De novo hepatic steatosis drives atherogenic risk in liver transplantation recipients

Liver Transplantation

Volumn 21, Issue 11, 2015, Pages 1395-1402

  Idowu, Michael O ^a   Chhatrala, Ravi ^a   Siddiqui, M Bilal ^b   Driscoll, Carolyn ^a   Stravitz, R Todd ^a   Sanyal, Arun J ^a   Bhati, Chandra ^a   Sargeant, Carol ^a   Luketic, Velimir A ^a   Sterling, Richard K ^a   Contos, Melissa ^a   Matherly, Scott ^a   Puri, Puneet ^a   Siddiqui, M Shadab ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APOLIPOPROTEIN B; CYCLOSPORIN; DESMOSTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TACROLIMUS; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; BIOLOGICAL MARKER; LIPOPROTEIN;

ACUTE LIVER FAILURE; ADULT; ARTICLE; ATHEROGENESIS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; DIABETES MELLITUS; FATTY ACID BLOOD LEVEL; FATTY LIVER; FEMALE; GRAFT RECIPIENT; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OBESITY; POSTOPERATIVE COMPLICATION; PREVALENCE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ATHEROSCLEROSIS; BIOPSY; BLOOD; COMPLICATION; LIVER; MIDDLE AGED; PATHOLOGY; PROCEDURES; RISK ASSESSMENT; RISK FACTOR; VIRGINIA;

ATHEROSCLEROSIS; BIOMARKERS; BIOPSY; BODY MASS INDEX; CHOLESTEROL, LDL; FATTY LIVER; FEMALE; HUMANS; LIPOPROTEINS; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; TRANSPLANT RECIPIENTS; VIRGINIA;

EID: 84945964497     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.24223     Document Type: Article

References (22)

1. Carey WD, Dumot JA, Pimentel RR, Barnes DS, Hobbs RE, Henderson JM, et al., The prevalence of coronary artery disease in liver transplant candidates over age 50. Transplantation 1995; 59: 859-864.
2. Tiukinhoy-Laing SD, Rossi JS, Bayram M, De Luca L, Gafoor S, Blei A, et al., Cardiac hemodynamic and coronary angiographic characteristics of patients being evaluated for liver transplantation. Am J Cardiol 2006; 98: 178-181.
3. Innes HA, McDonald SA, Dillon JF, Allen S, Hayes PC, Goldberg D, et al., Toward a more complete understanding of the association between a hepatitis C sustained viral response and cause-specific outcomes. Hepatology 2015; 62: 355-364.
4. Petta S, Torres D, Fazio G, Cammà C, Cabibi D, Di Marco V, et al., Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations. Hepatology 2012; 55: 1317-1323.
5. Targher G, Day CP, Bonora E,. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010; 363: 1341-1350.
6. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al., The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012; 55: 2005-2023.
7. Vernon G, Baranova A, Younossi ZM,. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-285.
8. Siddiqui MS, Fuchs M, Idowu MO, Luketic VA, Boyett S, Sargeant C, et al., Severity of nonalcoholic fatty liver disease and progression to cirrhosis are associated with atherogenic lipoprotein profile. Clin Gastroenterol Hepatol 2014; 13: 1000-1008.
9. Otvos JD, Collins D, Freedman DS, Shalaurova I, Schaefer EJ, McNamara JR, et al., Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 2006; 113: 1556-1563.
10. Cromwell WC, Otvos JD, Keyes MJ, Pencina MJ, Sullivan L, Vasan RS, et al., LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study-Implications for LDL management. J Clin Lipidol 2007; 1: 583-592.
11. Pruthi J, Medkiff KA, Esrason KT, Donovan JA, Yoshida EM, Erb SR, et al., Analysis of causes of death in liver transplant recipients who survived more than 3 years. Liver Transpl 2001; 7: 811-815.
12. Watt KD, Pedersen RA, Kremers WK, Heimbach JK, Charlton MR,. Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study. Am J Transplant 2010; 10: 1420-1427.
13. Mazuelos F, Abril J, Zaragoza C, Rubio E, Moreno JM, Turriõn VS, Cuervas-Mons V,. Cardiovascular morbidity and obesity in adult liver transplant recipients. Transplant Proc 2003; 35: 1909-1910.
14. Ciccarelli O, Kaczmarek B, Roggen F, DeReyck C, Goffette P, Danse E, et al., Long-term medical complications and quality of life in adult recipients surviving 10 years or more after liver transplantation. Acta Gastroenterol Belg 2005; 68: 323-330.
15. Chhatrala R, Siddiqui MB, Stravitz RT, Driscoll C, Sanyal A, Sargeant C, et al., Evolution of the serum atherogenic risk in liver transplant recipients; role of lipoproteins, metabolic and inflammatory markers. Liver Transpl 2015; 21: 623-630.
16. Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA,. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 2011; 141: 1249-1253.
17. Contos MJ, Cales W, Sterling RK, Luketic VA, Shiffman ML, Mills AS, et al., Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl 2001; 7: 363-373.
18. Simonen P, Kotronen A, Hallikainen M, Sevastianova K, Makkonen J, Hakkarainen A, et al., Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. J Hepatol 2011; 54: 153-159.
19. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ,. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351.
20. Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K,. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 2009; 50: 1087-1093.
21. Packard CJ,. Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein. Biochem Soc Trans 2003; 31 (pt 5): 1066-1069.
22. Zheng C, Khoo C, Furtado J, Sacks FM,. Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. Circulation 2010; 121: 1722-1734.