Clinical and biochemical determinants of the extent of liver steatosis in type 2 diabetes mellitus

European Journal of Gastroenterology and Hepatology

Volumn 27, Issue 12, 2015, Pages 1386-1391

  Cosma, Alessandra ^a   Cecchet, Diego ^a   Gaiani, Silvia ^b   Coracina, Anna ^a   Pellizzari, Paolo ^c   Pizzi, Claudio ^c   Veronese, Nicola ^a   Sacerdoti, David ^b   Tessari, Paolo ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

Author keywords

Hemoglobin A1c; insulin resistance; leptin; liver steatosis; metabolic control; multiple regression analysis; nonalcoholic fatty liver disease; predictive model; type 2 diabetes mellitus; visceral adiposity

Indexed keywords

BIOCHEMICAL MARKER; C REACTIVE PROTEIN; FIBRINOGEN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

AGED; ARTICLE; BODY MASS; CLINICAL FEATURE; DIASTOLIC BLOOD PRESSURE; FATTY LIVER; FEMALE; HUMAN; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREVALENCE; PRIORITY JOURNAL; SEX RATIO; WAIST HIP RATIO; ANTHROPOMETRY; BLOOD; COMPLICATION; ECHOGRAPHY; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSIOLOGY; PROCEDURES; STATISTICAL MODEL; WAIST CIRCUMFERENCE;

ADIPOSITY; AGED; ANTHROPOMETRY; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MODELS, STATISTICAL; NON-ALCOHOLIC FATTY LIVER DISEASE; WAIST CIRCUMFERENCE;

EID: 84947032384     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0000000000000462     Document Type: Article

References (22)

1. Sookoian S, Pirola CJ. Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol 2008; 49:600-607.
2. Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epipheno-menon? Diabetologia 2008; 51:1947-1953.
3. Marchesini G, Marzocchi R, Agostini F, Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Curr Opin Lipidol 2005; 16:421-427.
4. Yki-Järvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol 2014; 2:901-910.
5. Musso G, Gambino R, Bo S, Uberti B, Biroli G, Pagano G, Cassader M. Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects. Diabetes Care 2008; 31:562-568.
6. McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC, et al. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol 2008; 103:3029-3035.
7. Ducluzeau PH, Boursier J, Bertrais S, Dubois S, Gauthier A, Rohmer V, et al. MRI measurement of liver fat content predicts the metabolic syndrome. Diabetes Metab 2013; 39:314-321.
8. Cicero AF, D'Addato S, Reggi A, Marchesini G, Borghi C. Brisighella Heart Study. Gender difference in hepatic steatosis index and lipid accumulation product ability to predict incident metabolic syndrome in the historical cohort of the Brisighella Heart Study. Metab Syndr Relat Disord 2013; 11:412-416.
9. Juárez-Rojas JG, Medina-Urrutia AX, Jorge-Galarza E, González-Salazar C, Kimura-Hayama E, Cardoso-Saldaña G, et al. Fatty liver increases the association of metabolic syndrome with diabetes and atherosclerosis. Diabetes Care 2013; 36:1726-1728.
10. Dumas ME, Kinross J, Nicholson JK. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology 2014; 146:46-62.
11. Cannon CP. Mixed dyslipidemia, metabolic syndrome, diabetes melli-tus, and cardiovascular disease: clinical implications. Am J Cardiol 2008; 102 (12A):5L-9L.
12. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419.
13. Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 1986; 292:13-15.
14. R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2014. Available at: http://www.R-project.org/.
15. Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika 1965; 52 (3-4):591-611.
16. Green WH. Econometric analysis [chapter 18]. Upper Saddle River, NJ: Prentice Hall; 2012.
17. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112:2735-2752.
18. Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L, et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007; 30:1212-1218.
19. Petit JM, Guiu B, Terriat B, Loffroy R, Robin I, Petit V, et al. Nonalcoholic fatty liver is not associated with carotid intima-media thickness in type 2 diabetic patients. J Clin Endocrinol Metab 2009; 94:4103-4106.
20. Coracina A, Gaiani S, Cosma A, Pellizzari P, Pizzi C, de Kreutzenberg S, et al. No association between the degree of liver steatosis and early signs of vasculopathy in T2DM. Nutr Metab Cardiovasc Dis 2012; 22:e11-e12.
21. Chitturi S, Farrell G, Frost L, Kriketos A, Lin R, Fung C, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 2002; 36:403-409.
22. Myers MG Jr. Leptin receptor signalling and the regulation of mammalian physiology. Recent Prog Horm Res 2004; 59:287-304.