miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma

Tumor Biology

Volumn 36, Issue 9, 2015, Pages 7017-7026

  Long, Qing Zhi ^a   Du, Yue Feng ^a   Liu, Xiao Gang ^a   Li, Xiang ^a   He, Da Lin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Chemo resistance; FZD5; miR 124; P gp; PKC; Renal cell carcinoma

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DOXORUBICIN; FRIZZLED PROTEIN; MICRORNA 124; MULTIDRUG RESISTANCE PROTEIN; PROTEIN FZD5; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN PKCBETAII; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VINBLASTINE; WNT5A PROTEIN; FZD5 PROTEIN, HUMAN; MICRORNA; MIRN124 MICRORNA, HUMAN; ONCOPROTEIN; PROTEIN KINASE C; WNT PROTEIN; WNT5A PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CELL SURVIVAL; DOWN REGULATION; HUMAN; HUMAN CELL; IC50; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CARCINOMA, RENAL CELL; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; TUMOR CELL LINE; TUMOR RECURRENCE; WNT SIGNALING PATHWAY;

CARCINOMA, RENAL CELL; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM RECURRENCE, LOCAL; P-GLYCOPROTEIN; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; VINBLASTINE; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84947127053     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3369-3     Document Type: Article

References (26)

1. Walsh N, Larkin A, Kennedy S, et al. Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. BMC Urol. 2009;9:6.
2. Feng DD, Zhang H, Zhang P, et al. Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. J Cell Mol Med. 2011;15:2164–75.
3. Gowrishankar B, Ibragimova I, Zhou Y, et al. MicroRNA expression signatures of stage, grade, and progression in clear cell RCC. Cancer Biol Ther. 2014;15:329–41.
4. Gong J, Jaiswal R, Mathys JM, et al. Microparticles and their emerging role in cancer multidrug resistance. Cancer Treat Rev. 2012;38:226–34.
5. Bian HB, Pan X, Yang JS, Wang ZX, De W. Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). J Exp Clin Cancer Res. 2011;30:20.
6. Zhu H, Wu H, Liu X, et al. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol. 2008;76:582–8.
7. Chakravarthi BV, Pathi SS, Goswami MT, et al. The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. Oncotarget. 2014;5:6654–69.
8. Wan HY, Li QQ, Zhang Y, et al. MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells. Cancer Lett. 2014;355:148–58.
9. Jinushi T, Shibayama Y, Kinoshita I, et al. Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4. Cancer Med. 2014;34:1258–69.
10. Gebauer K, Peters I, Dubrowinskaja N, et al. Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma. Br J Cancer. 2013;108:131–8.
11. McDonald S, Silver A. The opposing roles of Wnt-5a in cancer. Br J Cancer. 2009;101:209–14.
12. Hirata H, Ueno K, Nakajima K, et al. Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells. Br J Cancer. 2013;108:2070–8.
13. Janssens N, Andries L, Janicot M, Perera T, Bakker A. Alteration of frizzled expression in renal cell carcinoma. Tumour Biol. 2004;25:161–71.
14. Kruck S, Eyrich C, Scharpf M, et al. Impact of an altered Wnt1/beta-catenin expression on clinicopathology and prognosis in clear cell renal cell carcinoma. Int J Mol Sci. 2013;14:10944–57.
15. Correa S, Binato R, Du Rocher B, et al. Wnt/beta-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia. BMC Cancer. 2012;12:303.
16. Pinzón-Daza ML, Salaroglio IC, Kopecka J, et al. The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood–brain barrier cells. J Cereb Blood Flow Metab. 2014;3:1544–52.
17. Long Q-Z, Zhou M, Liu X-G, et al. Interaction of CCN1 with αvβ3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells. Anticancer Drug. 2013;24:810–7.
18. Perez-Tomas R. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem. 2006;13:1859–76.
19. Slaby O, Redova M, Poprach A, et al. Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. Genes Chromosomes Cancer. 2012;51:707–16.
20. Zhang Y, Zheng L, Huang J, et al. MiR-124 radiosensitizes human colorectal cancer cells by targeting PRRX1. PLoS One. 2014;9:e93917.
21. Asuthkar S, Stepanova V, Lebedeva T, et al. Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer. Mol Biol Cell. 2013;24:2620–32.
22. Zang T, Zhuang L, Zhang Z, Xin D, Guo Y. Aberrant activity of Wnt/Frizzled signaling pathway in renal cancer cell lines. Chin Sci Bull. 2000;45:1703–7.
23. Rao Q, Liu XH, Zhou HB, et al. Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. Tumori. 2010;96:304–9.
24. Zhuang L, Zhang Z, Guo Y. Aberrant expression of growth factor Wnt-5A in six urinary malignant cell lines. Chin Med J (Engl). 1999;112:251–5.
25. Flescher E, Rotem R. Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells. Cell Signal. 2002;14:37–43.
26. Gill PK, Gescher A, Gant TW. Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes α and θ. Eur J Biochem. 2001;268:4151–7.