Design, synthesis, and biological evaluation of pyrimidine-2-carboxamide analogs: Investigation for novel RAGE inhibitors with reduced hydrophobicity and toxicity

Archives of Pharmacal Research

Volumn 38, Issue 11, 2015, Pages 1952-1962

  Kim, Seok Ho ^a   Han, Young Taek ^b  

^a CHA University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Drug like property; Pyrimidine 2 carboxamide; RAGE; RAGE inhibitor

Indexed keywords

2 CHLORO 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE; 2 [2 (DIETHYLAMINO)ETHOXY] 3 METHOXYANILINE; 2 [2 (DIETHYLAMINO)ETHOXY] 4 METHOXYANILINE; 2 [2 (DIETHYLAMINO)ETHOXY] 5 METHOXYANILINE; 2 [2 (DIETHYLAMINO)ETHOXY] 6 METHOXYANILINE; 3 [2 (DIETHYLAMINO)ETHOXY] 2 METHOXYANILINE; 3 [2 (DIETHYLAMINO)ETHOXY] 4 METHOXYANILINE; 3 [2 (DIETHYLAMINO)ETHOXY] 5 METHOXYANILINE; 4 [2 (DIETHYLAMINO)ETHOXY] 2 METHOXYANILINE; 4 [2 (DIETHYLAMINO)ETHOXY] 3 METHOXYANILINE; 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE 2 CARBONITRILE; 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE 2 CARBOXYLIC ACID; 5 [2 (DIETHYLAMINO)ETHOXY] 2 METHOXYANILINE; ADVANCED GLYCATION END PRODUCT RECEPTOR ANTAGONIST; AMIDE; N [2 [2 (2 DIETHYLAMINO)ETHOXY]PHENYL 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE 2 CARBOXAMIDE; N [3 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE 2 CARBOXAMIDE; N [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 4,6 BIS(4 FLUOROPHENYL)PYRIMIDINE 2 CARBOXAMIDE; N,N DETHYL 2 (5 METHOXY 2 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (2 METHOXY 3 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (2 METHOXY 4 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (2 METHOXY 5 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (2 METHOXY 6 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (3 METHOXY 2 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (3 METHOXY 4 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (3 METHOXY 5 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (4 METHOXY 2 NITROPHENOXY)ETHANAMINE; N,N DIETHYL 2 (4 METHOXY 3 NITROPHENOXY)ETHANAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ADVANCED GLYCATION END PRODUCT RECEPTOR;

AMIDATION; ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPHILICITY; HYDROPHOBICITY; MITSUNOBU REACTION; SUZUKI REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TOXICITY TESTING;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; CELL LINE; DRUG DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 84947127283     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0596-5     Document Type: Article

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