Different activations of toll-like receptors and antimicrobial peptides in chronic rhinosinusitis with or without nasal polyposis

European Archives of Oto-Rhino-Laryngology

Volumn 273, Issue 7, 2016, Pages 1779-1788

  Hirschberg, Andor ^a   Kiss, Maria ^b   Kadocsa, Edit ^b   Polyanka, Hilda ^b   Szabo, Kornelia ^b   Razga, Zsolt ^b   Bella, Zsolt ^b   Tiszlavicz, Laszlo ^b   Kemeny, Lajos ^b  

^a Saint John s Hospital   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antimicrobial peptide; Chronic rhinosinusitis; Nasal polyp; Toll like receptor

Indexed keywords

ACETYLSALICYLIC ACID; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 4; CATHELICIDIN; CYCLIC AMP; LACTOFERRIN; LYSOZYME; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR DEFB1; TRANSCRIPTION FACTOR DEFB102; TRANSCRIPTION FACTOR DEFB104A; TRANSCRIPTION FACTOR DEFB3; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR LTF; TRANSCRIPTION FACTOR LYZ; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; DEFB1 PROTEIN, HUMAN; LTF PROTEIN, HUMAN;

ALLERGIC ASTHMA; ARTICLE; CHRONIC RHINOSINUSITIS; CLINICAL ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG HYPERSENSITIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MACROPHAGE; MALE; NOSE POLYP; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOKING; UPREGULATION; ADULT; CASE CONTROL STUDY; CHRONIC DISEASE; GENETICS; HYPERSENSITIVITY; METABOLISM; MIDDLE AGED; NASAL POLYPS; PATHOLOGY; RHINITIS; SINUSITIS; YOUNG ADULT;

ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; HUMANS; HYPERSENSITIVITY; LACTOFERRIN; MALE; MIDDLE AGED; NASAL POLYPS; RHINITIS; RNA, MESSENGER; SINUSITIS; TOLL-LIKE RECEPTORS; YOUNG ADULT;

EID: 84945540287     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-015-3816-1     Document Type: Article

References (34)

1. Fokkens WJ, Lund VJ, Mullol J et al (2012) The European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 50(Suppl 23):1–299
2. Polzehl D, Moeller P, Riechelmann H et al (2006) Distinct features of chronic rhinosinusitis with and without nasal polyps. Allergy 61:1275–1279
3. Van Zele T, Claeys S, Gevaert P et al (2006) Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61:1280–1289
4. Akdis CA, Bachert C, Cingi C et al (2013) Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the european academy of allergy and clinical immunology and the american academy of allergy, asthma and immunology. J Allergy Clin Immunol 131:1479–1490
5. Abreu NA, Nagalingam NA, Song Y et al (2012) Sinus microbiome diversity depletion and corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med 4:151ra124
6. Tan BK, Schleimer RP, Kern RC (2010) Perspectives on the etiology of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 18:21–26
7. Kern RC, Conley DB, Walsh W et al (2008) Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol 22:549–559
8. Hennessy EJ, Parker AE, O’Neill LAJ (2010) Targeting Toll-like receptors: emerging therapeutics? Nat Rev 9:293–307
9. Lane AP, Truong-Tran QA, Schleimer RP (2006) Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol 20:138–144
10. Dong Z, Yang Z, Wang C (2005) Expression of TLR2 and TLR4 messenger RNA in the epithelial cells of the nasal airway. Am J Rhinol 19:236–239
11. Wang J, Matsukura S, Watanabe S et al (2007) Involvement of Toll-like receptors in the immune response of nasal polyp epithelial cells. Clin Immunol 124:345–352
12. Pitzurra L, Bellocchio S, Nocentini A et al (2004) Antifungal immune reactivity in nasal polyposis. Infect Immun 72:7275–7281
13. Claeys S, de Belder T, Holtappels G et al (2003) Human beta-defensins and toll-like receptors in the upper airway. Allergy 58:748–753
14. Zhang QI, Wang C-S, Han D-M et al (2013) Differential expression of Toll-like receptor pathway genes in chronic rhinosinusitis with or without nasal polyps. Acta Otolaryngol 133:165–173
15. Shin SH, Lee YH (2010) Airborne fungi induce nasal polyp epithelial cell activation and Toll-like receptor expression. Int Arch Allergy Immunol 153(1):46–52
16. Detwiller KY, Smith TL, Alt JA et al (2014) Differential expression of innate immunity genes in chronic rhinosinusitis. Am J Rhinol 28:374–377
17. Sun Y, Zhou B, Wang C et al (2012) Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Am J Rhinol 26(2):104–109
18. Zhao CY, Wang X, Liu M et al (2011) Microarray gene analysis of Toll-like receptor signaling elements in chronic rhinosinusitis with nasal polyps. Int Arch Allergy Immunol 156:297–304
19. Melvin TA, Lane AP, Nguyen MT et al (2013) Sinonasal epithelial cell expression of Toll-like receptor 9 is elevated in cystic fibrosis-associated chronic rhinosinusitis. Am J Rhinol 27(1):30–33
20. Ramanathan M, Lee W-K, Dubin MG et al (2007) Sinonasal epithelial cell expressions of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps. Am J Rhinol 21:110–116
21. Szabó K, Kiricsi Á, Révész M et al (2013) The −308 G > A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications. Int Immunol 25(6):383–388
22. Banks CA, Schlosser RJ, Wang EW et al (2014) Macrophage infiltrate is elevated in CRSwNP sinonasal tissue regardless of atopic status. Otolaryngol Head Neck Surg 151(2):215–220
23. Liu Z, Kim J, Sypek JP et al (2004) Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray. J Allergy Clin Immunol 114:783–790
24. Fukami M, Stierna P, Veress B et al (1993) Lysozyme and lactoferrin in human maxillary sinus mucosa during sinusitis. Eur Arch Otorhinolaryngol 250:133–139
25. Woods CM, Lee VS, Hussey DJ et al (2012) Lysozyme expression is increased in the sinus mucosa of patients with chronic rhinosinusitis. Rhinology 50:147–156
26. Chen PH, Fang SY (2004) Expression of human beta-defensin 2 in human nasal mucosa. Eur Arch Otorhinolaryngol 261:238–241
27. Lee SH, Kim JE, Lim HH et al (2002) Antimicrobial defensin peptides of the human nasal mucosa. Ann Otol Rhinol Laryngol 111:135–141
28. Kohlgraf KG, Pingel LC, Dietrich DE et al (2010) Defensins as anti-inflammatory compounds and mucosal adjuvants. Future Microbiol 5:99–113
29. Psaltis AJ, Wormald PJ, Ha KR et al (2008) Reduced levels of lactoferrin in biofilm-associated chronic rhinosinusitis. Laryngoscope 118(5):895–901
30. Thomas LL, Xu W, Ardon TT (2002) Immobilized lactoferrin is a stimulus for eosinophil activation. J Immunol 169:993–999
31. Nadolska B, Fraczek M, Krêcicki T et al (2010) Lactoferrin inhibits the growth of nasal polyp fibroblasts. Pharmacol Rep 62:1139–1147
32. van Zele T, Gevaert P, Watelet JB et al (2004) Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. JACI 114:981–983
33. Ooi EH, Psaltis AJ, Witterick IJ et al (2010) Innate Immunity. Otolaryngol Clin N Am 43:473–487
34. Payne SC, Han JK, Huyett P et al (2008) Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps. Am J Rhinol 22:568–581