Synthesis of an ORL-1 Receptor Antagonist via a Radical Bromination and Deoxyfluorination to Afford a gem-Difluorospirocycle

Organic Process Research and Development

Volumn 19, Issue 11, 2015, Pages 1568-1575

  Debaillie, Amy C ^a   Jones, Chauncey D ^a   Magnus, Nicholas A ^a   Mateos, Carlos ^b   Torrado, Alicia ^b   Wepsiec, James P ^a   Tokala, Ramachandar ^c   Raje, Prasad ^c  

^a ELI LILLY AND COMPANY   (United States)

^b ELI LILLY AND COMPANY   (Spain)

^c Research and Development Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROCESS ENGINEERING;

ACTIVE PHARMACEUTICAL INGREDIENTS; KEY PROCESS; PROCESS IMPROVEMENT; RECEPTOR ANTAGONISTS; SYNTHETIC SEQUENCE;

SYNTHESIS (CHEMICAL);

EID: 84947772498     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op5000094     Document Type: Article

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