Recommendations for transfusion therapy in neonatology

Blood Transfusion

Volumn 13, Issue 3, 2015, Pages 484-497

  Girelli, Gabriella ^a   Antoncecchi, Stefano ^b   Casadei, Anna Maria ^a   Del Vecchio, Antonio ^c   Isernia, Paola ^d   Motta, Mario ^e   Regoli, Daniela ^a   Romagnoli, Costantino ^f   Tripodi, Gino ^g   Velati, Claudio ^h  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Transfusion Medicine Unit   (Italy)

^c DI VENERE HOSPITAL   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^e SPEDALI CIVILI   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

^g G GASLINI INSTITUTE   (Italy)

^h Transfusion Medicine and Immunohaematology Department of Bologna Metropolitan Area   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FRESH FROZEN PLASMA; THROMBOCYTE CONCENTRATE;

BLOOD COMPONENT; BLOOD DONOR; BLOOD TRANSFUSION; CYTOMEGALOVIRUS INFECTION; ERYTHROCYTE; ERYTHROCYTE CONCENTRATE; EXCHANGE BLOOD TRANSFUSION; FETUS DISEASE; GRAFT VERSUS HOST REACTION; GRANULOCYTE; HEMOLYTIC ANEMIA; HUMAN; INFECTION PREVENTION; INTRAPERITONEAL TRANSFUSION; INTRAUTERINE BLOOD TRANSFUSION; INTRAVASCULAR TRANSFUSION; NEONATOLOGY; NEWBORN ANEMIA; NEWBORN DISEASE; NEWBORN PERIOD; REVIEW; SEROLOGY; VERY LOW BIRTH WEIGHT; ADVERSE EFFECTS; FEMALE; INFANT, NEWBORN, DISEASES; MALE; NEWBORN; PRACTICE GUIDELINE; PROCEDURES;

BLOOD TRANSFUSION; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MALE; PRACTICE GUIDELINES AS TOPIC;

EID: 84946828542     PISSN: 17232007     EISSN: 23852070     Source Type: Journal    
DOI: 10.2450/2015.0113-15     Document Type: Review

References (74)

1. Decree of the Italian Ministry of Health, March 3, 2005: [Caratteristiche e modalità per la donazione di sangue e di emocomponenti]. Gazzetta Ufficiale della Repubblica Italiana, Serie Generale, n. 85 of April 13, 2005. [In Italian].
2. Decree of the Italian Ministry of Health, March 3, 2005: [Protocolli per l'accertamento della idoneità del donatore di sangue e di emocomponenti]. Gazzetta Ufficiale della Repubblica Italiana, Serie Generale, n. 85 of April 13, 2005. [In Italian].
3. Italian Legislative Decree, December 20, 2007, n. 261. Revisione del DL 19 agosto 2005, n. 191, recante attuazione della direttiva 2002/98/CE che stabilisce norme di qualità e di sicurezza per la raccolta, il controllo, la lavorazione, la conservazione e la distribuzione del sangue umano e dei suoi componenti. Gazzetta Ufficiale della Repubblica Italiana, Serie Generale, n. 19 of January 23, 2008. [In Italian].
4. Italian Law n. 219 of October 21, 2005: [Nuova disciplina delle attività trasfusionali e della produzione nazionale degli emoderivati]. Gazzetta Ufficiale della Repubblica Italiana, Serie Generale, n. 251 of October 27, 2005. [In Italian].
5. Josephson CD, Castillejo MI, Caliendo AM, et al. Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤1500 g) using cytomegalovirus-seronegative and leukoreduced transfusions. Transfus Med Rev 2011; 25: 125-32.
6. Council of Europe. Guide to Preparation, Use and Quality Assurance of Blood Components. Recommendation No R (95) 15 on the preparation, use and quality assurance of blood components. 17th ed. Strasbourg: Council of Europe Publishing; 2013.
7. Ziemann M, Hennig H. Prevention of transfusion-transmitted cytomegalovirus infections: which is the optimal strategy? Transfus Med Hemother 2014; 41: 40-4.
8. Roback J, Grossman B, Harris T, Hillyer CD. Technical Manual. 17th ed. Bethesda, MD: American Association of Blood Banks; 2011. p. 645-760
9. Dwyre DM, Holland PV. Transfusion-associated graft-versushost disease. Vox Sang 2008; 95: 85-93.
10. British Committee for Standards in Haematology. Blood Transfusion Task Force. Guidelines on the use of irradiated blood components. Br J Haematol 2011; 152: 35-51.
11. Fasano RM, Luban NLC. Transfusion practices. In: De Alarcon PA, Werner EJ, Christensen RD. Neonatal Hematology, Pathogenesis, Diagnosis and Management of Hematologic Problems. 2nd ed. Cambridge University Press; 2013. p. 303-27.
12. Price TH. Standards for Blood Banks and Transfusion Services. 25th ed. Bethesda, MD: American Association of Blood Banks; 2008. p. 7-41.
13. Bennardello F, Curciarello G. Survey on the prevention and incidence of haemolytic disease of the newborn in Italy. Blood Transfus 2013; 11: 518-27.
14. Novak DJ, Tyler LN, Reddy RL, Barsoom MJ. Plasmapheresis and intravenous immunoglobulin for the treatment of D alloimmunization in pregnancy. J Clin Apher 2008; 23: 183-5.
15. Bellone M, Boctor FN. Therapeutic plasma exchange and intravenous immunoglobulin as primary therapy for D alloimmunization in pregnancy precludes the need for intrauterine transfusion. Transfusion 2014; 54: 2118-21.
16. Birchenall KA, Illanes SE, Denbow M. Neonatal outcomes of pregnancies affected by haemolytic disease of the foetus and newborn and managed with intrauterine transfusion: a service evaluation. Blood Transfus 2013; 11: 548-52.
17. Genova L, Slaghekke F, Klumper FJ, et al. Management of twin anemia-polycythemia sequence using intrauterine blood transfusion for the donor and partial exchange transfusion for the recipient. Fetal Diagn Ther 2013; 34: 121-6.
18. Mari G, for the Collaborative Group For Doppler Assessment of the Blood Velocity in Anemic Fetuses. Non-invasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal redcell alloimmunization. N Engl J Med 2000; 342: 9-14.
19. Altunyurt S, Okyay E, Saatli B, et al. Neonatal outcomes of foetuses receiving intrauterine transfusion for severe hydrops complicated by Rhesus hemolytic disease. Int J Gynaecol Obstet 2012; 117: 153-6.
20. Lindemburg ITM, van Kamp IL, van Zwet EW, et al. Increased perinatal loss after intrauterine transfusion for alloimmune anemia before 20 weeks of gestation. BJOG 2013; 120: 847-52.
21. Argoti PS, Bebbington M, Moise KJ. Serial intrauterine transfusions for a hydropic fetus with severe anemia and thrombocytopenia caused by Parvovirus: lessons learned. AJP Rep 2013; 3: 75-8.
22. Peterson JA, McFarland JG, Curtis BR, Aster RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol 2013; 161: 3-14.
23. AAP Subcommittee on hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004; 114: 297-316.
24. Pugni L, Riva E, Pietrasanta C, et al. Severe hypertriglyceridemia in a newborn with monogenic lipoprotein lipase deficiency: an unconventional therapeutic approch with Exchange Transfusion. JIMD Rep. 2014; 13: 59-64.
25. Babor F, Hadzik B, Stannigel H, et al. Successful management of neonatal hemochromatosis by exchange transfusion and immunoglobulin: a case report. J Perinatol 2013; 33: 83-5.
26. Kumar P, Chawla D, Deorari A. Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst Rew 2011; 7: CD007969.
27. Chitty HE, Ziegler N, Savoia H, et al. Neonatal exchange transfusion in the 21st century: a single hospital study. J Paediatr Child Health 2013; 49: 825-32.
28. Ramasethu J. Exchange transfusion. In: Macdonald MG, Ramasethu J, Rais-Bahrami K, editors. Atlas of Procedures in Neonatology. Philadelphia: Lippincott&Co; 2012. 5th ed 2013. p. 315-22.
29. Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database System Rev 2006; 18: CD004592.
30. Smiths-WintiJens VE, Rath ME, van Zwet EW, et al. Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease. Neonatology 2013; 103: 141-7.
31. Ozek E, Soll R, Schimmel MS. Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia. Cochrane Database Syst Rev 2010; 1: CD005089.
32. de Waal KA, Baerts W, Offringa M. Systematic review of the optimal fluid for dilutional exchange transfusion in neonatal polycythaemia. Arch Dis Child Fetal Neonatal Ed 2006; 91: F7-10.
33. Sarkar S, Rosenkratz TS. Neonatal polycythemia and hyperviscosity. Semin Fetal Neonatal Med 2008; 13: 248-55.
34. Lundstrom U, Siimes MA, Dallman PR. At what age does iron supplementation become necessary in low birth weight infants? J Pediatr 1977; 91: 882-6.
35. Bolton-Maggs PHB, Cohen H. Serious hazards of transfusion (SHOT) haemovigilance and progress is improving transfusion safety. Br J Haematol 2013; 163: 303-14.
36. Bifano EM, Curran TR. Minimizing donor blood exposure in the neonatal intensive care unit. Current trend and future prospects. Clin Perinatol 1995; 22: 657-69.
37. Pupella S, Girelli G, Casadei AM, et al. Protocollo operativo per la terapia trasfusionale del neonato: risultati preliminari. La Trasf del Sangue 1999; 44: 298-303.
38. Miyashiro AM, dos Santos N, Guinsburg R, et al. Strict red blood cell transfusion guideline reduces the need for transfusions in very-low-birth weight infants in the first 4 weeks of life: a multicentre trial. Vox Sang 2005; 88: 107-13.
39. Motta M, Testa M, Tripodi G, Radicioni M. Changes in neonatal transfusion practice after dissemination of neonatal recommendations. Pediatrics 2010; 125: e810-7.
40. Baer VL, Henry E, Lambert DK, et al. Implementing a program to improve compliance with neonatal intensive care unit transfusion guidelines was accompanied by a reduction in transfusion rate: a pre-post analysis within a multihospital health care system. Transfusion 2011; 51: 264-9.
41. Kasat K, Hendrics-Munoz H, Mally PV. Neonatal red blood cell transfusion: searching for better guidelines. Blood Transf 2011; 9: 86-94.
42. Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized controlled trial of restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149: 301-7.
43. Whyte RK, Kirpalani H, Asztalos EV, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009; 123: 207-13.
44. McCoy TE, Conrad AL, Richman LC, et al. Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol 2011; 17: 347-67.
45. Christensen RD. Association between "early" red blood transfusion and severe intraventricular hemorrhage, and between "late" red blood cell transfusion and necrotizing enterocolitis. Semin Perinatol 2012; 36: 283-9.
46. Paul DA, Mackley A, Novitsky A, et al. Increase odds of necrotizing enterocolitis after transfusion of red blood cell in premature infants. Pediatrics 2011; 127: 635-41.
47. Demirel G, Celik IH, Aksoy HT, et al. Transfusionassociated necrotizing enterocolitis in very low birth weight premature infants. Transfus Med 2012; 22: 332-7.
48. Sing R, Visintainer PF, Frantz ID, et al. Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants. J Perinatol 2011; 31: 176-82.
49. Chirico G, Beccagutti F, Sorini A, et al. Red blood cell transfusion in preterm infants: restrictive versus liberal policy. J Matern Fetal Neonatal Med 2011, 24 (Suppl 1): 20-2.
50. Widness JA. Treatment and prevention of neonatal anemia. Neoreviews 2008; 9: e526-33.
51. Dallman PR. Blood and blood-forming tissues. In: Rudolph A, editor. Pediatrics. 16th ed. New York: Appleton-Century-Crofts; 1977. p. 1111.
52. Yang L, Stanworth S, Hopewell S, et al. Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion 2012; 52: 1673-86.
53. Osborn DA, Evans N. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database Syst Rev 2004; 2: CD002055.
54. A randomized trial comparing the effect of prophylactic intravenous fresh frozen plasma, gelatin or glucose on early mortality and morbidity in preterm babies. The Northern Neonatal Nursing Initiative [NNNI] Trial Group. Eur J Pediatr 1996; 155: 580-8.
55. Christensen RD, Baer VL, Lambert DK, et al. Reference intervals for common coagulation tests of preterm infants. Transfusion 2014; 54: 627-32.
56. Andrew M, Paes B, Milner R, et al. Development of the human coagulation system in the healthy premature infant. Blood 1988; 72: 1651-7.
57. Andrew M, Vegh P, Johnston M, et al. Maturation of the hemostatic system during childhood. Blood 1992; 80: 1998-2005.
58. Tripodi A, Ramenghi LA, Chantarangkul V, et al. Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests. Haematologica 2008; 93: 1256-9.
59. Motta M, Del Vecchio A, Perrone B, et al. Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study. Arch Dis Child Fetal Neonatal Ed 2014; 99: F303-8.
60. Christensen RD, Henry E, Wiedmeier SE, et al. Thrombocytopenia among extremely low birth weight neonates: data from a multi hospital healthcare system. J Perinatol 2006; 26: 348-53.
61. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol 2009; 29: 130-6.
62. Andrew M, Vegh P, Caco C, et al. Randomised controlled trial of platelet transfusion in thrombocytopenic premature infants. J Pediatr 1993; 123: 285-91.
63. Del Vecchio A, Sola MC, Theriaque DW, et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 2001; 41: 803-8.
64. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003; 88: F359-64.
65. Del Vecchio A, Motta M, Radicioni M, Christensen RD. A consistent approach to platelet transfusion in the NICU. J Matern Fetal Neonatal Med 2012; 25: 93-6.
66. Baer VL, Lambert DK, Henry E, et al. Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multi hospital healthcare system. J Perinatol 2007; 27: 790-6.
67. Kline A, Mackley A, Taylor SM, et al. Thrombopoietin following transfusion of platelets in preterm neonates. Platelets 2008; 19: 428-31.
68. Murray NA, Howarth LJ, MaCloy MP, et al. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 2002; 12: 35-41.
69. Bakchoul T, Bassler D, Heckmann M, et al. Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin. Transfusion 2014; 54: 640-5.
70. Mohan P, Brocklehurst P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia. Cochrane Database Syst Rev 2003; 4: CD003956.
71. Ramasethu J, Luban NL. T activation. Br J Haematol 2001; 112: 259-63.
72. Osborn DA, Lui K, Pussell P, et al. T and Tk antigen activation in necrotizing enterocolitis: manifestations, severity of illness, and effectiveness of testing. Arch Dis Child Fetal Neonatal Ed 1999; 80: F192-7.
73. Eder AF, Manno CS. Does red cell T activation matter? Br J Haematol 2001; 114: 25-30.
74. Boralessa H, Modi N, Cockburn H, et al. RBC T activation and hemolysis in a neonatal intensive care population: implications for transfusion practice. Transfusion 2002; 42: 1428-34.