Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial

JACC: Cardiovascular Imaging

Volumn 8, Issue 11, 2015, Pages 1272-1281

  Ferencik, Maros ^a,b   Liu, Ting ^b,c   Mayrhofer, Thomas ^b   Puchner, Stefan B ^b,d   Lu, Michael T ^b   Maurovich Horvat, Pal ^e   Pope, J Hector ^f   Truong, Quynh A ^b,g   Udelson, James E ^h   Peacock, W Frank ⁱ   White, Charles S ^j   Woodard, Pamela K ^k   Fleg, Jerome L ^l   Nagurney, John T ^b   Januzzi, James L ^b   Hoffmann, Udo ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CHINA MEDICAL UNIVERSITY   (China)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e SEMMELWEIS UNIVERSITY   (Hungary)

^f BAYSTATE MEDICAL CENTER   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h TUFTS MEDICAL CENTER   (United States)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^k WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

more..

Author keywords

acute coronary syndrome; coronary computed tomography angiography; coronary plaque; emergency department; highly sensitive troponin; risk stratification

Indexed keywords

TROPONIN I; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; COHORT ANALYSIS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ARTERY DISEASE; DIAGNOSTIC ACCURACY; EMERGENCY WARD; FEMALE; HOSPITALIZATION; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK; STENOSIS; THORAX PAIN; ANGINA PECTORIS; ATHEROSCLEROTIC PLAQUE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; CORONARY BLOOD VESSEL; CORONARY STENOSIS; DIAGNOSTIC IMAGING; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; MULTICENTER STUDY; PREDICTIVE VALUE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; SEVERITY OF ILLNESS INDEX; UNITED STATES; VASCULAR CALCIFICATION; X-RAY COMPUTED TOMOGRAPHY;

ACUTE CORONARY SYNDROME; ADULT; ANGINA PECTORIS; BIOMARKERS; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY STENOSIS; CORONARY VESSELS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, X-RAY COMPUTED; TROPONIN I; UNITED STATES; VASCULAR CALCIFICATION;

EID: 84946738079     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2015.06.016     Document Type: Article

References (26)

1. F.S. Apple, and P.O. Collinson IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays Clin Chem 58 2012 54 61
2. T. Reichlin, W. Hochholzer, S. Bassetti, and et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays N Engl J Med 361 2009 858 867
3. T. Keller, T. Zeller, D. Peetz, and et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction N Engl J Med 361 2009 868 877
4. E. Giannitsis, K. Kurz, K. Hallermayer, J. Jarausch, A.S. Jaffe, and H.A. Katus Analytical validation of a high-sensitivity cardiac troponin T assay Clin Chem 56 2010 254 261
5. J.A. Goldstein, K.M. Chinnaiyan, A. Abidov, and et al. The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial J Am Coll Cardiol 58 2011 1414 1422
6. H.I. Litt, C. Gatsonis, B. Snyder, and et al. CT angiography for safe discharge of patients with possible acute coronary syndromes N Engl J Med 366 2012 1393 1403
7. U. Hoffmann, Q.A. Truong, D.A. Schoenfeld, and et al. Coronary CT angiography versus standard evaluation in acute chest pain N Engl J Med 367 2012 299 308
8. R. Body, S. Carley, G. McDowell, and et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay J Am Coll Cardiol 58 2011 1332 1339
9. T. Reichlin, C. Schindler, B. Drexler, and et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T Arch Intern Med 172 2012 1211 1218
10. M. Rubini Giménez, R. Hoeller, T. Reichlin, and et al. Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin Int J Cardiol 168 2013 3896 3901
11. C.L. Schlett, Q.A. Truong, W. Ahmed, and et al. High-sensitivity troponin T and C-reactive protein to identify patients without cardiac structural and functional abnormalities as assessed by cardiac CT and SPECT imaging: can biomarkers predict cardiac health? Int J Cardiovasc Imaging 29 2013 865 873
12. J.A. de Lemos, M.H. Drazner, T. Omland, and et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population JAMA 304 2010 2503 2512
13. S.B. Puchner, T. Liu, T. Mayrhofer, and et al. High-risk plaque detected on coronary CT angiography predicts acute coronary syndromes independent of significant stenosis in acute chest pain: results from the ROMICAT-II trial J Am Coll Cardiol 64 2014 684 692
14. J.A. Ladapo, F.A. Jaffer, U. Hoffmann, and et al. Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain J Am Coll Cardiol 54 2009 2409 2422
15. J.B. Shreibati, L.C. Baker, and M.A. Hlatky Association of coronary CT angiography or stress testing with subsequent utilization and spending among Medicare beneficiaries JAMA 306 2011 2128 2136
16. E. Hulten, C. Pickett, M.S. Bittencourt, and et al. Outcomes after coronary computed tomography angiography in the emergency department: a systematic review and meta-analysis of randomized, controlled trials J Am Coll Cardiol 61 2013 880 892
17. J.L. Januzzi, U. Sharma, P. Zakroysky, and et al. Sensitive troponin assays in patients with suspected acute coronary syndrome: results from the multicenter rule out myocardial infarction using computer assisted tomography II trial Am Heart J 169 2015 572 578.e1
18. G.L. Raff, A. Abidov, S. Achenbach, and et al. SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography J Cardiovasc Comput Tomogr 3 2009 122 136
19. R.S. Wright, J.L. Anderson, C.D. Adams, and et al. 2011 ACCF/AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 57 2011 e215 e367
20. E.R. Delong, D.M. Delong, and D.L. Clarke-Pearson Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Biometrics 44 1988 837 845
21. M.J. Pencina, R.B. D'Agostino, R.B. D' Agostino, and R.S. Vasan Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond Stat Med 27 2008 157 172 discussion 207-12
22. K. Wildi, T. Reichlin, R. Twerenbold, and et al. Serial changes in high-sensitivity cardiac troponin I in the early diagnosis of acute myocardial infarction Int J Cardiol 168 2013 4103 4110
23. N. Bandstein, R. Ljung, M. Johansson, and M.J. Holzmann Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction J Am Coll Cardiol 63 2014 2569 2578
24. T. Keller, T. Zeller, F. Ojeda, and et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction JAMA 306 2011 2684 2693
25. D.J. Diver, J.D. Bier, P.E. Ferreira, and et al. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA Trial) Am J Cardiol 74 1994 531 537
26. M.T. Roe, R.A. Harrington, D.M. Prosper, and et al. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease Circulation 102 2000 1101 1106