Comparative efficacy and safety of anticoagulant strategies for acute coronary syndromes: Comprehensive network meta-analysis of 42 randomised trials involving 117,353 patients

Thrombosis and Haemostasis

Volumn 114, Issue 5, 2015, Pages 933-944

  Navarese, Eliano Pio ^a,n   Andreotti, Felicita ^b,m   Kołodziejczak, Michalina ^a,c,n   Schulze, Volker ^a,n   Wolff, Georg ^a,n   Dias, Sofia ^d,n   Claessen, Bimmer ^e,n   Brouwer, Marc ^f,n   Tarantini, Giuseppe ^g   Iliceto, Sabino ^g   Brockmeyer, Maximilian ^a,n   Kowalewski, Mariusz ^h   Lin, Yingfeng ^a,n   Eikelboom, John ⁱ   Musumeci, Giuseppe ^j   Lee, Leong ^k   Lip, Gregory Y H ^k   Valgimigli, Marco ^l   Berti, Sergio ^m,n   Kelm, Malte ^a,n  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b CATHOLIC UNIVERSITY   (Italy)

^c NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^h 10th Military Research Hospital and Polyclinic   (Poland)

ⁱ MCMASTER UNIVERSITY   (Canada)

^j Azienda Ospedaliera Papa Giovanni XXIII Bergamo   (Italy)

^k UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^l ERASMUS MEDICAL CENTER   (Netherlands)

^m Heart Hospital   (Italy)

ⁿ Systematic Investigation and Research on Interventions and Outcomes (SIRIO) Medicine Research Network

more..

Author keywords

Acute coronary syndrome; Network meta analysis; Parenteral anticoagulant

Indexed keywords

FONDAPARINUX; HEPARIN; HIRULOG; LOW MOLECULAR WEIGHT HEPARIN; OTAMIXABAN; ANTICOAGULANT AGENT;

ACUTE CORONARY SYNDROME; ANTICOAGULANT THERAPY; BLEEDING; CARDIOVASCULAR MORTALITY; DRUG SAFETY; HEART INFARCTION; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVASCULARIZATION; REVIEW; SENSITIVITY ANALYSIS; STENT THROMBOSIS; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; COMPLICATION; HEMORRHAGE; MYOCARDIAL INFARCTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ACUTE CORONARY SYNDROME; ANTICOAGULANTS; DRUG THERAPY, COMBINATION; HEMORRHAGE; HUMANS; MYOCARDIAL INFARCTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84946548083     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-12-1066     Document Type: Review

References (25)

1. Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014; 64: e139-e228.
2. American College of Emergency, Physicians Society for Cardiovascular and Angiography Interventions, O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013; 61: e78–140.
3. Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999–3054.
4. Task Force on the management of S. T. segment elevation acute myocardial infarction of the European Society of Cardiology, Steg PG, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012; 33: 2569–2619.
5. Mehta SR, Granger CB, Eikelboom JW, et al. Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol 2007; 50: 1742–1751.
6. Stone G, McLaurin B, Cox D, et al. Bivalirudin for patients with acute coronary syndromes. N Engl J Med 2006; 355: 2203–2216.
7. Stone G, Witzenbichler B, Guagliumi G, et al. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 2008; 358: 2218–2230.
8. Yusuf S, Mehta S, Chrolavicius S, et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. J Am Med Assoc 2006; 295: 1519–1530.
9. Dias S, Welton NJ, Sutton AJ, et al. Evidence synthesis for decision making 1: introduction. Med Decision Making 2013; 33: 597–606.
10. Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med 2004; 23: 3105–3124.
11. Navarese EP, Tandjung K, Claessen B, et al. Safety and efficacy outcomes of first and second generation durable polymer drug eluting stents and biodegradable polymer biolimus eluting stents in clinical practice: comprehensive network meta-analysis. Br Med J 2013; 347: f6530.
12. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 2009; 151: W65–94.
13. Higgins J, Green D. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Cochrane Collaboration, 2011. www.cochrane-handbook.org.
14. Cutlip DE, Windecker S, Mehran R, et al. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 2007; 115: 2344–2351.
15. Dias S, Sutton AJ, Ades AE, et al. Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials. Med Decision Making 2013; 33: 607–617.
16. Welton NJ, Sutton AJ, Cooper NJ, et al. Evidence synthesis for decision making in healthcare 2012. New York, Wiley.
17. Dias S, Welton N, Caldwell D, et al. Checking consistency in mixed treatment comparison meta-analysis. Stat Med 2010; 29: 932–944.
18. Navarese EP, De Luca G, Castriota F, et al. Low-molecular-weight heparins vs. unfractionated heparin in the setting of percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis. J Thromb Haemost 2011; 9: 1902–1915.
19. Murphy SA, Gibson CM, Morrow DA, et al. Efficacy and safety of the low-molecular weight heparin enoxaparin compared with unfractionated heparin across the acute coronary syndrome spectrum: a meta-analysis. Eur Heart J 2007; 28: 2077–2086.
20. Shahzad A, Kemp I, Mars C, et al. Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial. Lancet 2014; Epub ahead of print.
21. Montalescot G, Zeymer U, Silvain J, et al. Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: the international randomised open-label ATOLL trial. Lancet 2011; 378: 693–703.
22. Navarese EP, Schulze V, Andreotti F et al. Comprehensive meta-analysis of safety and efficacy of bivalirudin versus heparin with or without routine glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndrome. JACC Cardiovasc Interv 2015; 8: 201–213.
23. Cavender MA, Sabatine MS. Bivalirudin versus heparin in patients planned for percutaneous coronary intervention: a meta-analysis of randomised controlled trials. Lancet 2014; 384: 599–606.
24. Steg PG, Huber K, Andreotti F, et al. Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J 2011; 32: 1854–1864.
25. Navarese EP, Andreotti F, Schulze V et al. Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug eluting stents: meta-analysis of randomised controlled trials. Br Med J 2015; Epub ahead of print.