Inclusion of functional information from perfusion SPECT improves predictive value of dose-volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study

Radiotherapy and Oncology

Volumn 117, Issue 1, 2015, Pages 9-16

  Farr, Katherina P ^a   Kallehauge, Jesper F ^a   Møller, Ditte S ^a   Khalil, Azza A ^a   Kramer, Stine ^a   Bluhme, Henrik ^a   Morsing, Anni ^a   Grau, Cai ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Functional imaging; IMRT; Non small cell lung cancer; Radiation pneumonitis; Radiation induced lung toxicity; SPECT CT

Indexed keywords

FLUORODEOXYGLUCOSE F 18; MACROSALB TC 99M; ANTINEOPLASTIC AGENT; CISPLATIN; DEOXYCYTIDINE; ETOPOSIDE; GEMCITABINE;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; HUMAN; HUMAN TISSUE; LUNG TOXICITY; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PNEUMONIA; TREATMENT PLANNING; ANALOGS AND DERIVATIVES; CANCER STAGING; CARCINOMA, NON-SMALL-CELL LUNG; LUNG NEOPLASMS; MIDDLE AGED; PATHOLOGY; PROCEDURES; PROSPECTIVE STUDY; RADIATION PNEUMONITIS; RADIATION RESPONSE; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; ETOPOSIDE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; RADIATION PNEUMONITIS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84945546885     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2015.08.005     Document Type: Article

References (42)

1. H. Murshed, H.H. Liu, Z. Liao, and et al. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer Int J Radiat Oncol Biol Phys 58 2004 1258 1267
2. J.D. Bradley, R. Paulus, R. Komaki, and et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study Lancet Oncol 16 2015 187 199
3. M. Partridge, M. Ramos, A. Sardaro, and M. Brada Dose escalation for non-small cell lung cancer: analysis and modelling of published literature Radiother Oncol 99 2011 6 11
4. G. Rodrigues, C. Oberije, S. Senan, and et al. Is intermediate radiation dose escalation with concurrent chemotherapy for stage III non-small-cell lung cancer beneficial? A multi-institutional propensity score matched analysis Int J Radiat Oncol Biol Phys 91 2015 133 139
5. J. Bradley, M.V. Graham, K. Winter, and et al. Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma Int J Radiat Oncol Biol Phys 61 2005 318 328
6. J.D. Cox Are the results of RTOG 0617 mysterious? Int J Radiat Oncol Biol Phys 82 2012 1042 1044
7. K.P. Farr, A.A. Khalil, M.M. Knap, D.S. Moller, and C. Grau Development of radiation pneumopathy and generalised radiological changes after radiotherapy are independent negative prognostic factors for survival in non-small cell lung cancer patients Radiother Oncol 107 2013 382 388
8. L. Claude, D. Perol, C. Ginestet, and et al. A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis Radiother Oncol 71 2004 175 181
9. D.A. Palma, S. Senan, K. Tsujino, and et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis Int J Radiat Oncol Biol Phys 85 2013 444 450
10. C. Dehing-Oberije, D. De Ruysscher, A. van Baardwijk, S. Yu, B. Rao, and P. Lambin The importance of patient characteristics for the prediction of radiation-induced lung toxicity Radiother Oncol 91 2009 421 426
11. A.L. Appelt, I.R. Vogelius, K.P. Farr, A.A. Khalil, and S.M. Bentzen Towards individualized dose constraints: adjusting the QUANTEC radiation pneumonitis model for clinical risk factors Acta Oncol 53 2014 605 612
12. G. Nalbantov, B. Kietselaer, K. Vandecasteele, and et al. Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients Radiother Oncol 109 2013 100 106
13. S.J. van der Veen, G. Ghobadi, R.A. de Boer, and et al. ACE inhibition attenuates radiation-induced cardiopulmonary damage Radiother Oncol 114 2015 96 103
14. G. Rodrigues, M. Lock, D. D'Souza, E. Yu, and J. Van Dyk Prediction of radiation pneumonitis by dose-volume histogram parameters in lung cancer - a systematic review Radiother Oncol 71 2004 127 138
15. K.P. Farr, S. Kramer, A.A. Khalil, A. Morsing, and C. Grau Role of perfusion SPECT in prediction and measurement of pulmonary complications after radiotherapy for lung cancer Eur J Nucl Med Mol Imaging 42 2015 1315 1324
16. L.B. Marks, S.M. Bentzen, J.O. Deasy, and et al. Radiation dose-volume effects in the lung Int J Radiat Oncol Biol Phys 76 2010 S70 6
17. R.P. Abratt, P.A. Willcox, and J.A. Smith Lung cancer in patients with borderline lung functions-zonal lung perfusion scans at presentation and lung function after high dose irradiation Radiother Oncol 19 1990 317 322
18. L.J. Boersma, E.M. Damen, R.W. de Boer, and et al. Dose-effect relations for local functional and structural changes of the lung after irradiation for malignant lymphoma Radiother Oncol 32 1994 201 209
19. L.B. Marks, D.P. Spencer, G.W. Sherouse, and et al. The role of three dimensional functional lung imaging in radiation treatment planning: the functional dose-volume histogram Int J Radiat Oncol Biol Phys 33 1995 65 75
20. Y. Seppenwoolde, M. Engelsman, K. De Jaeger, and et al. Optimizing radiation treatment plans for lung cancer using lung perfusion information Radiother Oncol 63 2002 165 177
21. J.A. Christian, M. Partridge, E. Nioutsikou, and et al. The incorporation of SPECT functional lung imaging into inverse radiotherapy planning for non-small cell lung cancer Radiother Oncol 77 2005 271 277
22. S.M. McGuire, S. Zhou, L.B. Marks, M. Dewhirst, F.F. Yin, and S.K. Das A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung Int J Radiat Oncol Biol Phys 66 2006 1543 1552
23. Y. Shioyama, S.Y. Jang, H.H. Liu, and et al. Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer Int J Radiat Oncol Biol Phys 68 2007 1349 1358
24. I. Munawar, B.P. Yaremko, J. Craig, and et al. Intensity modulated radiotherapy of non-small-cell lung cancer incorporating SPECT ventilation imaging Med Phys 37 2010 1863 1872
25. J. St-Hilaire, C. Lavoie, A. Dagnault, and et al. Functional avoidance of lung in plan optimization with an aperture-based inverse planning system Radiother Oncol 100 2011 390 395
26. K. Lavrenkov, S. Singh, J.A. Christian, and et al. Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study Radiother Oncol 91 2009 349 352
27. Y. Seppenwoolde, K. De Jaeger, L.J. Boersma, J.S. Belderbos, and J.V. Lebesque Regional differences in lung radiosensitivity after radiotherapy for non-small-cell lung cancer Int J Radiat Oncol Biol Phys 60 2004 748 758
28. S.M. McGuire, L.B. Marks, F.F. Yin, and S.K. Das A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung Phys Med Biol 55 2010 403 416
29. E.L. Bates, C.M. Bragg, J.M. Wild, M.Q. Hatton, and R.H. Ireland Functional image-based radiotherapy planning for non-small cell lung cancer: a simulation study Radiother Oncol 93 2009 32 36
30. Z. Kocak, G.R. Borst, J. Zeng, and et al. Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis Int J Radiat Oncol Biol Phys 67 2007 178 186
31. P.A. Lind, L.B. Marks, D. Hollis, and et al. Receiver operating characteristic curves to assess predictors of radiation-induced symptomatic lung injury Int J Radiat Oncol Biol Phys 54 2002 340 347
32. < www.lungecancer.dk >. The Danish Lung Cancer Group. The 2009 Annual Rapport.
33. A. Fogliata, G. Nicolini, E. Vanetti, A. Clivio, and L. Cozzi Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water Phys Med Biol 51 2006 1421 1438
34. D.A. Hoover, R.H. Reid, E. Wong, and et al. SPECT-based functional lung imaging for the prediction of radiation pneumonitis: a clinical and dosimetric correlation J Med Imaging Radiat Oncol 58 2014 214 222
35. National Cancer Institute. Common terminology criteria for adverse events: CTCAE; 2010. < http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE-4.03-2010-06-14-QuickReference-5x7.pdf >.
36. L. Yin, S. Shcherbinin, A. Celler, and et al. Incorporating quantitative single photon emission computed tomography into radiation therapy treatment planning for lung cancer: impact of attenuation and scatter correction on the single photon emission computed tomography-weighted mean dose and functional lung segmentation Int J Radiat Oncol Biol Phys 78 2010 587 594
37. C.W. Hodge, W.A. Tome, S.B. Fain, S.M. Bentzen, and M.P. Mehta On the use of hyperpolarized helium MRI for conformal avoidance lung radiotherapy Med Dosim 35 2010 297 303
38. D.A. Hoover, D.P. Capaldi, K. Sheikh, and et al. Functional lung avoidance for individualized radiotherapy (FLAIR): study protocol for a randomized, double-blind clinical trial BMC Cancer 14 2014 934
39. Y. Vinogradskiy, R. Castillo, E. Castillo, and et al. Use of 4-dimensional computed tomography-based ventilation imaging to correlate lung dose and function with clinical outcomes Int J Radiat Oncol Biol Phys 86 2013 366 371
40. S. Siva, R. Thomas, J. Callahan, and et al. High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer Radiother Oncol 115 2015 157 162
41. S.F. Petit, W.J. van Elmpt, C.J. Oberije, and et al. [18F]fluorodeoxyglucose uptake patterns in lung before radiotherapy identify areas more susceptible to radiation-induced lung toxicity in non-small-cell lung cancer patients Int J Radiat Oncol Biol Phys 81 2011 698 705
42. U. Bernchou, T. Schytte, A. Bertelsen, S.M. Bentzen, O. Hansen, and C. Brink Time evolution of regional CT density changes in normal lung after IMRT for NSCLC Radiother Oncol 109 2013 89 94