Frozen-thawed embryo transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: A RCT

Human Reproduction

Volumn 30, Issue 11, 2015, Pages 2552-2562

  Peeraer, Karen ^a   Couck, Isabelle ^a   Debrock, Sophie ^a   De Neubourg, Diane ^a   De Loecker, Peter ^a   Tomassetti, Carla ^a   Laenen, Annouschka ^b   Welkenhuysen, Myriam ^a   Meeuwis, Luc ^a   Pelckmans, Sofie ^a   Meuleman, Christel ^a   D'Hooghe, Thomas ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Leuven Biostatistics and Statistical Bioinformatics Centre   (Belgium)

Author keywords

ART; frozen thawed embryo transfer; HMG; natural cycle; RCT

Indexed keywords

BUSERELIN; CHORIONIC GONADOTROPIN; ESTRADIOL; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT FOLLITROPIN; TRIPTORELIN; UROFOLLITROPIN; FERTILITY PROMOTING AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG WITHDRAWAL; EMBRYO; EMBRYO CULTURE; EMBRYO TRANSFER; ENDOMETRIAL THICKNESS; ESTRADIOL BLOOD LEVEL; FEMALE; FETUS HEART RATE; FOLLICULAR ASPIRATION; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; FREEZE THAWING; HUMAN; LIVE BIRTH; LOW DRUG DOSE; LUTEAL PHASE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OOCYTE RETRIEVAL; OPEN STUDY; OUTCOME ASSESSMENT; OVULATION INDUCTION; PERINATAL MORTALITY; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; DRUG EFFECTS; NIDATION; PHYSIOLOGY; PROCEDURES;

ADULT; CRYOPRESERVATION; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; MENOTROPINS; OUTCOME ASSESSMENT (HEALTH CARE); OVULATION INDUCTION;

EID: 84946426919     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev224     Document Type: Article

References (51)

1. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update 2006;12:731-746.
2. Aerts M, Geys H, Molenberghs G, Ryan LM. Topics in Modelling of Clustered Data. London: Chapman & Hall/CRC, 2002.
3. Alpha Scientist in Reproductive Medicine. The Alpha consensus meeting on cryopreservation key performance indicators and benchmarks: proceedings of an expert meeting. Reprod Biomed Online 2012;25: 146-167.
4. AndersenCY, EzcurraD.Humansteroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins. Reprod Biol Endocrinol 2014;12:128.
5. Ashrafi M, Jahangiri N, Hassani F, Akhoond MR, Madani T. The factors affecting the outcome of frozen-thawed embryo transfer cycle. Taiwan J Obstet Gynecol 2011;50:159-164.
6. Balaban B, Urman B, Ata B, Isiklar A, Larman MG, Hamilton R, Gardner DK. A randomized controlled study of human Day 3 embryo cryopreservation by slow freezing or vitrification: vitrification is associated with higher survival, metabolism and blastocyst formation. Hum Reprod 2008; 23:1976-1982.
7. Belgisch Staatsblad June 2003. Koninklijk Besluit tot wijziging van het KB van 25 april 2002 betreffende de vaststelling en de vereffening van het budget van financiële middelen voor de ziekenhuizen, 16 June 2003:32133-32157, art II, bijlage 4.15. Modaliteiten voor de regeling inzake medisch geassisteerde voortplanting (http://www.ejustice.just.fgov.be).
8. Belgisch Staatsblad June 2007. Wet van 6/07/2007 betreffende de medisch begeleide voortplanting en de bestemming van de overtallige embryo's en de gameten, art 9. Belgisch Staatsblad 17 June 2007:38575-38586 (http://www.ejustice.just.fgov.be).
9. Bjuresten K, Landgren BM, Hovatta O, Stavreus-Evers A. Luteal phase progesterone increases live birth rate after frozen embryo transfer. Fertil Steril 2011;95:534-537.
10. Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update 2003;9:515-522.
11. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2011 assisted reproductive technology fertility clinic success rates report. Atlanta: U.S. Dept of Health and Human Services, 2013. Available at: http://nccd.cdc.gov/DRH-ART/Apps/NationalSummaryReport.aspx (14 April 2014, date last accessed).
12. Check JH, Choe JK, Nazari A, Fox F, Swenson K. Fresh embryo transfer is more effective than frozen for donor oocyte recipients but not for donors. Hum Reprod 2001;16:1403-1408.
13. Dancet EAF, Nelen WLDM, Sermeus W, De Leeuw L, Kremer JAM, D'Hooghe TM. The patients' perspective on fertility care: A systematic review. Hum Reprod Update 2010;16:467-487.
14. Dancet EAF, Van Empel IWH, Rober P, Nelen WLDM, Kremer JAM, D'Hooghe TM. Patient-centred infertility care: A qualitative study to listen to the patient's voice. Hum Reprod 2011;26:827-833.
15. Dancet EAF, D'HoogheTM, van der Veen F, Bossuyt P, SermeusW, MolBW, Repping S. 'Patient-centered fertility treatment': what is required? Fertil Steril 2014;101:924-926.
16. D'Angelo A, Amso NN. Embryo freezing for preventing ovarian hyperstimulation syndrome: A Cochrane review. Hum Reprod 2002;17: 2787-2794.
17. Debrock S, Spiessens C, Meuleman C, Segal L, De Loecker P, Meeuwis L, D'Hooghe TM. New Belgian legislation regarding the limitation of transferable embryos in in vitro fertilization cycles does not significantly influence the pregnancy rate but reduces the multiple pregnancy rate in a threefold way in the Leuven University Fertility Center. Fertil Steril 2005;83:1572-1574.
18. Debrock S, Melotte C, Spiessens C, Peeraer K, Vanneste E, Meeuwis L, Meuleman C, Frijns JP, Vermeesch JR, D'Hooghe TM. Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: A prospective randomized trial. Fertil Steril 2010;93:364-373.
19. Debrock S, Peeraer K, Spiessens S, Willemen D, De Loecker P, D'Hooghe TM. The effect of modified quarter laser-assisted zona thinning on the implantation rate per embryo in frozen/vitrifiedthawed/warmed embryo transfer cycles: A prospective randomized controlled trial. Hum Reprod 2011;26:1997-2007.
20. De Mouzon J, Lancaster P, Nygren KG, Sullivan E, Zegers-Hochschild F, Mansour R, Ishihara O, Adamson D. World collaborative report on assisted reproductive technology, 2002. HumReprod 2009;24:2310-2320.
21. De Neubourg D, Bogaerts K, Wyns C, Albert A, Camus M, Candeur M, Degueldre M, Delbaere A, Delvigne A, De Sutter P et al. The history of Belgian assisted reproduction technology cycle registration and control: A case study in reducing the incidence of multiple pregnancy. Hum Reprod 2013;28:2709-2719.
22. De Neubourg D, Peeraer K, Debrock S, D'Hooghe T. Belgium model of coupling reimbursement of ART costs to restriction in number of embryos transferred. BMJ 2014;348:1559.
23. Dor J, Rudak E, Davidson A, Levran D, Ben-Rafael Z, Mashiach S. Endocrine and biological factors influencing implantation of human embryos following cryopreservation. Gynecol Endocrinol 1991;5:203-211.
24. Eftekhar M, Rahsepar M, Rahmani E. Effect of progesterone supplementation on natural frozen-thawedembryo transfer cycles: A randomized controlled trial. Int J Fertil Steril 2013;7:13-20.
25. Eftekhar M, Rahmani E, Pourmasumi S. Evaluation of clinical factors influencing pregnancy rate in frozen embryo transfer. Iran J Reprod Med 2014;12:513-518.
26. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, Braude P. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril 2008; 89:832-839.
27. Ezoe K, Daikoku T, Yabuuchi A, Murata N, Kawano H, Abe T, Okuno T, Kobayashi T, Kato K. Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice. Mol Hum Reprod 2014;20:1101-1116.
28. Fasano G, Fontenelle N, Vannin A-S, Biramane J, Devreker F, Englert Y, Delbaere A. A randomized controlled trial comparing two vitrification methods versus slow-freezing for cryopreservation of human embryos. J Assist Reprod Genet 2014;31:241-247.
29. Gardner DK, Schoolcraft WB. In vitro culture of the human blastocyst. In: Jansen R, Mortimer D (eds). Towards Reproductive Certainty: Infertility and Genetics Beyond 1999. Carnforth, UK: Parthenon Publishing, 1999, 378-388.
30. Gera PS, Tatpati LL, Allemand MC, Wentworth MA, Coddington CC. Ovarian hyperstimulation syndrome: steps to maximize success and minimize effect for assisted reproductive outcome. Fertil Steril 2010; 94:173-178.
31. Ghobara T, Vandekerckhove P. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev 2008;1:CD003414.
32. Glujovsky D, Pesce R, Fiszbajn G, Sueldo C, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev 2010; 20:CD006359.
33. Groenewoud ER, Cantineau AE, Kollen BJ, Macklon NS, Cohlen BJ. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2013;19:458-470.
34. Imthurn B, Macas E, Rosselli M, Keller P. Effect of a programmed short-term stimulation protocol on the regulation of cryopreserved embryos. J Assist Reprod Genet 1996;13:709-712.
35. Khan KS, Daya S, Collins JA,Walter SD. Empirical evidence of bias in infertility research: overestimation of treatment effect in crossover trials using pregnancy as the outcome measure. Fertil Steril 1996;65:939-945.
36. Kolibianakis EM, Bourgain C, Platteau P, Albano C, Van Steirteghem AC, Devroey P. Abnormal endometrial development occurs during the luteal phase of nonsupplemented donor cycles treated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertil Steril 2003;80:464-466.
37. Konc J, Kanyo K, Varga E, Kriston R, Cseh S. The effect of cycle regimen used for endometrium preparation on the outcome of day 3 frozen embryo transfer cycle. Fertil Steril 2010;94:767-768.
38. KupkaMS, FerrarettiAP, deMouzon J, Erb K, D'HoogheT,Castilla JA,Calhaz-Jorge C,DeGeyter C, Goossens V; European IVF-Monitoring Consortium, for the European Society of Human Reproduction and Embryology. Assisted reproductive technology in Europe, 2010: results generated from European registers by ESHRE. Hum Reprod 2014;10:2099-2113.
39. Kyrou D, Fatemi HM, Popovic-Todorovic B, Van den Abbeel E, Camus M, Devroey P. Vaginal progesterone supplementation has no effect on ongoing pregnancy rate in hCG-induced natural frozen-thawed embryo transfer cycles. Eur J Obstet Gynecol Reprod Biol 2010;150:175-179.
40. Levi AJ, Drews MR, Bergh PA, Miller BT, Scott RT Jr. Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles. Fertil Steril 2001;76:670-674.
41. Mandelbaum J, Junca AM, Plachot M, Alnot MO, Salat-Baroux J, Alvarez S, Tibi C, Cohen J, Debache C, Tesquier L. Cryopreservation on human embryos and oocytes. Hum Reprod 1988;3:117-119.
42. Peeraer K, Debrock S, De Loecker P, Tomassetti C, Laenen A, Welkenhuysen M, Meeuwis L, Pelckmans S, Mol BW, Spiessens C et al. Low-dose human menopausal gonadotrophin versus clomiphene citrate in subfertile couples treated with intrauterine insemination: A randomized controlled trial. Hum Reprod 2015;30:1079-1088.
43. Society for Assisted ReproductiveTechnology. National data summary 2012. Available at: https://www.sartcorsonline.com/rptCSR-PublicMultYear. aspx?ClinicPKID=0 (14 April 2014, date last accessed).
44. Tanos V, Friedler S, Zajicek G, Neiger M, Lewin A, Schenker JG. The impact of endometrial preparation on implantation following cryopreservedthawed-embryo transfer. Gynecol Obstet Invest 1996;41:227-231.
45. Testart J, Lassalle B, Forman R, Gazengel A, Belaisch-Allart J, Hazout A, Rainhorn JD, Frydman R. Factors influencing the success rate of human embryo freezing in an in vitro fertilization and embryo transfer program. Fertil Steril 1987;48:107-112.
46. Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature 1983;305: 707-709.
47. Van der Auwera I, Meuleman C, Koninckx PR. Human menopausal gonadotrophin increases pregnancy rate in comparison with clomiphene citrate during replacement cycles of frozen/thawed pronucleate ova. Hum Reprod 1994;9:556-560.
48. Veleva Z, Orava M, Nuojua-Huttunen S, Tapanainen JS, Martikainen H. Factors affecting the outcome of frozen-thawed embryo transfer. Hum Reprod 2013;28:2425-2431.
49. Wang JX, Yap YY, Matthews CD. Frozen-thawed embryo transfer: influence of clinical factors on implantation rate and risk of multiple conception.Hum Reprod 2001;16:2316-2319.
50. Wilding MG, Capobianco C, Montanaro N, Kabili G, Di Matteo L, Fusco E, Dale B. Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction. J Assist Reprod Genet 2010;27:549-554.
51. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nigren K, Sullivan E, Vanderpoel S. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 2009;92:1520-1524.