Time to initial antibiotic administration, and short-term mortality among patients admitted with community-acquired severe infections with and without the presence of systemic inflammatory response syndrome: A follow-up study

Emergency Medicine Journal

Volumn 32, Issue 11, 2015, Pages 846-853

  Henriksen, Daniel Pilsgaard ^a   Laursen, Christian B ^a   Hallas, Jesper ^a,b   Pedersen, Court ^a   Lassen, Annmarie Touborg ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CANCER REGISTRY; CLINICAL PRACTICE; COMMUNITY ACQUIRED INFECTION; COMORBIDITY; EMERGENCY WARD; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MEDICAL SOCIETY; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UNIVERSITY HOSPITAL; VITAL SIGN; COMMUNITY-ACQUIRED INFECTIONS; COMPLICATION; EMERGENCY HEALTH SERVICE; HOSPITAL MORTALITY; MIDDLE AGED; MULTIPLE ORGAN FAILURE; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; EMERGENCY SERVICE, HOSPITAL; FEMALE; FOLLOW-UP STUDIES; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

EID: 84947028212     PISSN: 14720205     EISSN: 14720213     Source Type: Journal    
DOI: 10.1136/emermed-2014-204565     Document Type: Article

References (34)

1. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-6.
2. Kaukonen K-M, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014;311:1308-16.
3. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546-54.
4. Osborn TM, Nguyen HB, Rivers EP. Emergency medicine and the surviving sepsis campaign: an international approach to managing severe sepsis and septic shock. Ann Emerg Med 2005;46:228-31.
5. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165-228.
6. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-96.
7. Puskarich M A, Trzeciak S, Shapiro NI, et al. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011;39:2066-71.
8. Gaieski DF, Mikkelsen ME, Band R A, et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010;38:1045-53.
9. Shapiro N, Howell MD, Bates DW, et al. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med 2006;48:583-90, 590.e1.
10. Henriksen DP, Laursen CB, Jensen TG, et al. Incidence rate of community-acquired sepsis among hospitalized acute medical patients-A population-based survey. Crit Care Med 2015;43:13-21.
11. Horan TC, Andrus M, Dudeck M A. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309-32.
12. Frank L. Epidemiology. When an entire country is a cohort. Science 2000;287:2398-9.
13. Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health 2011;39:30-3.
14. Hallas J. Conducting pharmacoepidemiologic research in Denmark. Pharmacoepidemiol Drug Saf 2001;10:619-23.
15. Gjerstorff ML. The Danish Cancer Registry. Scand J Public Health 2011;39:42-5.
16. Pedersen CB. The Danish Civil Registration System. Scand J Public Health 2011;39:22-5.
17. Bone R, Balk R, Cerra F, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644-55.
18. Shapiro NI, Wolfe RE, Moore RB, et al. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med 2003;31:670-5.
19. Gille-Johnson P, Hansson KE, Gårdlund B. Severe sepsis and systemic inflammatory response syndrome in emergency department patients with suspected severe infection. Scand J Infect Dis 2012;2008:1-8.
20. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-83. http://www.ncbi.nlm.nih.gov/pubmed/3558716 (accessed 8 Oct. 2012).
21. Royston P, Ambler G, Sauerbrei W. The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 1999;28:964-74.
22. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994;81:515-26.
23. Von Elm E, Altman DG, Egger M, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 2007;335:806-8.
24. Vincent JL. Dear SIRS, I'm sorry to say that I don't like you.... Crit Care Med 1997;25:372-4.
25. Vincent J-L, Opal SM, Marshall JC, et al. Sepsis definitions: time for change. Lancet 2013;381:774-5.
26. Lynn L A. The diagnosis of sepsis revisited-a challenge for young medical scientists in the 21st century. Patient Saf Surg 2014;8:1.
27. Gaieski DF, Goyal M. What is sepsis? What is severe sepsis? What is septic shock? Searching for objective definitions among the winds of doctrines and wild theories. Expert Rev Anti Infect Ther 2013;11:867-71.
28. Klein Klouwenberg PMC, Ong DSY, Bonten MJM, et al. Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria. Intensive Care Med 2012;38:811-19.
29. Cullen M, Fogg T, Delaney A. Timing of appropriate antibiotics in patients with septic shock: a retrospective cohort study. Emerg Med Australas 2013;25:308-15.
30. Vilella AL, Seifert CF. Timing and appropriateness of initial antibiotic therapy in newly presenting septic patients. Am J Emerg Med 2014;32:7-13.
31. Mok K, Christian MD, Nelson S, et al. Time to administration of antibiotics among inpatients with severe sepsis or septic shock. Can J Hosp Pharm 2014;67:213-19. http://www.ncbi.nlm.nih.gov/pubmed/24970941 (accessed 3 Jul. 2014).
32. Patel GP, Balk R A. Systemic steroids in severe sepsis and septic shock. Am J Respir Crit Care Med 2012;185:133-9.
33. Whittaker S-A, Mikkelsen ME, Gaieski DF, et al. Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population. Crit Care Med 2013;41:945-53.
34. Wilhelms SB, Huss FR, Granath G, et al. Assessment of incidence of severe sepsis in Sweden using different ways of abstracting International Classification of Diseases codes: difficulties with methods and interpretation of results. Crit Care Med 2010;38:1442-9.