No time to waste - The ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells

EMBO Reports

Volumn 16, Issue 11, 2015, Pages 1421-1426

  Caplan, Arthur L ^a   Parent, Brendan ^a   Shen, Michael ^a   Plunkett, Carolyn ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; DNA; GUIDE RNA; RNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE;

ARTICLE; CANCER IMMUNOTHERAPY; CHROMOSOME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA MODIFICATION; DNA SEQUENCE; EMBRYO CELL; GENE; GENETIC DISORDER; GENETIC VARIABILITY; GENOME; GERM LINE; HUMAN; MUTATION; NATIONAL HEALTH ORGANIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN ENGINEERING; RISK ASSESSMENT; SAFETY; SCIENTIST; STEM CELL TRANSPLANTATION; TECHNOLOGY; TRANSGENIC ORGANISM; ANIMAL; CRISPR CAS SYSTEM; ETHICS; GENETIC ENGINEERING; GENETICS; GERM CELL; LEGISLATION AND JURISPRUDENCE; RESEARCH ETHICS;

ANIMALS; CRISPR-CAS SYSTEMS; ETHICS, RESEARCH; GENETIC ENGINEERING; GENOME; GERM CELLS; HUMANS; ORGANISMS, GENETICALLY MODIFIED;

EID: 84946488904     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201541337     Document Type: Article

References (10)

1. Doudna JA, Charpentier E, (2014) Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346: 1258096
2. Lanphier E, Urnov F, Haecker SE, Werner M, Smolenski J, (2015) Don't edit the human germ line. Nature 519: 410-411
3. Sugarman J, (2015) Ethics and germline gene editing. EMBO Rep 16: 879-880
4. Ledford H, (2015) CRISPR, the disruptor. Nature 522: 20-24
5. Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, et al, (2015) Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell doi: 10.1016/j.cell.2015.09.038
6. Holdren J, Shelanski H, Vetter D, Goldfuss C, (2015) Improving transparency and ensuring continued safety in biotechnology. Off Sci Technol Policy. Available at: https://www.whitehouse.gov/blog/2015/07/02/improving-transparency-and-ensuring-continued-safety-biotechnology
7. Larson C, (2014) Genome Editing: the ability to create primates with intentional mutations could provide powerful new ways to study complex and genetically baffling brain disorders. MIT Technol Rev. Available at: http://www.technologyreview.com/featuredstory/526511/genome-editing/
8. Oye KA, Esvelt K, Appleton E, Catteruccia F, Church G, Kuiken T, Lightfoot SB-Y, McNamara J, Smidler A, Collins JP, (2014) Biotechnology. Regulating gene drives. Science 345: 626-628
9. Esvelt KM, Smidler AL, Catteruccia F, Church GM, (2014) Concerning RNA-guided gene drives for the alteration of wild populations. Elife 3: e03401
10. World Health Organization [WHO] (2014) The Guidance Framework for testing genetically modified mosquitoes. Available at: http://www.who.int/tdr/publications/year/2014/guide-fmrk-gm-mosquit/en/