Significance of vascular endothelial growth factor (VEGF)-C and VEGF-D in the progression of cutaneous melanoma

International Journal of Surgical Pathology

Volumn 23, Issue 8, 2015, Pages 629-637

  Špirić, Zorica ^a   Eri, Živka ^b   Erić, Mirela ^b  

^a Clinical Center of Banja Luka   (Bosnia and Herzegovina)

^b UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

lymph node metastasis; lymphangiogenesis; melanoma; VEGF C; VEGF D

Indexed keywords

VASCULOTROPIN C; VASCULOTROPIN D; TUMOR MARKER; VEGFC PROTEIN, HUMAN; VEGFD PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER GROWTH; CANCER PATIENT; CONTROLLED STUDY; CUTANEOUS MELANOMA; DISEASE FREE SURVIVAL; FEMALE; FIBROBLAST; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MELANOMA CELL; METASTATIC MELANOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL TIME; TUMOR ASSOCIATED LEUKOCYTE; AGED; BIOSYNTHESIS; DISEASE COURSE; MELANOMA; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR; YOUNG ADULT;

ADULT; AGED; BIOMARKERS, TUMOR; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; SKIN NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D; YOUNG ADULT;

EID: 84947434933     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896915583694     Document Type: Article

References (27)

1. Cueni LN, Detmar M,. New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol. 2006; 126: 2167-2177.
2. Tobler NE, Detmar M,. Tumor and lymph node lymphangiogenesis-impact on cancer metastasis. J Leukoc Biol. 2006; 80: 691-696.
3. Cao J,. Why and how do tumors stimulate lymphangiogenesis? Lymphat Res Biol. 2008; 6: 145-148.
4. Rinderknecht M, Detmar M,. Tumor lymphangiogenesis and melanoma metastasis. J Cell Physiol. 2008; 216: 347-354.
5. Schoppmann SF, Birner P, Stockl J, et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol. 2002; 161: 947-956.
6. Schoppmann SF, Fenzl A, Nagy K, et al. VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: impact on lymphangiogenesis and survival. Surgery. 2006; 139: 839-846.
7. Ueda M, Hung YC, Terai Y, et al. Vascular endothelial growth factor-C expression and invasive phenotype in ovarian carcinomas. Clin Cancer Res. 2005; 11: 3225-3232.
8. Yokoyama Y, Charnock-Jones DS, Licence D, et al. Expression of vascular endothelial growth factor (VEGF)-D and its receptor, VEGF receptor 3, as a prognostic factor in endometrial carcinoma. Clin Cancer Res. 2003; 9: 1361-1369.
9. Mohammed RA, Green A, El-Shikh S, Paish EC, Ellis IO, Martin SG,. Prognostic significance of vascular endothelial cell growth factors-A, -C, and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer. 2007; 96: 1092-1100.
10. Shida A, Fujioka S, Ishibashi Y, et al. Prognostic significance of vascular endothelial growth factor D in gastric carcinoma. World J Surg. 2005; 29: 1600-1607.
11. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med. 2001; 7: 192-198.
12. Liu B, Ma J, Wang X, et al. Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma. Anat Rec (Hoboken). 2008; 291: 1227-1235.
13. Gallego E, Vicioso L, Alvarez M, et al. Stromal expression of vascular endothelial growth factor C is relevant to predict sentinel lymph node status in melanomas. Virchows Arch. 2011; 458: 621-630.
14. Boone B, Blokx W, De Bacquer D, Lambert J, Ruiter D, Brochez L,. The role of VEGF-C staining in predicting regional metastasis in melanoma. Virchows Arch. 2008; 453: 257-265.
15. Cianfarani F, Mastroeni S, Odorisio T, et al. Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity. J Cutan Pathol. 2012; 39: 826-834.
16. Onogawa S, Kitadai Y, Tanaka S, Kuwai T, Kimura S, Chayama K,. Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci. 2004; 95: 32-39.
17. Kurahara H, Takao S, Maemura K, Shinchi H, Natsugoe S, Aikou T,. Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis. Clin Cancer Res. 2004; 10: 8413-8420.
18. Feng HC, Song YF, Wen YM,. Correlation between expression of vascular endothelial growth factor-C in tumor-associated macrophages and lymphatic metastasis in oral cancer [in Chinese]. Ai Zheng. 2004; 23: 278-281.
19. Dadras SS, Lange-Asschenfeldt B, Velasco P, et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol. 2005; 18: 1232-1242.
20. Dadras SS, Paul T, Bertoncini J, et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol. 2003; 162: 1951-1960.
21. Massi D, Puig S, Franchi A, et al. Tumor lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study. J Clin Pathol. 2006; 59: 166-173.
22. Shields JD, Borsetti M, Rigby H, et al. Lymphatic density and metastatic spread in human malignant melanoma. Br J Cancer. 2004; 90: 693-700.
23. Schietroma C, Cianfarani F, Lacal PM, et al. Vascular endothelial growth factor-C expression correlates with lymph node localization of human melanoma metastases. Cancer. 2003; 98: 789-797.
24. Koyama H, Kobayashi N, Harada M, et al. Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am J Pathol. 2008; 172: 179-193.
25. Krishnan J, Kirkin V, Steffen A, et al. Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res. 2003; 63: 713-722.
26. Kalluri R, Zeisberg M,. Fibroblasts in cancer. Nat Rev Cancer. 2006; 6: 392-401.
27. Mandriota SJ, Jussila L, Jeltsch M, et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 2001; 20: 672-682.