VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density

Tumor Biology

Volumn 36, Issue 9, 2015, Pages 7285-7292

  Ariotti, Carla ^a   Wagner, Vivian Petersen ^a   Salvadori, Gabriela ^b   Carrard, Vinicius Coelho ^a   Martins, Marco Antônio Trevizani ^c   Filho, Joao Julio da Cunha ^a   Meurer, Luise ^a   Martins, Manoela Domingues ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF OSLO   (Norway)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Actinic cheilitis; Angiogenesis; Oral squamous cell carcinoma; Potentially malignant disorders; Vascular endothelial growth factor

Indexed keywords

CD31 ANTIGEN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;

ACTINIC CHEILITIS; ARTICLE; BRAZIL; CAPILLARY DENSITY; CARCINOGENESIS; CHEILITIS; CONTROLLED STUDY; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LIP CARCINOGENESIS; LOWER LIP SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MEDICAL RECORD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; BIOSYNTHESIS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LIP TUMOR; MALE; METABOLISM; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY;

CARCINOGENESIS; CARCINOMA, SQUAMOUS CELL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIP NEOPLASMS; MALE; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84947130366     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3454-7     Document Type: Article

References (47)

1. Savage NW, McKay C, Faulkner C. Actinic cheilitis in dental practice. Aust Dent J. 2010;55 Suppl 1:78–84.
2. dos Santos JN, de Sousa SO, Nunes FD, Sotto MN, de Araujo VC. Altered cytokeratin expression in actinic cheilitis. J Cutan Pathol. 2003;4:237–41.
3. Corso FM, Wild C, Gouveia LO, Ribas MO. Actinic cheilitis: prevalence in dental clinics from PUCPR, Curitiba, Brazil. Clin Pesq Odontol. 2006;2:227–81.
4. Henrique PR, Junior MB, Araujo VC, Junqueira JLC, Furuse C. Prevalence of oral mucosal changes in the adult population from Uberaba, Minas Gerais. RGO. 2009;57:261–7.
5. de Souza Lucena EE, Costa DC, da Silveira EJ, Lima KC. Prevalence and factors associated to actinic cheilitis in beach workers. Oral Dis. 2012;18(6):575–9.
6. Miranda AM, Soares LG, Ferrari TM, Silva DG, Falabella ME, Tinoco EM. Prevalence of actinic cheilitis in a population of agricultural sugarcane workers. Acta Odontol Latinoam. 2012;25(2):201–6.
7. Sugerman PB, Savage NW. Oral cancer in Australia: 1983–1996. Aust Dent J. 2002;47(1):45–56.
8. Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind JS. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014;8(1):105–18.
9. Sasahira T, Kirita T, Kuniyasu H. Update of molecular pathobiology in oral cancer: a review. Int J Clin Oncol. 2014;19(3):431–6.
10. Robinson CJ, Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci. 2001;114(Pt 5):853–65.
11. Wey JS, Stoeltzing O, Ellis LM. Vascular endothelial growth factor receptors: expression and function in solid tumors. Clin Adv Hematol Oncol. 2004;2(1):37–45.
12. Shibuya M. Role of VEGF-flt receptor system in normal and tumor angiogenesis. Adv Cancer Res. 1995;67:281–316.
13. Margaritescu C, Pirici D, Simionescu C, Mogoanta L, Raica M, Stinga A, et al. VEGF and VEGFRs expression in oral squamous cell carcinoma. Rom J Morphol Embryol Rev Roum Morphol Embryol. 2009;50(4):527–48.
14. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18(1):4–25.
15. Reinmuth N, Liu W, Jung YD, Ahmad SA, Shaheen RM, Fan F, et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J Off Publ Fed Am Soc Exp Biol. 2001;15(7):1239–41.
16. Dias S, Hattori K, Heissig B, Zhu Z, Wu Y, Witte L, et al. Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc Natl Acad Sci U S A. 2001;98(19):10857–62.
17. Kyzas PA, Stefanou D, Agnantis NJ. Immunohistochemical expression of vascular endothelial growth factor correlates with positive surgical margins and recurrence in T1 and T2 squamous cell carcinoma (SCC) of the lower lip. Oral Oncol. 2004;40(9):941–7.
18. Margaritescu C, Pirici D, Stinga A, Simionescu C, Raica M, Mogoanta L, et al. VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study. Clin Exp Med. 2010;10(4):209–14.
19. Stinga AC, Margaritescu O, Stinga AS, Pirici D, Ciurea R, Bunget A, et al. VEGFR1 and VEGFR2 immunohistochemical expression in oral squamous cell carcinoma: a morphometric study. Rom J Morphol Embryol Rev Roum Morphol Embryol. 2011;52(4):1269–75.
20. Cabebe E, Wakelee H. Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options in Oncol. 2007;8(1):15–27.
21. Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, et al. FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011;121(7):2668–78.
22. Florence ME, Massuda JY, Brocker EB, Metze K, Cintra ML, Souza EM. Angiogenesis in the progression of cutaneous squamous cell carcinoma: an immunohistochemical study of endothelial markers. Clinics. 2011;66(3):465–8.
23. Konger RL, Xu Z, Sahu RP, Rashid BM, Mehta SR, Mohamed DR, et al. Spatiotemporal assessments of dermal hyperemia enable accurate prediction of experimental cutaneous carcinogenesis as well as chemopreventive activity. Cancer Res. 2013;73(1):150–9.
24. Shinkaruk S, Bayle M, Lain G, Deleris G. Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy. Curr Med Chem Anti Cancer Agents. 2003;3(2):95–117.
25. Michi Y, Morita I, Amagasa T, Murota S. Human oral squamous cell carcinoma cell lines promote angiogenesis via expression of vascular endothelial growth factor and upregulation of KDR/flk-1 expression in endothelial cells. Oral Oncol. 2000;36(1):81–8.
26. Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ. Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth factor receptor-2. Mod Pathol Off J U S Can Acad Pathol Inc. 2005;18(4):485–94.
27. Moriyama M, Kumagai S, Kawashiri S, Kojima K, Kakihara K, Yamamoto E. Immunohistochemical study of tumour angiogenesis in oral squamous cell carcinoma. Oral Oncol. 1997;33(5):369–74.
28. Lalla RV, Boisoneau DS, Spiro JD, Kreutzer DL. Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129(8):882–8.
29. Ciurea R, Margaritescu C, Simionescu C, Stepan A, Ciurea M. VEGF and his R1 and R2 receptors expression in mast cells of oral squamous cells carcinomas and their involvement in tumoral angiogenesis. Rom J Morphol Embryol Rev Roum Morphol Embryol. 2011;52(4):1227–32.
30. Thompson L. Health Organization classification of tumours. Pathology and genetics of tumours of the head and neck. Ear Nose Throat J. 2005;85(2):74.
31. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166(4):375–81.
32. Dhakal HP, Naume B, Synnestvedt M, Borgen E, Kaaresen R, Schlichting E, et al. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptors 1 and 2 in invasive breast carcinoma: prognostic significance and relationship with markers for aggressiveness. Histopathology. 2012;61(3):350–64.
33. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma. N Engl J Med. 1991;324(1):1–8.
34. Christopoulos A, Ahn SM, Klein JD, Kim S. Biology of vascular endothelial growth factor and its receptors in head and neck cancer: beyond angiogenesis. Head Neck. 2011;33(8):1220–9.
35. Raica M, Cimpean AM, Ribatti D. Angiogenesis in pre-malignant conditions. Eur J Cancer. 2009;45(11):1924–34.
36. Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nor JE. VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Differ. 2010;17(3):499–512.
37. Jackson MW, Roberts JS, Heckford SE, Ricciardelli C, Stahl J, Choong C, et al. A potential autocrine role for vascular endothelial growth factor in prostate cancer. Cancer Res. 2002;62(3):854–9.
38. Kyzas PA, Cunha IW, Ioannidis JP. Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis. Clin Cancer Res Off J Am Assoc Cancer Res. 2005;11(4):1434–40.
39. Carlile J, Harada K, Baillie R, Macluskey M, Chisholm DM, Ogden GR, et al. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2001;30(8):449–57.
40. Johnstone S, Logan RM. The role of vascular endothelial growth factor (VEGF) in oral dysplasia and oral squamous cell carcinoma. Oral Oncol. 2006;42(4):337–42.
41. Gandolfo M, Keszler A, Lanfranchi H, Itoiz ME. Increased subepithelial vascularization and VEGF expression reveal potentially malignant changes in human oral mucosa lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(4):486–93.
42. Sawane M, Kajiya K. Ultraviolet light-induced changes of lymphatic and blood vasculature in skin and their molecular mechanisms. Exp Dermatol. 2012;21 Suppl 1:22–5.
43. Li Y, Bi Z, Yan B, Wan Y. UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. Int J Mol Med. 2006;18(4):713–9.
44. Shintani S, Li C, Ishikawa T, Mihara M, Nakashiro K, Hamakawa H. Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma. Oral Oncol. 2004;40(1):13–20.
45. Astekar M, Joshi A, Ramesh G, Metgud R. Expression of vascular endothelial growth factor and microvessel density in oral tumorigenesis. J Oral Maxillofac Pathol JOMFP. 2012;16(1):22–6.
46. Ravi D, Ramadas K, Mathew BS, Nalinakumari KR, Nair MK, Pillai MR. Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation. Oral Oncol. 1998;34(6):543–8.
47. Macluskey M, Baillie R, Chandrachud LM, Pendleton N, Schor AM. High levels of apoptosis are associated with improved survival in non-small cell lung cancer. Anticancer Res. 2000;20(3B):2123–8.