S100A4 upregulation suppresses tissue ossification and enhances matrix degradation in experimental periodontitis models

Acta Pharmacologica Sinica

Volumn 36, Issue 11, 2015, Pages 1388-1394

  Zhou, Min ^a   Li, Zhuo Quan ^b   Wang, Zuo Lin ^a  

^a TONGJI UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALVASCULIN; COLLAGENASE 3; GELATINASE A; MESSENGER RNA; OSTEOCALCIN; SHORT HAIRPIN RNA; INTERLEUKIN 1BETA; PROTEIN S 100; S100A4 PROTEIN, HUMAN; S100A4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; OSSIFICATION; PATHOGENESIS; PERIODONTAL LIGAMENT; PERIODONTITIS; PLASMID; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; UPREGULATION; WESTERN BLOTTING; ADULT; ANIMAL; CELL CULTURE; CELL LINE; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ADULT; ANIMALS; CELL LINE; CELLS, CULTURED; HUMANS; INTERLEUKIN-1BETA; MALE; OSTEOGENESIS; PERIODONTAL LIGAMENT; PERIODONTITIS; RATS, SPRAGUE-DAWLEY; S100 CALCIUM-BINDING PROTEIN A4; S100 PROTEINS; TRANSFECTION; UP-REGULATION;

EID: 84946553881     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2015.77     Document Type: Article

References (30)

1. EI-Awady AR, Messer RL, Gamal AY, Sharawy MM, Wenger KH, Lapp CA. Periodontal ligament fibroblasts sustain destructive immune modulators of chronic periodontitis. J Periodontol 2010; 81: 1324-35.
2. Liu Y, Liu W, Hu C, Xue Z, Wang G, Ding B, et al. MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis. Stem Cells 2011; 29: 1804-16.
3. Kato H, Taguchi Y, Tominaga K, Umeda M, Tanaka A. Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes proinflammatory cytokine production in human periodontal ligament stem cells. Arch Oral Biol 2014; 59: 167-75.
4. Havemose-Poulsen A, Holmstrup P. Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature. Crit Rev Oral Biol Med 1997; 8: 217-36.
5. Osterreicher CH, Penz-Osterreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, et al. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 2011; 108: 308-13.
6. Chen K, Xiong H, Huang Y, Liu C. Comparative analysis of in vitro periodontal characteristics of stem cells from apical papilla (SCAP) and periodontal ligament stem cells (PDLSCs). Arch Oral Biol 2013; 58: 997-1006.
7. Chen N, Sato D, Saiki Y, Sunamura M, Fukushige S, Horii A. S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility. Biochem Biophys Res Commun 2014; 447: 459-64.
8. Garrett SC, Varney KM, Weber DJ, Bresnick AR. S100A4, a mediator of metastasis. J Biol Chem 2006; 281: 677-80.
9. Duarte WR, Iimura T, Takenaga K, Ohya K, Ishikawa I, Kasugai S. Extracellular role of S100A4 calcium-binding protein in the periodontal ligament. Biochem Biophys Res Commun 1999; 255: 416-20.
10. Kato C, Kojima T, Komaki M, Mimori K, Duarte WR, Takenaga K, et al. S100A4 inhibition by RNAi up-regulates osteoblast related genes in periodontal ligament cells. Biochem Biophys Res Commun 2004; 326: 147-53.
11. Duarte WR, Kasugai S, Iimura T, Oida S, Takenaga K, Ohya K, et al. cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues. J Dent Res 1998; 77: 1694-9.
12. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995; 130: 393-405.
13. Duarte WR, Shibata T, Takenaga K, Takahashi E, Kubota K, Ohya K, et al. S100A4: a novel negative regulator of mineralization and osteoblast differentiation. J Bone Miner Res 2003; 18: 493-501.
14. Oslejskova L, Grigorian M, Gay S, Neidhart M, Senolt L. The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behaviour of rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 2008; 67: 1499-504.
15. Cerezo LA, Remakova M, Tomcik M, Gay S, Neidhart M, Lukanidin E, et al. The metastasis-associated protein S100A4 promotes the inflammatory response of mononuclear cells via the TLR4 signalling pathway in rheumatoid arthritis. Rheumatology (Oxford) 2014; 53: 1520-6.
16. Boch JA , Wara-aswapati N, Auron PE. Interleukin 1 signal transduction-current concepts and relevance to periodontitis. J Dent Res 2001; 80: 400-7.
17. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364: 149-55.
18. Oh SH, Hwang YC, Yang H, Kang JH, Hur SW, Jung NR, et al. SHP is involved in BMP2-induced odontoblast differentiation. J Dent Res 2012; 91: 1124-9.
19. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontology 2000 1997; 14: 9-11.
20. Jang YJ, Kim ME, Ko SY. n-Butanol extracts of Panax notoginseng suppress LPS-induced MMP-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing MAPK in LPS-activated RAW264. 7 cells. Arch Oral Biol 2011; 56: 1319-27.
21. Chang YC, Yang SF, Lai CC, Liu JY, Hsieh YS. Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures. J Periodontal Res 2002; 37: 196-203.
22. Pattamapun K, Tiranathanagul S, Yongchaitrakul T, Kuwatanasuchat J, Pavasant P. Activation of MMP-2 by Porphyromonas gingivalis in human periodontal ligament cells. J Periodontal Res 2003; 38: 115-21.
23. Xiang J, Li C, Dong W, Cao Z, Liu L. Expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and extracellular metalloproteinase inducer in human periodontal ligament cells stimulated with interleukin-1 beta. J Periodontal Res 2009; 44: 784-93.
24. Hernandez M, Martinez B, Tejerina JM, Valenzuela MA, Gamonal J. MMP-13 and TIMP-1 determinations in progressive chronic periodontitis. J Clin Periodontol 2007; 34: 729-35.
25. Ahn SJ, Rhim EM, Kim JY, Kim KH, Lee HW, Kim EC, et al. Tumor necrosis factor-alpha induces matrix metalloproteinases-3, -10, and -13 in human periodontal ligament cells. J Periodontol 2014; 85: 490-7.
26. Rossa C Jr, Liu M, Bronson P, Kirkwood KL. Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase. J Endotoxin Res 2007; 13: 85-93.
27. Erlandsson MC, Svensson MD, Jonsson IM, Bian L, Ambartsumian N, Andersson S, et al. Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function. Biochim Biophys Acta 2013; 1833: 2653-63.
28. Bian L, Strzyz P, Jonsson IM, Erlandsson M, Hellvard A, Brisslert M, et al. S100A4 deficiency is associated with efficient bacterial clearance and protects against joint destruction during Staphylococcal infection. J Infect Dis 2011; 204: 722-30.
29. Miranda KJ, Loeser RF, Yammani RR. Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem 2010; 285: 31517-24.
30. Nie J, Zhang B, Gu B, Liu N. Effects of p38 mitogen-activated protein kinase on osteogenic differentiation of human periodontal ligament stem cells in inflammatory microenvironment. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2015; 37: 1-7.