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Volumn 24, Issue 11, 2015, Pages 1447-1458

Current Phase II drugs under investigation for the treatment of limb ischemia

Author keywords

critical limb ischemia; drug therapy; drug coated balloons; drug eluting stents; endovascualar treatment; Phase II trials; therapeutic angiogenesis

Indexed keywords

ANTICOAGULANT AGENT; DEXAMETHASONE; EVEROLIMUS; FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PACLITAXEL; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1; TICAGRELOR; UROKINASE; VASCULOTROPIN; NEW DRUG;

EID: 84947044380     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2015.1081894     Document Type: Review
Times cited : (6)

References (70)
  • 1
    • 33846497950 scopus 로고    scopus 로고
    • Inter-society consensus for the management of peripheral arterial disease (TASC II)
    • Norgren L, Hiatt WR, Dormandy JA, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 2007; 45 (Suppl S): S5-67
    • (2007) J Vasc Surg , vol.45 , pp. S5-67
    • Norgren, L.1    Hiatt, W.R.2    Dormandy, J.A.3
  • 2
    • 28244470064 scopus 로고    scopus 로고
    • Bypass versus angioplasty in severe ischaemia of the leg (BASIL): Multicentre, randomised controlled trial
    • Adam DJ, Beard JD, Cleveland T, et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet 2005; 366 (9501): 1925-34
    • (2005) Lancet , vol.366 , Issue.9501 , pp. 1925-1934
    • Adam, D.J.1    Beard, J.D.2    Cleveland, T.3
  • 3
    • 84964313255 scopus 로고    scopus 로고
    • MSCs isolated from patients with ischemic vascular disease have normal angiogenic potential
    • Sanz-Nogues C, OBrien T. MSCs isolated from patients with ischemic vascular disease have normal angiogenic potential. Mol Ther 2014; 22 (11): 1888-9
    • (2014) Mol Ther , vol.22 , Issue.11 , pp. 1888-1889
    • Sanz-Nogues, C.1    O'Brien, T.2
  • 4
    • 33748855436 scopus 로고    scopus 로고
    • A collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery
    • quiz 1398 ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower extremity, renal, mesenteric, and abdominal aortic)
    • Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease) - summary of recommendations. J Vasc Interv Radiol 2006; 17 (9): 1383-97; quiz 1398
    • (2006) J Vasc Interv Radiol , vol.17 , Issue.9 , pp. 1383-1397
    • Hirsch, A.T.1    Haskal, Z.J.2    Hertzer, N.R.3
  • 5
  • 6
    • 84890570942 scopus 로고    scopus 로고
    • Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model
    • Yazdani SK, Pacheco E, Nakano M, et al. Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model. Catheter Cardiovasc Interv 2014; 83 (1): 132-40
    • (2014) Catheter Cardiovasc Interv , vol.83 , Issue.1 , pp. 132-140
    • Yazdani, S.K.1    Pacheco, E.2    Nakano, M.3
  • 7
    • 84897837638 scopus 로고    scopus 로고
    • Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery
    • e8
    • Katsanos K, Spiliopoulos S, Karunanithy N, et al. Bayesian network meta-analysis of nitinol stents, covered stents, drug-eluting stents, and drug-coated balloons in the femoropopliteal artery. J Vasc Surg 2014; 59 (4): 1123-1133 e8
    • (2014) J Vasc Surg , vol.59 , Issue.4 , pp. 1123-1133
    • Katsanos, K.1    Spiliopoulos, S.2    Karunanithy, N.3
  • 8
    • 84908130786 scopus 로고    scopus 로고
    • Drug-eluting balloon versus standard balloon angioplasty for infrapopliteal arterial revascularization in critical limb ischemia: 12-month results from the IN.PACT DEEP randomized trial
    • Zeller T, Baumgartner I, Scheinert D, et al. Drug-eluting balloon versus standard balloon angioplasty for infrapopliteal arterial revascularization in critical limb ischemia: 12-month results from the IN.PACT DEEP randomized trial. J Am Coll Cardiol 2014; 64 (15): 1568-76
    • (2014) J Am Coll Cardiol , vol.64 , Issue.15 , pp. 1568-1576
    • Zeller, T.1    Baumgartner, I.2    Scheinert, D.3
  • 9
    • 84881121434 scopus 로고    scopus 로고
    • Drug-eluting balloon in peripheral intervention for below the knee angioplasty evaluation (DEBATE-BTK): A randomized trial in diabetic patients with critical limb ischemia
    • Liistro F, Porto I, Angioli P, et al. Drug-eluting balloon in peripheral intervention for below the knee angioplasty evaluation (DEBATE-BTK): a randomized trial in diabetic patients with critical limb ischemia. Circulation 2013; 128 (6): 615-21
    • (2013) Circulation , vol.128 , Issue.6 , pp. 615-621
    • Liistro, F.1    Porto, I.2    Angioli, P.3
  • 10
    • 84900455221 scopus 로고    scopus 로고
    • The "dEBELLUM" - Lower limb multilevel treatment with drug eluting balloon - Randomized trial: 1-year results
    • Fanelli F, Cannavale A, Corona M, et al. The "DEBELLUM" - lower limb multilevel treatment with drug eluting balloon - randomized trial: 1-year results. J Cardiovasc Surg (Torino) 2014; 55 (2): 207-16
    • (2014) J Cardiovasc Surg (Torino) , vol.55 , Issue.2 , pp. 207-216
    • Fanelli, F.1    Cannavale, A.2    Corona, M.3
  • 11
    • 41149176136 scopus 로고    scopus 로고
    • Comparison of a polymer-free rapamycin-eluting stent (YUKON) with a polymer-based paclitaxel-eluting stent (TAXUS) in real-world coronary artery lesions
    • Ruef J, Störger H, Schwarz F, Haase J. Comparison of a polymer-free rapamycin-eluting stent (YUKON) with a polymer-based paclitaxel-eluting stent (TAXUS) in real-world coronary artery lesions. Catheter Cardiovasc Interv 2008; 71 (3): 333-9
    • (2008) Catheter Cardiovasc Interv , vol.71 , Issue.3 , pp. 333-339
    • Ruef, J.1    Störger, H.2    Schwarz, F.3    Haase, J.4
  • 12
    • 84870211605 scopus 로고    scopus 로고
    • A prospective randomized multicenter comparison of balloon angioplasty and infrapopliteal stenting with the sirolimus-eluting stent in patients with ischemic peripheral arterial disease: 1-year results from the ACHILLES trial
    • Scheinert D, Katsanos K, Zeller T, et al. A prospective randomized multicenter comparison of balloon angioplasty and infrapopliteal stenting with the sirolimus-eluting stent in patients with ischemic peripheral arterial disease: 1-year results from the ACHILLES trial. J Am Coll Cardiol 2012; 60 (22): 2290-5
    • (2012) J Am Coll Cardiol , vol.60 , Issue.22 , pp. 2290-2295
    • Scheinert, D.1    Katsanos, K.2    Zeller, T.3
  • 13
    • 84856120442 scopus 로고    scopus 로고
    • Randomized comparison of everolimus-eluting versus bare-metal stents in patients with critical limb ischemia and infrapopliteal arterial occlusive disease
    • Bosiers M, Scheinert D, Peeters P, et al. Randomized comparison of everolimus-eluting versus bare-metal stents in patients with critical limb ischemia and infrapopliteal arterial occlusive disease. J Vasc Surg 2012; 55 (2): 390-8
    • (2012) J Vasc Surg , vol.55 , Issue.2 , pp. 390-398
    • Bosiers, M.1    Scheinert, D.2    Peeters, P.3
  • 14
    • 79951787896 scopus 로고    scopus 로고
    • Primary everolimus-eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of critical limb ischemia
    • Karnabatidis D, Spiliopoulos S, Diamantopoulos A, et al. Primary everolimus-eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of critical limb ischemia. J Endovasc Ther 2011; 18 (1): 1-12
    • (2011) J Endovasc Ther , vol.18 , Issue.1 , pp. 1-12
    • Karnabatidis, D.1    Spiliopoulos, S.2    Diamantopoulos, A.3
  • 15
    • 84925232347 scopus 로고    scopus 로고
    • Antiplatelet therapy in critical limb ischemia: Update on clopidogrel and cilostazol
    • Spiliopoulos S. Antiplatelet therapy in critical limb ischemia: update on clopidogrel and cilostazol. J Cardiovasc Surg (Torino) 2014; 55 (5): 631-40
    • (2014) J Cardiovasc Surg (Torino) , vol.55 , Issue.5 , pp. 631-640
    • Spiliopoulos, S.1
  • 16
    • 84878952038 scopus 로고    scopus 로고
    • Platelet responsiveness to clopidogrel treatment after peripheral endovascular procedures: The PRECLOP study: Clinical impact and optimal cutoff value of on-treatment high platelet reactivity
    • Spiliopoulos S, Pastromas G, Katsanos K, et al. Platelet responsiveness to clopidogrel treatment after peripheral endovascular procedures: the PRECLOP study: clinical impact and optimal cutoff value of on-treatment high platelet reactivity. J Am Coll Cardiol 2013; 61 (24): 2428-34
    • (2013) J Am Coll Cardiol , vol.61 , Issue.24 , pp. 2428-2434
    • Spiliopoulos, S.1    Pastromas, G.2    Katsanos, K.3
  • 17
    • 84890025521 scopus 로고    scopus 로고
    • Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding
    • Tantry US, Bonello L, Aradi D, et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol 2013; 62 (24): 2261-73
    • (2013) J Am Coll Cardiol , vol.62 , Issue.24 , pp. 2261-2273
    • Tantry, U.S.1    Bonello, L.2    Aradi, D.3
  • 18
    • 84893183646 scopus 로고    scopus 로고
    • Initial experience with ticagrelor in patients with critical limb ischemia and high on-clopidogrel platelet reactivity undergoing complex peripheral endovascular procedures
    • Spiliopoulos S, et al. Initial experience with ticagrelor in patients with critical limb ischemia and high on-clopidogrel platelet reactivity undergoing complex peripheral endovascular procedures. Cardiovasc Intervent Radiol 2014; 37 (6): 1450-7
    • (2014) Cardiovasc Intervent Radiol , vol.37 , Issue.6 , pp. 1450-1457
    • Spiliopoulos, S.1
  • 19
    • 0035975974 scopus 로고    scopus 로고
    • Perivascular inflammation after balloon angioplasty of porcine coronary arteries
    • Okamoto E, Katsanos K, Pastromas G, et al. Perivascular inflammation after balloon angioplasty of porcine coronary arteries. Circulation 2001; 104 (18): 2228-35
    • (2001) Circulation , vol.104 , Issue.18 , pp. 2228-2235
    • Okamoto, E.1    Katsanos, K.2    Pastromas, G.3
  • 20
    • 0035683548 scopus 로고    scopus 로고
    • Perivascular responses after angioplasty which may contribute to postangioplasty restenosis: A role for circulating myofibroblast precursors?
    • discussion 90-2
    • Wilcox JN, Okamoto EI, Nakahara KI, et al. Perivascular responses after angioplasty which may contribute to postangioplasty restenosis: a role for circulating myofibroblast precursors? Ann N Y Acad Sci 2001; 947: 68-90; discussion 90-2
    • (2001) Ann N y Acad Sci , vol.947 , pp. 68-90
    • Wilcox, J.N.1    Okamoto, E.I.2    Nakahara, K.I.3
  • 21
    • 84897088972 scopus 로고    scopus 로고
    • Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization
    • Owens CD, Gasper WJ, Walker JP, et al. Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization. J Vasc Surg 2014; 59 (4): 1016-24
    • (2014) J Vasc Surg , vol.59 , Issue.4 , pp. 1016-1024
    • Owens, C.D.1    Gasper, W.J.2    Walker, J.P.3
  • 22
    • 84155192521 scopus 로고    scopus 로고
    • Noninvasive management of the diabetic foot with critical limb ischemia: Current options and future perspectives
    • Weck M, Slesaczeck T, Rietzsch H, et al. Noninvasive management of the diabetic foot with critical limb ischemia: current options and future perspectives. Ther Adv Endocrinol Metab 2011; 2 (6): 247-55
    • (2011) Ther Adv Endocrinol Metab , vol.2 , Issue.6 , pp. 247-255
    • Weck, M.1    Slesaczeck, T.2    Rietzsch, H.3
  • 23
    • 51349124818 scopus 로고    scopus 로고
    • Intermittent intravenous urokinase for critical limb ischemia in diabetic foot ulceration
    • Weck M, Rietzsch H, Lawall H, et al. Intermittent intravenous urokinase for critical limb ischemia in diabetic foot ulceration. Thromb Haemost 2008; 100 (3): 475-82
    • (2008) Thromb Haemost , vol.100 , Issue.3 , pp. 475-482
    • Weck, M.1    Rietzsch, H.2    Lawall, H.3
  • 24
    • 84921743862 scopus 로고    scopus 로고
    • Effect of systemic urokinase infusion after lower limb percutaneous transluminal angioplasty on limb salvage rate in patients with late-stage critical limb ischemia
    • Yen HT, Hsieh MJ, Wu CC, Lee FY. Effect of systemic urokinase infusion after lower limb percutaneous transluminal angioplasty on limb salvage rate in patients with late-stage critical limb ischemia. Eur J Vasc Endovasc Surg 2014; 48 (4): 414-22
    • (2014) Eur J Vasc Endovasc Surg , vol.48 , Issue.4 , pp. 414-422
    • Yen, H.T.1    Hsieh, M.J.2    Wu, C.C.3    Lee, F.Y.4
  • 25
    • 63049135007 scopus 로고    scopus 로고
    • Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model
    • Katsanos K, Karnabatidis D, Diamantopoulos A, et al. Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model. J Vasc Surg 2009; 49 (4): 1000-12
    • (2009) J Vasc Surg , vol.49 , Issue.4 , pp. 1000-1012
    • Katsanos, K.1    Karnabatidis, D.2    Diamantopoulos, A.3
  • 26
    • 79958118819 scopus 로고    scopus 로고
    • Effect of fibroblast growth factor NV1FGF on amputation and death: A randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    • Belch J, Hiatt WR, Baumgartner I, et al. Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet 2011; 377 (9781): 1929-37
    • (2011) Lancet , vol.377 , Issue.9781 , pp. 1929-1937
    • Belch, J.1    Hiatt, W.R.2    Baumgartner, I.3
  • 27
    • 34249680152 scopus 로고    scopus 로고
    • Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease
    • Mac Gabhann F, Ji JW, Popel AS. Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease. Ann Biomed Eng 2007; 35 (6): 982-94
    • (2007) Ann Biomed Eng , vol.35 , Issue.6 , pp. 982-994
    • Mac Gabhann, F.1    Ji, J.W.2    Popel, A.S.3
  • 28
    • 0032979424 scopus 로고    scopus 로고
    • Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy
    • Morishita R, Ji JW, Popel AS, et al. Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy. Hypertension 1999; 33 (6): 1379-84
    • (1999) Hypertension , vol.33 , Issue.6 , pp. 1379-1384
    • Morishita, R.1    Ji, J.W.2    Popel, A.S.3
  • 29
    • 50949129278 scopus 로고    scopus 로고
    • Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia
    • Powell RJ, Simons M, Mendelsohn FO, et al. Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 2008; 118 (1): 58-65
    • (2008) Circulation , vol.118 , Issue.1 , pp. 58-65
    • Powell, R.J.1    Simons, M.2    Mendelsohn, F.O.3
  • 30
    • 78650184311 scopus 로고    scopus 로고
    • Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial
    • Powell RJ, Goodney P, Mendelsohn FO, et al. Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: results of the HGF-0205 trial. J Vasc Surg 2010; 52 (6): 1525-30
    • (2010) J Vasc Surg , vol.52 , Issue.6 , pp. 1525-1530
    • Powell, R.J.1    Goodney, P.2    Mendelsohn, F.O.3
  • 31
    • 84868119129 scopus 로고    scopus 로고
    • Re: Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia
    • Teraa M, Sprengers RW, Leiner T, Verhaar MC. Re: Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia. Cell Transplant 2012; 21 (8): 1803-4
    • (2012) Cell Transplant , vol.21 , Issue.8 , pp. 1803-1804
    • Teraa, M.1    Sprengers, R.W.2    Leiner, T.3    Verhaar, M.C.4
  • 32
    • 0036665610 scopus 로고    scopus 로고
    • Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
    • Makinen K, Manninen H, Hedman M, et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 2002; 6 (1): 127-33
    • (2002) Mol Ther , vol.6 , Issue.1 , pp. 127-133
    • Makinen, K.1    Manninen, H.2    Hedman, M.3
  • 33
    • 0142023866 scopus 로고    scopus 로고
    • Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: A phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication
    • Rajagopalan S, Mohler ER III, Lederman RJ, et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 2003; 108 (16): 1933-8
    • (2003) Circulation , vol.108 , Issue.16 , pp. 1933-1938
    • Rajagopalan, S.1    Mohler, E.R.2    Lederman, R.J.3
  • 34
    • 73249140173 scopus 로고    scopus 로고
    • Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice
    • Sarkar K, Fox-Talbot K, Steenbergen C, et al. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci USA 2009; 106 (44): 18769-74
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.44 , pp. 18769-18774
    • Sarkar, K.1    Fox-Talbot, K.2    Steenbergen, C.3
  • 35
    • 0034739533 scopus 로고    scopus 로고
    • Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
    • Vincent KA, Shyu KG, Luo Y, et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000; 102 (18): 2255-61
    • (2000) Circulation , vol.102 , Issue.18 , pp. 2255-2261
    • Vincent, K.A.1    Shyu, K.G.2    Luo, Y.3
  • 36
    • 80054960235 scopus 로고    scopus 로고
    • Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication
    • Creager MA, Shyu KG, Luo Y, et al. Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication. Circulation 2011; 124 (16): 1765-73
    • (2011) Circulation , vol.124 , Issue.16 , pp. 1765-1773
    • Creager, M.A.1    Shyu, K.G.2    Luo, Y.3
  • 37
    • 2542464782 scopus 로고    scopus 로고
    • Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: Next-generation chemokine therapy for therapeutic neovascularization
    • Hiasa K, Ishibashi M, Ohtani K, et al. Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation 2004; 109 (20): 2454-61
    • (2004) Circulation , vol.109 , Issue.20 , pp. 2454-2461
    • Hiasa, K.1    Ishibashi, M.2    Ohtani, K.3
  • 38
    • 84973379615 scopus 로고    scopus 로고
    • Abstract 19419: A Phase IIa Randomized Double-Blind, Placebo Controlled Study to Evaluate Plasmid Stromal Cell-Derived Factor-1 for Treatment of Critical Limb Ischemia - The STOP-CLI Trial
    • Kibbe MR. Abstract 19419: A Phase IIa Randomized Double-Blind, Placebo Controlled Study to Evaluate Plasmid Stromal Cell-Derived Factor-1 for Treatment of Critical Limb Ischemia-The STOP-CLI Trial. Circulation 2014; 130 (Suppl 2): A19419
    • (2014) Circulation , vol.130 , pp. A19419
    • Kibbe, M.R.1
  • 39
    • 84973897576 scopus 로고    scopus 로고
    • Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia
    • Epub ahead of print
    • Kumagai M, Marui A, Tabata Y, et al. Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia. Heart Vessels 2015; Epub ahead of print
    • (2015) Heart Vessels
    • Kumagai, M.1    Marui, A.2    Tabata, Y.3
  • 40
    • 80054958024 scopus 로고    scopus 로고
    • Concise review: Circulating endothelial progenitor cells for vascular medicine
    • Asahara T, Kawamoto A, Masuda H. Concise review: Circulating endothelial progenitor cells for vascular medicine. Stem Cells 2011; 29 (11): 1650-5
    • (2011) Stem Cells , vol.29 , Issue.11 , pp. 1650-1655
    • Asahara, T.1    Kawamoto, A.2    Masuda, H.3
  • 41
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85 (3): 221-8
    • (1999) Circ Res , vol.85 , Issue.3 , pp. 221-228
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3
  • 42
    • 0034721785 scopus 로고    scopus 로고
    • Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
    • Crosby JR, Kaminski WE, Schatteman G, et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res 2000; 87 (9): 728-30
    • (2000) Circ Res , vol.87 , Issue.9 , pp. 728-730
    • Crosby, J.R.1    Kaminski, W.E.2    Schatteman, G.3
  • 43
    • 84873153223 scopus 로고    scopus 로고
    • Bone marrow alterations and lower endothelial progenitor cell numbers in critical limb ischemia patients
    • Teraa M, Sprengers RW, Westerweel PE, et al. Bone marrow alterations and lower endothelial progenitor cell numbers in critical limb ischemia patients. PLoS ONE 2013; 8 (1): e55592
    • (2013) PLoS ONE , vol.8 , Issue.1 , pp. e55592
    • Teraa, M.1    Sprengers, R.W.2    Westerweel, P.E.3
  • 44
    • 0035852662 scopus 로고    scopus 로고
    • Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    • Shintani S, Murohara T, Ikeda H, et al. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 2001; 103 (6): 897-903
    • (2001) Circulation , vol.103 , Issue.6 , pp. 897-903
    • Shintani, S.1    Murohara, T.2    Ikeda, H.3
  • 45
    • 0037055666 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomised controlled trial
    • Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002; 360 (9331): 427-35
    • (2002) Lancet , vol.360 , Issue.9331 , pp. 427-435
    • Tateishi-Yuyama, E.1    Matsubara, H.2    Murohara, T.3
  • 46
    • 84864867010 scopus 로고    scopus 로고
    • Concise review: Bone marrow mononuclear cells for the treatment of ischemic syndromes: Medicinal product or cell transplantation?
    • Cuende N, Rico L, Herrera C. Concise review: bone marrow mononuclear cells for the treatment of ischemic syndromes: medicinal product or cell transplantation? Stem Cells Transl Med 2012; 1 (5): 403-8
    • (2012) Stem Cells Transl Med , vol.1 , Issue.5 , pp. 403-408
    • Cuende, N.1    Rico, L.2    Herrera, C.3
  • 47
    • 79954448926 scopus 로고    scopus 로고
    • Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: A randomized-start, placebo-controlled pilot trial (PROVASA)
    • Walter DH, Krankenberg H, Balzer JO, et al. Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA). Circ Cardiovasc Interv 2011; 4 (1): 26-37
    • (2011) Circ Cardiovasc Interv , vol.4 , Issue.1 , pp. 26-37
    • Walter, D.H.1    Krankenberg, H.2    Balzer, J.O.3
  • 48
    • 80053355891 scopus 로고    scopus 로고
    • The role of amputation as an outcome measure in cellular therapy for critical limb ischemia: Implications for clinical trial design
    • Benoit E, O'Donnell TF Jr, Iafrati MD, et al. The role of amputation as an outcome measure in cellular therapy for critical limb ischemia: implications for clinical trial design. J Transl Med 2011; 9: 165
    • (2011) J Transl Med , vol.9 , pp. 165
    • Benoit, E.1    O'Donnell, T.F.2    Iafrati, M.D.3
  • 49
    • 84873692312 scopus 로고    scopus 로고
    • A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia
    • Losordo DW, et al. A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia. Circ Cardiovasc Interv 2012; 5 (6): 821-30
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.6 , pp. 821-830
    • Losordo, D.W.1
  • 50
    • 84885601136 scopus 로고    scopus 로고
    • Autologous bone marrow mononuclear cells transplant in patients with critical leg ischemia: Preliminary clinical results
    • Li M, Kibbe MR, Mendelsohn F, et al. Autologous bone marrow mononuclear cells transplant in patients with critical leg ischemia: preliminary clinical results. Exp Clin Transplant 2013; 11 (5): 435-9
    • (2013) Exp Clin Transplant , vol.11 , Issue.5 , pp. 435-439
    • Li, M.1    Kibbe, M.R.2    Mendelsohn, F.3
  • 51
    • 84929516694 scopus 로고    scopus 로고
    • Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: The randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial
    • Teraa M, Sprengers RW, Schutgens RE, et al. Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial. Circulation 2015; 131 (10): 851-60
    • (2015) Circulation , vol.131 , Issue.10 , pp. 851-860
    • Teraa, M.1    Sprengers, R.W.2    Schutgens, R.E.3
  • 52
    • 0022464077 scopus 로고
    • Molecular and cellular differentiation of muscle, cartilage, and bone in the developing limb
    • Caplan AI. Molecular and cellular differentiation of muscle, cartilage, and bone in the developing limb. Prog Clin Biol Res 1986; 217B: 307-18
    • (1986) Prog Clin Biol Res , vol.217 B , pp. 307-318
    • Caplan, A.I.1
  • 53
    • 0021806501 scopus 로고
    • Characterization of fibroblastic stromal cells from murine bone marrow
    • Piersma A.H, et al. Characterization of fibroblastic stromal cells from murine bone marrow. Exp Hematol 1985; 13 (4): 237-43
    • (1985) Exp Hematol , vol.13 , Issue.4 , pp. 237-243
    • Piersma, A.H.1
  • 54
    • 0034468279 scopus 로고    scopus 로고
    • Mesenchymal precursor cells in the blood of normal individuals
    • Zvaifler NJ, Brockbank KG, Ploemacher RE, et al. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res 2000; 2 (6): 477-88
    • (2000) Arthritis Res , vol.2 , Issue.6 , pp. 477-488
    • Zvaifler, N.J.1    Brockbank, K.G.2    Ploemacher, R.E.3
  • 55
    • 18744373595 scopus 로고    scopus 로고
    • Human adipose tissue is a source of multipotent stem cells
    • Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13 (12): 4279-95
    • (2002) Mol Biol Cell , vol.13 , Issue.12 , pp. 4279-4295
    • Zuk, P.A.1    Zhu, M.2    Ashjian, P.3
  • 56
    • 0034881402 scopus 로고    scopus 로고
    • Multipotent mesenchymal stem cells from adult human synovial membrane
    • De Bari C, DellAccio F, Tylzanowski P, et al. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 2001; 44 (8): 1928-42
    • (2001) Arthritis Rheum , vol.44 , Issue.8 , pp. 1928-1942
    • De Bari, C.1    DellAccio, F.2    Tylzanowski, P.3
  • 57
    • 57449102937 scopus 로고    scopus 로고
    • Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells
    • Barlow S, Brooke G, Chatterjee K, et al. Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev 2008; 17 (6): 1095-107
    • (2008) Stem Cells Dev , vol.17 , Issue.6 , pp. 1095-1107
    • Barlow, S.1    Brooke, G.2    Chatterjee, K.3
  • 58
    • 34547217039 scopus 로고    scopus 로고
    • The in vitro migration capacity of human bone marrow mesenchymal stem cells: Comparison of chemokine and growth factor chemotactic activities
    • Ponte AL, Marais E, Gallay N, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 2007; 25 (7): 1737-45
    • (2007) Stem Cells , vol.25 , Issue.7 , pp. 1737-1745
    • Ponte, A.L.1    Marais, E.2    Gallay, N.3
  • 59
    • 34247472169 scopus 로고    scopus 로고
    • Towards in situ tissue repair: Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2
    • Ringe J, Strassburg S, Neumann K, et al. Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem 2007; 101 (1): 135-46
    • (2007) J Cell Biochem , vol.101 , Issue.1 , pp. 135-146
    • Ringe, J.1    Strassburg, S.2    Neumann, K.3
  • 60
    • 84878722277 scopus 로고    scopus 로고
    • A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia
    • Gupta PK, Chullikana A, Parakh R, et al. A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia. J Transl Med 2013; 11: 143
    • (2013) J Transl Med , vol.11 , pp. 143
    • Gupta, P.K.1    Chullikana, A.2    Parakh, R.3
  • 61
    • 79954575328 scopus 로고    scopus 로고
    • Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: A double-blind, randomized, controlled trial
    • Lu D, Chen B, Liang Z, et al. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract 2011; 92 (1): 26-36
    • (2011) Diabetes Res Clin Pract , vol.92 , Issue.1 , pp. 26-36
    • Lu, D.1    Chen, B.2    Liang, Z.3
  • 62
    • 84925157072 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for critical limb ischemia
    • Ko SH, Bandyk DF. Therapeutic angiogenesis for critical limb ischemia. Semin Vasc Surg 2014; 27 (1): 23-31
    • (2014) Semin Vasc Surg , vol.27 , Issue.1 , pp. 23-31
    • Ko, S.H.1    Bandyk, D.F.2
  • 64
    • 84928941108 scopus 로고    scopus 로고
    • Nanoscale strategies: Treatment for peripheral vascular disease and critical limb ischemia
    • Tu C, Das S, Baker AB, et al. Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia. ACS Nano 2015; 9 (4): 3436-52
    • (2015) ACS Nano , vol.9 , Issue.4 , pp. 3436-3452
    • Tu, C.1    Das, S.2    Baker, A.B.3
  • 65
    • 84861866655 scopus 로고    scopus 로고
    • Cellular therapy with Ixmyelocel-T to treat critical limb ischemia: The randomized, double-blind, placebo-controlled RESTORE-CLI trial
    • Powell RJ, Marston WA, Berceli SA, et al. Cellular therapy with Ixmyelocel-T to treat critical limb ischemia: the randomized, double-blind, placebo-controlled RESTORE-CLI trial. Mol Ther 2012; 20 (6): 1280-6
    • (2012) Mol Ther , vol.20 , Issue.6 , pp. 1280-1286
    • Powell, R.J.1    Marston, W.A.2    Berceli, S.A.3
  • 67
    • 84907297786 scopus 로고    scopus 로고
    • Venous drug-eluting vs. Bare-metal stenting: An experimental animal study using frequency domain optical coherence tomography
    • Kitrou PM, Spiliopoulos S, Katsanos K, et al. Venous drug-eluting vs. bare-metal stenting: an experimental animal study using frequency domain optical coherence tomography. Hellenic J Cardiol 2014; 55 (5): 386-92
    • (2014) Hellenic J Cardiol , vol.55 , Issue.5 , pp. 386-392
    • Kitrou, P.M.1    Spiliopoulos, S.2    Katsanos, K.3
  • 68
    • 84856715087 scopus 로고    scopus 로고
    • Frequency-domain intravascular optical coherence tomography of the femoropopliteal artery
    • Karnabatidis D, Katsanos K, Paraskevopoulos I, et al. Frequency-domain intravascular optical coherence tomography of the femoropopliteal artery. Cardiovasc Intervent Radiol 2011; 34 (6): 1172-81
    • (2011) Cardiovasc Intervent Radiol , vol.34 , Issue.6 , pp. 1172-1181
    • Karnabatidis, D.1    Katsanos, K.2    Paraskevopoulos, I.3
  • 69
    • 76149140928 scopus 로고    scopus 로고
    • Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    • Srinivasan VJ, Jiang JY, Yaseen MA, et al. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography. Opt Lett 2010; 35 (1): 43-5
    • (2010) Opt Lett , vol.35 , Issue.1 , pp. 43-45
    • Srinivasan, V.J.1    Jiang, J.Y.2    Yaseen, M.A.3
  • 70
    • 84886818072 scopus 로고    scopus 로고
    • Simultaneous magnetic resonance angiography and perfusion (MRAP) measurement: Initial application in lower extremity skeletal muscle
    • Wright KL, Seiberlich N, Jesberger JA, et al. Simultaneous magnetic resonance angiography and perfusion (MRAP) measurement: initial application in lower extremity skeletal muscle. J Magn Reson Imaging 2013; 38 (5): 1237-44
    • (2013) J Magn Reson Imaging , vol.38 , Issue.5 , pp. 1237-1244
    • Wright, K.L.1    Seiberlich, N.2    Jesberger, J.A.3


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