Gene duplication and divergence affecting drug content in Cannabis sativa

New Phytologist

Volumn 208, Issue 4, 2015, Pages 1241-1250

  Weiblen, George D ^a   Wenger, Jonathan P ^a   Craft, Kathleen J ^a   ElSohly, Mahmoud A ^b   Mehmedic, Zlatko ^b   Treiber, Erin L ^a   Marks, M David ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Cannabidiol (CBD); Cannabinoids; Domestication; Hemp; Marijuana; Tetrahydrocannabinol (THC)

Indexed keywords

DOMESTICATION; DRUG; GENETIC ANALYSIS; GENETIC MARKER; PHENOTYPE;

CANNABIS SATIVA;

CANNABIDIOLIC ACID; CANNABIDIOLIC ACID SYNTHASE; CANNABINOID; CANNABIS; DRONABINOL; GENETIC MARKER; ISOMERASE;

ALLELE; CROSS BREEDING; GENE DUPLICATION; GENETIC LINKAGE; GENETIC MARKER; GENETICS; METABOLISM; PHENOTYPE; PHYLOGENY; PLANT GENE; PLANT SEED; QUANTITATIVE TRAIT LOCUS; SPECIES DIFFERENCE;

ALLELES; CANNABINOIDS; CANNABIS; CROSSES, GENETIC; DRONABINOL; GENE DUPLICATION; GENES, PLANT; GENETIC LINKAGE; GENETIC MARKERS; INTRAMOLECULAR OXIDOREDUCTASES; PHENOTYPE; PHYLOGENY; QUANTITATIVE TRAIT LOCI; SEEDS; SPECIES SPECIFICITY;

EID: 84946491644     PISSN: 0028646X     EISSN: 14698137     Source Type: Journal    
DOI: 10.1111/nph.13562     Document Type: Article

References (43)

1. Alghanim HJ, Almirall JR. 2003. Development of microsatellite markers in Cannabis sativa for DNA typing and genetic relatedness analyses. Analytical and Bioanalytical Chemistry 376: 1225-1233.
2. van Bakel H, Stout JM, Cote AG, Tallon CM, Sharpe AG, Hughes TR, Page JE. 2011. The draft genome and transcriptome of Cannabis sativa. Genome Biology 12: R102.
3. Bostwick JM. 2012. Blurred boundaries: the therapeutics and politics of medical marijuana. Mayo Clinic Proceedings 87: 172-186.
4. Datwyler SL, Weiblen GD. 2006. Genetic variation in and (Cannabis sativa L.) according to amplified fragment length polymorphisms. Journal of Forensic Sciences 51: 371-375.
5. 9-THC and other cannabinoids in confiscated from 1980-1997. Journal of Forensic Sciences 45: 24-30.
6. Faeti V, Mandolino G, Ranalli P. 1996. Genetic diversity of Cannabis sativa germplasm based on RAPD markers. Plant Breeding 115: 367-370.
7. 13C-labeled glucoses. European Journal of Biochemistry 268: 1596-1604.
8. Forapani S, Carboni A, Pioletti C, Moliterni VMC, Ranalli P, Mandolino G. 2001. Comparison of varieties using random amplified polymorphic DNA markers. Crop Science 41: 1682-1689.
9. Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE. 2012. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proceedings of the National Academy of Sciences, USA 109: 12811-12816.
10. Gilmore S, Peakall R. 2003. Isolation of microsatellite markers in Cannabis sativa L. (marijuana). Molecular Ecology Notes 3: 105-107.
11. Hennink S. 1994. Optimisation of breeding for agronomic traits in fibre (Cannabis sativa L.) by study of parent-offspring relationships. Euphytica 78: 69-76.
12. Hirata K. 1927. Sex determination in (Cannabis sativa L.). Journal of Genetics 19: 65-79.
13. Huelsenbeck JP, Ronquist FR. 2001. MRBAYES: Bayesian inference of phylogeny. Biometrics 17: 754-755.
14. Kim ES, Mahlberg PG. 1997. Immunochemical localization of tetrahydrocannabinol (THC) in cryofixed glandular trichomes Cannabis (Cannabaceae). American Journal of Botany 84: 336-342.
15. Kojoma M, Seki H, Yoshida S, Muranaka T. 2006. DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L. Forensic Science International 159: 132-140.
16. Kosakovsky Pond SL, Frost SDW, Muse SV. 2005. HyPhy: hypothesis testing using phylogenies. Bioinformatics 21: 676-679.
17. Kosambi DD. 1944. The estimation of map distances from recombination values. Annals of Eugenics 12: 172-175.
18. Lynch M, Force A. 2000. The probability of duplicate gene preservation by subfunctionalization. Genetics 154: 459-473.
19. Mandolino G, Carboni A, Forapani S, Faeti V, Ranalli P. 1999. Identification of DNA markers linked to the male sex in dioecious (Cannabis sativa L.). TAG. Theoretical and Applied Genetics 98: 86-92.
20. Marks MD, Tian L, Wenger JP, Omburo SN, Soto-Fuentes W, Ji H, Gang D, Weiblen GD, Dixon RA. 2009a. Identification of candidate genes affecting delta-9-tetrahydrocannabinol biosynthesis in Cannabis sativa. Journal of Experimental Botany 13: 3175-3726.
21. Marks MD, Wenger JP, Gilding E, Jilk R, Dixon RA. 2009b. Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Molecular Plant 2: 803-822.
22. Mechoulam R, Shani A, Yagnitinsky B, Ben-Zvi Z, Braun P, Gaoni Y. 1970. Some aspects of cannabinoid chemistry. In: Joyce CRB, Curry SH, eds. The botany and chemistry of Cannabis. London, UK: Churchill, 93-115.
23. de Meijer EPM, Bagatta M, Carboni A, Crucitti P, Moliterni VMC, Ranalli P, Mandolino G. 2003. The inheritance of chemical phenotype in Cannabis sativa L. Genetics 163: 335-346.
24. de Meijer EPM, van der Kamp HJ, van Eeuwijk FA. 1992. Characterisation of Cannabis accessions with regard to cannabinoid content in relation to other plant characters. Euphytica 62: 187-200.
25. Mignoni G. 1997. Cannabis as a licit crop: recent developments in Europe. Bulletin on Narcotics 49: 23-44.
26. Miron JA. 2008. The budgetary implications of drug prohibition. Report to the Criminal Justice Policy Foundation. Silver Spring, MD, USA.
27. Natsume S, Takagi H, Shiraishi A, Murata H, Toyonaga J, Patzak J, Takagi M, Yaegashi H, Uemura A, Mitsuoka C et al. 2015. The draft genome of hop (Humulus lupulus), an essence for brewing. Plant and Cell Physiology 56: 428-441.
28. Pacifico D, Miselli F, Micheler M, Carboni A, Ranalli P, Mandolino G. 2006. Genetics and marker-assisted selection of the chemotype in Cannabis sativa L. Molecular Breeding 17: 257-268.
29. Page JE, Nagel J. 2006. Biosynthesis of terpenophenolic metabolites in hop and cannabis. In: Romeo JT, ed. Recent advances in phytochemistry. Oxford, UK: Elsevier Ltd, 179-210.
30. Petri G, Veszki P, Oroszlan P, Turiak G. 1996. Cannabinoid content of foreign and domestic fibre varieties cultivated in Hungary. Acta Agronomica Hungarica 44: 133-140.
31. Ram HYM, Sett R. 1982. Induction of fertile male flowers in genetically female Cannabis sativa plants by silver nitrate and silver thiosulfate anionic complex. Theoretical and Applied Genetics 62: 369-375.
32. Rodriguez-Riano T, Dafni A. 2000. A new procedure to assess pollen viability. Sexual Plant Reproduction 12: 241-244.
33. Shoyama Y, Yagi M, Nishioka I, Yamauchi T. 1975. Biosynthesis of cannabinoid acids. Phytochemistry 14: 2189-2192.
34. 1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. Journal of Biological Chemistry 279: 39767-39774.
35. Small E, Naraine SGU. 2015. Size matters: evolution of large drug-secreting resin glands in elite pharmaceutical strains of Cannabis sativa (marijuana). Genetic Resources and Crop Evolution 254: doi: 10.1007/s10722-015-0254-2.
36. Szendrei K. 1997. Cannabis as an illicit crop: recent developments in cultivation and product quality. Bulletin on Narcotics 49: 1-22.
37. Taura F, Morimoto S, Shoyama Y. 1995. Cannabinerolic acid, a cannabinoid from Cannabis sativa. Phytochemistry 39: 457-458.
38. Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S. 2007. Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. FEBS Letters 581: 2929-2934.
39. Taylor JS, Raes J. 2004. Duplication and divergence: the evolution of new genes and old ideas. Annual Review of Genetics 38: 615-643.
40. Vogelmann AF, Turner JC, Mahlberg PG. 1987. Cannabinoid occurrence in seedlings of Cannabis sativa L.: quantitation in seedlings of known age and primary leaf length. Botanical Gazette 148: 468-474.
41. Wang S, Basten CJ, Zeng ZB. 2006. Windows QTL Cartographer 2.5. North Carolina State University, Raleigh, NC, USA: Department of Statistics.
42. Zerega NJC, Clement WL, Datwyler SL, Weiblen GD. 2005. Biogeography and divergence times in the mulberry family (Moraceae). Molecular Phylogenetics and Evolution 37: 402-416.
43. Zhang J. 2005. Evolution by gene duplication: an update. Trends in Ecology and Evolution 16: 292-298.