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Volumn 201, Issue 3, 2015, Pages 1201-1211

The genomic impacts of drift and selection for hybrid performance in maize

Author keywords

Artificial selection; Genetic drift; Heterosis; Maize; Recurrent selection

Indexed keywords

ARTICLE; GENETIC DRIFT; GENETIC SELECTION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HYBRID; INBRED STRAIN; MAIZE; NONHUMAN; PLANT GENOME; POPULATION STRUCTURE; PRIORITY JOURNAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETIC VARIATION; GENETICS; HYBRIDIZATION;

EID: 84946944411     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.115.182410     Document Type: Article
Times cited : (39)

References (56)
  • 1
    • 0012623934 scopus 로고
    • The sources of effective germ-plasm in hybrid maize
    • Anderson, E., 1944 The sources of effective germ-plasm in hybrid maize. Ann. Mo. Bot. Gard. 31: 355-361.
    • (1944) Ann. Mo. Bot. Gard , vol.31 , pp. 355-361
    • Anderson, E.1
  • 3
    • 84901296551 scopus 로고    scopus 로고
    • A genome-wide scan for evidence of selection in a maize population under long-term artificial selection for ear number
    • Beissinger, T. M., C. N. Hirsch, B. Vaillancourt, S. Deshpande, K. Barry et al., 2014 A genome-wide scan for evidence of selection in a maize population under long-term artificial selection for ear number. Genetics 196: 829-840.
    • (2014) Genetics , vol.196 , pp. 829-840
    • Beissinger, T.M.1    Hirsch, C.N.2    Vaillancourt, B.3    Deshpande, S.4    Barry, K.5
  • 4
    • 79961177868 scopus 로고    scopus 로고
    • Selection and adaptation to high plant density in the Iowa stiff stalk synthetic maize (l.) population
    • Brekke, B., J. Edwards, and A. Knapp, 2011a Selection and adaptation to high plant density in the Iowa stiff stalk synthetic maize (l.) population. Crop Sci. 51: 1965-1972.
    • (2011) Crop Sci , vol.51 , pp. 1965-1972
    • Brekke, B.1    Edwards, J.2    Knapp, A.3
  • 5
    • 80053653978 scopus 로고    scopus 로고
    • Selection and adaptation to high plant density in the Iowa stiff stalk synthetic maize (l.) population: Ii. plant morphology
    • Brekke, B., J. Edwards, and A. Knapp, 2011b Selection and adaptation to high plant density in the Iowa stiff stalk synthetic maize (l.) population: Ii. plant morphology. Crop Sci. 51: 2344-2351.
    • (2011) Crop Sci , vol.51 , pp. 2344-2351
    • Brekke, B.1    Edwards, J.2    Knapp, A.3
  • 6
    • 77957346489 scopus 로고    scopus 로고
    • Genome-wide analysis of a long-term evolution experiment with Drosophila
    • Burke, M. K., J. P. Dunham, P. Shahrestani, K. R. Thornton, M. R. Rose et al., 2010 Genome-wide analysis of a long-term evolution experiment with Drosophila. Nature 467: 587-590.
    • (2010) Nature , vol.467 , pp. 587-590
    • Burke, M.K.1    Dunham, J.P.2    Shahrestani, P.3    Thornton, K.R.4    Rose, M.R.5
  • 7
    • 84863007735 scopus 로고    scopus 로고
    • Maize hapmap2 identifies extant variation from a genome in flux
    • Chia, J. M., C. Song, P. J. Bradbury, D. Costich, N. de Leon et al., 2012 Maize hapmap2 identifies extant variation from a genome in flux. Nat. Genet. 44: 803-807.
    • (2012) Nat. Genet , vol.44 , pp. 803-807
    • Chia, J.M.1    Song, C.2    Bradbury, P.J.3    Costich, D.4    de Leon, N.5
  • 8
    • 0000590129 scopus 로고
    • Breeding procedure designed to make maximum use of both general and specific combining ability
    • Comstock, R. E., H. Robinson, and P. Harvey, 1949 Breeding procedure designed to make maximum use of both general and specific combining ability. Agron. J. 41: 360-367.
    • (1949) Agron. J , vol.41 , pp. 360-367
    • Comstock, R.E.1    Robinson, H.2    Harvey, P.3
  • 9
    • 0003828030 scopus 로고
    • Prophets of Plenty, Rutgers University Press, New Brunswick, NJ
    • Crabb, A. R., and H. Hughes, 1947 The Hybrid-Corn Makers. Prophets of Plenty, Rutgers University Press, New Brunswick, NJ.
    • (1947) The Hybrid-Corn Makers
    • Crabb, A.R.1    Hughes, H.2
  • 10
    • 0032013722 scopus 로고    scopus 로고
    • 90 years ago: The beginning of hybrid maize
    • Crow, J. F., 1998 90 years ago: the beginning of hybrid maize. Genetics 148: 923-928.
    • (1998) Genetics , vol.148 , pp. 923-928
    • Crow, J.F.1
  • 11
    • 0000311626 scopus 로고
    • 1985 United States farm maize germplasm base and commercial breeding strategies
    • Darrah, L., and M. Zuber, 1986 1985 United States farm maize germplasm base and commercial breeding strategies. Crop Sci. 26: 1109-1113.
    • (1986) Crop Sci , vol.26 , pp. 1109-1113
    • Darrah, L.1    Zuber, M.2
  • 12
    • 33645020712 scopus 로고    scopus 로고
    • The contribution of breeding to yield advances in maize (Zea mays l.)
    • Duvick, D. N., 2005 The contribution of breeding to yield advances in maize (Zea mays l.). Adv. Agron. 86: 83-145.
    • (2005) Adv. Agron , vol.86 , pp. 83-145
    • Duvick, D.N.1
  • 13
    • 3042751667 scopus 로고    scopus 로고
    • Long-term selection in a commercial hybrid maize breeding program
    • Duvick, D. N., J. Smith, and M. Cooper, 2004 Long-term selection in a commercial hybrid maize breeding program. Plant Breed. Rev. 24: 109-152.
    • (2004) Plant Breed. Rev , vol.24 , pp. 109-152
    • Duvick, D.N.1    Smith, J.2    Cooper, M.3
  • 14
    • 80053652839 scopus 로고    scopus 로고
    • Changes in plant morphology in response to recurrent selection in the Iowa stiff stalk synthetic maize population
    • Edwards, J., 2011 Changes in plant morphology in response to recurrent selection in the Iowa stiff stalk synthetic maize population. Crop Sci. 51: 2352-2361.
    • (2011) Crop Sci , vol.51 , pp. 2352-2361
    • Edwards, J.1
  • 15
    • 33746406779 scopus 로고    scopus 로고
    • Temporal trends in SSR allele frequencies associated with long-term selection for yield of maize
    • Feng, L., S. Sebastian, S. Smith, and M. Cooper, 2006 Temporal trends in SSR allele frequencies associated with long-term selection for yield of maize. Maydica 51: 293.
    • (2006) Maydica , vol.51 , pp. 293
    • Feng, L.1    Sebastian, S.2    Smith, S.3    Cooper, M.4
  • 16
    • 82955201636 scopus 로고    scopus 로고
    • A large maize (Zea mays L.) SNP genotyping array: Development and germplasm genotyping, and genetic mapping to compare with the B73 reference genome
    • Ganal, M. W., G. Durstewitz, A. Polley, A. Bérard, E. S. Buckler et al., 2011 A large maize (Zea mays L.) SNP genotyping array: development and germplasm genotyping, and genetic mapping to compare with the B73 reference genome. PLoS One 6: e28334.
    • (2011) PLoS One , vol.6
    • Ganal, M.W.1    Durstewitz, G.2    Polley, A.3    Bérard, A.4    Buckler, E.S.5
  • 17
    • 70450204614 scopus 로고    scopus 로고
    • A firstgeneration haplotype map of maize
    • Gore, M., J. Chia, R. Elshire, Q. Sun, E. Ersoz et al., 2009 A firstgeneration haplotype map of maize. Science 326: 1115-1117.
    • (2009) Science , vol.326 , pp. 1115-1117
    • Gore, M.1    Chia, J.2    Elshire, R.3    Sun, Q.4    Ersoz, E.5
  • 18
    • 84892707434 scopus 로고    scopus 로고
    • Maize argos1 (zar1) transgenic alleles increase hybrid maize yield
    • Guo, M., M. A. Rupe, J. Wei, C. Winkler, M. Goncalves-Butruille et al., 2014 Maize argos1 (zar1) transgenic alleles increase hybrid maize yield. J. Exp. Bot. 65: 249-260.
    • (2014) J. Exp. Bot , vol.65 , pp. 249-260
    • Guo, M.1    Rupe, M.A.2    Wei, J.3    Winkler, C.4    Goncalves-Butruille, M.5
  • 19
    • 0037339471 scopus 로고    scopus 로고
    • Molecular genetic diversity among progenitors and derived elite lines of bsss and bscb1 maize populations
    • Hagdorn, S., K. R. Lamkey, M. Frisch, P. E. Guimaraes, and A. E. Melchinger, 2003 Molecular genetic diversity among progenitors and derived elite lines of bsss and bscb1 maize populations. Crop Sci. 43: 474-482.
    • (2003) Crop Sci , vol.43 , pp. 474-482
    • Hagdorn, S.1    Lamkey, K.R.2    Frisch, M.3    Guimaraes, P.E.4    Melchinger, A.E.5
  • 20
    • 0343922032 scopus 로고
    • Registration of maize germplasm1 (reg. no. gp 26 to gp 34)
    • Hallauer, A. R., S. Eberhart, and W. Russell, 1974 Registration of maize germplasm1 (reg. no. gp 26 to gp 34). Crop Sci. 14: 341- 342.
    • (1974) Crop Sci , vol.14 , pp. 341-342
    • Hallauer, A.R.1    Eberhart, S.2    Russell, W.3
  • 21
    • 27644597001 scopus 로고    scopus 로고
    • Population genetic diversity in a maize reciprocal recurrent selection program
    • Hinze, L. L., S. Kresovich, J. D. Nason, and K. R. Lamkey, 2005 Population genetic diversity in a maize reciprocal recurrent selection program. Crop Sci. 45: 2435-2442.
    • (2005) Crop Sci , vol.45 , pp. 2435-2442
    • Hinze, L.L.1    Kresovich, S.2    Nason, J.D.3    Lamkey, K.R.4
  • 22
    • 84937511064 scopus 로고    scopus 로고
    • Insights into the effects of long-term artificial selection on seed size in maize
    • Hirsch, C. N., S. A. Flint-Garcia, T. M. Beissinger, S. R. Eichten, S. Deshpande et al., 2014 Insights into the effects of long-term artificial selection on seed size in maize. Genetics 198: 409-421.
    • (2014) Genetics , vol.198 , pp. 409-421
    • Hirsch, C.N.1    Flint-Garcia, S.A.2    Beissinger, T.M.3    Eichten, S.R.4    Deshpande, S.5
  • 23
    • 25444524895 scopus 로고    scopus 로고
    • Extent and distribution of genetic variation in US maize: Historically important lines and their open-pollinated dent and flint progenitors
    • Ho, J., S. Kresovich, and K. Lamkey, 2005 Extent and distribution of genetic variation in US maize: historically important lines and their open-pollinated dent and flint progenitors. Crop Sci. 45: 1891-1900.
    • (2005) Crop Sci , vol.45 , pp. 1891-1900
    • Ho, J.1    Kresovich, S.2    Lamkey, K.3
  • 24
    • 0029174873 scopus 로고
    • Population means and genetic variances in selected and unselected Iowa stiff stalk synthetic maize populations
    • Holthaus, J. F., and K. R. Lamkey, 1995 Population means and genetic variances in selected and unselected Iowa stiff stalk synthetic maize populations. Crop Sci. 35: 1581-1589.
    • (1995) Crop Sci , vol.35 , pp. 1581-1589
    • Holthaus, J.F.1    Lamkey, K.R.2
  • 25
    • 0026512283 scopus 로고
    • A statistical test for detecting geographic subdivision
    • Hudson, R., D. D. Boos, and N. Kaplan, 1992 A statistical test for detecting geographic subdivision. Mol. Biol. Evol. 9: 138-151.
    • (1992) Mol. Biol. Evol , vol.9 , pp. 138-151
    • Hudson, R.1    Boos, D.D.2    Kaplan, N.3
  • 26
    • 84862993359 scopus 로고    scopus 로고
    • Comparative population genomics of maize domestication and improvement
    • Hufford, M., X. Xu, J. van Heerwaarden, T. Pyhajarvi, J. Chia et al., 2012 Comparative population genomics of maize domestication and improvement. Nat. Genet. 44: 808-811.
    • (2012) Nat. Genet , vol.44 , pp. 808-811
    • Hufford, M.1    Xu, X.2    van Heerwaarden, J.3    Pyhajarvi, T.4    Chia, J.5
  • 27
    • 84862981255 scopus 로고    scopus 로고
    • Genomewide genetic changes during modern breeding of maize
    • Jiao, Y., H. Zhao, L. Ren, W. Song, B. Zeng et al., 2012 Genomewide genetic changes during modern breeding of maize. Nat. Genet. 44: 812-815.
    • (2012) Nat. Genet , vol.44 , pp. 812-815
    • Jiao, Y.1    Zhao, H.2    Ren, L.3    Song, W.4    Zeng, B.5
  • 28
    • 0002964028 scopus 로고
    • Responses to reciprocal recurrent selection in bsss and bscb1 maize populations
    • Keeratinijakal, V., and K. R. Lamkey, 1993 Responses to reciprocal recurrent selection in bsss and bscb1 maize populations. Crop Sci. 33: 73-77.
    • (1993) Crop Sci , vol.33 , pp. 73-77
    • Keeratinijakal, V.1    Lamkey, K.R.2
  • 29
    • 0030893371 scopus 로고    scopus 로고
    • Molecular genetic diversity after reciprocal recurrent selection in bsss and bscb1 maize populations
    • Labate, J. A., K. R. Lamkey, M. Lee, and W. L. Woodman, 1997 Molecular genetic diversity after reciprocal recurrent selection in bsss and bscb1 maize populations. Crop Sci. 37: 416- 423.
    • (1997) Crop Sci , vol.37 , pp. 416-423
    • Labate, J.A.1    Lamkey, K.R.2    Lee, M.3    Woodman, W.L.4
  • 30
    • 84894881640 scopus 로고    scopus 로고
    • Relative effect of drift and selection in diverging populations within a reciprocal recurrent selection program
    • Lamkey, C., and A. Lorenz, 2014 Relative effect of drift and selection in diverging populations within a reciprocal recurrent selection program. Crop Sci. 54: 576-585.
    • (2014) Crop Sci , vol.54 , pp. 576-585
    • Lamkey, C.1    Lorenz, A.2
  • 31
    • 84859989060 scopus 로고    scopus 로고
    • Morphological changes in parental lines of pioneer brand maize hybrids in the us central corn belt
    • Lauer, S., B. D. Hall, E. Mulaosmanovic, S. R. Anderson, B. Nelson et al., 2012 Morphological changes in parental lines of pioneer brand maize hybrids in the us central corn belt. Crop Sci. 52: 1033-1043.
    • (2012) Crop Sci , vol.52 , pp. 1033-1043
    • Lauer, S.1    Hall, B.D.2    Mulaosmanovic, E.3    Anderson, S.R.4    Nelson, B.5
  • 32
    • 0036010768 scopus 로고    scopus 로고
    • Expanding the genetic map of maize with the intermated B73 3 Mo17 (IBM) population
    • Lee, M., N. Sharopova, W. D. Beavis, D. Grant, M. Katt et al., 2002 Expanding the genetic map of maize with the intermated B73 3 Mo17 (IBM) population. Plant Mol. Biol. 48: 453-461.
    • (2002) Plant Mol. Biol , vol.48 , pp. 453-461
    • Lee, M.1    Sharopova, N.2    Beavis, W.D.3    Grant, D.4    Katt, M.5
  • 33
    • 68449094455 scopus 로고    scopus 로고
    • Genetic properties of the maize nested association mapping population
    • McMullen, M., S. Kresovich, H. Villeda, P. Bradbury, H. Li et al., 2009 Genetic properties of the maize nested association mapping population. Science 325: 737-740.
    • (2009) Science , vol.325 , pp. 737-740
    • McMullen, M.1    Kresovich, S.2    Villeda, H.3    Bradbury, P.4    Li, H.5
  • 34
    • 73349108482 scopus 로고    scopus 로고
    • A genealogical interpretation of principal components analysis
    • McVean, G., 2009 A genealogical interpretation of principal components analysis. PLoS Genet. 5: e1000686.
    • (2009) PLoS Genet , vol.5
    • McVean, G.1
  • 35
    • 0002807217 scopus 로고
    • Genetic diversity among progenitors and elite lines from the Iowa stiff stalk synthetic (bsss) maize population: Comparison of allozyme and rflp data
    • Messmer, M., A. Melchinger, M. Lee, W. Woodman, E. Lee et al., 1991 Genetic diversity among progenitors and elite lines from the Iowa stiff stalk synthetic (bsss) maize population: comparison of allozyme and rflp data. Theor. Appl. Genet. 83: 97-107.
    • (1991) Theor. Appl. Genet , vol.83 , pp. 97-107
    • Messmer, M.1    Melchinger, A.2    Lee, M.3    Woodman, W.4    Lee, E.5
  • 36
    • 84892716897 scopus 로고    scopus 로고
    • The pattern and distribution of deleterious mutations in maize
    • Mezmouk, S., and J. Ross-Ibarra, 2014 The pattern and distribution of deleterious mutations in maize. G3 (Bethesda) 4: 163- 171.
    • (2014) G3 (Bethesda) , vol.4 , pp. 163-171
    • Mezmouk, S.1    Ross-Ibarra, J.2
  • 37
    • 0001149682 scopus 로고
    • Twenty years of reciprocal recurrent selection with two synthetic varieties of maize (Zea mays l.)
    • Penny, L. H, and S. Eberhart, 1971 Twenty years of reciprocal recurrent selection with two synthetic varieties of maize (Zea mays l.). Crop Sci. 11: 900-903.
    • (1971) Crop Sci , vol.11 , pp. 900-903
    • Penny, L.H.1    Eberhart, S.2
  • 40
    • 84863561618 scopus 로고    scopus 로고
    • Effect of recurrent selection on the genetic structure of two broad-based spanish maize populations
    • Romay, M. C., A. Butrón, A. Ordás, P. Revilla, and B. Ordás, 2012 Effect of recurrent selection on the genetic structure of two broad-based spanish maize populations. Crop Sci. 52: 1493-1502.
    • (2012) Crop Sci , vol.52 , pp. 1493-1502
    • Romay, M.C.1    Butrón, A.2    Ordás, A.3    Revilla, P.4    Ordás, B.5
  • 41
    • 0021695885 scopus 로고
    • Ribosomal DNA spacer-length polymorphisms in barley: Mendelian inheritance, chromosomal location, and populationdynamics
    • Saghai-Maroof, M. A., K. M. Soliman, R. A. Jorgensen, and R. W. Allard, 1984 Ribosomal DNA spacer-length polymorphisms in barley: Mendelian inheritance, chromosomal location, and populationdynamics. Proc. Natl. Acad. Sci. USA 81: 8014-8018.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 8014-8018
    • Saghai-Maroof, M.A.1    Soliman, K.M.2    Jorgensen, R.A.3    Allard, R.W.4
  • 42
    • 33644974019 scopus 로고    scopus 로고
    • A fast and flexible statistical model for large-scale population genotype data: Applications to inferring missing genotypes and haplotypic phase
    • Scheet, P., and M. Stephens, 2006 A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am. J. Hum. Genet. 78: 629-644.
    • (2006) Am. J. Hum. Genet , vol.78 , pp. 629-644
    • Scheet, P.1    Stephens, M.2
  • 43
    • 70450202132 scopus 로고    scopus 로고
    • The B73 maize genome: Complexity, diversity, and dynamics
    • Schnable, P. S., D. Ware, R. S. Fulton, J. C. Stein, F. Wei et al., 2009 The B73 maize genome: complexity, diversity, and dynamics. Science 326: 1112-1115.
    • (2009) Science , vol.326 , pp. 1112-1115
    • Schnable, P.S.1    Ware, D.2    Fulton, R.S.3    Stein, J.C.4    Wei, F.5
  • 44
    • 0002964024 scopus 로고
    • Interpopulation genetic variance after reciprocal recurrent selection in bsss and bscb1 maize populations
    • Schnicker, B. J., and K. R. Lamkey, 1993 Interpopulation genetic variance after reciprocal recurrent selection in bsss and bscb1 maize populations. Crop Sci. 33: 90-95.
    • (1993) Crop Sci , vol.33 , pp. 90-95
    • Schnicker, B.J.1    Lamkey, K.R.2
  • 45
    • 0031846993 scopus 로고    scopus 로고
    • Utility of ssrs for determining genetic similarities an relationships in maize using an agarose gel system
    • Senior, M., J. Murphy, M. Goodman, and C. Stuber, 1998 Utility of ssrs for determining genetic similarities an relationships in maize using an agarose gel system. Crop Sci. 38: 1088-1098.
    • (1998) Crop Sci , vol.38 , pp. 1088-1098
    • Senior, M.1    Murphy, J.2    Goodman, M.3    Stuber, C.4
  • 46
    • 0000514357 scopus 로고
    • Early testing of inbred lines of corn
    • Sprague, G. F., 1946 Early testing of inbred lines of corn. J. Am. Soc. Agron. 38: 108-117.
    • (1946) J. Am. Soc. Agron , vol.38 , pp. 108-117
    • Sprague, G.F.1
  • 47
    • 0002601860 scopus 로고
    • Evaluation of recurrent selection in bsss, bscb1, and bs13 maize populations
    • Smith, O., 1983 Evaluation of recurrent selection in bsss, bscb1, and bs13 maize populations. Crop Sci. 23: 35-40.
    • (1983) Crop Sci , vol.23 , pp. 35-40
    • Smith, O.1
  • 50
    • 0344464730 scopus 로고    scopus 로고
    • Libsequence: A c++ class library for evolutionary genetic analysis
    • Thornton, K., 2003 Libsequence: a c++ class library for evolutionary genetic analysis. Bioinformatics 19: 2325-2327.
    • (2003) Bioinformatics , vol.19 , pp. 2325-2327
    • Thornton, K.1
  • 51
    • 84889362987 scopus 로고    scopus 로고
    • The historical and biological basis of the concept of heterotic patterns in corn belt dent maize
    • Blackwell, Ames, IA
    • Tracy, W., and M. Chandler, 2006 The historical and biological basis of the concept of heterotic patterns in corn belt dent maize pp. 219-233 in Plant Breeding: The Arnel R. Hallauer International Symposium. Blackwell, Ames, IA.
    • (2006) Plant Breeding: The Arnel R. Hallauer International Symposium , pp. 219-233
    • Tracy, W.1    Chandler, M.2
  • 52
    • 0033012987 scopus 로고    scopus 로고
    • Background of US hybrid corn
    • Troyer, A. F., 1999 Background of US hybrid corn. Crop Sci. 39: 601-626.
    • (1999) Crop Sci , vol.39 , pp. 601-626
    • Troyer, A.F.1
  • 53
    • 79953735688 scopus 로고    scopus 로고
    • Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster
    • Turner, T. L., A. D. Stewart, A. T. Fields, W. R. Rice and A. M. Tarone, 2011 Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster. PloS Genet. 7: e1001336.
    • (2011) PloS Genet , vol.7
    • Turner, T.L.1    Stewart, A.D.2    Fields, A.T.3    Rice, W.R.4    Tarone, A.M.5
  • 56
    • 0038124403 scopus 로고    scopus 로고
    • On the determination of recombination rates in intermated recombinant inbred populations
    • Winkler, C. R., N. M. Jensen, M. Cooper, D. W. Podlich, and O. S. Smith, 2003 On the determination of recombination rates in intermated recombinant inbred populations. Genetics 164: 741- 745.
    • (2003) Genetics , vol.164 , pp. 741-745
    • Winkler, C.R.1    Jensen, N.M.2    Cooper, M.3    Podlich, D.W.4    Smith, O.S.5


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