Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Chen, Chuck T ^a   Kitson, Alex P ^a   Hopperton, Kathryn E ^a   Domenichiello, Anthony F ^a   Trépanier, Marc Olivier ^a   Lin, Lauren E ^a   Ermini, Leonardo ^b   Post, Martin ^b   Thies, Frank ^c   Bazinet, Richard P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; LYSOPHOSPHATIDYLCHOLINE;

ANIMAL; BIOLOGICAL MODEL; BLOOD; BRAIN; DIAGNOSTIC IMAGING; METABOLISM; RADIOGRAPHY; RAT;

ANIMALS; BRAIN; DOCOSAHEXAENOIC ACIDS; LYSOPHOSPHATIDYLCHOLINES; MODELS, BIOLOGICAL; RADIOGRAPHY; RATS;

EID: 84946140531     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15791     Document Type: Article

References (49)

1. Diau, G. Y. et al. The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC Med 3, 11, doi: 10. 1186/1741-7015-3-11 (2005)
2. Serhan, C. N. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92-101, doi: 10. 1038/nature13479 (2014)
3. Kim, H. Y., Spector, A. A. & Xiong, Z. M. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. Prostaglandins Other Lipid Mediat 96, 114-120, doi: 10. 1016/j. prostaglandins. 2011. 07. 002S1098-8823(11)00063-3 (2011)
4. Bazinet, R. P. & Laye, S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15, 771-785, doi: 10. 1038/nrn3820nrn3820 (2014)
5. Kim, H. Y. Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem 282, 18661-18665, doi: R70001520010. 1074/ jbc. R700015200 (2007)
6. Liu, J. J., Green, P., John Mann, J., Rapoport, S. I. & Sublette, M. E. Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease. Brain research 1597C, 220-246, doi: S0006-8993(14)01666-710. 1016/j. brainres. 2014. 11. 059 (2015)
7. Cao, D. et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem 111, 510-521, doi: 10. 1111/j. 1471-4159. 2009. 06335. xJNC6335 (2009)
8. Kim, H. Y. Neuroprotection by docosahexaenoic acid in brain injury. Military medicine 179, 106-111, doi: 10. 7205/ MILMED-D-14-00162 (2014)
9. Calon, F. et al. Docosahexaenoic acid protects from dendritic pathology in an Alzheimers disease mouse model. Neuron 43, 633-645, doi: 10. 1016/j. neuron. 2004. 08. 013S0896627304005227 (2004)
10. Calon, F. Omega-3 polyunsaturated fatty acids in Alzheimers disease: key questions and partial answers. Curr Alzheimer Res 8, 470-478, doi: BSP/CAR/0173 (2011)
11. Palacios-Pelaez, R., Lukiw, W. J. & Bazan, N. G. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol 41, 367-374, doi: 10. 1007/s12035-010-8139-z (2010)
12. Salem, N. Jr., Vandal, M. & Calon, F. The benefit of docosahexaenoic acid for the adult brain in aging and dementia. Prostaglandins, leukotrienes, and essential fatty acids 92, 15-22, doi: 10. 1016/j. plefa. 2014. 10. 003 (2015)
13. Rapoport, S. I., Rao, J. S. & Igarashi, M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids 77, 251-261, doi: S0952-3278(07)00155-X10. 1016/j. plefa. 2007. 10. 023 (2007)
14. Scott, B. L. & Bazan, N. G. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proceedings of the National Academy of Sciences of the United States of America 86, 2903-2907 (1989)
15. DeMar, J. C. Jr., Ma, K., Chang, L., Bell, J. M. & Rapoport, S. I. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 94, 1063-1076 (2005)
16. DeMar, J. C. Jr., Ma, K., Bell, J. M. & Rapoport, S. I. Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. Journal of neurochemistry 91, 1125-1137, doi: 10. 1111/j. 1471-4159. 2004. 02789. x (2004)
17. Chen, C. T. & Bazinet, R. P. beta-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels. Prostaglandins, leukotrienes, and essential fatty acids 92, 33-40, doi: 10. 1016/j. plefa. 2014. 05. 007 (2015)
18. Dietschy, J. M. Central nervous system: cholesterol turnover, brain development and neurodegeneration. Biol Chem 390, 287-293, doi: 10. 1515/BC. 2009. 035 (2009)
19. Thies, F., Pillon, C., Moliere, P., Lagarde, M. & Lecerf, J. Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. The American journal of physiology 267, R1273-1279 (1994)
20. Thies, F., Delachambre, M. C., Bentejac, M., Lagarde, M. & Lecerf, J. Unsaturated fatty acids esterified in 2-acyl-llysophosphatidylcholine bound to albumin are more efficiently taken up by the young rat brain than the unesterified form. J Neurochem 59, 1110-1116 (1992)
21. Green, P. & Yavin, E. Mechanisms of docosahexaenoic acid accretion in the fetal brain. J Neurosci Res 52, 129-136, doi: 10. 1002/ (SICI)1097-4547(19980415)52:2 3. 0. CO;2-C (1998)
22. Nguyen, L. N. et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509, 503-506, doi: 10. 1038/nature13241 (2014)
23. Robinson, P. J. et al. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Brain Res Rev 17, 187-214 (1992)
24. Purdon, D., Arai, T. & Rapoport, S. No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat. J Lipid Res 38, 526-530 (1997)
25. Chen, C. T. et al. The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms. J Lipid Res 54, 2410-2422, doi: 10. 1194/jlr. M038505 (2013)
26. Lin, L. E. et al. Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids. Journal of lipid research 56, 390-402, doi: 10. 1194/jlr. M055590 (2015)
27. Croset, M., Brossard, N., Polette, A. & Lagarde, M. Characterization of plasma unsaturated lysophosphatidylcholines in human and rat. Biochem J 345 Pt 1, 61-67 (2000)
28. Rapoport, S. I., Chang, M. C. & Spector, A. A. Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. Journal of lipid research 42, 678-685 (2001)
29. Kamp, F. & Hamilton, J. A. pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proceedings of the National Academy of Sciences of the United States of America 89, 11367-11370 (1992)
30. Kamp, F., Zakim, D., Zhang, F., Noy, N. & Hamilton, J. A. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry 34, 11928-11937 (1995)
31. Ouellet, M. et al. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochemistry international 55, 476-482 (2009)
32. Kamp, F. & Hamilton, J. A. How fatty acids of different chain length enter and leave cells by free diffusion. Prostaglandins Leukot Essent Fatty Acids 75, 149-159, doi: S0952-3278(06)00081-010. 1016/j. plefa. 2006. 05. 003 (2006)
33. Hamilton, J. A., Guo, W. & Kamp, F. Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins? Molecular and cellular biochemistry 239, 17-23 (2002)
34. Lemaitre-Delaunay, D. et al. Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine. J Lipid Res 40, 1867-1874 (1999)
35. Lagarde, M. et al. Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain. Prostaglandins Leukot Essent Fatty Acids 92, 63-65, doi: 10. 1016/j. plefa. 2014. 01. 005S0952-3278(14)00019-2 (2015)
36. Hussein, N. et al. Artificial rearing of infant mice leads to n-3 fatty acid deficiency in cardiac, neural and peripheral tissues. Lipids 44, 685-702, doi: 10. 1007/s11745-009-3318-2 (2009)
37. Lafourcade, M. et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci 14, 345-350, doi: 10. 1038/nn. 2736 (2011)
38. Umhau, J. C. et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. PloS one 8, e75333, doi: 10. 1371/journal. pone. 0075333 (2013)
39. Umhau, J. C. et al. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res 50, 1259-1268, doi: 10. 1194/jlr. M800530-JLR200 (2009)
40. Frayn, K. N., Summers, L. K. & Fielding, B. A. Regulation of the plasma non-esterified fatty acid concentration in the postprandial state. Proc Nutr Soc 56, 713-721, doi: S0029665197000244 (1997)
41. Salem, N. M. et al. Distribution of omega-6 and omega-3 polyunsaturated fatty acids in the whole rat body and 25 compartments. Prostaglandins Leukot Essent Fatty Acids, doi: S0952-3278(15)00122-210. 1016/j. plefa. 2015. 06. 002 (2015)
42. Domenichiello, A. F., Kitson, A. P. & Bazinet, R. P. Is docosahexaenoic acid synthesis from alpha-linolenic acid sufficient to supply the adult brain? Progress in lipid research 59, 54-66, doi: 10. 1016/j. plipres. 2015. 04. 002S0163-7827(15)00022-3 (2015)
43. Hong, S. H., Belayev, L., Khoutorova, L., Obenaus, A. & Bazan, N. G. Docosahexaenoic acid confers enduring neuroprotection in experimental stroke. J Neurol Sci 338, 135-141, doi: 10. 1016/j. jns. 2013. 12. 033S0022-510X(13)03104-3 (2014)
44. Eady, T. N. et al. Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. Neurobiol Dis 62, 1-7, doi: 10. 1016/j. nbd. 2013. 09. 008S0969-9961(13)00254-4 (2014)
45. Barrett, E. C., McBurney, M. I. & Ciappio, E. D. omega-3 fatty acid supplementation as a potential therapeutic aid for the recovery from mild traumatic brain injury/concussion. Advances in nutrition 5, 268-277, doi: 10. 3945/an. 113. 005280 (2014)
46. Vandal, M. et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. Journal of neurochemistry 129, 516-526, doi: 10. 1111/jnc. 12640 (2014)
47. Taha, A. Y., Burnham, W. M. & Auvin, S. Polyunsaturated fatty acids and epilepsy. Epilepsia 51, 1348-1358, doi: 10. 1111/j. 1528- 1167. 2010. 02654. x (2010)
48. Chen, C. T., Liu, Z. & Bazinet, R. P. Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. J Neurochem 116, 363-373, doi: 10. 1111/j. 1471-4159. 2010. 07116. x (2011)
49. Wang, W. Q. & Gustafson, A. One-dimensional thin-layer chromatographic separation of phospholipids and lysophospholipids from tissue lipid extracts. J Chromatogr 581, 139-142 (1992)