Loss of hypermucoviscosity and increased fitness cost in colistin-resistant klebsiella pneumoniae sequence type 23 strains

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 11, 2015, Pages 6763-6773

  Choi, Myung Jin ^a   Ko, Kwan Soo ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; LIPID A; LIPOPOLYSACCHARIDE; PALMITIC ACID; PIPERACILLIN PLUS TAZOBACTAM; POLYMYXIN B; POLYSACCHARIDE; PROTEIN; PROTEIN MAGA; PROTEIN PBGP; PROTEIN PHOQ; PROTEIN PMRB; PROTEIN PMRD; PROTEIN RMPA2; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL POLYSACCHARIDE; BACTERIAL PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BIOFILM; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SEROTYPE; SURVIVAL RATE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOFILMS; COLISTIN; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; KLEBSIELLA PNEUMONIAE; POLYSACCHARIDES, BACTERIAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84946200308     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00952-15     Document Type: Article

References (37)

1. Braiteh F, Golden MP. 2007. Cryptogenic invasive Klebsiella pneumoniae liver abscess syndrome. Int J Infect Dis 11:16-22. http://dx.doi.org/10.1016/j.ijid.2005.10.006.
2. Shon AS, Bajwa RP, Russo TA. 2013. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4:107-118. http://dx.doi.org/10.4161/viru.22718.
3. Siu LK, Fung CP, Chang FY, Lee N, Yeh KM, Koh TH, Ip M. 2011. Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan. J Clin Microbiol 49:3761-3765. http://dx.doi.org/10.1128/JCM.00977-11.
4. Vila A, Cassata A, Pagella H, Amadio C, Yeh KM, Chang FY, Siu LK. 2011. Appearance of Klebsiella pneumoniae liver abscess syndrome in Argentina: case report and review of molecular mechanisms of pathogenesis. Open Microbiol J 5:107-113. http://dx.doi.org/10.2174/1874285801105010107.
5. Ah YM, Kim AJ, Lee JY. 2014. Colistin resistance in Klebsiella pneumoniae. Int J Antimicrob Agents 44:8-15. http://dx.doi.org/10.1016/j.ijantimicag.2014.02.016.
6. Olaitan AO, Diene SM, Kempf M, Berrazeg M, Bakour S, Gupta SK, Thongmalayvong B, Akkhavong K, Somphavong S, Paboriboune P, Chaisiri K, Komalamisra C, Adelowo OO, Fagade OE, Banjo OA, Oke AJ, Adler A, Assous MV, Morand S, Raoult D, Rolain JM. 2014. Worldwide emergence of colistin resistance in Klebsiella pneumoniaefrom healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study. Int J Antimicrob Agents 44:500-507. http://dx.doi.org/10.1016/j.ijantimicag.2014.07.020.
7. Suh JY, Son JS, Chung DR, Peck KR, Ko KS, Song JH. 2010. Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. Antimicrob Agents Chemother 54:560-562. http://dx.doi.org/10.1128/AAC.00762-09.
8. Llobet E, Campos MA, Giménez P, Moranta D, Bengoechea JA. 2011. Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors. Infect Immun 79:3718-3732. http://dx.doi.org/10.1128/IAI.05226-11.
9. Campos MA, Vargas MA, Regueiro V, Llompart CM, Albertí S, Bengoechea JA. 2004. Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides. Infect Immun 72:7107-7114. http://dx.doi.org/10.1128/IAI.72.12.7107-7114.2004.
10. Beceiro A, Moreno A, Fernández N, Vallejo JA, Aranda J, Adler B, Harper M, Boyce JD, Bou G. 2014. Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii. Antimicrob Agents Chemother 58:518-526. http://dx.doi.org/10.1128/AAC.01597-13.
11. López-Rojas R, Domínguez-Herrera J, McConnell MJ, Docobo-Peréz F, Smani Y, Fernández-Reyes M, Rivas L, Pachón J. 2011. Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii. J Infect Dis 203:545-548. http://dx.doi.org/10.1093/infdis/jiq086.
12. Cannatelli A, Di Pilato V, Giani T, Arena F, Ambretti S, Gaibani P, D'Andrea MM, Rossolini GM. 2014. In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment. Antimicrob Agents Chemother 58:4399-4403. http://dx.doi.org/10.1128/AAC.02555-14.
13. CLSI. 2013. Performance standards for antimicobial susceptibility testing: 23rd informational supplement. CLSI document M100-S21. CLSI, Wayne, PA.
14. Domenico P, Schwartz S, Cunha BA. 1989. Reduction of capsular poly-saccharide production in Klebsiella pneumoniae by sodium salicylate. Infect Immun 57:3778-3782.
15. Kim SY, Choi HJ, Ko KS. 2014. Differential expression of two-component systems, pmrAB and phoPQ, with different growth phases of Klebsiella pneumoniae in the presence or absence of colistin. Curr Microbiol 69:37-41. http://dx.doi.org/10.1007/s00284-014-0549-0.
16. Fey A, Eichler S, Flavier S, Christen R, Höfle MG, Guzmán CA. 2004. Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism. Appl Environ Microbiol 70:3618-3623. http://dx.doi.org/10.1128/AEM.70.6.3618-3623.2004.
17. Jadhav S, Hussain A, Devi S, Kumar A, Parveen S, Gandham N, Wieler LH, Ewers C, Ahmed N. 2011. Virulence characteristics and genetic affinities of multiple drug resistant uropathogenic Escherichia coli from a semi urban locality in India. PLoS One 6:e18063. http://dx.doi.org/10.1371/journal.pone.0018063.
18. Wu MC, Lin TL, Hsieh PF, Yang HC, Wang JT. 2011. Isolation of genes involved in biofilm formation of a Klebsiella pneumoniae strain causing pyogenic liver abscess. PLoS One 6:e23500. http://dx.doi.org/10.1371/journal.pone.0023500.
19. Fernández A, Pérez A, Ayala JA, Mallo S, Rumbo-Feal S, Tomás M, Poza M, Bou G. 2012. Expression of OXA-type and SFO-1 β-lactamases induces changes in peptidoglycan composition and affects bacterial fitness. Antimicrob Agents Chemother 56:1877-1884. http://dx.doi.org/10.1128/AAC.05402-11.
20. Clements A, Tull D, Jenney AW, Farn JL, Kim SH, Bishop RE, McPhee JB, Hancock RE, Hartland EL, Pearse MJ, Wijburg OL, Jackson DC, McConville MJ, Strugnell RA. 2007. Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem 282:15569-15577. http://dx.doi.org/10.1074/jbc.M701454200.
21. Edwards RA, Keller LH, Schifferli DM. 1998. Improved allelic exchange vectors and their use to analyze 987P fimbria gene expression. Gene 30: 149-157.
22. Song JH, Ko KS. 2008. Detection of essential genes in Streptococcus pneumoniae using bioinformatics and allelic replacement mutagenesis. Methods Mol Biol 416:401-408. http://dx.doi.org/10.1007/978-1-59745-321-9-28.
23. Hsu CR, Lin TL, Chen YC, Chou HC, Wang JT. 2011. The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited. Microbiology 157:3446-3457. http://dx.doi.org/10.1099/mic.0.050336-0.
24. Sachdev DD, Yin MT, Horowitz JD, Mukkamala SK, Lee SE, Ratner AJ. 2013. Klebsiella pneumoniaeK1 liver abscess and septic endophthalmitis in a U.S. resident. J Clin Microbiol 51:1049-1051. http://dx.doi.org/10.1128/JCM.02853-12.
25. Holmås K, Fostervold A, Stahlhut SG, Struve C, Holter JC. 2014. Emerging K1 serotype Klebsiella pneumoniae primary liver abscess: three cases presenting to a single university hospital in Norway. Clin Case Rep 2:122-127. http://dx.doi.org/10.1002/ccr3.77.
26. Chung DR, Lee HR, Lee SS, Kim SW, Chang HH, Jung SI, Oh MD, Ko KS, Kang CI, Peck KR, Song JH. 2008. Evidence for clonal dissemination of the serotype K1 Klebsiella pneumoniae strain causing invasive liver abscesses in Korea. J Clin Microbiol 46:4061-4063. http://dx.doi.org/10.1128/JCM.01577-08.
27. Cheng HY, Chen YF, Peng HL. 2010. Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43. J Biomed Sci 17:60. http://dx.doi.org/10.1186/1423-0127-17-60.
28. Gunn JS, Ryan SS, Van Velkinburgh JC, Ernst RK, Miller SI. 2000. Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar Typhimurium. Infect Immun 68:6139-6146. http://dx.doi.org/10.1128/IAI.68.11.6139-6146.2000.
29. Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. 2004. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 199:697-705. http://dx.doi.org/10.1084/jem.20030857.
30. Cheng HY, Chen YS, Wu CY, Chang HY, Lai YC, Peng HL. 2010. RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J Bacteriol 192:3144-3158. http://dx.doi.org/10.1128/JB.00031-10.
31. Srinivasan VB, Rajamohan G. 2013. KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance. Anti-microb Agents Chemother 57:4449-4462. http://dx.doi.org/10.1128/AAC.02284-12.
32. Sahly H, Aucken H, Benedí VJ, Forestier C, Fussing V, Hansen DS, Ofek I, Podschun R, Sirot D, Tomás JM, Sandvang D, Ullmann U. 2004. Increased serum resistance in Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases. Antimicrob Agents Chemother 48: 3477-3482. http://dx.doi.org/10.1128/AAC.48.9.3477-3482.2004.
33. Sarkar S, Ulett GC, Totsika M, Phan MD, Schembri MA. 2014. Role of capsule and O antigen in the virulence of uropathogenic Escherichia coli. PLoS One 9:e94786. http://dx.doi.org/10.1371/journal.pone.0094786.
34. Leying H, Suerbaum S, Kroll HP, Stahl D, Opferkuch W. 1990. The capsular polysaccharide is a major determinant of serum resistance in K-1-positive blood culture isolates of Escherichia coli. Infect Immun 58: 222-227.
35. Zhu J, Mekalanos JJ. 2003. Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Dev Cell 5:647-656. http://dx.doi.org/10.1016/S1534-5807(03)00295-8.
36. Boddicker JD, Anderson RA, Jagnow J, Clegg S. 2006. Signature-tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material. Infect Immun 74:4590-4597. http://dx.doi.org/10.1128/IAI.00129-06.
37. Wright MS, Suzuki Y, Jones MB, Marshall SH, Rudin SD, van Duin D, Kaye K, Jacobs MR, Bonomo RA, Adams MD. 2015. Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance. Antimicrob Agents Chemother 59:536-543. http://dx.doi.org/10.1128/AAC.04037-14.