Assessment of combination therapy in BALB/c mice injected with carbapenem-resistant Enterobacteriaceae strains

Frontiers in Microbiology

Volumn 6, Issue SEP, 2015, Pages

  Salloum, Noor A ^a   Kissoyan, Kohar Annie B ^a   Fadlallah, Sukayna ^a   Cheaito, Katia ^a   Araj, George F ^a   Wakim, Rima ^a   Kanj, Souha ^a   Kanafani, Zeina ^a   Dbaibo, Ghassan ^a   Matar, Ghassan M ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Carbapenem resistance; Carbapenemase; Combination therapy; Enterobacteriaceae; Gene transcript; In vivo

Indexed keywords

CEFTAZIDIME; COLISTIN; FOSFOMYCIN; KANAMYCIN; MEROPENEM; RIFAMPICIN; TIGECYCLINE;

ADULT; ANIMAL EXPERIMENT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CLINICAL ASSESSMENT; DRUG EFFICACY; FEMALE; KLEBSIELLA PNEUMONIAE; LD50; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84946751789     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00999     Document Type: Article

References (34)

1. Andersson, D. I. (2006). The biological cost of mutational antibiotic resistance: any practical conclusions? Curr. Opin. Microbiol. 9, 461-465. doi: 10.1016/j.mib.2006.07.002
2. Baroud, M., Dandache, I., Araj, G. F., Wakim, R., Kanj, S., Kanafani, Z., et al. (2013). Underlying mechanisms of carbapenem resistance in extended-spectrum beta-lactamase-producing klebsiella pneumoniae and Escherichia coli isolates at a tertiary care centre in lebanon: role of OXA-48 and NDM-1 carbapenemases. Int. J. Antimicrob. Agents 41, 75-79. doi: 10.1016/j.ijantimicag.2012.08.010
3. CDC (2014). Carbapenem Resistant Enterobacteriaceae. Atlanta, GA: Centers for Disease Control and Prevention. Available at: http://www.cdc.gov.
4. Chen, T. L., Fung, C. P., and Lee, S. D. (2011). Spontaneous eradication of a NDM-1 positive klebsiella pneumoniae that colonized the intestine of an asymptomatic carrier. J. Chin. Med. Assoc. 74:104. doi: 10.1016/j.jcma.2011.01.022
5. Clinical and Laboratory Standards Institute [CLSI] (2013). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement M100-S23. Wayne, PA: Clinical and Laboratory Standards Institute.
6. Davies, S. N., Martin, D., Millar, J. D., Aram, J. A., Church, J., and Lodge, D. (1988). Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands. Eur. J. Pharmacol. 145, 141-151. doi: 10.1016/0014-2999(88)90225-7
7. Delcour, A. H. (2009). Outer membrane permeability and antibiotic resistance. Biochim. Biophys. Acta 1794, 808-816. doi: 10.1016/j.bbapap.2008.11.005
8. Depardieu, F., Podglajen, I., Leclercq, R., Collatz, E., and Courvalin, P. (2007). Modes and modulations of antibiotic resistance gene expression. Clin. Microbiol. Rev. 20, 79-114. doi: 10.1128/CMR.00015-06
9. El-Herte, R. I., Kanj, S. S., Matar, G. M., and Araj, G. F. (2012). The threat of carbapenem-resistant Enterobacteriaceae in lebanon: an update on the regional and local epidemiology. J. Infect. Public Health 5, 233-243. doi: 10.1016/j.jiph.2012.02.003
10. El-Srougy, R., Kalabalik, J., Kim, C., and Song, A. (2012). Carbapenem-resistant Enterobacteriaceae: an emerging threat. US Pharm. 38, HS2-HS5.
11. Falagas, M. E, Lourida, P., Poulikakos, P., Rafailidis, P. I., and Tansarli, G. S. (2014). Antibiotic treatment of infections due to carbapenem-resistant Enterobacteriaceae: systematic evaluation of the available evidence. Antimicrob. Agents Chemother. 58, 654-663. doi: 10.1128/AAC.01222-13
12. Herbert, S., Barry, P., and Novick, R. P. (2001). Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in staphylococcus aureus. Infect. Immun. 69, 2996-3003. doi: 10.1128/IAI.69.5.2996-3003.2001
13. Kmeid, J. G., Youssef, M. M., Kanafani, Z. A., and Kanj, S. S. (2013). Combination therapy for gram-negative bacteria: what is the evidence? Exp. Rev. Anti Infect. Ther. 11, 1355-1362. doi: 10.1586/14787210.2013.846215
14. Kohanski, M. A., Dwyer, D. J., and Collins, J. J. (2010). How antibiotics kill bacteria: from targets to networks. Nat. Rev. Microbiol. 8, 423-435. doi: 10.1038/nrmicro2333
15. Lim, T. P., Tan, T. Y., Lee, W., Sasikala, S., Tan, T. T., Hsu, L. Y., et al. (2011). In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore. PLoS ONE 21:e18485. doi: 10.1371/journal.pone.0018485
16. National Research Council [USA] (2011). Committee for the Update of the Guide for the Care. (and) Use of Laboratory Animals. Washington, DC: National Academies Press.
17. Nordmann, P., Poirel, L., and Dortet, L. (2012). Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerg. Infect. Dis. 18, 1503-1507. doi: 10.3201/eid1809.120355
18. Nowotny, A. (1971). "Determination of toxicity," Basic Exercises in Immunochemistry, Part 3 (Berlin: Springer), 303-305.
19. Opazo, A., Dominguez, M., Bello, H., Amyes, S. G., and Gonzalez-Rocha, G. (2012). OXA-type carbapenemases in acinetobacter baumannii in south america. J. Infect. Dev. Ctries. 6, 311-316.
20. Pagès, J. M., James, C. E., and Winterhalter, M. (2008). The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat. Rev. Microbiol. 6, 893-903. doi: 10.1038/nrmicro19942
21. Perez, F., and Van Duin, D. (2013). Carbapenem-resistant Enterobacteriaceae: a menace to our most vulnerable patients. Cleve. Clin. J. Med. 80, 225-233. doi: 10.3949/ccjm.80a.12182
22. Polak, S. (2013). In vitro to human in vivo translation-pharmacokinetics and pharmacodynamics of quinidine. Altex 30, 309-318. doi: 10.14573/altex.2013.3.309
23. Queenan, A. M., and Bush, K. (2007). Carbapenemases: the versatile beta-lactamases. Clin. Microbiol. Rev. 20, 440-458. doi: 10.1128/CMR.00001-07
24. Rahal, E. A., Kazzi, N., Kanbar, A., Abdelnoor, A. M., and Matar, G. M. (2011). Role of rifampicin in limiting Escherichia coli O157:H7 shiga-like toxin expression and enhancement of survival of infected BALB/c mice. Int. J. Antimicrob. Agents 37, 135-139. doi: 10.1016/j.ijantimicag.2010.10.009
25. Samuelsen, O., Thilesen, C. M., Heggelund, L., Vada, A. N., Kummel, A., and Sundsfjord, A. (2011). Identification of NDM-1-producing Enterobacteriaceae in norway. J. Antimicrob. Chemother. 66, 670-672. doi: 10.1093/jac/dkq483
26. Satlin, M. J., Jenkins, S. G., and Walsh, T. J. (2014). The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin. Infect. Dis. 58, 1274-1283. doi: 10.1093/cid/ciu052
27. Skurnik, D., Roux, D., Cattoir, V., Danilchanka, O., Lu, X., Yoder-Himes, D. R., et al. (2013). Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc. Natl. Acad. Sci. U.S.A. 110, 20747-20752. doi: 10.1073/pnas.1221552110
28. Swayne, R. L., Ludlam, H. A., Shet, V. G., Woodford, N., and Curran, M. D. (2011). Real-time TaqMan PCR for rapid detection of genes encoding five types of non-metallo-(class A and D) carbapenemases in Enterobacteriaceae. Int. J. Antimicrob. Agents 38, 35-38. doi: 10.1016/j.ijantimicag.2011.03.010
29. Tängdén, T. (2012). Multidrug-Resistant Escherichia coli and Klebsiella pneumonia Treatment, Selection and International Spread. Ph.D. thesis, Uppsala, Universitatis Upsaliensis.
30. The European Committee on Antimicrobial Susceptibility Testing [EUCAST]. (2014). Breakpoint Tables for Interpretation of MICs and Zone Diameters. Version 4.0. Available at: http://www.eucast.org [acessed April 20, 2014].
31. Tsai, Y. K., Fung, C. P., Lin, J. C., Chen, J. H., Chang, F. Y., Chen, T. L., et al. (2011). Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob. Agents Chemother. 55, 1485-1493. doi: 10.1128/AAC.01275-10
32. van Duin, D., Kaye, K. S., Neuner, E. A., and Bonomo, R. A. (2013). Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn. Microbiol. Infect. Dis. 75, 115-120. doi: 10.1016/j.diagmicrobio.2012.11.009
33. Xu, L., Ensor, V., Gossain, S., Nye, K., and Hawkey, P. (2005). Rapid and simple detection of blaCTX-M genes by multiplex PCR assay. J. Med. Microbiol. 54, 1183-1187. doi: 10.1099/jmm.0.46160-0
34. Zheng, F., Sun, J., Cheng, C., and Rui, Y. (2013). The establishment of a duplex real-time PCR assay for rapid and simultaneous detection of blaNDM and blaKPC genes in bacteria. Ann. Clin. Microbiol. Antimicrob. 12:30. doi: 10.1186/1476-0711-12-30