Effect of pregnancy on the uterine vasoconstrictor response to exercise in rats

Physiological Reports

Volumn 3, Issue 3, 2015, Pages

  Lashley, Christopher J ^a,b   Supik, David A ^a   Atkinson, James T ^a   Murphy, Robert J ^b   O’Hagan, Kathleen P ^b  

^a MIDWESTERN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

Author keywords

Exercise; Gestation; Physical activity; Pregnancy; Rat; Uterine blood flow

Indexed keywords

ARTERY BLOOD FLOW; ARTERY CATHETER; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CONTROLLED STUDY; ESTRUS CYCLE; EUTHANASIA; EXERCISE; FEMALE; FETUS OUTCOME; GESTATION PERIOD; HEART RATE; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PREGNANCY; RAT; TREADMILL EXERCISE; UTERUS BLOOD FLOW; VASOCONSTRICTION;

EID: 84946151926     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12337     Document Type: Article

References (59)

1. Brauer, M. M., and P. G. Smith. 2015. Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity. Auton Neurosci. 187C:1-17
2. Brooks, V. L., C. M. Kane, and D. M. Van Winkle. 1997. Altered heart rate baroreflex during pregnancy: role of sympathetic and parasympathetic nervous systems. Am. J. Physiol. Regul. Integr. Comp. Physiol. 273:R960-R966
3. Brooks, V. L., J. M. Mulvaney, A. S. Azar, D. Zhao, and R. K. Goldman. 2010. Pregnancy impairs baroreflex control of heart rate in rats: role of insulin sensitivity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298:R419-R426
4. Brooks, V. L., P. A. Cassaglia, D. Zhao, and R. K. Goldman. 2012. Baroreflex function in females: changes with the reproductive cycle and pregnancy. Gend. Med. 9:61-67
5. Buckwalter, J. B., and P. S. Clifford. 2001. The paradox of sympathetic vasoconstriction in exercising skeletal muscle. Exerc. Sport Sci. Rev. 29:159-163
6. Chartrel, N. C., M. T. Clabaut, F. A. Boismare, and J. C. Schrub. 1990. Uteroplacental hemodynamic disturbances in establishment of fetal growth retardation in streptozocin-induced diabetic rats. Diabetes 39:743-746
7. Cipolla, M., and G. Osol. 1994. Hypertrophic and hyperplastic effects of pregnancy on the rat uterine arterial wall. Am. J. Obstet. Gynecol. 171:805-811
8. Clapp, J. F. III. 1989. Oxygen consumption during treadmill exercise before, during, and after pregnancy. Am. J. Obstet. Gynecol. 161:1458-1464
9. Clapp, J. F. III. 2003. The effects of maternal exercise on fetal oxygenation and feto-placental growth. Eur. J. Obstet. Gynecol. Reprod. Biol. 110:S80-S85
10. Curran-Everett, D., and D. J. Benos. 2004. Guidelines for reporting statistics in journals published by the American Physiological Society. Adv. Physiol. Educ. 28:85-87
11. Damasceno, D. C., H. P. Silva, G. F. Vaz, F. A. Vasques-Silva, I. M. Calderon, M. V. Rudge, et al. 2013. Diabetic rats exercised prior to and during pregnancy: maternal reproductive outcome, biochemical profile, and frequency of fetal anomalies. Reprod. Sci. 20:730-738
12. D’Angelo, G., and G. Osol. 1993. Regional variation in resistance artery diameter responses to alpha-adrenergic stimulation during pregnancy. Am. J. Physiol. 264:H78-H85
13. Dorward, P. K., W. Riedel, S. L. Burke, J. Gipps, and P. I. Korner. 1985. The renal sympathetic baroreflex in the rabbit: arterial and cardiac baroreceptor influences, resetting, and effect of anesthesia. Circ. Res. 57:618-633
14. Dowell, R. T., and C. D. Kauer. 1993. Uteroplacental blood flow at rest and during exercise in late-gestation conscious rats. J. Appl. Physiol. 74:2079-2085
15. Dowell, R. T., and C. D. Kauer. 1997. Maternal hemodynamics and uteroplacental blood flow throughout gestation in conscious rats. Methods Find. Exp. Clin. Pharmacol. 19:613-625
16. Erkkola, R. U., J. P. Pirhonen, and A. K. Kivijarvi. 1992. Flow velocity waveforms in uterine and umbilical arteries during submaximal bicycle exercise in normal pregnancy. Obstet. Gynecol. 79:611-615
17. Fuller, E. O., P. M. Galletti, J. W. Manning, and T. F. Fitzgerald. 1979. Responses of the uterine circulation to sympathetic nerve stimulation. J. Dev. Physiol. 1: 209-218
18. Genest, D. S., S. Falcao, J. Gutkowska, and J. L. Lavoie. 2012. Impact of exercise training on preeclampsia: potential preventive mechanisms. Hypertension 60:1104-1109
19. Gilbert, J. S., C. T. Banek, A. J. Bauer, A. Gingery, and H. C. Dreyer. 2012. Placental and vascular adaptations to exercise training before and during pregnancy in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303:R520-R526
20. Gnanamanickam, G. J., and I. J. Llewellyn-Smith. 2011. Innervation of the rat uterus at estrus: a study in fullthickness, immunoperoxidase-stained whole-mount preparations. J. Comp. Neurol. 519:621-643
21. Gokina, N. I., A. D. Bonev, A. P. Gokin, and G. Goloman. 2013. Role of impaired endothelial cell Ca(2+) signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy. Am. J. Physiol. Heart Circ. Physiol. 304:H935-H945
22. Gonzalez, N. C., R. L. Clancy, and P. D. Wagner. 1993. Determinant of maximal oxygen uptake in rats acclimated to simulated altitude. J. Appl. Physiol. 75:1608-1614
23. Haase, E. B., J. Buchman, A. E. Tietz, and L. P. Schramm. 1997. Pregnancy-induced uterine neuronal degeneration in the rat. Cell Tissue Res. 288:293-306
24. Hackett, G. A., T. Cohen-Overbeek, and S. Campbell. 1992. The effect of exercise on uteroplacental Doppler waveforms in normal and complicated pregnancies. Obstet. Gynecol. 79:919-923
25. Hales, J. R. S., and J. Ludbrook. 1988. Baroreflex participation in redistribution of cardiac output at onset of exercise. J. Appl. Physiol. 64:627-634
26. Heesch, C. M., and R. C. Rogers. 1995. Effects of pregnancy and progesterone metabolites on regulation of sympathetic outflow. Clin. Exp. Pharmacol. Physiol. 22:136-142
27. Hohimer, A. R., J. M. Bissonnette, J. Metcalfe, and T. A. McKean. 1984. Effect of exercise on uterine blood flow in the pregnant pygmy goat. Am. J. Physiol. Heart Circ. Physiol. 246:H207-H212
28. Hutchison, S. M., A. E. Tietz, K. A. Trostel, and L. P. Schramm. 1997. Uterine arterial vasoconstrictions mediated by ovarian nerves in virgin and postpartum rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 272:R318-R325
29. Jones, M. T., K. I. Norton, D. R. Dengel, and R. B. Armstrong. 1990. Effects of training on reproductive tissue blood flow in exercising pregnant rats. J. Appl. Physiol. 69:2097-2103
30. Kennelly, M. M., M. Geary, N. McCaffrey, P. McLoughlin, A. Staines, and P. McKenna. 2003. Exercise-related changes in umbilical and uterine artery waveforms as assessed by Doppler ultrasound scans. Am. J. Obstet. Gynecol. 187:661-666
31. Klukovits, A., R. Gaspar, P. Santha, G. Jansco, and G. Falkay. 2002. Functional and histochemical characterization of a uterine adrenergic denervation process in pregnant rats. Biol. Reprod. 67:1013-1017
32. Knock, G. A., A. L. McCarthy, C. Lowy, and L. Poston. 1997. Association of gestational diabetes with abnormal maternal vascular endothelial function. Br. J. Obstet. Gynaecol. 104:229-234
33. Konje, J. C., P. Kaufmann, S. C. Bell, and D. J. Taylor. 2001. A longitudinal study of quantitative uterine blood flow with the use of color power angiography in appropriate for gestational age pregnancies. Am. J. Obstet. Gynecol. 285:608-613
34. Lang, U., R. S. Baker, G. Braems, M. Zygmunt, W. Künzel, and K. E. Clark. 2003. Uterine blood flow-a determinant of fetal growth. Eur. J. Obstet. Gynecol. Reprod. Biol. 110:S55-S61
35. Li, J., B. LaMarca, and J. F. Reckelhoff. 2012. A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model. Am. J. Physiol. Heart Circ. Physiol. 303:H1-H8
36. Lotgering, F. K., R. D. Gilbert, and L. D. Longo. 1983. Exercise responses in pregnant sheep: oxygen consumption, uterine blood flow, and blood volume. J. Appl. Physiol. 55:834-941
37. Lotgering, F. K., M. B. Van Doorn, P. C. Struijk, J. Pool, and H. C. S. Wallenburg. 1991. Maximal aerobic exercise in pregnant women: heart rate, O2 consumption, CO2 production, and ventilation. J. Appl. Physiol. 70:1016-1023
38. Marcondes, F. K., F. J. Bianchi, and A. P. Tanno. 2002. Determination of the estrous cycle phases of rats: some helpful considerations. Braz. J. Biol. 62:609-614
39. Melzer, K., Y. Schutz, M. Boulvain, and B. Kayser. 2010. Physical activity and pregnancy: cardiovascular adaptations, recommendations and pregnancy outcomes. Sports Med. 40:493-507
40. Mione, M. C., and G. Gabella. 1991. Nerve fibres in the uterine artery increase in number in pregnant guinea-pigs. NeuroReport 2:537-540
41. Morrow, R. J., J. W. Ritchie, and S. B. Bull. 1989. Fetal and maternal hemodynamic responses to exercise in pregnancy assessed by Doppler ultrasonography. Am. J. Obstet. Gynecol. 160:138-140
42. Mueller, P. J., K. P. O’Hagan, K. A. Skogg, J. B. Buckwalter, and P. S. Clifford. 1998. Renal hemodynamic responses to dynamic exercise in rabbits. J. Appl. Physiol. 85:1605-1614
43. Musch, T. I., A. Bruno, G. E. Bradford, A. Vayonis, and R. L. Moore. 1998. Measurements of metabolic rate in rats: a comparison of techniques. J. Appl. Physiol. 65:964-970
44. Nesbitt, A. E., R. J. Murphy, and K. P. O’Hagan. 2005. Effect of gestational stage on uterine artery blood flow during exercise in rabbits. J. Appl. Physiol. 99:2159-2165
45. Ni, Y., M. Meyer, and G. Osol. 1997. Gestation increases nitric oxide-mediated vasodilation in rat uterine arteries. Am. J. Obstet. Gynecol. 176:856-864
46. O’Hagan, K. P., and J. A. Alberts. 2003. Uterine artery blood flow and renal sympathetic nerve activity during exercise in rabbit pregnancy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285:R1135-R1144
47. O’Hagan, K. P., and S. M. Casey. 1998. Arterial baroreflex during pregnancy and renal sympathetic nerve activity during parturition in rabbits. Am. J. Physiol. Heart Circ. Physiol. 274:H1635-H1642
48. O’Hagan, K. P., K. A. Skogg, and J. B. Stevenson. 2001. AT1 receptor block does not affect arterial baroreflex during pregnancy in rabbits. Am. J. Physiol. Heart Circ. Physiol. 280:H1996-H2005
49. O’Leary, D. S. 1991. Regional vascular resistance vs. conductance: which index for baroreflex responses? Am. J. Physiol. Heart Circ. Physiol. 260: H632-H637
50. Osol, G., and M. Cipolla. 1993. Interaction of myogenic and adrenergic mechanisms in isolated, pressurized uterine radial arteries from late-pregnant and nonpregnant rats. Am. J. Obstet. Gynecol. 168:697-705
51. Osol, G., and L. G. Moore. 2014. Maternal uterine vascular remodeling during pregnancy. Microcirculation 21:38-47
52. Pietryga, M., J. Brazert, E. Wender-Oegowska, R. Biczysko, M. Dubiel, and S. Gudmundsson. 2005. Abnormal uterine Doppler is related to vasculopathy in pregestational diabetes mellitus. Circulation 112:2496-2500
53. Rowell, L. B. 1993. Control of regional blood flow during dynamic exercise. Pp. 209-218 Human cardiovascular control. Oxford University Press, New York.
54. Rowell, L. B., J. R. Blackmon, M. A. Kenny, and P. Escourrou. 1984. Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans. Am. J. Physiol. 247:H251-H258
55. Ryan, M. J., K. E. Clark, and M. J. Brody. 1974. Neurogenic and mechanical control of canine uterine vascular resistance. Am. J. Physiol. 227:547-555
56. Stanley, J. L., N. Ashton, M. J. Taggart, S. T. Davidge, and P. N. Baker. 2009. Uterine artery function in a mouse model of pregnancy complicated by diabetes. Vascul. Pharmacol. 50:8-13
57. Thaler, I., D. Manor, J. Itskovitz, S. Rottem, N. Levit, I. Timor-Tritsch, et al. 1990. Changes in uterine blood flow during human pregnancy. Am. J. Obstet. Gynecol. 162: 121-125
58. Valdes, G., P. Kaufmann, J. Corthorn, R. Erices, K. B. Brosnihan, and J. Joyner-Grantham. 2009. Vasodilator factors in the systemic and local adaptations to pregnancy. Reprod. Biol. Endocrinol. 7:79.
59. Xiao, D., Y. Liu, W. J. Pearce, and L. Zhang. 1999. Endothelial nitric oxide release in isolated perfused ovine uterine arteries: effect of pregnancy. Eur. J. Pharmacol. 367:223-230