Protective effects of exercise in metabolic disorders are mediated by inhibition of mitochondrial-derived sterile inflammation

Medical Hypotheses

Volumn 85, Issue 6, 2015, Pages 707-709

  Peeri, Maghsoud ^a   Amiri, Shayan ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CRYOPYRIN; DAMAGE ASSOCIATED MOLECULAR PATTERN PROTEIN; INFLAMMASOME; NUCLEAR PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; AUTOPHAGY; BIOGENESIS; EXERCISE PHYSIOLOGY; GLUCOSE TRANSPORT; HUMAN; INFLAMMATION; LIFESPAN; MAJOR DEPRESSION; METABOLIC DISORDER; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PREVENTIVE MEDICINE; PROTEIN FUNCTION; BIOLOGICAL MODEL; EVIDENCE BASED MEDICINE; EXERCISE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INNATE IMMUNITY; KINESIOTHERAPY; METABOLIC DISEASES; PHYSIOLOGICAL STRESS; PROCEDURES; TREATMENT OUTCOME;

EVIDENCE-BASED MEDICINE; EXERCISE THERAPY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; INFLAMMATION; METABOLIC DISEASES; MITOCHONDRIA; MODELS, IMMUNOLOGICAL; PHYSICAL EXERTION; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; TREATMENT OUTCOME;

EID: 84947443362     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2015.10.026     Document Type: Article

References (22)

1. Simpson R.J., Bosch J.A. Special issue on exercise immunology: current perspectives on aging, health and extreme performance. Brain Behav Immun 2014, 39:1-7.
2. Ströhle A. Physical activity, exercise, depression and anxiety disorders. J Neural Transm 2009, 116:777-784.
3. Church T. Exercise in obesity, metabolic syndrome, and diabetes. Prog Cardiovasc Dis 2011, 53:412-418.
4. Krause M., Rodrigues-Krause J.da Costa Extracellular heat shock proteins (eHSP70) in exercise: possible targets outside the immune system and their role for neurodegenerative disorders treatment. Med Hypotheses 2011, 76:286-290.
5. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
6. Bo H., Jiang N., Ji L.L., Zhang Y. Mitochondrial redox metabolism in aging: effect of exercise interventions. J Sport Health Sci 2013, 2:67-74.
7. Choi A.J.S., Ryter S.W. Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol Cell 2014, 37:441.
8. Anisman H. Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci 2009, 34:4.
9. Chen G.Y., Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010, 10:826-837.
10. Zhou R., Yazdi A.S., Menu P., Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
11. He C., Sumpter R., Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy 2012, 8:1548-1551.
12. Marosi K., Mattson M.P. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 2014, 25:89-98.
13. Chen A., Xiong L.J., Tong Y., Mao M. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep 2013, 8:1011-1016.
14. Koltai E., Hart N., Taylor A.W., et al. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol 2012, 303:R127-R134.
15. Nakahira K., Haspel J.A., Rathinam V.A.K., et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011, 12:222-230.
16. Iwata M., Ota K.T., Duman R.S. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 2013, 31:105-114.
17. Galluzzi L., Kepp O., Kroemer G. Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol 2012, 13:780-788.
18. De Felice F.G., Ferreira S.T. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 2014, 63:2262-2272.
19. Zimmet P.Z., Magliano D.J., Herman W.H., Shaw J.E. Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol 2014, 2:56-64.
20. Alzheimer's Association 2013 Alzheimer's disease facts and figures. Alzheimers Dement 2013, 9:208-245.
21. Kessler R.C., Aguilar-Gaxiola S., Alonso J., et al. The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. Epidemiol Psichiatr Soc 2009, 18:23-33.
22. Ristow M., Zarse K. How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 2010, 45:410-418.