APOE ε4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhage

Neurology

Volumn 85, Issue 4, 2015, Pages 349-356

  Raffeld, Miriam R ^a   Biffi, Alessandro ^a   Battey, Thomas W K ^a   Ayres, Alison M ^a   Viswanathan, Anand ^a   Greenberg, Steven M ^a   Rosand, Jonathan ^a   Anderson, Christopher D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; LIPID; LOW DENSITY LIPOPROTEIN; LIPOPROTEIN;

AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN REGION; CARDIOVASCULAR RISK; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; BLOOD; GENETIC PREDISPOSITION; GENETICS; PROSPECTIVE STUDY;

AGED; APOLIPOPROTEIN E4; CEREBRAL HEMORRHAGE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIPOPROTEINS; MALE; PROSPECTIVE STUDIES; RECURRENCE; RISK FACTORS;

EID: 84946893984     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001790     Document Type: Article

References (22)

1. Krishnamurthi RV, Moran AE, Forouzanfar MH, et al. The global burden of hemorrhagic stroke: a summary of findings from the GBD 2010 study. Glob Heart 2014;9:101-106.
2. Poon MT, Fonville AF, Al-Shahi Salman R. Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 2014;85:660-667.
3. Biffi A, Halpin A, Towfighi A, et al. Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology 2010;75:693-698.
4. Weimar C, Benemann J, Terborg C, et al. Recurrent stroke after lobar and deep intracerebral hemorrhage: a hospital-based cohort study. Cerebrovasc Dis 2011;32:283-288.
5. Biffi A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 2011;7:1-9.
6. Biffi A, Sonni A, Anderson CD, et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010;68:934-943.
7. Badjatia N, Rosand J. Intracerebral hemorrhage. Neurologist 2005;11:311-324.
8. Woo D, Deka R, Falcone GJ, et al. Apolipoprotein E, statins, and risk of intracerebral hemorrhage. Stroke 2013;44:3013-3017.
9. Wang X, Dong Y, Qi X, Huang C, Hou L. Cholesterol levels and risk of hemorrhagic stroke: a systematic review and meta-analysis. Stroke 2013;44:1833-1839.
10. Biffi A, Anderson CD, Jagiella JM, et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol 2011;10:702-709.
11. Gong JS, Kobayashi M, Hayashi H, et al. Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J Biol Chem 2002;277:29919-29926.
12. Fagan AM, Holtzman DM, Munson G, et al. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 1999;274:30001-30007.
13. Nathan BP, Bellosta S, Sanan DA, et al. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 1994;264:850-852.
14. Bellosta S, Nathan BP, Orth M, et al. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem 1995;270:27063-27071.
15. Trommer BL, Shah C, Yun SH, et al. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport 2004;15:2655-2658.
16. Gibson GE, Haroutunian V, Zhang H, et al. Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. Ann Neurol 2000;48:297-303.
17. Biffi A, Cortellini L, Nearnberg CM, et al. Body mass index and etiology of intracerebral hemorrhage. Stroke 2011;42:2526-2530.
18. Khan TA, Shah T, Prieto D, et al. Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol 2013;42:475-492.
19. Stancu CS, Toma L, Sima AV. Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis. Cell Tissue Res 2012;349:433-446.
20. Song Y, Kenworthy AK, Sanders CR. Cholesterol as a co-solvent and a ligand for membrane proteins. Protein Sci 2014;23:1-22.
21. Flaherty ML, Woo D, Haverbusch M, et al. Racial variations in location and risk of intracerebral hemorrhage. Stroke 2005;36:934-937.
22. Labovitz DL, Halim A, Boden-Albala B, Hauser WA, Sacco RL. The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and Hispanics. Neurology 2005;65:518-522.