Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review

Intensive Care Medicine

Volumn 41, Issue 12, 2015, Pages 2087-2097

  Ng, Monica Suet Ying ^a,b,c   Ng, Angela Suet Yeung ^a,b   Chan, Jessica ^b   Tung, John Paul ^a,b,c   Fraser, John Francis ^a,b  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

Author keywords

Blood storage; Erythrocyte transfusion; Meta analysis; Red blood cells; Systematic review; Transfusion

Indexed keywords

ERYTHROCYTE CONCENTRATE; ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; HEART SURGERY; HUMAN; INFECTIOUS COMPLICATION; INTENSIVE CARE; KIDNEY FAILURE; LENGTH OF STAY; META ANALYSIS; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; REVIEW; SYSTEMATIC REVIEW; BLOOD STORAGE; ERYTHROCYTE; STATISTICS AND NUMERICAL DATA; TIME FACTOR; TREATMENT OUTCOME;

BLOOD PRESERVATION; CARDIAC SURGICAL PROCEDURES; ERYTHROCYTE TRANSFUSION; ERYTHROCYTES; HUMANS; MULTIPLE ORGAN FAILURE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84946486214     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-4078-5     Document Type: Review

References (71)

1. Chen J, Singhapricha T, Memarzadeh M, Ziman A, Yuan S, Hu KQ, Steadman RH, Busuttil RW, Xia VW (2012) Storage age of transfused red blood cells during liver transplantation and its intraoperative and postoperative effects. World J Surg 36:2436–2442
2. Hassan M, Pham TN, Cuschieri J, Warner KJ, Nester T, Maier RV, Shalhub S, O’Keefe GE (2011) The association between the transfusion of older blood and outcomes after trauma. Shock 35:3–8
3. Kaukonen KM, Vaara ST, Pettila V, Bellomo R, Tuimala J, Cooper DJ, Krusius T, Kuitunen A, Reinikainen M, Koskenkari J, Uusaro A (2013) Age of red blood cells and outcome in acute kidney injury. Crit Care 17:R222
4. Kekre N, Chou A, Tokessey M, Doucette S, Tinmouth A, Tay J, Allan DS (2011) Storage time of transfused red blood cells and impact on clinical outcomes in hematopoietic stem cell transplantation. Transfusion 51:2488–2494
5. Pettila V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips LE, Street A, French C, Murray L, Orford N, Santamaria JD, Bellomo R, Cooper DJ (2011) Age of red blood cells and mortality in the critically ill. Crit Care 15:R116
6. Weinberg JA, McGwin G Jr, Marques MB, Cherry SA 3rd, Reiff DA, Kerby JD, Rue LW 3rd (2008) Transfusions in the less severely injured: does age of transfused blood affect outcomes? J Trauma 65:794–798
7. Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH (2008) Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 358:1229–1239
8. Sanders J, Patel S, Cooper J, Berryman J, Farrar D, Mythen M, Montgomery HE (2011) Red blood cell storage is associated with length of stay and renal complications after cardiac surgery. Transfusion 51:2286–2294
9. Spinella PC, Carroll CL, Staff I, Gross R, Mc Quay J, Keibel L, Wade CE, Holcomb JB (2009) Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care 13:R151
10. Lebiedz P, Glasmeyer S, Hilker E, Yilmaz-Neuhaus A, Karaboutas T, Reinecke H, Sibrowski W, Nofer JR (2012) Influence of red blood cell storage time on clinical course and cytokine profile in septic shock patients. Transfus Med Hemother 39:271–276
11. Voorhuis FTR, Dieleman JM, De Vooght KMK, Van Dijk D, Van Herwerden LA, Peelen LM, Van Klei WA (2013) Storage time of red blood cell concentrates and adverse outcomes after cardiac surgery: a cohort study. Ann Hematol 92:1701–1706
12. Cartotto R, Yeo C, Camacho F, Callum J (2013) Does the storage age of transfused blood affect outcome in burn patients? J Burn Care Res 24:186–197
13. Dunn LK, Thiele RH, Ma JZ, Sawyer RG, Nemergut EC (2012) Duration of red blood cell storage and outcomes following orthotopic liver transplantation. Liver Transpl 18:475–481
14. Kadar A, Chechik O, Katz E, Blum I, Meghiddo G, Salai M, Steinberg E, Sternheim A (2013) The effects of ‘old’ red blood cell transfusion on mortality and morbidity in elderly patients with hip fractures—a retrospective study. Injury 44:747–750
15. Aubron C, Nichol A, Cooper DJ, Bellomo R (2013) Age of red blood cells and transfusion in critically ill patients. Ann Intensive Care 3:2
16. Edelstein SB (2012) Blood product storage: does age really matter? Semin Cardiothorac Vasc Anesth 16:160–165
17. Triulzi DJ, Yazer MH (2010) Clinical studies of the effect of blood storage on patient outcomes. Transfus Apher Sci 43:95–106
18. van de Watering LM, Brand A (2008) Effects of storage of red cells. Transfus Med Hemother 35:359–367
19. Lelubre C, Piagnerelli M, Vincent JL (2009) Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? Transfusion 49:1384–1394
20. Lelubre C, Vincent JL (2013) Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review. Crit Care 17:R66
21. Vamvakas EC (2010) Meta-analysis of clinical studies of the purported deleterious effects of “old” (versus “fresh”) red blood cells: are we at equipoise? Transfusion 50:600–610
22. Vamvakas EC (2011) Purported deleterious effects of “old” versus “fresh” red blood cells: an updated meta-analysis. Transfusion 51:1122–1123
23. Wang D, Sun J, Solomon SB, Klein HG, Natanson C (2012) Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 52:1184–1195
24. University of Texas School of Public Health (2013) Search filters for various databases. http://libguides.sph.uth.tmc.edu/pubmed_filters. Accessed 20 Oct 2013
25. Gavins FN, Li G, Russell J, Perretti M, Granger DN (2011) Microvascular thrombosis and CD40/CD40L signaling. J Thromb Haemost 9:574–581
26. Edgren G, Kamper-Jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullum H, Murphy EL, Busch MP, Reilly M, Melbye M, Hjalgrim H, Nyren AO (2010) Duration of red blood cell storage and survival of transfused patients. Transfusion 50:1185–1195
27. Lacroix J, Hebert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D, ABLE Investigators, The Canadian Critical Care Trials Group (2015) Age of transfused blood in critically ill adults. N Engl J Med 372:1410–1418
28. Aubron C, Syres G, Nichol A, Bailey M, Board J, Magrin G, Murray L, Presneill J, Sutton J, Vallance S, Morrison S, Bellomo R, Cooper DJ (2012) A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients. Transfusion 52:1196–1202
29. Bennett-Guerrero E, Stafford-Smith M, Waweru PM, Bredehoeft SJ, Campbell ML, Haley NR, Phillips-Bute B, Newman MF, Bandarenko N (2009) A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion 49:1375–1383
30. Heddle NM, Cook RJ, Arnold DM, Crowther MA, Warkentin TE, Webert KE, Hirsh J, Barty RL, Liu Y, Lester C, Eikelboom JW (2012) The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. Transfusion 52:1203–1212
31. Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O (2012) Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 185:842–850
32. Steiner ME, Ness PM, Assmann SF, Triulzi DJ, Sloan SR, Delaney M, Granger S, Bennett-Guerrero E, Blajchman MA, Scavo V, Carson JL, Levy JH, Whitman G, D’Andrea P, Pulkrabek S, Ortel TL, Bornikova L, Raife T, Puca KE, Kaufman RM, Nuttall GA, Young PP, Youssef S, Engelman R, Greilich PE, Miles R, Josephson CD, Bracey A, Cooke R, McCullough J, Hunsaker R, Uhl L, McFarland JG, Park Y, Cushing MM, Klodell CT, Karanam R, Roberts PR, Dyke C, Hod EA, Stowell CP (2015) Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med 372:1419–1429
33. Schulman CI, Nathe K, Brown M, Cohn SM (2002) Impact of age of transfused blood in the trauma patient. J Trauma 52:1224–1225
34. Engoren M, Mitchell E, Perring P, Sferra J (2008) The effect of erythrocyte blood transfusions on survival after surgery for hip fracture. J Trauma 65:1411–1415
35. Kekre N, Mallick R, Allan D, Tinmouth A, Tay J (2013) The impact of prolonged storage of red blood cells on cancer survival. PLoS One 8:e68820
36. Leal-Noval SR, Munoz-Gomez M, Arellano-Orden V, Marin-Caballos A, Amaya-Villar R, Marin A, Puppo-Moreno A, Ferrandiz-Millon C, Flores-Cordero JM, Murillo-Cabezas F (2008) Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury. Crit Care Med 36:1290–1296
37. Saager L, Turan A, Dalton JE, Figueroa PI, Sessler DI, Kurz A (2013) Erythrocyte storage duration is not associated with increased mortality in noncardiac surgical patients: a retrospective analysis of 6,994 patients. Anesthesiology 118:51–58
38. Mynster T, Nielsen HJ (2001) Storage time of transfused blood and disease recurrence after colorectal cancer surgery. Dis Colon Rectum 44:955–964
39. Katsios C, Griffith L, Spinella P, Lacroix J, Crowther M, Hebert P, Meade M, Geerts W, Rabbat C, Cook D (2011) Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study. Crit Care 2:R263
40. Friedman R, Homering M, Holberg G, Berkowitz SD (2014) Allogeneic blood transfusions and postoperative infections after total hip or knee arthroplasty. J Bone Joint Surg Am 96:272–278
41. Keller ME, Jean R, LaMorte WW, Millham F, Hirsch E (2002) Effects of age of transfused blood on length of stay in trauma patients: a preliminary report. J Trauma 53:1023–1025
42. Min JJ, Bae JY, Kim TK, Hong DM, Hwang HY, Kim KB, Han KS, Jeon Y (2014) Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery: a retrospective study. BMC Anesthesiol 14:95
43. Andreasen JJ, Dethlefsen C, Modrau IS, Baech J, Schonheyder HC, Moeller JK, Johnsen SP, North-West Denmark Transfusion Study Group (2011) Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass grafting. Eur J Cardiothorac Surg 39:329–334
44. Basora M, Pereira A, Soriano A, Martinez-Pastor JC, Sanchez-Etayo G, Tio M, Salazar F (2010) Allogeneic blood transfusion does not increase the risk of wound infection in total knee arthroplasty. Vox Sang 98:124–129
45. Cywinski JB, You J, Argalious M, Irefin S, Parker BM, Fung JJ, Koch CG (2013) Transfusion of older red blood cells is associated with decreased graft survival after orthotopic liver transplantation. Liver Transpl 19:1181–1188
46. Eikelboom JW, Cook RJ, Liu Y, Heddle NM (2010) Duration of red cell storage before transfusion and in-hospital mortality. Am Heart J 159:737–743
47. McKenny M, Ryan T, Tate H, Graham B, Young VK, Dowd N (2011) Age of transfused blood is not associated with increased postoperative adverse outcome after cardiac surgery. Brit J Anaesth 106:643–649
48. Murrell Z, Haukoos JS, Putnam B, Klein SR (2005) The effect of older blood on mortality, need for ICU care, and the length of ICU stay after major trauma. Am Surg 71:781–785
49. Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC (2002) Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 137:711–716
50. Phelan HA, Eastman AL, Aldy K, Carroll EA, Nakonezny PA, Jan T, Howard JL, Chen Y, Friese RS, Minei JP (2012) Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study. Am J Surg 203:198–204
51. Phelan HA, Gonzalez RP, Patel HD, Caudill JB, Traylor RK, Yancey LR, Sperry JL, Friese RS, Nakonezny PA (2010) Prestorage leukoreduction ameliorates the effects of aging on banked blood. J Trauma 69:330–337
52. Robinson SD, Janssen C, Fretz EB, Berry B, Chase AJ, Siega AD, Carere RG, Fung A, Simkus G, Klinke WP, Hilton JD (2010) Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention. Am Heart J 159:876–881
53. van de Watering L, Lorinser J, Versteegh M, Westendord R, Brand A (2006) Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 46:1712–1718
54. Gajic O, Rana R, Mendez JL, Rickman OB, Lymp JF, Hubmayr RD, Moore SB (2004) Acute lung injury after blood transfusion in mechanically ventilated patients. Transfusion 44:1468–1474
55. Juffermans NP, Prins DJ, Vlaar AP, Nieuwland R, Binnekade JM (2011) Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study. Shock 35:355–359
56. Juffermans NP, Vlaar AP, Prins DJ, Goslings JC, Binnekade JM (2012) The age of red blood cells is associated with bacterial infections in critically ill trauma patients. Blood Transfus 10:290–295
57. Middelburg RA, Van de Watering LMG, Briet E, Van der Bom JG (2013) Storage time of red blood cells and mortality of transfusion recipients. Transfus Med Rev 27:36–43
58. van Straten AH, Soliman Hamad MA, van Zundert AA, Martens EJ, ter Woorst JF, de Wolf AM, Scharnhorst V (2011) Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting. J Thorac Cardiovasc Surg 141:231–237
59. van de Watering L (2011) Red cell storage and prognosis. Vox Sang 100:36–45
60. Pereira A (2013) Will clinical studies elucidate the connection between the length of storage of transfused red blood cells and clinical outcomes? An analysis based on the simulation of randomized controlled trials. Transfusion 53:34–40
61. Hendrickson JE, Hod EA, Hudson KE, Spitalnik SL, Zimring JC (2011) Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells. Transfusion 51:2695–2702
62. Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM (2012) Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion 52:1410–1422
63. Tung JP, Fraser JF, Nataatmadja M, Colebourne KI, Barnett AG, Glenister KM, Zhou AY, Wood P, Silliman CC, Fung YL (2012) Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Crit Care 16:R19
64. Weinberg JA, McGwin G Jr, Griffin RL, Huynh VQ, Cherry SA 3rd, Marques MB, Reiff DA, Kerby JD, Rue LW 3rd (2008) Age of transfused blood: an independent predictor of mortality despite universal leukoreduction. J Trauma 65:279–282
65. Hess JR, Sparrow RL, van der Meer PF, Acker JP, Cardigan RA, Devine DV (2009) Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions. Transfusion 49:2599–2603
66. Maturu P, Varadacharyulu N (2012) Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men. Hum Exp Toxicol 31:652–661
67. Raval JS, Waters JH, Seltsam A, Scharberg EA, Richter E, Kameneva MV, Yazer MH (2011) Menopausal status affects the susceptibility of stored RBCs to mechanical stress. Vox Sang 100:418–421
68. Flatt JF, Bawazir WM, Bruce LJ (2014) The involvement of cation leaks in the storage lesion of red blood cells. Frontiers in physiology 5:214
69. Sparrow RL (2012) Time to revisit red blood cell additive solutions and storage conditions: a role for “omics” analyses. Blood Transfus 10:S7–S11
70. Roback JD (2011) Vascular effects of the red blood cell storage lesion. Hematology Am Soc Hematol Educ Program 2011:475–479
71. Vincent JL, Sakr Y, Lelubre C (2014) The future of observational research and randomized controlled trials in red blood cell transfusion medicine. Shock 41:S98–S101