Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome?

Asian Journal of Andrology

Volumn 17, Issue 6, 2015, Pages 991-995

  Yang, Yi Hong ^a,b   Zhao, Ming Jia ^c   Zhou, Shan Jie ^d   Lu, Wen Hong ^b   Liang, Xiao Wei ^b   Xiong, Cheng Liang ^e   Wan, Chang Chun ^f   Shang, Xue Jun ^g   Gu, Yi Qun ^a,b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

^c Maternity and Child Health Care Hospital   (China)

^d Tianjin United Family Hospital   (China)

^e HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^f The People's Hospital of Jinhu   (China)

^g NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

Author keywords

Metabolic syndrome; Sex hormone binding globulin; Testosterone

Indexed keywords

SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGE; AGED; ARTICLE; BODY MASS; CHINESE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DRINKING; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTICENTER STUDY; PREVALENCE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEX HORMONE BINDING GLOBULIN BLOOD LEVEL; SMOKING; TESTOSTERONE BLOOD LEVEL; CHINA; CLINICAL TRIAL; METABOLISM; MIDDLE AGED; ODDS RATIO; RISK FACTOR; STATISTICAL MODEL; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; CHINA; CROSS-SECTIONAL STUDIES; HUMANS; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; ODDS RATIO; PREVALENCE; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; YOUNG ADULT;

EID: 84946226577     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.4103/1008-682X.150845     Document Type: Article

References (40)

1. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-A new world?wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-80.
2. Oh JY, Hong YS, Sung YA, Barrett?Connor E. Prevalence and factor analysis of metabolic syndrome in an urban Korean population. Diabetes Care 2004; 27: 2027-32.
3. Das M, Pal S, Ghosh A. Prevalence of the metabolic syndrome in people of Asian Indian origin: outcomes by definitions. Cardiovasc J Afr 2011; 22: 303-5.
4. Mohamud WN, Ismail AA, Sharifuddin A, Ismail IS, Musa KI, et al. Prevalence of metabolic syndrome and its risk factors in adult Malaysians: results of a nationwide survey. Diabetes Res Clin Pract 2011; 91: 239-45.
5. Brand JS, van der Tweel I, Grobbee DE, Emmelot?Vonk MH, van der Schouw YT. Testosterone, sex hormone?binding globulin and the metabolic syndrome: a systematic review and meta?analysis of observational studies. Int J Epidemiol 2011; 40: 189-207.
6. Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, et al. Low sex hormone?binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 2006; 91: 843-50.
7. Rodriguez A, Muller DC, Metter EJ, Maggio M, Harman SM, et al. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 2007; 92: 3568-72.
8. Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract 2006; 60: 762-9.
9. Litman HJ, Bhasin S, Link CL, Araujo AB, McKinlay JB. Serum androgen levels in black, Hispanic, and white men. J Clin Endocrinol Metab 2006; 91: 4326-34.
10. Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, et al. Identification of late?onset hypogonadism in middle?aged and elderly men. N Engl J Med 2010; 363: 123-35.
11. Haider A, Gooren LJ, Padungtod P, Saad F. Improvement of the metabolic syndrome and of non?alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate. Exp Clin Endocrinol Diabetes 2010; 118: 167-71.
12. Rosner W, Hryb DJ, Kahn SM, Nakhla AM, Romas NA. Interactions of sex hormone?binding globulin with target cells. Mol Cell Endocrinol 2010; 316: 79-85.
13. Bhasin S, Jasjua GK, Pencina M, D'Agostino R Sr, Coviello AD, et al. Sex hormone?binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study. Diabetes Care 2011; 34: 2464-70.
14. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-72.
15. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-52.
16. Liao CH, Huang CY, Li HY, Yu HJ, Chiang HS, et al. Testosterone and sex hormone?binding globulin have significant association with metabolic syndrome in Taiwanese men. Aging Male 2012; 15: 1-6.
17. He Y, Jiang B, Wang J, Feng K, Chang Q, et al. Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J Am Coll Cardiol 2006; 47: 1588-94.
18. Chubb SA, Hyde Z, Almeida OP, Flicker L, Norman PE, et al. Lower sex hormone?binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study. Eur J Endocrinol 2008; 158: 785-92.
19. Hong D, Kim YS, Son ES, Kim KN, Kim BT, et al. Total testosterone and sex hormone?binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men. Maturitas 2013; 74: 148-53.
20. Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, et al. Association between hormones and metabolic syndrome in older Italian men. J Am Geriatr Soc 2006; 54: 1832-8.
21. Chin KY, Ima?Nirwana S, Mohamed IN, Aminuddin A, Ngah WZ. Total testosterone and sex hormone?binding globulin are significantly associated with metabolic syndrome in middle-aged and elderly men. Exp Clin Endocrinol Diabetes 2013; 121: 407-12.
22. Liao M, Guo X, Yu X, Pang G, Zhang S, et al. Role of metabolic factors in the association between osteocalcin and testosterone in Chinese men. J Clin Endocrinol Metab 2013; 98: 3463-9.
23. Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone?binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 2010; 33: 1618-24.
24. Hajamor S, Després JP, Couillard C, Lemieux S, Tremblay A, et al. Relationship between sex hormone?binding globulin levels and features of the metabolic syndrome. Metabolism 2003; 52: 724-30.
25. Katabami T, Kato H, Asahina T, Hinohara S, Shin T, et al. Serum free testosterone and metabolic syndrome in Japanese men. Endocr J 2010; 57: 533-9.
26. Muller M, Grobbee DE, den Tonkelaar I, Lamberts SW, van der Schouw YT. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab 2005; 90: 2618-23.
27. Haring R, Völzke H, Spielhagen C, Nauck M, Wallaschofski H. The role of sex hormone?binding globulin and testosterone in the risk of incident metabolic syndrome. Eur J Prev Cardiol 2013; 20: 1061-8.
28. Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79: 997-1000.
29. Santaniemi M, Kesäniemi YA, Ukkola O. Low plasma adiponectin concentration is an indicator of the metabolic syndrome. Eur J Endocrinol 2006; 155: 745-50.
30. Gannagé?Yared MH, Khalife S, Semaan M, Fares F, Jambart S, et al. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non?diabetic elderly men. Eur J Endocrinol 2006; 155: 167-76.
31. Bataille V, Perret B, Evans A, Amouyel P, Arveiler D, et al. Sex hormone?binding globulin is a major determinant of the lipid profile: the PRIME study. Atherosclerosis 2005; 179: 369-73.
32. Selva DM, Hammond GL. Peroxisome?proliferator receptor gamma represses hepatic sex hormone?binding globulin expression. Endocrinology 2009; 150: 2183-9.
33. Wang L, Szklo M, Folsom AR, Cook NR, Gapstur SM, et al. Endogenous sex hormones, blood pressure change, and risk of hypertension in postmenopausal women: the Multi?Ethnic Study of Atherosclerosis. Atherosclerosis 2012; 224: 228-34.
34. Phillips GB, Jing TY, Laragh JH, Sealey JE. Serum sex hormone levels and renin?sodium profile in men with hypertension. Am J Hypertens 1995; 8: 626-9.
35. Zhang J, Huang X, Liao M, Gao Y, Tan A, et al. Both total testosterone and sex hormone?binding globulin are independent risk factors for metabolic syndrome: results from Fangchenggang Area Male Health and Examination Survey in China. Diabetes Metab Res Rev 2013; 29: 391-7.
36. Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA. Sex hormone?binding globulin mediates steroid hormone signal transduction at the plasma membrane. J Steroid Biochem Mol Biol 1999; 69: 481-5.
37. Daka B, Rosen T, Jansson PA, Larsson CA, Råstam L, et al. Low sex hormone?binding globulin is associated with hypertension: a cross?sectional study in a Swedish population. BMC Cardiovasc Disord 2013; 13: 30.
38. Pang XN, Yuan Y, Sun Y, Shen JP, Zha XY, et al. The relationship of sex hormone?binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males. Aging Clin Exp Res 2014; 26: 583-9.
39. Lotti F, Corona G, Vignozzi L, Rossi M, Maseroli E, et al. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. Asian J Androl 2014; 16: 295-304.
40. Bonnet F, Velayoudom Cephise FL, Gautier A, Dubois S, Massart C, et al. Role of sex steroids, intrahepatic fat and liver enzymes in the association between SHBG and metabolic features. Clin Endocrinol (Oxf) 2013; 79: 517-22.