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Volumn 8, Issue , 2015, Pages 367-378

New developments in the treatment of drug-resistant tuberculosis: Clinical utility of bedaquiline and delamanid

Author keywords

Group 5 drugs; MDR TB; Tuberculosis drugs; XDR TB

Indexed keywords

BEDAQUILINE; CILASTATIN PLUS IMIPENEM; CLOFAZIMINE; DELAMANID; ISONIAZID; LEVOFLOXACIN; LINEZOLID; MEROPENEM; MOXIFLOXACIN; PRETOMANID; PYRAZINAMIDE;

EID: 84946551645     PISSN: None     EISSN: 11786973     Source Type: Journal    
DOI: 10.2147/IDR.S68351     Document Type: Review
Times cited : (54)

References (63)
  • 1
    • 84894198937 scopus 로고    scopus 로고
    • Geneva, Switzerland: World Health Organization, Accessed July 11, 2015
    • World Health Organisation. Global Tuberculosis Report 2014. Geneva, Switzerland: World Health Organization; 2014. Available from: http://www.who.int/tb/publications/global_report/en/. Accessed July 11, 2015.
    • (2014) Global Tuberculosis Report 2014
  • 4
    • 84946605291 scopus 로고    scopus 로고
    • WHO End TB Strategy
    • Accessed July 11, 2015
    • World Health Organisation. WHO End TB Strategy. Geneva: World Health Organization. Available from: http://www.who.int/tb/post2015_strategy/en/. Accessed July 11, 2015.
    • Geneva: World Health Organization
  • 6
    • 84946550541 scopus 로고    scopus 로고
    • European Medicine Agency. Situro. London, England: European Medicine Agency. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2013/12/news_detail_001999.jsp&mid=WC0b01ac058004d5c1.
    • Situro. London, England: European Medicine Agency
  • 7
    • 84907363801 scopus 로고    scopus 로고
    • Silver Spring, MD: Food and Drug Administration, Accessed July 11, 2015
    • Food and Drug Administration. Sirturo (bedaquiline) Product Insert. Silver Spring, MD: Food and Drug Administration. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/204384s000lbl.pdf. Accessed July 11, 2015.
    • Sirturo (Bedaquiline) Product Insert
  • 8
    • 84868004842 scopus 로고    scopus 로고
    • Nuermberger EL. World Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: Unclear efficacy or untapped potential?
    • Dooley KE, Obuku EA, Durakovic N, Belitsky V, Mitnick C, Nuermberger EL. World Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: unclear efficacy or untapped potential? J Infect Dis. 2013;207(9):1352-1358. doi:10.1093/infdis/jis460.
    • (2013) J Infect Dis , vol.207 , Issue.9 , pp. 1352-1358
    • Dooley, K.E.1    Obuku, E.A.2    Durakovic, N.3    Belitsky, V.4    Mitnick, C.5
  • 9
    • 84931444776 scopus 로고    scopus 로고
    • Clofazimine in the treatment of extensively drug-resistant tuberculosis with HIV coinfection in South Africa: A retrospective cohort study
    • Padayatchi N. Clofazimine in the treatment of extensively drug-resistant tuberculosis with HIV coinfection in South Africa: a retrospective cohort study. J Antimicrob Chemother. 2014;69(11):3103-3107. doi:101093/jac/dku235.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.11 , pp. 3103-3107
    • Padayatchi, N.1
  • 10
    • 84880454871 scopus 로고    scopus 로고
    • Systematic review of clofazimine for the treatment of drug-resistant tuberculosis
    • Gopal M, Padayatchi N, Metcalfe JZ, O’Donnell MR. Systematic review of clofazimine for the treatment of drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2013;17(8):1001-1007. doi:10.5588/ijtld.12.0144.
    • (2013) Int J Tuberc Lung Dis , vol.17 , Issue.8 , pp. 1001-1007
    • Gopal, M.1    Padayatchi, N.2    Metcalfe, J.Z.3    O’Donnell, M.R.4
  • 11
    • 84861864703 scopus 로고    scopus 로고
    • Delamanid for multidrug-resistant pulmonary tuberculosis
    • Gler MT, Skripconoka V, Sanchez-Garavito E, et al. Delamanid for multidrug-resistant pulmonary tuberculosis. N Engl J Med. 2012;366(23):2151-2160. doi:10.1056/NEJMoa1112433.
    • (2012) N Engl J Med , vol.366 , Issue.23 , pp. 2151-2160
    • Gler, M.T.1    Skripconoka, V.2    Sanchez-Garavito, E.3
  • 12
    • 84878776777 scopus 로고    scopus 로고
    • Delamanid improves outcomes and reduces mortality in multidrug-resistant tuberculosis
    • Skripconoka V, Danilovits M, Pehme L, et al. Delamanid improves outcomes and reduces mortality in multidrug-resistant tuberculosis. Eur Respir J. 2013;41(6):1393-1400. doi:10.1183/09031936.00125812.
    • (2013) Eur Respir J , vol.41 , Issue.6 , pp. 1393-1400
    • Skripconoka, V.1    Danilovits, M.2    Pehme, L.3
  • 13
    • 84922169897 scopus 로고    scopus 로고
    • Profile of delamanid for the treatment of multidrug-resistant tuberculosis
    • Szumowski JD, Lynch JB. Profile of delamanid for the treatment of multidrug-resistant tuberculosis. Drug Des Devel Ther. 2015;9:677-682. doi:10.2147/DDDT.S60923.
    • (2015) Drug Des Devel Ther , vol.9 , pp. 677-682
    • Szumowski, J.D.1    Lynch, J.B.2
  • 15
    • 77953242571 scopus 로고    scopus 로고
    • TMC207: The first compound of a new class of potent anti-tuberculosis drugs
    • Matteelli A, Carvalho ACC, Dooley KE, et al. TMC207: the first compound of a new class of potent anti-tuberculosis drugs. Future Microbiol. 2010;5(6):849-858.
    • (2010) Future Microbiol , vol.5 , Issue.6 , pp. 849-858
    • Matteelli, A.1    Carvalho, A.2    Dooley, K.E.3
  • 16
    • 84907377122 scopus 로고    scopus 로고
    • Multidrug-resistant tuberculosis and culture conversion with bedaquiline for the TMC207-C208 study group*
    • Diacon AH, Pym A, Grobusch MP, et al. Multidrug-resistant tuberculosis and culture conversion with bedaquiline for the TMC207-C208 study group*. N Engl J Med. 2014;8371(21):723-732. doi:10.1056/NEJMoa1313865.
    • (2014) N Engl J Med , vol.8371 , Issue.21 , pp. 723-732
    • Diacon, A.H.1    Pym, A.2    Grobusch, M.P.3
  • 17
    • 84946605292 scopus 로고    scopus 로고
    • New York, NY: Treatment Action Group
    • Treatment Action Group. HIV-HCV-TB Pipeline Report. New York, NY: Treatment Action Group; 2014.
    • (2014) HIV-HCV-TB Pipeline Report
  • 19
    • 84895161544 scopus 로고    scopus 로고
    • Geneva, Switzerland: World Health Organisation; 2013
    • World Health Organisation. WHO interim guidance on the use of bedaquiline to treat MDR-TB. Geneva, Switzerland: World Health Organisation; 2013. Available from: http://www.who.int/mediacentre/news/notes/2013/bedaquiline_mdr_tb_20130613/en/. Accessed July 11, 2015.
    • WHO Interim Guidance on the Use of Bedaquiline to Treat MDR-TB
  • 20
    • 84886093724 scopus 로고    scopus 로고
    • Geneva, Switzerland: World Health Organisation; 2014, Accessed July 11, 2015
    • World Health Organisation. The Use of Delamanid in the Treatment of Multidrug-Resistant Tuberculosis. Geneva, Switzerland: World Health Organisation; 2014. Available from: http://apps.who.int/iris/bitstream/10665/137334/1/WHO_HTM_TB_2014.23_eng.pdf?ua=1. Accessed July 11, 2015.
    • The Use of Delamanid in the Treatment of Multidrug-Resistant Tuberculosis
  • 22
    • 84946574897 scopus 로고    scopus 로고
    • Geneva, Switzerland: World Health Organisation; 2012, Accessed July 11, 2015
    • World Health Organisation. World Health Organisation Prequalification.WH0 Prequalification. Geneva, Switzerland: World Health Organisation; 2012. Available from: http://apps.who.int/prequal/query/ProductRegistry.aspx?list=all. Accessed July 11, 2015.
    • World Health Organisation Prequalification.Wh0 Prequalification
  • 23
    • 84872371975 scopus 로고    scopus 로고
    • Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: A systematic review and meta-analysis
    • Dey T, Brigden G, Cox H, Shubber Z, Cooke G, Ford N. Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis. J Antimicrob Chemother. 2013;68(2):284-293. doi:10.1093/jac/dks389.
    • (2013) J Antimicrob Chemother , vol.68 , Issue.2 , pp. 284-293
    • Dey, T.1    Brigden, G.2    Cox, H.3    Shubber, Z.4    Cooke, G.5    Ford, N.6
  • 24
    • 0028933435 scopus 로고
    • Gangadharam PR. Chemotherapeutic activity of clofazimine and its analogs against mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies
    • Jagannath C, Reddy MV, Kailasam S, O’Sullivan JF, Gangadharam PR. Chemotherapeutic activity of clofazimine and its analogs against mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies. Am J Respir Crit Care Med. 1995;151(4):1083-1086.
    • (1995) Am J Respir Crit Care Med , vol.151 , Issue.4 , pp. 1083-1086
    • Jagannath, C.1    Reddy, M.V.2    Kailasam, S.3    O’Sullivan, J.F.4
  • 25
    • 84907020883 scopus 로고    scopus 로고
    • Successful “9-month Bangladesh regimen” for multidrug-resistant tuberculosis among over 500 consecutive patients
    • Aung KJM, Van Deun A, Declercq E, et al. Successful “9-month Bangladesh regimen” for multidrug-resistant tuberculosis among over 500 consecutive patients. Int J Tuberc Lung Dis. 2014;18(10):1180-1187. doi:10.5588/ijtld.14.0100.
    • (2014) Int J Tuberc Lung Dis , vol.18 , Issue.10 , pp. 1180-1187
    • Aung, K.1    Van Deun, A.2    Declercq, E.3
  • 26
    • 84907033159 scopus 로고    scopus 로고
    • High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: No relapses
    • Piubello A, Harouna SH, Souleymane MB, et al. High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: no relapses. Int J Tuberc Lung Dis. 2014;18(10):1188-1194. doi:10.5588/ijtld.13.0075.
    • (2014) Int J Tuberc Lung Dis , vol.18 , Issue.10 , pp. 1188-1194
    • Piubello, A.1    Harouna, S.H.2    Souleymane, M.B.3
  • 27
    • 84907022895 scopus 로고    scopus 로고
    • Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): Study protocol for a randomized controlled trial
    • Accessed July 11, 2015
    • Nunn AJ, Rusen I, Van Deun A, et al. Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a randomized controlled trial. Trials. 2014;15:353. Available from: http://www.trialsjournal.com/content/15/1/353. Accessed July 11, 2015.
    • (2014) Trials , vol.15 , pp. 353
    • Nunn, A.J.1    Rusen, I.2    Van Deun, A.3
  • 28
    • 84946546819 scopus 로고    scopus 로고
    • 14 Day EBA Study of PA-824 bedaquiline *pyrazinamide and clofazimine in smear positive TB patients
    • Boston, MA, Accessed July 11, 2015
    • Diacon SM, Dawson R, Niekerk CV, et al. 14 Day EBA Study of PA-824 bedaquiline *pyrazinamide and clofazimine in smear positive TB patients. In: CROI; 2014; Boston, MA. Available from: http://www.croiconference.org/sessions/14-day-eba-study-pa-824-bedaquiline-pyrazinamide-and-clofazimine-smear-positive-tb-patients. Accessed July 11, 2015.
    • (2014) CROI
    • Diacon, S.M.1    Dawson, R.2    Niekerk, C.V.3
  • 29
    • 84863584732 scopus 로고    scopus 로고
    • New drugs for the treatment of tuberculosis: Hope and reality
    • Grosset JH, Singer TG, Bishai WR, Grosset JH. New drugs for the treatment of tuberculosis: hope and reality. Int J Tuberc Lung Dis. 2012;16(8):1005-1014. doi:10.5588/ijtld.12.0277.
    • (2012) Int J Tuberc Lung Dis , vol.16 , Issue.8 , pp. 1005-1014
    • Grosset, J.H.1    Singer, T.G.2    Bishai, W.R.3    Grosset, J.H.4
  • 30
    • 84858657770 scopus 로고    scopus 로고
    • Linezolid for the treatment of complicated drug-resistant tuberculosis: A systematic review and meta-analysis
    • Cox H, Ford N. Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis. Int J Tuberc Lung Dis. 2012;16(4):447-454. doi:10.5588/ijtld.11.0451.
    • (2012) Int J Tuberc Lung Dis , vol.16 , Issue.4 , pp. 447-454
    • Cox, H.1    Ford, N.2
  • 31
    • 77952547476 scopus 로고    scopus 로고
    • Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: A retrospective cohort study
    • Dheda K, Shean K, Zumla A, et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet. 2010;375(9728):1798-1807. doi:10.1016/S0140-6736(10)60492-8.
    • (2010) Lancet , vol.375 , Issue.9728 , pp. 1798-1807
    • Dheda, K.1    Shean, K.2    Zumla, A.3
  • 32
    • 84867614599 scopus 로고    scopus 로고
    • Linezolid for treatment of chronic extensively drug-resistant tuberculosis
    • Accessed July 11, 2015
    • Lee M, Lee J, Carroll MW, et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N Engl J Med. 2012;367:1508-1518. Available from: http://www.nejm.org/doi/full/10.1056/NEJMoa1201964. Accessed July 11, 2015.
    • (2012) N Engl J Med , vol.367 , pp. 1508-1518
    • Lee, M.1    Lee, J.2    Carroll, M.W.3
  • 34
    • 84870747517 scopus 로고    scopus 로고
    • Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB
    • De Lorenzo S, Alffenaar JW, Sotgiu G, et al. Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB. Eur Respir J. 2013; 41(6):1386-1392. doi:10.1183/09031936.00124312.
    • (2013) Eur Respir J , vol.41 , Issue.6 , pp. 1386-1392
    • De Lorenzo, S.1    Alffenaar, J.W.2    Sotgiu, G.3
  • 35
    • 85052355294 scopus 로고    scopus 로고
    • Médecins Sans Frontières Access CampaignReady set slow down, Accessed July 11, 2015
    • Médecins Sans Frontières Access Campaign. Ready set slow down. [Issue brief]. Available from: https://www.msfaccess.org/sites/default/files/MSF_assets/TB/Docs/MSF_IssueBrief_DRTB_ReadySet Slowdown.pdf. Accessed July 11, 2015.
  • 36
    • 84924420073 scopus 로고    scopus 로고
    • Compassionate use of bedaquiline for the treatment of multidrug-resistant and extensively drug-resistant tuberculosis: Interim analysis of a French cohort
    • Guglielmetti L, Le Dû D, Jachym M, et al. Compassionate use of bedaquiline for the treatment of multidrug-resistant and extensively drug-resistant tuberculosis: interim analysis of a French cohort. Clin Infect Dis. 2015;60(2):188-194. doi:10.1093/cid/ciu786.
    • (2015) Clin Infect Dis , vol.60 , Issue.2 , pp. 188-194
    • Guglielmetti, L.1    Le Dû, D.2    Jachym, M.3
  • 37
    • 84938255826 scopus 로고    scopus 로고
    • Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: An interim cohort analysis
    • Ndjeka, N, Conradie F, Schnippel K, et al. Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: an interim cohort analysis. Int J Tuberc Lung Dis. 2015; 19(8):979-985.
    • (2015) Int J Tuberc Lung Dis , vol.19 , Issue.8 , pp. 979-985
    • Ndjeka, N.1    Conradie, F.2    Schnippel, K.3
  • 38
    • 84946605294 scopus 로고    scopus 로고
    • Armenian experience on treatment of XDR and pre-XDR patients with new drugs under compassionate use program
    • February 17-18, Accessed July 11, 2015
    • Yeghiazaryan L. Armenian experience on treatment of XDR and pre-XDR patients with new drugs under compassionate use program. Presented at: Tuberculosis Symposium-Eastern Europe and Central Asia; February 17-18, 2015. Available at: http://www.tb-symposium.org/documents/en/presentations/Lusine_Yeghiazaryan_BDQ_practical_use_eng.pdf. Accessed July 11, 2015.
    • (2015) Presented At: Tuberculosis Symposium-Eastern Europe and Central Asia
    • Yeghiazaryan, L.1
  • 39
    • 53749083142 scopus 로고    scopus 로고
    • Treatment of extensively drug-resistant tuberculosis in Tomsk, Russia: A retrospective cohort study
    • Keshavjee S, Gelmanova IY, Farmer PE, et al. Treatment of extensively drug-resistant tuberculosis in Tomsk, Russia: a retrospective cohort study. Lancet. 2008;372(9647):1403-1409. doi:10.1016/S0140-6736 (08)61204-0.
    • (2008) Lancet , vol.372 , pp. 1403-1409
    • Keshavjee, S.1    Gelmanova, I.Y.2    Farmer, P.E.3
  • 40
    • 84897499466 scopus 로고    scopus 로고
    • Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: A cohort study
    • Pietersen E, Ignatius E, Streicher EM, et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. Lancet. 2014;383(9924):1230-1239. doi:10.1016/S0140-6736(13)62675-6.
    • (2014) Lancet , vol.383 , Issue.9924 , pp. 1230-1239
    • Pietersen, E.1    Ignatius, E.2    Streicher, E.M.3
  • 41
    • 84865514086 scopus 로고    scopus 로고
    • Predictors of poor outcomes among patients treated for multidrug-resistant tuberculosis at DOTS-plus projects
    • Kurbatova EV, Taylor A, Gammino VM, et al. Predictors of poor outcomes among patients treated for multidrug-resistant tuberculosis at DOTS-plus projects. Tuberculosis. 2012;92(5):397-403.
    • (2012) Tuberculosis , vol.92 , Issue.5 , pp. 397-403
    • Kurbatova, E.V.1    Taylor, A.2    Gammino, V.M.3
  • 42
    • 70349141401 scopus 로고    scopus 로고
    • Treatment outcomes of multidrug-resistant tuberculosis: A systematic review and meta-analysis
    • Johnston JC, Shahidi NC, Sadatsafavi M, Fitzgerald JM. Treatment outcomes of multidrug-resistant tuberculosis: a systematic review and meta-analysis. PLoS One. 2009;4(9):e6914. doi:10.1371/journal.pone.0006914.
    • (2009) Plos One , vol.4 , Issue.9
    • Johnston, J.C.1    Shahidi, N.C.2    Sadatsafavi, M.3    Fitzgerald, J.M.4
  • 43
    • 33646463191 scopus 로고    scopus 로고
    • Time to sputum culture conversion in multidrug-resistant tuberculosis: Predictors and relationship to treatment outcome
    • Accessed July 11, 2012
    • Holtz TH, Sternberg M, Kammerer S, et al. Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome. Ann Intern Med. 2006;144(9):650-659. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16670134. Accessed July 11, 2012.
    • (2006) Ann Intern Med , vol.144 , Issue.9 , pp. 650-659
    • Holtz, T.H.1    Sternberg, M.2    Kammerer, S.3
  • 45
    • 84946605295 scopus 로고    scopus 로고
    • Effectiveness of the WHO regimen for treatment of multidrug resistant tuberculosis
    • Accessed July 11, 2015
    • Bonnet M. Effectiveness of the WHO regimen for treatment of multidrug resistant tuberculosis. Presented at: European Respiratory Society Annual Congress, 2013. Available from: http://erj.ersjournals.com/content/42/Suppl_57/190.short. Accessed July 11, 2015.
    • (2013) Presented At: European Respiratory Society Annual Congress
    • Bonnet, M.1
  • 46
    • 84891546754 scopus 로고    scopus 로고
    • Policy and practice principles for designing future regimens for multidrug-resistant tuberculosis
    • Brigden G, Nyang ’wa B-T, Du Cros P, et al. Policy and practice principles for designing future regimens for multidrug-resistant tuberculosis. Bull World Heal Organ. 2014;92:68-74. doi:10.2471/BLT.13.122028.
    • (2014) Bull World Heal Organ , vol.92 , pp. 68-74
    • Brigden, G.1    Nyang ’Wa, B.-T.2    Du Cros, P.3
  • 47
    • 84864518733 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: Systematic review and meta-analysis
    • Sotgiu G, Centis R, D’Ambrosio L, et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J. 2012;40(6):1430-1442. doi:10.1183/09031936.00022912.
    • (2012) Eur Respir J , vol.40 , Issue.6 , pp. 1430-1442
    • Sotgiu, G.1    Centis, R.2    D’Ambrosio, L.3
  • 48
  • 51
    • 84946546313 scopus 로고    scopus 로고
    • Bedaquiline (Sirturo): Summary of Product Characteristics, Accessed March 01, 2015
    • Bedaquiline (Sirturo): Summary of Product Characteristics. European Medicines Agency. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002614/human_med_001730.jsp&mid=WC0b01ac058001d124. Accessed March 01, 2015.
    • European Medicines
  • 53
    • 84946605297 scopus 로고    scopus 로고
    • homepage on the Internet, Accessed July 11, 2015
    • ERS/WHO Tuberculosis Consilium [homepage on the Internet]. Available from: https://www.tbconsilium.org/. Accessed July 11, 2015.
  • 54
    • 83155165270 scopus 로고    scopus 로고
    • QT prolongation and torsade de pointes induced by fluoroquinolones: Infrequent side effects from commonly used medications
    • Briasoulis A, Agarwal V, Pierce WJ. QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications. Cardiology. 2011;120(22):103-110.
    • (2011) Cardiology , vol.120 , Issue.22 , pp. 103-110
    • Briasoulis, A.1    Agarwal, V.2    Pierce, W.J.3
  • 55
    • 84910092131 scopus 로고    scopus 로고
    • Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro
    • Shimokawa Y, Sasahara K, Yoda N, Mizuno K, Umehara K. Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro. Biol Pharm Bull. 2014;37(11):1727-1735.
    • (2014) Biol Pharm Bull , vol.37 , Issue.11 , pp. 1727-1735
    • Shimokawa, Y.1    Sasahara, K.2    Yoda, N.3    Mizuno, K.4    Umehara, K.5
  • 56
    • 84874755953 scopus 로고    scopus 로고
    • Absence of clinically relevant drug interaction between delamanid, a new drug for multidrug-resistant tuberculosis (MDR-TB) and tenofovir or lopinavir/ritonavir in healthy subjects
    • Washington, DC
    • Paccaly AJ, Petersen C, Patil S, et al. Absence of clinically relevant drug interaction between delamanid, a new drug for multidrug-resistant tuberculosis (MDR-TB) and tenofovir or lopinavir/ritonavir in healthy subjects. In: 19th International AIDS Conference; 2012; Washington, DC.
    • (2012) 19Th International AIDS Conference
    • Paccaly, A.J.1    Petersen, C.2    Patil, S.3
  • 57
    • 84898619017 scopus 로고    scopus 로고
    • Cross-resistance between clofazimine and bedaquiline through upregulation of mmpl5 in mycobacterium tuberculosis
    • Hartkoorn RC, Uplekar S, Cole ST. Cross-resistance between clofazimine and bedaquiline through upregulation of mmpl5 in mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014;58(5):2979-2981. doi:10.1128/AAC.00037-14
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.5 , pp. 2979-2981
    • Hartkoorn, R.C.1    Uplekar, S.2    Cole, S.T.3
  • 58
    • 84922202908 scopus 로고    scopus 로고
    • A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment
    • Somoskovi A. A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment. Eur Respir Soc J. 2015;45(2):554-557.
    • (2015) Eur Respir Soc J , vol.45 , Issue.2 , pp. 554-557
    • Somoskovi, A.1
  • 59
    • 84946605299 scopus 로고    scopus 로고
    • Presentation, 2014, Accessed July 11, 2015
    • Global Drug Facility. GDF Impact on SLD Dynamics: 2011 vs 2013 Treatment Cost Comparison. Presentation, 2014. Available at: http://www.stoptb.org/assets/documents/gdf/whatis/SecondLineDrugs.pdf. Accessed July 11, 2015.
    • GDF Impact on SLD Dynamics: 2011 Vs 2013 Treatment Cost Comparison
  • 60
    • 85052357867 scopus 로고    scopus 로고
    • 3rd ed. Paris, France: Médecins Sans Frontières
    • Médecins Sans Frontières. Under the Microscope. 3rd ed. Paris, France: Médecins Sans Frontières; 2013.
    • (2013) Under the Microscope
  • 61
    • 84946605300 scopus 로고    scopus 로고
    • Accessed July 11, 2015
    • USAID. USAID and Johnson & Johnson to tackle antibiotic resistant TB. Available from: http://www.usaid.gov/news-information/press-releases/dec-11-2014-usaid-and-johnson-johnson-tackle-antibiotic-resistant-tuberculosis. Accessed July 11, 2015.
    • USAID and Johnson & Johnson to Tackle Antibiotic Resistant TB
  • 62
    • 84946543622 scopus 로고    scopus 로고
    • World Health Organization
    • Tuberculosis (TB). An initiative to extend access to a new TB drug. World Health Organization. Available from: http://www.who.int/tb/features_archive/otsuka_2015/en/. Accessed July 11, 2015.
    • An Initiative to Extend Access to a New TB Drug
  • 63
    • 84913573933 scopus 로고    scopus 로고
    • Updated May 2015, Accessed July 11, 2015
    • RESIST-TB. DR-TB Clinical Trial Progress Report. Updated May 2015. Available from: http://www.resisttb.org/?page_id=1602. Accessed July 11, 2015.
    • DR-TB Clinical Trial Progress Report


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.