Accelerated longitudinal gait speed decline in HIV-infected older men

Journal of Acquired Immune Deficiency Syndromes

Volumn 70, Issue 4, 2015, Pages 370-376

  Schrack, Jennifer A ^a   Althoff, Keri N ^a   Jacobson, Lisa P ^a   Erlandson, Kristine M ^b   Jamieson, Beth D ^c,h   Koletar, Susan L ^d   Phair, John ^e   Ferrucci, Luigi ^f   Brown, Todd T ^a,g   Margolick, Joseph B ^a   Bream, Jay H ^a   Crain, Barbara ^a   Dobs, Adrian ^a   Johnson Hill, Lisette ^a   Leng, Sean ^a   Munro, Cynthia ^a   Plankey, Michael W ^a   Post, Wendy ^a   Sacktor, Ned ^a   Thio, Chloe ^a   Wolinsky, Steven M ^e   Phair, John P ^e   Badri, Sheila ^e   O'Gorman, Maurice ^e   Ostrow, David ^e   Palella, Frank ^e   Ragin, Ann ^e   Detels, Roger ^h   Martínez Maza, Otoniel ^h   Aronow, Aaron ^h   Bolan, Robert ^h   Breen, Elizabeth ^h   Butch, Anthony ^h   Miller, Eric N ^h   Oishi, John ^h   Vinters, Harry ^h   Wiley, Dorothy ^h   Witt, Mallory ^h   Yang, Otto ^h   Young, Stephen ^h   Zhang, Zuo Feng ^h   Rinaldo, Charles R ⁱ   Kingsley, Lawrence A ⁱ   Becker, James T ⁱ   Cranston, Ross D ⁱ   Martinson, Jeremy J ⁱ   Mellors, John W ⁱ   Silvestre, Anthony J ^a   Stall, Ronald D ⁱ   Munoz, Alvaro ^a   Abraham, Alison ^a   Cox, Christopher ^a   Deal, Jennifer ^a   D'Souza, Gypsyamber ^a   Duggal, Priya ^a   Schollenberger, Janet ^a   Seaberg, Eric C ^a   Su, Sol ^a   Surkan, Pamela ^a   more..

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aging; Disability; Functional decline; Gait speed; HIV infection

Indexed keywords

ADULT; AGING; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DETERIORATION; DISABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; OUTCOME ASSESSMENT; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RISK ASSESSMENT; WALKING SPEED; AGED; CLINICAL TRIAL; COHORT ANALYSIS; COMPLICATION; GAIT DISORDERS, NEUROLOGIC; INCIDENCE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; AGING; COHORT STUDIES; GAIT DISORDERS, NEUROLOGIC; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; MIDDLE AGED;

EID: 84945924072     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000731     Document Type: Article

References (40)

1. CDC. Prevalence of Diagnosed and Undiagnosed HIV Infection-United States, 2008-2012. MMWR. 2015;64:657-662.
2. Wada N, Jacobson LP, Cohen M, et al. Cause-specific mortality among HIV-infected individuals, by CD4(+) cell count at HAART initiation, compared with HIV-uninfected individuals. AIDS. 2014;28:257-265.
3. Torres RA, Lewis W. Aging and HIV/AIDS: pathogenetic role of therapeutic side effects. Lab Invest. 2014;94:120-128.
4. Bruunsgaard H, Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003;23:15-39.
5. Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141-155.
6. Deeks SG. Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med. 2009;17:118-123.
7. Hasse B, Ledergerber B, Furrer H, et al.Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis. 2011;53:1130-1139.
8. Samji H, Cescon A, Hogg RS, et al. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS One. 2013;8:e81355.
9. Fried LP, Bandeen-Roche K, Chaves PH, et al. Preclinical mobility disability predicts incident mobility disability in older women. J Gerontol A Biol Med Sci. 2000;55:M43-M52.
10. Cesari M, Kritchevsky SB, Penninx BWHJ, et al. Prognostic value of usual gait speed in well-functioning older people: results from the health, aging and body composition study. J Am Geriatr Soc. 2005;53: 1675-1680.
11. Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Med Sci. 2000;55:M221-M231.
12. Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011;305:50-58.
13. Ferrucci L, Penninx BW, Leveille SG, et al. Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function. J Am Geriatr Soc. 2000;48:1102-1110.
14. Shah K, Hilton TN, Myers L, et al. A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus. J Am Geriatr Soc. 2012;60:545-549.
15. Erlandson KM, Allshouse AA, Jankowski CM, et al. Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy. HIV Clin Trials. 2012;13:324-334.
16. Richert L, Brault M, Mercie P, et al. Decline in locomotor functions over time in HIV-infected patients. AIDS. 2014;28:1441-1449.
17. Greene M, Covinsky K, Astemborski J, et al. The relationship of physical performance with HIV disease and mortality. AIDS. 2014;28:2711-2719.
18. Cummings SR, Studenski S, Ferrucci L. A diagnosis of dismobility-giving mobility clinical visibility: a Mobility Working Group recommendation. JAMA. 2014;311:2061-2062.
19. Martin J, Volberding P. HIV and premature aging: a field still in its infancy. Ann Intern Med. 2010;153:477-479.
20. Dudley J, Jin S, Hoover D, et al. The multicenter AIDS cohort study: retention after 9 1/2 years. Am J Epidemiol. 1995;142:323-330.
21. Ware JE Jr. SF-36 health survey update. Spine (Phila Pa 1976). 2000;25: 3130-3139.
22. Hultin LE, Menendez FA, Hultin PM, et al. Assessing immunophenotyping performance: proficiency-validation for adopting improved flow cytometry methods. Cytometry B Clin Cytom. 2007;72:249-255.
23. Department of Health and Human Services. Panel on antiretroviral guidelines for adults and adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Available at: http://www. aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed on June 27, 2014.
24. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1992;41:1-19.
25. U.S. Department of Health and Human Services. AIDS.gov. Available at: http://www.aids.gov/hiv-aids-basics/just-diagnosed-with-hiv-aids/understandyour-test-results/cd4-count/. Accessed November 25, 2014.
26. Schrack JA, Simonsick EM, Ferrucci L. The relationship of the energetic cost of slow walking and peak energy expenditure to gait speed in midto-late life. Am J Phys Med Rehabil. 2013;92:28-35.
27. Perera S, Mody SH, Woodman RC, et al. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc. 2006;54:743-749.
28. Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI Study. J Am Geriatr Soc. 2000;48: 1618-1625.
29. Guralnik JM, Ferrucci L, Simonsick EM, et al. Lower extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332:556-561.
30. Schrack JA, Simonsick EM, Chaves PHM, et al. The role of energetic cost in the age-related slowing of gait speed. J Am Geriatr Soc. 2012;60: 1811-1816.
31. Federal Interagency Forum on Aging-Related Statistics. Older Americans 2012: Key Indicators of Well-Being. Federal Interagency Forum on Aging Related Statistics. Washington, DC: US Government Printing Office. June 2012. pg 116.
32. Althoff KN, Jacobson LP, Cranson R, et al. Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men. J Gerontol A Biol Sci Med Sci. 2014;69:189-198.
33. Piggott DA, Muzaale AD, Mehta SH, et al. Frailty, HIV infection, and mortality in an aging cohort of injection drug users. PLoS One. 2013;8: e54910.
34. Oursler KK, Goulet JL, Crystal S, et al. Association of age and comorbidity with physical function in HIV-infected and uninfected patients: results from the Veterans Aging Cohort Study. AIDS Patient Care and STDS. 2011;25:13-20.
35. Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53:1120-1126.
36. Thorpe RJ Jr, Koster A, Kritchevsky SB, et al. Race, socioeconomic resources, and late-life mobility and decline: findings from the Health, Aging, and Body Composition study. J Gerontol A Biol Sci Med Sci. 2011;66:1114-1123.
37. Koster A, Penninx BW, Bosma H, et al. Is there a biomedical explanation for socioeconomic differences in incident mobility limitation? J Gerontol A Biol Sci Med Sci. 2005;60:1022-1027.
38. Ianas V, Berg E, Mohler MJ, et al. Antiretroviral therapy protects against frailty in HIV-1 infection. J Int Assoc Provid AIDS Care. 2013;12:62-66.
39. Center for Disease Control and Prevention. HIV Among Older Americans. National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention. November 2013. Pg 1.
40. Pahor M, Guralnik JM, Ambrosius WT, et al. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311:2387-2396.