Carotid Plaque Morphology Is Significantly Associated with Sex, Age, and History of Neurological Symptoms

Stroke

Volumn 46, Issue 11, 2015, Pages 3213-3219

  Wendorff, Carina ^a   Wendorff, Heiko ^a   Pelisek, Jaroslav ^a,b   Tsantilas, Pavlos ^a   Zimmermann, Alexander ^a   Zernecke, Alma ^a,c   Kuehnl, Andreas ^a   Eckstein, Hans Henning ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

age factors; atherosclerosis; carotid stenosis; sex

Indexed keywords

COLLAGEN; ELASTIN;

AGE; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY OBSTRUCTION; CAROTID ATHEROSCLEROSIS; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; HISTOLOGY; HUMAN; INFLAMMATORY INFILTRATE; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MEDICAL SOCIETY; NEOVASCULARIZATION (PATHOLOGY); NEUROIMAGING; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; SEX; SEX DIFFERENCE; BLOOD VESSEL CALCIFICATION; CAROTID ENDARTERECTOMY; CAROTID STENOSIS; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY; PLAQUE, ATHEROSCLEROTIC; STATISTICAL MODEL; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; CAROTID STENOSIS; COHORT STUDIES; COLLAGEN; CROSS-SECTIONAL STUDIES; ELASTIN; ENDARTERECTOMY, CAROTID; FEMALE; HUMANS; INFLAMMATION; LOGISTIC MODELS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PLAQUE, ATHEROSCLEROTIC; SEX FACTORS; VASCULAR CALCIFICATION;

EID: 84945921441     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.010558     Document Type: Article

References (37)

1. Bonati LH, Dobson J, Algra A, Branchereau A, Chatellier G, Fraedrich G, Carotid Stenting Trialists' Collaboration Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data. Lancet 2010 376 1062 1073. doi: 10.1016/S0140-6736(10)61009-4
2. Halliday A, Harrison M, Hayter E, Kong X, Mansfield A, Marro J, Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. Lancet 2010 376 1074 1084. doi: 10.1016/S0140-6736(10)61197-X
3. van Lammeren GW, Reichmann BL, Moll FL, Bots ML, de Kleijn DP, de Vries JP, Atherosclerotic plaque vulnerability as an explanation for the increased risk of stroke in elderly undergoing carotid artery stenting. Stroke 2011 42 2550 2555. doi: 10.1161/STROKEAHA.110.607382
4. Eckstein HH, Kühnl A, Dörfler A, Kopp IB, Lawall H, Ringleb PA, Multidisciplinary German-Austrian Guideline Based on Evidence and Consensus The diagnosis, treatment and follow-up of extracranial carotid stenosis. Dtsch Arztebl Int 2013 110 468 476. doi: 10.3238/arztebl.2013.0468
5. Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Ferguson GG, Haynes RB, Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1998 339 1415 1425. doi: 10.1056/NEJM199811123392002
6. Kuehnl A, Soellner H, Eckstein HH, Epidemiology and inpatient treatment of vascular diseases in Germany. Gefässchirurgie 2015 20 204 213
7. Bhatnagar P, Wickramasinghe K, Williams J, Rayner M, Townsend N, The epidemiology of cardiovascular disease in the UK 2014. Heart 2015 101 1182 1189. doi: 10.1136/heartjnl-2015-307516
8. Seo SR, Kim SY, Lee SY, Yoon TH, Park HG, Lee SE, The incidence of stroke by socioeconomic status, age, sex, and stroke subtype: a nationwide study in Korea. J Prev Med Public Health 2014 47 104 112. doi: 10.3961/jpmph.2014.47.2.104
9. Jacobs BS, Boden-Albala B, Lin IF, Sacco RL, Stroke in the young in the northern Manhattan stroke study. Stroke 2002 33 2789 2793
10. Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation 2015 131 2104 2113. doi: 10.1161/CIRCULATIONAHA.114.014310
11. Pelisek J, Eckstein HH, Zernecke A, Pathophysiological mechanisms of carotid plaque vulnerability: impact on ischemic stroke. Arch Immunol Ther Exp (Warsz) 2012 60 431 442. doi: 10.1007/s00005-012-0192-z
12. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R, Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med 1997 336 1276 1282. doi: 10.1056/NEJM199705013361802
13. Falk E, Shah PK, Fuster V, Coronary plaque disruption. Circulation 1995 92 657 671
14. Verhoeven B, Hellings WE, Moll FL, de Vries JP, de Kleijn DP, de Bruin P, Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. J Vasc Surg 2005 42 1075 1081. doi: 10.1016/j.jvs.2005.08.009
15. Hellings WE, Pasterkamp G, Verhoeven BA, De Kleijn DP, De Vries JP, Seldenrijk KA, Gender-associated differences in plaque phenotype of patients undergoing carotid endarterectomy. J Vasc Surg 2007 45 289 296. doi: 10.1016/j.jvs.2006.09.051
16. Redgrave JN, Lovett JK, Rothwell PM, Histological features of symptomatic carotid plaques in relation to age and smoking: the oxford plaque study. Stroke 2010 41 2288 2294. doi: 10.1161/STROKEAHA.110.587006
17. van Oostrom O, Velema E, Schoneveld AH, de Vries JP, de Bruin P, Seldenrijk CA, Age-related changes in plaque composition: a study in patients suffering from carotid artery stenosis. Cardiovasc Pathol 2005 14 126 134. doi: 10.1016/j.carpath.2005.03.002
18. Stary HC, Natural history and histological classification of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol 2000 20 1177 1178
19. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 1992 12 120 134
20. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995 92 1355 1374
21. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 1994 14 840 856
22. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM, Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000 20 1262 1275
23. Redgrave JN, Gallagher P, Lovett JK, Rothwell PM, Critical cap thickness and rupture in symptomatic carotid plaques: the oxford plaque study. Stroke 2008 39 1722 1729. doi: 10.1161/STROKEAHA.107.507988
24. Ota H, Reeves MJ, Zhu DC, Majid A, Collar A, Yuan C, Sex differences of high-risk carotid atherosclerotic plaque with less than 50% stenosis in asymptomatic patients: an in vivo 3T MRI study. AJNR Am J Neuroradiol 2013 34 1049 1155, S1. doi: 10.3174/ajnr.A3399
25. Vrijenhoek JE, Den Ruijter HM, De Borst GJ, de Kleijn DP, De Vries JP, Bots ML, Sex is associated with the presence of atherosclerotic plaque hemorrhage and modifies the relation between plaque hemorrhage and cardiovascular outcome. Stroke 2013 44 3318 3323. doi: 10.1161/STROKEAHA.113.002633
26. van den Bouwhuijsen QJ, Bos D, Ikram MA, Hofman A, Krestin GP, Franco OH, Coexistence of calcification, intraplaque hemorrhage and lipid core within the asymptomatic atherosclerotic carotid plaque: the Rotterdam study. Cerebrovasc Dis 2015 39 319 324. doi: 10.1159/000381138
27. Hellings WE, Peeters W, Moll FL, Piers SR, van Setten J, Van der Spek PJ, Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study. Circulation 2010 121 1941 1950. doi: 10.1161/CIRCULATIONAHA.109.887497
28. Park JS, Kwak HS, Lee JM, Koh EJ, Chung GH, Hwang SB, Association of carotid intraplaque hemorrhage and territorial acute infarction in patients with acute neurological symptoms using carotid magnetization-prepared rapid acquisition with gradient-echo. J Korean Neurosurg Soc 2015 57 94 99. doi: 10.3340/jkns.2015.57.2.94
29. Saam T, Hetterich H, Hoffmann V, Yuan C, Dichgans M, Poppert H, Meta-analysis and systematic review of the predictive value of carotid plaque hemorrhage on cerebrovascular events by magnetic resonance imaging. J Am Coll Cardiol 2013 62 1081 1091. doi: 10.1016/j.jacc.2013.06.015
30. Wasserman BA, Advanced contrast-enhanced MRI for looking beyond the lumen to predict stroke: building a risk profile for carotid plaque. Stroke 2010 41 10 suppl S12 S16. doi: 10.1161/STROKEAHA.110.596288
31. Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, Moody AR, Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg 2008 47 337 342. doi: 10.1016/j.jvs.2007.09.064
32. Truijman MT, de Rotte AA, Aaslid R, van Dijk AC, Steinbuch J, Liem MI, Intraplaque hemorrhage, fibrous cap status, and microembolic signals in symptomatic patients with mild to moderate carotid artery stenosis: the Plaque at RISK study. Stroke 2014 45 3423 3426. doi: 10.1161/STROKEAHA.114.006800
33. Howard DP, van Lammeren GW, Rothwell PM, Redgrave JN, Moll FL, de Vries JP, Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk. Stroke 2015 46 182 189. doi: 10.1161/STROKEAHA.114.007221
34. Davaine JM, Quillard T, Brion R, Lapérine O, Guyomarch B, Merlini T, Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability. PLoS One 2014 9 e107642. doi: 10.1371/journal.pone.0107642
35. Pelisek J, Hahntow IN, Eckstein HH, Ockert S, Reeps C, Heider P, Impact of chronic kidney disease on carotid plaque vulnerability. J Vasc Surg 2011 54 1643 1649. doi: 10.1016/j.jvs.2011.05.049
36. van Lammeren GW, den Hartog AG, Pasterkamp G, Vink A, de Vries JP, Moll FL, Asymptomatic carotid artery stenosis: identification of subgroups with different underlying plaque characteristics. Eur J Vasc Endovasc Surg 2012 43 632 636. doi: 10.1016/j.ejvs.2012.03.011
37. van Lammeren GW, den Ruijter HM, Vrijenhoek JE, van der Laan SW, Velema E, de Vries JP, Time-dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery. Circulation 2014 129 2269 2276. doi: 10.1161/CIRCULATIONAHA.113.007603