4CS00370E
    • (2015) Chem. Soc. Rev. , vol.44 , pp. 2963-2997
    • Wu, L.1    Qu, X.2
  • 3
    • 84869166856 scopus 로고    scopus 로고
    • The Magic of Bicelles Lights Up Membrane Protein Structure
    • Dürr, U. N.; Gildenberg, M.; Ramamoorthy, A. The Magic of Bicelles Lights Up Membrane Protein Structure Chem. Rev. 2012, 112, 6054-6074 10.1021/cr300061w
    • (2012) Chem. Rev. , vol.112 , pp. 6054-6074
    • Dürr, U.N.1    Gildenberg, M.2    Ramamoorthy, A.3
  • 4
    • 84875035670 scopus 로고    scopus 로고
    • Identification of VAR2CSA Domain-Specific Inhibitory Antibodies of the Plasmodium Falciparum Erythrocyte Membrane Protein 1 Using a Novel Flow Cytometry Assay
    • Obiakor, H.; Avril, M.; MacDonald, N. J.; Srinivasan, P.; Reiter, K.; Anderson, C.; Holmes, K. L.; Fried, M.; Duffy, P. E.; Smith, J. D. et al. Identification of VAR2CSA Domain-Specific Inhibitory Antibodies of the Plasmodium Falciparum Erythrocyte Membrane Protein 1 Using a Novel Flow Cytometry Assay Clin. Vaccine Immunol. 2013, 20, 433-442 10.1128/CVI.00638-12
    • (2013) Clin. Vaccine Immunol. , vol.20 , pp. 433-442
    • Obiakor, H.1    Avril, M.2    MacDonald, N.J.3    Srinivasan, P.4    Reiter, K.5    Anderson, C.6    Holmes, K.L.7    Fried, M.8    Duffy, P.E.9    Smith, J.D.10
  • 5
    • 77953082093 scopus 로고    scopus 로고
    • A Sandwich Enzyme-Linked Immunosorbent Assay for the Quantification of Insoluble Membrane and Scaffold Proteins
    • Geumann, C.; Gronborg, M.; Hellwig, M.; Martens, H.; Jahn, R. A Sandwich Enzyme-Linked Immunosorbent Assay for the Quantification of Insoluble Membrane and Scaffold Proteins Anal. Biochem. 2010, 402, 161-169 10.1016/j.ab.2010.03.037
    • (2010) Anal. Biochem. , vol.402 , pp. 161-169
    • Geumann, C.1    Gronborg, M.2    Hellwig, M.3    Martens, H.4    Jahn, R.5
  • 6
    • 77955876447 scopus 로고    scopus 로고
    • Mass Spectrometry-Based Proteomics in Cell Biology
    • Walther, T. C.; Mann, M. Mass Spectrometry-Based Proteomics in Cell Biology J. Cell Biol. 2010, 190, 491-500 10.1083/jcb.201004052
    • (2010) J. Cell Biol. , vol.190 , pp. 491-500
    • Walther, T.C.1    Mann, M.2
  • 7
    • 84879839483 scopus 로고    scopus 로고
    • Detection and Quantification of Proteins and Cells by Use of Elemental Mass Spectrometry: Progress and Challenges
    • Yan, X.; Yang, L.; Wang, Q. Detection and Quantification of Proteins and Cells by Use of Elemental Mass Spectrometry: Progress and Challenges Anal. Bioanal. Chem. 2013, 405, 5663-5670 10.1007/s00216-013-6886-1
    • (2013) Anal. Bioanal. Chem. , vol.405 , pp. 5663-5670
    • Yan, X.1    Yang, L.2    Wang, Q.3
  • 9
    • 84896789329 scopus 로고    scopus 로고
    • Spatially Marking and Quantitatively Counting Membrane Immunoglobulin M in Live Cells via Ag Cluster-Aptamer Probes
    • Liu, R.; Zhai, J.; Liu, Li.; Wang, Y.; Wei, Y.; Jiang, X.; Gao, L.; Zhu, H.; Zhao, Y.; Chai, Z. et al. Spatially Marking and Quantitatively Counting Membrane Immunoglobulin M in Live Cells via Ag Cluster-Aptamer Probes Chem. Commun. 2014, 50, 3560-3563 10.1039/c3cc49036j
    • (2014) Chem. Commun. , vol.50 , pp. 3560-3563
    • Liu, R.1    Zhai, J.2    Liu, Li.3    Wang, Y.4    Wei, Y.5    Jiang, X.6    Gao, L.7    Zhu, H.8    Zhao, Y.9    Chai, Z.10
  • 10
    • 84868595033 scopus 로고    scopus 로고
    • Integrin-Targeted Trifunctional Probe for Cancer Cells: A "Seeing and Counting"? Approach
    • Zhang, Z.; Luo, Q.; Yan, X.; Li, Z.; Luo, Y.; Yang, L.; Zhang, Bo.; Chen, H.; Wang, Q. Integrin-Targeted Trifunctional Probe for Cancer Cells: A "Seeing and Counting"? Approach Anal. Chem. 2012, 84, 8946-8951 10.1021/ac302029w
    • (2012) Anal. Chem. , vol.84 , pp. 8946-8951
    • Zhang, Z.1    Luo, Q.2    Yan, X.3    Li, Z.4    Luo, Y.5    Yang, L.6    Zhang, Bo.7    Chen, H.8    Wang, Q.9
  • 12
    • 84884224916 scopus 로고    scopus 로고
    • Nanomaterials with Enzyme-Like Characteristics (Nanozymes): Next-Generation Artificial Enzymes
    • Wei, H.; Wang, E. Nanomaterials with Enzyme-Like Characteristics (Nanozymes): Next-Generation Artificial Enzymes Chem. Soc. Rev. 2013, 42, 6060-6093 10.1039/c3cs35486e
    • (2013) Chem. Soc. Rev. , vol.42 , pp. 6060-6093
    • Wei, H.1    Wang, E.2
  • 13
    • 84898872232 scopus 로고    scopus 로고
    • Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
    • Lin, Y.; Ren, J.; Qu, X. Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes Acc. Chem. Res. 2014, 47, 1097-1105 10.1021/ar400250z
    • (2014) Acc. Chem. Res. , vol.47 , pp. 1097-1105
    • Lin, Y.1    Ren, J.2    Qu, X.3
  • 14
    • 56549095384 scopus 로고    scopus 로고
    • Magnetite Nanoparticle-Linked Immunosorbent Assay
    • Gao, L.; Wu, J.; Lyle, S.; Zehr, K.; Cao, L.; Gao, D. Magnetite Nanoparticle-Linked Immunosorbent Assay J. Phys. Chem. C 2008, 112, 17357-17361 10.1021/jp805994h
    • (2008) J. Phys. Chem. C , vol.112 , pp. 17357-17361
    • Gao, L.1    Wu, J.2    Lyle, S.3    Zehr, K.4    Cao, L.5    Gao, D.6
  • 15
    • 81255151205 scopus 로고    scopus 로고
    • Enzyme-Mimic Activity of Ferric Nano-Core Residing in Ferritin and Its Biosensing Applications
    • Tang, Z.; Wu, H.; Zhang, Y.; Li, Z.; Lin, Y. Enzyme-Mimic Activity of Ferric Nano-Core Residing in Ferritin and Its Biosensing Applications Anal. Chem. 2011, 83, 8611-8616 10.1021/ac202049q
    • (2011) Anal. Chem. , vol.83 , pp. 8611-8616
    • Tang, Z.1    Wu, H.2    Zhang, Y.3    Li, Z.4    Lin, Y.5
  • 16
    • 84930173533 scopus 로고    scopus 로고
    • Highly Sensitive and Robust Peroxidase-Like Activity of Porous Nanorods of Ceria and Their Application for Breast Cancer Detection
    • Tian, Z.; Li, J.; Zhang, Z.; Gao, W.; Zhou, X.; Qu, Y. Highly Sensitive and Robust Peroxidase-Like Activity of Porous Nanorods of Ceria and Their Application for Breast Cancer Detection Biomaterials 2015, 59, 116-124 10.1016/j.biomaterials.2015.04.039
    • (2015) Biomaterials , vol.59 , pp. 116-124
    • Tian, Z.1    Li, J.2    Zhang, Z.3    Gao, W.4    Zhou, X.5    Qu, Y.6
  • 17
    • 84877263081 scopus 로고    scopus 로고
    • Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity over a Broad pH Range and Its Application for Cancer Cell Detection
    • Tao, Y.; Lin, Y.; Huang, Z.; Ren, J.; Qu, X. Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and Its Application for Cancer Cell Detection Adv. Mater. 2013, 25, 2594-2599 10.1002/adma.201204419
    • (2013) Adv. Mater. , vol.25 , pp. 2594-2599
    • Tao, Y.1    Lin, Y.2    Huang, Z.3    Ren, J.4    Qu, X.5
  • 18
    • 84929180123 scopus 로고    scopus 로고
    • Cancer Cell Detection and Therapeutics Using Peroxidase-Active Nanohybrid of Gold Nanoparticle-Loaded Mesoporous Silica-Coated Graphene
    • Maji, S. K.; Mandal, A. K.; Nguyen, K. T.; Borah, P.; Zhao, Y. Cancer Cell Detection and Therapeutics Using Peroxidase-Active Nanohybrid of Gold Nanoparticle-Loaded Mesoporous Silica-Coated Graphene ACS Appl. Mater. Interfaces 2015, 7, 9807-9816 10.1021/acsami.5b01758
    • (2015) ACS Appl. Mater. Interfaces , vol.7 , pp. 9807-9816
    • Maji, S.K.1    Mandal, A.K.2    Nguyen, K.T.3    Borah, P.4    Zhao, Y.5
  • 19
    • 84900856237 scopus 로고    scopus 로고
    • Dual Responsive Enzyme Mimicking Activity of AgX (X = Cl, Br, I) Nanoparticles and Its Application for Cancer Cell Detection
    • Wang, G.; Xu, X.; Qiu, L.; Dong, Y.; Li, Z.; Zhang, C. Dual Responsive Enzyme Mimicking Activity of AgX (X = Cl, Br, I) Nanoparticles and Its Application for Cancer Cell Detection ACS Appl. Mater. Interfaces 2014, 6, 6434-6442 10.1021/am501830v
    • (2014) ACS Appl. Mater. Interfaces , vol.6 , pp. 6434-6442
    • Wang, G.1    Xu, X.2    Qiu, L.3    Dong, Y.4    Li, Z.5    Zhang, C.6
  • 20
    • 79955015411 scopus 로고    scopus 로고
    • Selective and Quantitative Cancer Cell Detection Using Target-Directed Functionalized Graphene and Its Synergetic Peroxidase-Like activity
    • Song, Y.; Chen, Y.; Feng, L.; Ren, J.; Qu, X. Selective and Quantitative Cancer Cell Detection Using Target-Directed Functionalized Graphene and Its Synergetic Peroxidase-Like activity Chem. Commun. 2011, 47, 4436-4438 10.1039/c0cc05533f
    • (2011) Chem. Commun. , vol.47 , pp. 4436-4438
    • Song, Y.1    Chen, Y.2    Feng, L.3    Ren, J.4    Qu, X.5
  • 23
    • 0025076251 scopus 로고
    • iIb Subunits of the Integrin Family in Spreading Human Erythroleukemia Cells
    • IIb Subunits of the Integrin Family in Spreading Human Erythroleukemia Cells Blood 1990, 76, 570-577
    • (1990) Blood , vol.76 , pp. 570-577
    • Ylanne, J.1    Cheresh, D.A.2    Virtanen, I.3
  • 24
    • 77958456592 scopus 로고    scopus 로고
    • Positively-Charged Gold Nanoparticles as Peroxidiase Mimic and Their Application in Hydrogen Peroxide and Glucose Detection
    • Jv, Y.; Li, B.; Cao, R. Positively-Charged Gold Nanoparticles as Peroxidiase Mimic and Their Application in Hydrogen Peroxide and Glucose Detection Chem. Commun. 2010, 46, 8017-8019 10.1039/c0cc02698k
    • (2010) Chem. Commun. , vol.46 , pp. 8017-8019
    • Jv, Y.1    Li, B.2    Cao, R.3
  • 26
    • 0742321804 scopus 로고    scopus 로고
    • Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology
    • Daniel, M.; Astruc, D. Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology Chem. Rev. 2004, 104, 293-346 10.1021/cr030698+
    • (2004) Chem. Rev. , vol.104 , pp. 293-346
    • Daniel, M.1    Astruc, D.2
  • 27
    • 0023008334 scopus 로고
    • Vibrational Spectroscopy and Conformation of Peptides, Polypeptides, and Proteins
    • Krimm, S.; Bandekar, J. Vibrational Spectroscopy and Conformation of Peptides, Polypeptides, and Proteins Adv. Protein Chem. 1986, 38, 181-364 10.1016/S0065-3233(08)60528-8
    • (1986) Adv. Protein Chem. , vol.38 , pp. 181-364
    • Krimm, S.1    Bandekar, J.2
  • 28
    • 34548094323 scopus 로고    scopus 로고
    • Fourier Transform Infrared Spectroscopic Analysis of Protein Secondary Structures
    • Kong, J.; Yu, S. Fourier Transform Infrared Spectroscopic Analysis of Protein Secondary Structures Acta Biochim. Biophys. Sin. 2007, 39, 549-559 10.1111/j.1745-7270.2007.00320.x
    • (2007) Acta Biochim. Biophys. Sin. , vol.39 , pp. 549-559
    • Kong, J.1    Yu, S.2
  • 30
    • 84880132715 scopus 로고    scopus 로고
    • Quantitative Analysis of Complex Amino Acids and RGD Peptides by X-ray Photoelectron Spectroscopy (XPS)
    • Stevens, J. S.; de Luca, A. C.; Pelendritis, M.; Terenghi, G.; Downes, S.; Schroeder, S. Quantitative Analysis of Complex Amino Acids and RGD Peptides by X-ray Photoelectron Spectroscopy (XPS) Surf. Interface Anal. 2013, 45, 1238-1246 10.1002/sia.5261
    • (2013) Surf. Interface Anal. , vol.45 , pp. 1238-1246
    • Stevens, J.S.1    De Luca, A.C.2    Pelendritis, M.3    Terenghi, G.4    Downes, S.5    Schroeder, S.6
  • 31
    • 84904744159 scopus 로고    scopus 로고
    • Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro
    • Gao, L.; Liu, R.; Gao, F.; Wang, Y.; Jiang, X.; Gao, X. Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro ACS Nano 2014, 8, 7260-7271 10.1021/nn502325j
    • (2014) ACS Nano , vol.8 , pp. 7260-7271
    • Gao, L.1    Liu, R.2    Gao, F.3    Wang, Y.4    Jiang, X.5    Gao, X.6
  • 32
    • 84942498448 scopus 로고
    • Some Aspects of the Chromogen 3, 3′, 5, 5′-Tetramethylbenzidine as Hydrogen Donor in A Horseradish Peroxidase Assay
    • Bally, R. W.; Gribnau, T. C. Some Aspects of the Chromogen 3, 3′, 5, 5′-Tetramethylbenzidine as Hydrogen Donor in A Horseradish Peroxidase Assay Clin. Chem. Lab. Med. 1989, 27, 791-796 10.1515/cclm.1989.27.10.791
    • (1989) Clin. Chem. Lab. Med. , vol.27 , pp. 791-796
    • Bally, R.W.1    Gribnau, T.C.2
  • 33
    • 84868445547 scopus 로고    scopus 로고
    • Intrinsic Catalytic Activity of Au Nanoparticles with Respect to Hydrogen Peroxide Decomposition and Superoxide Scavenging
    • He, W.; Zhou, Y.; Wamer, W. G.; Hu, X.; Wu, X.; Zheng, Z.; Boudreau, M. D.; Yin, J. Intrinsic Catalytic Activity of Au Nanoparticles with Respect to Hydrogen Peroxide Decomposition and Superoxide Scavenging Biomaterials 2013, 34, 765-773 10.1016/j.biomaterials.2012.10.010
    • (2013) Biomaterials , vol.34 , pp. 765-773
    • He, W.1    Zhou, Y.2    Wamer, W.G.3    Hu, X.4    Wu, X.5    Zheng, Z.6    Boudreau, M.D.7    Yin, J.8
  • 34
    • 0038202057 scopus 로고    scopus 로고
    • On the Interactions of Free Radicals with Gold Nanoparticles
    • Zhang, Z.; Berg, A.; Levanon, H.; Fessenden, R. W.; Meisel, D. On the Interactions of Free Radicals with Gold Nanoparticles J. Am. Chem. Soc. 2003, 125, 7959-7963 10.1021/ja034830z
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 7959-7963
    • Zhang, Z.1    Berg, A.2    Levanon, H.3    Fessenden, R.W.4    Meisel, D.5
  • 35
    • 84893520328 scopus 로고    scopus 로고
    • Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis
    • Hu, D.; Sheng, Z.; Fang, S.; Wang, Y.; Gao, D.; Zhang, P.; Gong, P.; Ma, Y.; Cai, L. Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis Theranostics 2014, 4, 142-153 10.7150/thno.7266
    • (2014) Theranostics , vol.4 , pp. 142-153
    • Hu, D.1    Sheng, Z.2    Fang, S.3    Wang, Y.4    Gao, D.5    Zhang, P.6    Gong, P.7    Ma, Y.8    Cai, L.9
  • 36
    • 84859220003 scopus 로고    scopus 로고
    • Comparison of the Peroxidase-Like Activity of Unmodified, Amino-Modified, and Citrate-Capped Gold Nanoparticles
    • Wang, S.; Chen, W.; Liu, A.; Hong, L.; Deng, H.; Lin, X. Comparison of the Peroxidase-Like Activity of Unmodified, Amino-Modified, and Citrate-Capped Gold Nanoparticles ChemPhysChem 2012, 13, 1199-1204 10.1002/cphc.201100906
    • (2012) ChemPhysChem , vol.13 , pp. 1199-1204
    • Wang, S.1    Chen, W.2    Liu, A.3    Hong, L.4    Deng, H.5    Lin, X.6
  • 37
    • 84911937002 scopus 로고    scopus 로고
    • Aptamer-Mediated 'Turn-Off/Turn-On' Nanozyme Activity of Gold Nanoparticles for Kanamycin Detection
    • Sharma, T. K.; Ramanathan, R.; Weerathunge, P.; Mohammadtaheri, M.; Daima, H. K.; Shukla, R.; Bansal, V. Aptamer-Mediated 'Turn-Off/Turn-On' Nanozyme Activity of Gold Nanoparticles for Kanamycin Detection Chem. Commun. 2014, 50, 15856-15859 10.1039/C4CC07275H
    • (2014) Chem. Commun. , vol.50 , pp. 15856-15859
    • Sharma, T.K.1    Ramanathan, R.2    Weerathunge, P.3    Mohammadtaheri, M.4    Daima, H.K.5    Shukla, R.6    Bansal, V.7
  • 38
    • 84879079346 scopus 로고    scopus 로고
    • Two-Photon Induced Photoluminescence and Singlet Oxygen Generation from Aggregated Gold Nanoparticles
    • Jiang, C.; Zhao, T.; Yuan, P.; Gao, N.; Pan, Y.; Guan, Z.; Zhou, N.; Xu, Q. Two-Photon Induced Photoluminescence and Singlet Oxygen Generation from Aggregated Gold Nanoparticles ACS Appl. Mater. Interfaces 2013, 5, 4972-4977 10.1021/am4007403
    • (2013) ACS Appl. Mater. Interfaces , vol.5 , pp. 4972-4977
    • Jiang, C.1    Zhao, T.2    Yuan, P.3    Gao, N.4    Pan, Y.5    Guan, Z.6    Zhou, N.7    Xu, Q.8
  • 39
    • 84906231453 scopus 로고    scopus 로고
    • Shape-Dependent Two-Photon Photoluminescence of Single Gold Nanoparticles
    • Gao, N.; Chen, Y.; Li, L.; Guan, Z.; Zhao, T.; Zhou, N.; Yuan, P.; Yao, S.; Xu, Q. Shape-Dependent Two-Photon Photoluminescence of Single Gold Nanoparticles J. Phys. Chem. C 2014, 118, 13904-13911 10.1021/jp502038v
    • (2014) J. Phys. Chem. C , vol.118 , pp. 13904-13911
    • Gao, N.1    Chen, Y.2    Li, L.3    Guan, Z.4    Zhao, T.5    Zhou, N.6    Yuan, P.7    Yao, S.8    Xu, Q.9
  • 41
    • 84864054123 scopus 로고    scopus 로고
    • Peroxidase-Mimic Bismuth-Gold Nanoparticles for Determining the Activity of Thrombin and Drug Screening
    • Lien, C.; Huang, C.; Chang, H. Peroxidase-Mimic Bismuth-Gold Nanoparticles for Determining the Activity of Thrombin and Drug Screening Chem. Commun. 2012, 48, 7952-7954 10.1039/c2cc32833j
    • (2012) Chem. Commun. , vol.48 , pp. 7952-7954
    • Lien, C.1    Huang, C.2    Chang, H.3
  • 42
    • 84899479261 scopus 로고    scopus 로고
    • ICP-MS-Based Characterization of Inorganic Nanoparticles-Sample Preparation and Off-Line Fractionation Strategies
    • Fabricius, A.; Duester, L.; Meermann, B.; Ternes, T. A. ICP-MS-Based Characterization of Inorganic Nanoparticles-Sample Preparation and Off-Line Fractionation Strategies Anal. Bioanal. Chem. 2014, 406, 467-479 10.1007/s00216-013-7480-2
    • (2014) Anal. Bioanal. Chem. , vol.406 , pp. 467-479
    • Fabricius, A.1    Duester, L.2    Meermann, B.3    Ternes, T.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.