Peripheral chemoreflex inhibition with low-dose dopamine: New insight into mechanisms of extreme apnea

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 309, Issue 9, 2015, Pages R1162-R1171

  Bain, Anthony R ^a   Dujic, Zeljko ^b   Hoiland, Ryan L ^a   Barak, Otto F ^b   Madden, Dennis ^b   Drvis, Ivan ^c   Stembridge, Mike ^d   Macleod, David B ^e   Macleod, Douglas M ^f   Ainslie, Philip N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF SPLIT   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

^d CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f EMORY UNIVERSITY   (United States)

Author keywords

Blood pressure; Breath hold; Carotid body; Cerebral

Indexed keywords

DOPAMINE; OXYGEN;

ADULT; APNEA; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BREATH HOLDING; BREATHING MECHANICS; CARDIOVASCULAR EFFECT; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; DIVER; FEMALE; FORCED VITAL CAPACITY; HEART RATE; HEMODYNAMICS; HUMAN; HYPERCAPNIA; HYPOXIA; INTERNAL CAROTID ARTERY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY; PRIORITY JOURNAL; RESPIRATORY FUNCTION; TOTAL LUNG CAPACITY; BLOOD; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; LUNG VENTILATION; MIDDLE AGED; NEUROVASCULAR COUPLING; PATHOPHYSIOLOGY; PRESSORECEPTOR REFLEX; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX;

ADULT; APNEA; BAROREFLEX; BLOOD PRESSURE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEUROVASCULAR COUPLING; OXYGEN; PULMONARY VENTILATION; SEVERITY OF ILLNESS INDEX;

EID: 84946031218     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00271.2015     Document Type: Article

References (35)

1. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296: R1473-R1495, 2009.
2. Ainslie PN, Hoiland RL. Transcranial Doppler ultrasound: valid, invalid, or both? J Appl Physiol 117: 1081-1083, 2014.
3. Butler PJ, Jones DR. Physiology of diving of birds and mammals. Physiol Rev 77: 837-899, 1997.
4. Dangmann R. An insulin based model to explain changes and interactions in human breath-holding. Med Hypotheses 84: 532-538, 2015.
5. de Burgh Daly M, Kirkman E, Wood LM. Cardiovascular responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration. J Physiol 407: 349-362, 1988.
6. Dujic Z, Uglesic L, Breskovic T, Valic Z, Heusser K, Marinovic J, Ljubkovic M, Palada I. Involuntary breathing movements improve cerebral oxygenation during apnea struggle phase in elite divers. J Appl Physiol 107: 1840-1846, 2009.
7. Ernsting J. The effect of brief profound hypoxia upon the arterial and venous oxygen tensions in man. J Physiol 169: 292-311, 1963.
8. Feiner JR, Bickler PE, Severinghaus JW. Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol 100: 213-222, 1995.
9. Ferretti G. Extreme human breath-hold diving. Eur J Appl Physiol 84: 254-271, 2001.
10. Gonzalez C, Almaraz L, Obeso A, Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74: 829-898, 1994.
11. Grassi B, Ferretti G, Costa M, Ferrigno M, Panzacchi A, Lundgren CE, Marconi C, Cerretelli P. Ventilatory responses to hypercapnia and hypoxia in elite breath-hold divers. Respir Physiol 97: 323-332, 1994.
12. Gross PM, Whipp BJ, Davidson JT, Koyal SN, Wasserman K. Role of the carotid bodies in the heart rate response to breath holding in man. J Appl Physiol 41: 336-340, 1976.
13. Heusser K, Dzamonja G, Tank J, Palada I, Valic Z, Bakovic D, Obad A, Ivancev V, Breskovic T, Diedrich A, Joyner MJ, Luft FC, Jordan J, Dujic Z. Cardiovascular regulation during apnea in elite divers. Hypertension 53: 719-724, 2009.
14. Joyner MJ, Barnes JN, Hart EC, Wallin BG, Charkoudian N. Neural control of the circulation: how sex and age differences interact in humans. Compr Physiol 5: 193-215, 2015.
15. Kawakami Y, Natelson BH, DuBois AR. Cardiovascular effects of face immersion and factors affecting diving reflex in man. J Appl Physiol 23: 964-970, 1967.
16. Lauschke A, Teichgraber UK, Frei U, Eckardt KU. "Low-dose" dopamine worsens renal perfusion in patients with acute renal failure. Kidney Int 69: 1669-1674, 2006.
17. Lin YC. Breath-hold diving in terrestrial mammals. Exercise Sport Sci Rev 10: 270-307, 1982.
18. Masuda Y, Yoshida A, Hayashi F, Sasaki K, Honda Y. The ventilatory responses to hypoxia and hypercapnia in the Ama. Jpn J Physiol 31: 187-197, 1981.
19. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: from structure to function. Physiol Rev 78: 189-225, 1998.
20. Neubauer JA, Sunderram J. Oxygen-sensing neurons in the central nervous system. J Appl Physiol 96: 367-374, 2004.
21. Niewinski P, Tubek S, Banasiak W, Paton JF, Ponikowski P. Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans. J Physiol 592: 1295-1308, 2014.
22. Noble MI, Eisele JR, Frankel HL, Else W, Guz A. The role of the diaphragm in the sensation of holding the breath. Clin Sci 41: 275-283, 1971.
23. Nunn JF. Applied Respiratory Physiology (3rd ed.). London, UK: Butterworth, 1987.
24. Parkes MJ. Breath-holding and its breakpoint. Exp Physiol 91: 1-15, 2006.
25. Parkes MJ. The limits of breath holding. Sci Am 306: 74-79, 2012.
26. Ponikowski P, Chua TP, Piepoli M, Ondusova D, Webb-Peploe K, Harrington D, Anker SD, Volterrani M, Colombo R, Mazzuero G, Giordano A, Coats AJ. Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation 96: 2586-2594, 1997.
27. Schaller BJ. Trigeminocardiac reflex. J Neurosurg 107: 243-244, 2007.
28. Somers VK, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87: 1953-1957, 1991.
29. 2 gas gradients at low- and high-altitude during dynamic end-tidal forcing. Am J Physiol Regul Integr Comp Physiol 308: R895-R906, 2015.
30. van de Borne P, Oren R, Somers VK. Dopamine depresses minute ventilation in patients with heart failure. Circulation 98: 126 -131, 1998.
31. Willie CK, Ainslie PN, Drvis I, MacLeod DB, Bain AR, Madden D, Maslov PZ, Dujic Z. Regulation of brain blood flow and oxygen delivery in elite breath-hold divers. J Cereb Blood Flow Metab 35: 66 -73, 2015.
32. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ, Smirl JD, Day TA, Lucas SJ, Eller LK, Ainslie PN. Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196: 221-237, 2011.
33. Woodman RJ, Playford DA, Watts GF, Cheetham C, Reed C, Taylor RR, Puddey IB, Beilin LJ, Burke V, Mori TA, Green D. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J Appl Physiol 91: 929-937, 2001.
34. Zapata P. Effects of dopamine on carotid chemo- and baroreceptors in vitro. J Physiol 244: 235-251, 1975.
35. Zapata P, Hess A, Bliss EL, Eyzaguirre C. Chemical, electron microscopic and physiological observations on the role of catecholamines in the carotid body. Brain Res 14: 473-496, 1969.