Mechanical strain promotes osteogenesis of BMSCs from ovariectomized rats via the ERK1/2 but not p38 or JNK-MAPK signaling pathways

Current Molecular Medicine

Volumn 15, Issue 8, 2015, Pages 780-789

  Zhang, P ^a   Dai, Q ^a   Ouyang, N ^a   Yang, X ^a   Wang, J ^a   Zhou, S ^a   He, N ^a   Fang, B ^a   Jiang, L ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Bone mesenchymal stem cell; Intermittent mechanical strain; MAPKs; Osteogenesis; Osteoporosis; Runx2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL) IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE INHIBITOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; NONHUMAN; OVARIECTOMY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; FEMALE; MECHANICAL STRESS; MESENCHYMAL STROMA CELL; METABOLISM; OSTEOPOROSIS; PATHOLOGY;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMALE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MESENCHYMAL STROMAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOGENESIS; OSTEOPOROSIS; OVARIECTOMY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 84945924635     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524015666150824143830     Document Type: Article

References (33)

1. Martin TJ, Seeman E. Bone remodelling: its local regulation and the emergence of bone fragility. Best Pract Res Clin Endocrinol Metab 2008; 22(5): 701-22.
2. Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am 2005; 34(4): 1015-30, xi.
3. Licata AA. Discovery, clinical development, and therapeutic uses of bisphosphonates. Ann Pharmacother 2005; 39(4): 668-77.
4. Fitzpatrick LA. Estrogen therapy for postmenopausal osteoporosis. Arq Bras Endocrinol Metabol 2006; 50(4): 705- 19.
5. Howe TE, Shea B, Dawson LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev 2011: (7): CD000333.
6. Bidwell JP, Alvarez MB, Hood M, Jr, et al. Functional impairment of bone formation in the pathogenesis of osteoporosis: the bone marrow regenerative competence. Curr Osteoporos Rep 2013; 11(2): 117-25.
7. Weyts FA, Bosmans B, Niesing R, et al. Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation. Calcif Tissue Int 2003; 72(4): 505-12.
8. Costessi A, Pines A, D'Andrea P, et al. Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 2005; 36(3): 418-32.
9. Liedert A, Kaspar D, Blakytny R, et al. Signal transduction pathways involved in mechanotransduction in bone cells. Biochem Biophys Res Commun 2006; 349(1): 1-5.
10. Ducy P, Zhang R, Geoffroy V, et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997; 89(5): 747-54.
11. Byers BA, Pavlath GK, Murphy TJ, et al. Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal. J Bone Miner Res 2002; 17(11): 1931-44.
12. Ziros PG, Gil AP, Georgakopoulos T, et al. The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 2002; 277(26): 23934-41.
13. Baksh D, Boland GM, Tuan RS. Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. J Cell Biochem 2007; 101(5): 1109-24.
14. David V, Martin A, Lafage-Proust MH, et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 2007; 148(5): 2553-62.
15. Arnsdorf EJ, Tummala P, Kwon RY, et al. Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci 2009; 122(Pt 4): 546- 53.
16. Harada H, Tagashira S, Fujiwara M, et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 1999; 274(11): 6972-8.
17. Lee KS, Kim HJ, Li QL, et al. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 2000; 20(23): 8783-92.
18. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298(5600): 1911-2.
19. Jessop HL, Rawlinson SC, Pitsillides AA, et al. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 2002; 31(1): 186-94.
20. Matsuda N, Morita N, Matsuda K, et al. Proliferation and differentiation of human osteoblastic cells associated with differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem Biophys Res Commun 1998; 249(2): 350-4.
21. Thompson DD, Simmons HA, Pirie CM, et al. FDA Guidelines and animal models for osteoporosis. Bone 1995; 17(4 Suppl): 125S-33S.
22. Friedenstein AJ, Latzinik NV, Gorskaya Yu F, et al. Bone marrow stromal colony formation requires stimulation by haemopoietic cells. Bone Miner 1992; 18(3): 199-213.
23. Vande Geest JP, Di Martino ES, Vorp DA. An analysis of the complete strain field within Flexercell membranes. J Biomech 2004; 37(12): 1923-8.
24. Dufour C, Holy X, Marie PJ. Skeletal unloading induces osteoblast apoptosis and targets alpha5beta1-PI3K-Bcl-2 signaling in rat bone. Exp Cell Res 2007; 313(2): 394-403.
25. Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review. Osteoporos Int 2002; 13(9): 688-700.
26. Sadie-Van Gijsen H, Crowther NJ, Hough FS, et al. The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity. Cell Mol Life Sci 2013; 70(13): 2331- 49.
27. Zhou S, Greenberger JS, Epperly MW, et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 2008; 7(3): 335-43.
28. Nakashima K, de Crombrugghe B. Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 2003; 19(8): 458-66.
29. Otto F, Thornell AP, Crompton T, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997; 89(5): 765-71.
30. Mundlos S, Otto F, Mundlos C, et al. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 1997; 89(5): 773-9.
31. Franceschi RT, Xiao G, Jiang D, et al. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. Connect Tissue Res 2003; 44 Suppl 1: 109-16.
32. Ge C, Xiao G, Jiang D, et al. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 2007; 176(5): 709-18.
33. Greenblatt MB, Shim JH, Zou W, et al. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest 2010; 120(7): 2457-73.